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Immunomodulatory properties of Mycoplasma pulmonis. I. Characterization of the immunomodulatory activity.

Abstract：

:For many years, it has been recognized that Mycoplasma infection affects the host's immune system in different ways. In this work, experiments were performed to characterize the influence of Mycoplasma pulmonis infection on various immunological parameters and to follow the kinetics of their variations. A Balb/c mouse model was used to assess hematological evaluations, changes in spleen weight, antibody responses against sheep erythrocytes, neutrophil phagocytosis, colloidal carbon clearance, and anti-Mycoplasma antibody responses. At the hematological level, infected animals were found to have significantly increased total lymphocyte and polymorphonuclear leukocyte counts and an augmentation in spleen weight. Seven days after Mycoplasma infection, antibody responses against sheep erythrocytes were considerably diminished, and at days 7 and 14 after infection, phagocytic activity was also reduced. After 1 week of infection, the colloidal carbon clearance pattern was decreased, and during the whole infectious process, anti-Mycoplasma antibody titers were found to be low. Results from this part of research show a persistent infection that does not resolve in a short period, which is associated with a general dysfunction in the immune system and poor immune responses against several different antigens.

journal_name

Int Immunopharmacol

journal_title

International immunopharmacology

authors

Romero-Rojas A,Ponce-Hernández C,Ciprián A,Estrada-Parra S,Hadden JW

doi

10.1016/s1567-5769(01)00078-9

keywords:

subject

Has Abstract

pub_date

2001-09-01 00:00:00

pages

1679-88

issue

9-10

eissn

1567-5769

issn

1878-1705

pii

S1567-5769(01)00078-9

journal_volume

1

pub_type

杂志文章

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