当前位置： SCI文献检索 > INTERNATIONAL IMMUNOPHARMACOLOGY期刊下所有文献 > CD24hiCD38hi B regulatory cells from patients with end plate inflammation presented reduced functional potency.

CD24hiCD38hi B regulatory cells from patients with end plate inflammation presented reduced functional potency.

Abstract：

:Problem due to disc degeneration is frequently found in the aging population. However, severe pain and accompanying end plate inflammation is only found in a small subset of patients, who can be of a younger age than most people with severe disc degeneration, with no apparent cause. We hypothesized that deficiencies in B regulatory (Breg) cells might contribute to the aberrant inflammation in these patients. However, we found that the frequency of CD24hiCD38hi Breg cells was significantly higher in patients than in controls. To investigate Breg function, CD24hiCD38hi Breg cells were stimulated via CD40L/αIg and via Staphylococcus aureus Cowan. Interestingly, the expression of IL-10 and TGF-β1 was significantly lower in patients than in controls. The expression of PD-L1 was comparable between patient CD24hiCD38hi Bregs and control CD24hiCD38hi Bregs. Control CD24hiCD38hi Bregs, but not patient CD24hiCD38hi Bregs, could suppress the expression of TBX21 and RORC2 in stimulated CD4+ T cells, in a manner that was dependent on IL-10 and PD-L1. The expression of FOXP3, on the other hand, was dependent on TGF-β. In addition, PD-L1 reduced the viability of CD4+ T cells. Together, we demonstrated that the patients with end plate inflammation did not present a reduction in CD19+CD24hiCD38hi Breg frequency, but presented a reduction in CD19+CD24hiCD38hi Breg function.

journal_name

Int Immunopharmacol

journal_title

International immunopharmacology

authors

Xu C,Zhang M,Li K,Ni M,Bai Y,Zhang J,Song X,Wang J

doi

10.1016/j.intimp.2019.02.034

subject

Has Abstract

pub_date

2019-05-01 00:00:00

pages

295-301

eissn

1567-5769

issn

1878-1705

pii

S1567-5769(18)31383-3

journal_volume

70

pub_type

杂志文章

相关文献

INTERNATIONAL IMMUNOPHARMACOLOGY文献大全
  • DA-9601 suppresses 2, 4-dinitrochlorobenzene and dust mite extract-induced atopic dermatitis-like skin lesions.

    abstract：:DA-9601 (Stillen™) is a novel anti-peptic formulation prepared from the ethanol extracts of Artemisia asiatica possessing anti-oxidative, anti-allergic and anti-inflammatory activities. However, their effect on atopic dermatitis (AD) has not been studied yet. In this study, we report that topical application of DA-960...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2011.04.005

    authors： Choi EJ,Lee S,Hwang JS,Im SH,Jun CD,Lee HS,Kim SH

    更新日期：2011-09-01 00:00:00

  • Ampelopsin reduces endotoxic inflammation via repressing ROS-mediated activation of PI3K/Akt/NF-κB signaling pathways.

    abstract：:Ampelopsin (AMP), a plant flavonoid, has potent anti-inflammatory properties in vitro and in vivo. The molecular mechanisms of ampelopsin on pharmacological and biochemical actions of RAW264.7 macrophages in inflammation have not been clearly elucidated yet. In the present study, non-cytotoxic level of ampelopsin sign...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2011.12.001

    authors： Qi S,Xin Y,Guo Y,Diao Y,Kou X,Luo L,Yin Z

    更新日期：2012-01-01 00:00:00

  • Analysis of the anthraquinones aloe-emodin and aloin by gas chromatography/mass spectrometry.

    abstract：:A procedure was developed for the determination of low levels of the anthraquinones aloe-emodin and aloin A (barbalin) in aloe products based on gas chromatography/mass spectrometry (GC/MS) of the trimethyl silyl (TMS) derivatives of these analytes in the presence of Chrysophanol used as internal standard. The method ...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2004.07.005

    authors： ElSohly MA,Gul W,Murphy TP

    更新日期：2004-12-20 00:00:00

  • Angiotensin II contributes to intratumoral immunosuppressionvia induction of PD-L1 expression in non-small cell lung carcinoma.

