Abstract:
:Phospholipase C (PLC)gamma and phospholipase D (PLD) play pivotal roles in the signal transduction required for various cellular responses, including cell proliferation and differentiation. Dendritic cells (DCs), which are professional antigen-presenting cells, can be generated from human monocytes by stimulating the cells with granulocyte-macrophage colony-stimulating factor (GM-CSF) and interleukin 4 (IL-4). We investigated whether PLCgamma and PLD expression levels can be changed during the differentiation of the human monocytes into DCs. The enzymatic activity and protein level of PLC gamma1 were significantly increased in the human monocyte-derived DCs by GM-CSF/IL-4, but the protein levels of PLC gamma2 were unaltered. Moreover, the enzymatic activity and protein level of PLD1b and PLD2 were up-regulated during the differentiation of human monocytes to DCs, but those of PLD1a were not changed. A higher phagocytic activity of DCs was found to be correlated with the up-regulations of PLCgamma1 and PLD, and the phagocytic activity of DCs was inhibited by a PLC-specific inhibitor (U73122) and by a phosphatidic acid acceptor (n-butanol), but to be increased by phosphatidic acid. Thus, suggesting that PLC and PLD participate in the process. This study suggests that the up-regulations of PLCgamma1 and PLD are accompanied by the differentiation of monocytes into DCs, which results in increased phagocytic activity.
journal_name
Int Immunopharmacoljournal_title
International immunopharmacologyauthors
Kang HK,Lee HY,Lee YN,Jo EJ,Kim JI,Kim GY,Park YM,Min DS,Yano A,Kwak JY,Bae YSdoi
10.1016/j.intimp.2004.04.001keywords:
subject
Has Abstractpub_date
2004-07-01 00:00:00pages
911-20issue
7eissn
1567-5769issn
1878-1705pii
S1567-5769(04)00119-5journal_volume
4pub_type
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pub_type: 杂志文章
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pub_type: 杂志文章
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journal_title:International immunopharmacology
pub_type: 杂志文章
doi:10.1016/j.intimp.2008.09.004
更新日期:2008-12-20 00:00:00
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journal_title:International immunopharmacology
pub_type: 杂志文章
doi:10.1016/j.intimp.2012.03.012
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pub_type: 杂志文章,评审
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