Abstract：
:A body of evidence indicates that the therapeutic activity of antidepressants is connected with their modulatory effect on the inflammatory response system and cell-mediated immunity. The present study was carried out to examine the effects of antidepressant agents, such as imipramne, venlafaxine, l-5-hydroxytryptophan, fluoxetine and a combination of l-5-hydroxytryptophan and fluoxetine, on the production of the pleotrophic cytokines TNF-alpha and IL-6. Diluted whole blood from fluoxetine-treated patients with treatment-resistant depression (TRD) (mean age: 50.6+/-3.9 years), age-matched healthy controls (mean age: 51.6+/-1.7 years) and younger healthy volunteers (mean age: 35.4+/-1.7 years) was stimulated with phytohemagglutinin (PHA) and lipopolysaccharide (LPS) for 48 h with or without incubation with the antidepressants at 10(-6) and 10(-5) M. The major findings of this study are: (1). imipramine and venlafaxine (at the higher concentration), 5-HTP (at lower and higher concentrations) and a combination of 5-HTP and fluoxetine (both at the lower concentration) increased the production of IL-6; (2). all drugs used did not affect TNF-alpha production. IL-6 production was significantly higher in depressed patients than in age-matched volunteers, whereas TNF-alpha production was significantly higher in older volunteers than in younger ones. We speculate that the therapeutic activity of these antidepressants is at least partly connected with their effect on the cytokine network and IL-6 production.
journal_name
Int Immunopharmacoljournal_title
International immunopharmacologyauthors
Kubera M,Kenis G,Bosmans E,Kajta M,Basta-Kaim A,Scharpe S,Budziszewska B,Maes Mdoi
10.1016/j.intimp.2003.11.006keywords:
subject
Has Abstractpub_date
2004-02-01 00:00:00pages
185-92issue
2eissn
1567-5769issn
1878-1705pii
S1567-5769(03)00285-6journal_volume
4pub_type
杂志文章abstract：OBJECTIVE:To evaluate the efficacy, safety and tolerability of β-d-mannuronic acid (M2000) in the treatment of ankylosing spondylitis (AS). METHODS:The study was a 12-week randomized, double-blind, placebo-controlled, phase I/II clinical trial with 3 treatment arms: placebo, β-d-mannuronic acid and naproxen. Patients ...
journal_title：International immunopharmacology
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.intimp.2017.11.003
更新日期：2018-01-01 00:00:00
abstract：:Histamine can modulate the balance between T helper lymphocytes 1 and 2 (Th1 and Th2), and there is evidence that allergic reactions can be associated with excessive histamine production causing shifts toward Th2 responses. As signal transduction in Th-cells is specifically correlated to signal transducer and activato...
journal_title：International immunopharmacology
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abstract：:The possible onset of Cytokine Release Syndrome (CRS) is an important consideration in the development of monoclonal antibody (mAb) therapeutics. In this study, several machine learning approaches are used to analyze CRS data. The analyzed data come from a human blood in vitro assay which was used to assess the potent...
journal_title：International immunopharmacology
pub_type： 杂志文章
doi：10.1016/j.intimp.2014.07.024
更新日期：2014-10-01 00:00:00
abstract：:Oxidized low density lipoprotein (ox-LDL) can induce the proliferation and differentiation of endothelial cells, which is one of the important mechanisms of ox-LDL atherosclerosis. Adiponectin is an endogenous bioactive polypeptide secreted by adipocytes, it participates in the metabolism of fat and glucose. It has th...
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journal_title：International immunopharmacology
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abstract：:Dendritic cells (DCs) are the most potent antigen presenting cells of the immune system as they can act as initiators, stimulators and regulators of the immune response. Human DCs are most commonly generated for clinical use by in vitro differentiation of monocytes with exogenous cytokines. Here, we investigate the ef...
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journal_title：International immunopharmacology
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abstract：:Antarctic bacteria are a novel source of polysaccharides which might have potential applications as biological response modifiers (BRM). A heteropolysaccharide (PEP) was isolated from the liquid culture broth of the Antarctic bacterium Pseudoaltermonas sp.S-5. PEP contained Mannose, Glucose, and Galactose in a ratio o...
journal_title：International immunopharmacology
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更新日期：2019-10-01 00:00:00
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journal_title：International immunopharmacology
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journal_title：International immunopharmacology
pub_type： 杂志文章,评审
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更新日期：2009-05-01 00:00:00
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更新日期：2020-06-01 00:00:00
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journal_title：International immunopharmacology
pub_type： 杂志文章
doi：10.1016/s1567-5769(02)00018-8
更新日期：2002-05-01 00:00:00
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更新日期：2020-11-01 00:00:00
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pub_type： 杂志文章
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更新日期：2016-03-01 00:00:00
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doi：10.1016/j.intimp.2006.11.003
更新日期：2007-03-01 00:00:00
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journal_title：International immunopharmacology
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更新日期：2005-06-01 00:00:00
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更新日期：2011-04-01 00:00:00
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journal_title：International immunopharmacology
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更新日期：2004-07-01 00:00:00
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更新日期：2013-10-01 00:00:00
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journal_title：International immunopharmacology
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