    abstract：:The formation of an immunosuppressive microenvironment and up-regulation of PD-L1 protein are the main causes of tumor immune escape. Previous reports suggest that Angiotensin II (Ang II) can modulate the immune status of tumor microenvironment in non-small cell lung cancer (NSCLC), but the underlying mechanism remain...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2020.106507

    authors： Yang K,Zhou J,Chen Y,Chen Y,Chen L,Zhang P,Ma L,Jiang Z,Bian J,Yin W

    更新日期：2020-07-01 00:00:00

  • Chlorogenic acid ameliorated concanavalin A-induced hepatitis by suppression of Toll-like receptor 4 signaling in mice.

    abstract：:Chlorogenic acid (CGA), one of the most abundant dietary polyphenolic compounds, has been reported to exhibit anti-inflammatory ability. However, the hepatoprotective effects and molecular mechanisms of CGA on concanavalin A (Con A)-induced hepatitis have not been explored. In the present study, we found that pretreat...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2017.01.017

    authors： Yuan Y,Gong X,Zhang L,Jiang R,Yang J,Wang B,Wan J

    更新日期：2017-03-01 00:00:00

  • Inhibition of neuroinflammation by thymoquinone requires activation of Nrf2/ARE signalling.

    abstract：:Thymoquinone is an antioxidant phytochemical that has been shown to inhibit neuroinflammation. However, little is known about the potential roles of intracellular antioxidant signalling pathways in its anti-inflammatory activity. The objective of this study was to elucidate the roles played by activation of the Nrf2/A...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2017.04.018

    authors： Velagapudi R,Kumar A,Bhatia HS,El-Bakoush A,Lepiarz I,Fiebich BL,Olajide OA

    更新日期：2017-07-01 00:00:00

  • Enhanced hematopoietic protection from radiation by the combination of genistein and captopril.

    abstract：:The hematopoietic system is sensitive to radiation injury, and mortality can occur due to blood cell deficiency and stem cell loss. Genistein and the angiotensin converting enzyme (ACE) inhibitor captopril are two agents shown to protect the hematopoietic system from radiation injury. In this study we examined the com...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2012.12.029

    authors： Day RM,Davis TA,Barshishat-Kupper M,McCart EA,Tipton AJ,Landauer MR

    更新日期：2013-02-01 00:00:00

  • TRIP6 accelerates the proliferation and migration of fetal airway smooth muscle cells by enhancing YAP activation.

    abstract：:The thyroid receptor interactor protein 6 (TRIP6) has emerged as a key regulator for the proliferation and migration of various cells. However, whether TRIP6 is involved in regulating the proliferation and migration of airway smooth muscle (ASM) cells in the progression of pediatric asthma remains undetermined. The pr...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2020.106366

    authors： Wei F,Hao Y

    更新日期：2020-03-06 00:00:00

  • Salvinorin A protects against methicillin resistant staphylococcus aureus-induced acute lung injury via Nrf2 pathway.

    abstract：:Salvinorin A (SA), a neoclerodane diterpene, is isolated from the dried leaves ofSalvia divinorum. SA has traditionally been used treatments for chronic pain diseases. Recent research has demonstrated that SA possesses the anti-inflammatory property. The present study aim to explore the effects and potentialmechanisms...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2020.107221

    authors： Zeng S,Chen D,Liu G,Wu YX,Gao ZQ,Su Y,Yuan JN,Liu L,Shan JC,Pang QF,Zhu T

    更新日期：2021-01-01 00:00:00

  • Immunotherapeutic effects of cytokine-induced killer cells combined with CCL21/IL15 armed oncolytic adenovirus in TERT-positive tumor cells.

    abstract：:The effective antitumor immune responses are dependent on coordinate interaction of various effector cells. Thus, the combination of adoptive immunotherapy and target gene therapy is capable of efficiently generating a productive antitumor immune response. We investigated whether combination of cytokine-induced killer...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2016.06.028

    authors： Ye JF,Lin YQ,Yu XH,Liu MY,Li Y

    更新日期：2016-09-01 00:00:00

  • Ca2+ signalling of kinins in cells expressing rat, mouse and human B1/B2-receptor.

