Abstract:
:In a preliminary experiment, it was found that oleanolic acid (OA), which is widely distributed in food and medicinal plants, inhibited interleukin (IL)-6/tumor growth factor beta-induced differentiation of splenic T cells into Th17 cells. Moreover, OA induced the differentiation of splenic T cells into Treg cells. Therefore, we examined the anti-inflammatory effect of OA in mice with dextran sodium sulfate (DSS)-induced colitis. Oral administration of OA significantly inhibited DSS-induced colon shortening, macroscopic score, and myeloperoxidase activity. Treatment with OA inhibited DSS-induced differentiation to Th17 cells and downregulated the expression of RORγt and IL-17 in the lamina propria of colon and Treg cell differentiation and Foxp3 and IL-10 expression were increased. OA treatment increased the DSS-suppressed expression of tight junction proteins such as ZO-1, occludin, and claudin-1 in the colon. Moreover, OA treatment inhibited DSS-induced expression of tumor necrosis factor-α, interleukin (IL)-1β, and IL-17, the activation of NF-κB and mitogen-activated protein kinases, and increased IL-10 expression. OA also inhibited the activation of NF-κB and expression of proinflammatory cytokines in LPS-stimulated peritoneal macrophages. These findings suggest that OA may ameliorate inflammatory diseases such as colitis by inhibiting Th17 cell differentiation and increasing Treg cell differentiation.
journal_name
Int Immunopharmacoljournal_title
International immunopharmacologyauthors
Kang GD,Lim S,Kim DHdoi
10.1016/j.intimp.2015.10.024subject
Has Abstractpub_date
2015-12-01 00:00:00pages
393-400issue
2eissn
1567-5769issn
1878-1705pii
S1567-5769(15)30158-2journal_volume
29pub_type
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journal_title:International immunopharmacology
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journal_title:International immunopharmacology
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journal_title:International immunopharmacology
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pub_type: 杂志文章
doi:10.1016/j.intimp.2004.08.008
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journal_title:International immunopharmacology
pub_type: 杂志文章
doi:10.1016/j.intimp.2016.04.002
更新日期:2016-06-01 00:00:00
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journal_title:International immunopharmacology
pub_type: 杂志文章
doi:10.1016/j.intimp.2009.07.008
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journal_title:International immunopharmacology
pub_type: 杂志文章,评审
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doi:10.1016/j.intimp.2013.08.020
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journal_title:International immunopharmacology
pub_type: 杂志文章
doi:10.1016/j.intimp.2009.08.008
更新日期:2009-11-01 00:00:00
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journal_title:International immunopharmacology
pub_type: 杂志文章
doi:10.1016/j.intimp.2009.02.004
更新日期:2009-05-01 00:00:00
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journal_title:International immunopharmacology
pub_type: 杂志文章
doi:10.1016/s0162-3109(00)00268-x
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doi:10.1016/j.intimp.2018.11.039
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journal_title:International immunopharmacology
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pub_type: 杂志文章
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更新日期:2019-02-01 00:00:00
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journal_title:International immunopharmacology
pub_type: 杂志文章
doi:10.1016/j.intimp.2017.04.002
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journal_title:International immunopharmacology
pub_type: 杂志文章
doi:10.1016/j.intimp.2012.01.010
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