    abstract：:With respect to functional aspects, the kallikrein-kinin-system can be divided into a plasma kallikrein-kinin-system and a tissue kallikrein-kinin-system. At least four functional kinin peptides act via two different G-protein-coupled receptors, an inducible B1-receptor and a constitutively expressed B2-receptor. B1R ...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2007.10.001

    authors： Zubakova R,Gille A,Faussner A,Hilgenfeldt U

    更新日期：2008-02-01 00:00:00

  • Immunomodulatory properties of Mycoplasma pulmonis. I. Characterization of the immunomodulatory activity.

    abstract：:For many years, it has been recognized that Mycoplasma infection affects the host's immune system in different ways. In this work, experiments were performed to characterize the influence of Mycoplasma pulmonis infection on various immunological parameters and to follow the kinetics of their variations. A Balb/c mouse...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/s1567-5769(01)00078-9

    authors： Romero-Rojas A,Ponce-Hernández C,Ciprián A,Estrada-Parra S,Hadden JW

    更新日期：2001-09-01 00:00:00

  • Complement factor H and hemolytic uremic syndrome.

    abstract：:Factor H is a 150 kDa single chain plasma glycoprotein that plays a pivotal role in the regulation of the alternative pathway of complement. Primary sequence analysis reveals a structural organization of this plasma protein, in 20 homologous units, called Short Consensus Repeats (SCRs), each about 60 amino acids long....

    journal_title：International immunopharmacology

    pub_type： 杂志文章,评审

    doi：10.1016/s1567-5769(00)00047-3

    authors： Zipfel PF,Skerka C,Caprioli J,Manuelian T,Neumann HH,Noris M,Remuzzi G

    更新日期：2001-03-01 00:00:00

  • Noninvasive monitoring of rejection therapy based on intramyocardial electrograms after orthotopic heart transplantation. Initial experience with 14 cases.

    abstract：:Despite the use of increasingly specific immunosuppressive therapy, rejection remains the leading cause of death in cardiac transplant patients. Endomyocardial biopsy (EMB) is the gold standard for early detection and monitoring of cardiac transplant rejection. However, this approach is invasive and not suitable for r...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2004.09.019

    authors： Zupan I,Vrtovec B,Breskvar UD,Gabrijelcic T

    更新日期：2005-01-01 00:00:00

  • Severe impairment of anti-cancer effect of lipoteichoic acid-related molecule isolated from a penicillin-killed Streptococcus pyogenes in toll-like receptor 4-deficient mice.

    abstract：:A lipoteichoic acid-related molecule (OK-PSA) isolated from OK-432, a penicillin-killed Streptococcus pyogenes, is a potent inducer of Th1 cytokines, and elicits anti-cancer effect in tumor-bearing mice. Toll-like receptor (TLR) 4 is a member of the recently identified toll-like receptor family of proteins that has be...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/s1567-5769(01)00103-5

    authors： Okamoto M,Oshikawa T,Ohe G,Nishikawa H,Furuichi S,Tano T,Moriya Y,Saito M,Sato M

    更新日期：2001-09-01 00:00:00

  • Comprehensive analysis of elastase-induced pulmonary emphysema in mice: effects of ambient existing particulate matters.

    abstract：:Pulmonary exposure of rodents to porcine pancreatic elastase (PPE) induces lesions that morphologically resemble human panacinar emphysema. However, there has been little work on the comprehensive analysis of this model. The present study was designed to extensively examine the biological effects of PPE on inflammatio...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2010.07.016

    authors： Inoue K,Koike E,Takano H

    更新日期：2010-11-01 00:00:00

  • Differential anti-inflammatory and analgesic effects by enantiomers of zaltoprofen in rodents.

    abstract：:In the present study, we investigated the effect of zaltoprofen enantiomers on inflammation and pain and compared their effect with racemic zaltoprofen. S(+)-zaltoprofen potently inhibited the inflammatory response in carrageenan-induced paw edema model, whereas R(-)-zaltoprofen did not. Moreover, the anti-inflammator...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2013.05.008

    authors： Cho IJ,Lee CW,Lee MY,Kang MR,Yun J,Oh SJ,Han SB,Lee K,Park SK,Kim HM,Jung SH,Kang JS

    更新日期：2013-08-01 00:00:00

  • Oridonin inhibits LPS-induced inflammation in human gingival fibroblasts by activating PPARγ.

    abstract：:Oridonin, the major terpene isolated from Rabdosia rubescens, has been used as dietary supplement. Recently, it has been known to exhibit anti-inflammatory effect. This study we employed an in vitro model of LPS-stimulated human gingival fibroblasts to investigate the anti-inflammatory effects and mechanism of oridoni...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2019.04.006

    authors： Yu T,Xie W,Sun Y

    更新日期：2019-07-01 00:00:00

  • Effects of RO27-3225 on neurogenesis, PDGFRβ+ cells and neuroinflammation after cerebral infarction.

    abstract：:Cerebral infarction causes severe social and economic burdens to patients due to its high morbidity and mortality rates, and the available treatments are limited. RO27-3225 is a highly selective melanocortin receptor 4 agonist that alleviates damage in many nervous system diseases, such as cerebral hemorrhage, traumat...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2020.106281

    authors： Zhang Y,Wang J,Zhang D,Lu Z,Man J

    更新日期：2020-04-01 00:00:00

  • Big Potassium (BK) ion channels in biology, disease and possible targets for cancer immunotherapy.

    abstract：:The Big Potassium (BK) ion channel is commonly known by a variety of names (Maxi-K, KCNMA1, slo, stretch-activated potassium channel, KCa1.1). Each name reflects a different physical property displayed by this single ion channel. This transmembrane channel is found on nearly every cell type of the body and has its own...

    journal_title：International immunopharmacology

    pub_type： 杂志文章,评审

    doi：10.1016/j.intimp.2014.06.040

    authors： Ge L,Hoa NT,Wilson Z,Arismendi-Morillo G,Kong XT,Tajhya RB,Beeton C,Jadus MR

    更新日期：2014-10-01 00:00:00

  • Immune responses modulation by curcumin and allergen encapsulated into PLGA nanoparticles in mice model of rhinitis allergic through sublingual immunotherapy.

    abstract：:The purpose of this study was the combination of curcumin and ovalbumin in free form or encapsulated into PLGA NPs (polylactic co-glycolic acid nanoparticles) to enhance their sublingual immunotherapy (SLIT) efficiency in mouse model of rhinitis allergic. PLGA NPs containing curcumin (CUR), ovalbumin (OVA) or both wer...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2020.106525

    authors： Shahgordi S,Sankian M,Yazdani Y,Mashayekhi K,Hasan Ayati S,Sadeghi M,Saeidi M,Hashemi M

    更新日期：2020-07-01 00:00:00

  • The therapeutic potential of microbial proteasome inhibitors.

    abstract：:The proteasome influences cellular homeostasis through the degradation of regulatory proteins, many of which are also involved in disease pathogenesis. In particular, numerous regulatory proteins associated with tumor growth, such as cyclins, cyclin-dependent kinase inhibitors, tumor suppressors, and NF-κB inhibitors ...

    journal_title：International immunopharmacology

    pub_type： 杂志文章,评审

    doi：10.1016/j.intimp.2015.11.013

    authors： Momose I,Kawada M

    更新日期：2016-08-01 00:00:00

  • S-allyl cysteine protects against lipopolysaccharide-induced acute kidney injury in the C57BL/6 mouse strain: Involvement of oxidative stress and inflammation.

    abstract：:Sepsis is a serious and life-threatening medical condition with a higher rate of patients' morbidity and mortality and with complications such as acute kidney injury (AKI). S-allyl cysteine (SAC) is the active constituent of the medicinal plant garlic (Allium sativum) with multiple beneficial effects including anti-in...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2019.01.026

    authors： Khajevand-Khazaei MR,Azimi S,Sedighnejad L,Salari S,Ghorbanpour A,Baluchnejadmojarad T,Mohseni-Moghaddam P,Khamse S,Roghani M

    更新日期：2019-04-01 00:00:00

  • A non-peptide antagonist unusually selective for the human form of the bradykinin B2 receptor.

    abstract：:Analgesic and anti-inflammatory applications for non-peptide bradykinin (BK) B2 receptor antagonists have been documented in rats. However, very large species differences in affinity were also noted within this class of drugs, making the preclinical development of relevant drugs difficult. Bradyzide is a potent antago...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/S1567-5769(03)00180-2

    authors： Marceau F,Fortin JP,Morissette G,Dziadulewicz EK

    更新日期：2003-10-01 00:00:00

  • Kinin system in lupus nephritis.

    abstract：:There are few studies regarding the evaluation of the kinin system in patients with systemic lupus erythematosus (SLE). In this study, we evaluated the plasma levels of high-molecular weight kininogen (HKg), low-molecular weight kininogen (LKg) and plasma kallikrein; the plasma activity of tissue kallikrein and kinina...

    journal_title：International immunopharmacology

    pub_type： 临床试验,杂志文章

    doi：10.1016/s1567-5769(01)00109-6

    authors： Dellalibera-Joviliano R,Reis ML,Donadi EA

    更新日期：2001-09-01 00:00:00

  • Imperatorin suppresses IL-1β-induced iNOS expression via inhibiting ERK-MAPK/AP1 signaling in primary human OA chondrocytes.

    abstract：:Joint inflammation is a key player in the pathogenesis of osteoarthritis (OA). Imperatorin, a plant-derived small molecule has been reported to have anti-inflammatory properties; however, its effect on chondrocytes is not known. Here, we investigated the effects of Imperatorin on interleukin-1β (IL-1β) induced express...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2020.106612

    authors： Ahmad N,Ansari MY,Bano S,Haqqi TM

    更新日期：2020-08-01 00:00:00

  • Recombinant expression of human mannan-binding lectin.

    abstract：:Mannan-binding lectin (MBL) constitutes an important part of the innate immune defence by effecting the deposition of complement on microbial surfaces. MBL deficiency is among the most common primary immunodeficiencies and is associated with recurrent infections and symptoms of poor immune complex clearance. Plasma-de...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/s1567-5769(00)00052-7

    authors： Vorup-Jensen T,Sørensen ES,Jensen UB,Schwaeble W,Kawasaki T,Ma Y,Uemura K,Wakamiya N,Suzuki Y,Jensen TG,Takahashi K,Ezekowitz RA,Thiel S,Jensenius JC

    更新日期：2001-04-01 00:00:00

  • Specific binding of intravenous immunoglobulin products to tau peptide fragments.

    abstract：:The effects of intravenous immunoglobulin (IVIG) products are being evaluated in Alzheimer's disease (AD) patients. IVIG contains antibodies to tau protein, the main constituent of neurofibrillary tangles (NFTs). Tau has microtubule binding domain (MBD) repeats which are thought to be necessary for its aggregation, a ...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2014.05.009

    authors： Smith LM,Coffey MP,Loeffler DA

    更新日期：2014-08-01 00:00:00

  • Administration of SB239063, a potent p38 MAPK inhibitor, alleviates acute lung injury induced by intestinal ischemia reperfusion in rats associated with AQP4 downregulation.

    abstract：:Acute lung injury (ALI), induced by intestinal ischemia reperfusion (II/R) injury, is characterized by pulmonary edema and inflammation. Aquaporin 4 (AQP4), has been pointed out recently involving in edema development. Previous studies have shown that p38 mitogen activated protein kinase (MAPK) activation resulted in ...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2016.03.036

    authors： Xiong LL,Tan Y,Ma HY,Dai P,Qin YX,Yang RA,Xu YY,Deng Z,Zhao W,Xia QJ,Wang TH,Zhang YH

    更新日期：2016-09-01 00:00:00

  • Sirolimus as a new drug to treat RIF patients with elevated Th17/Treg ratio: A double-blind, phase II randomized clinical trial.

    abstract：BACKGROUND:RIF is clinically defined as the failure of good quality embryos to implant into the uterus following at least three cycles of In Vitro Fertilization/Embryo Transfer (IVF/ET). During human pregnancy, a genetically different fetus is allowed to survive within the uterus despite the maternal recognition of fet...

    journal_title：International immunopharmacology

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.intimp.2019.105730

    authors： Ahmadi M,Abdolmohamadi-Vahid S,Ghaebi M,Dolati S,Abbaspour-Aghdam S,Danaii S,Berjis K,Madadi-Javid R,Nouri Z,Siahmansouri H,Babaloo Z,Nouri M,Yousefi M

    更新日期：2019-09-01 00:00:00