Astilbin promotes the induction of regulatory NK1.1- CD4+ NKG2D+ T cells through the PI3K, STAT3, and MAPK signaling pathways.


:Astilbin is a potential agent for autoimmune and inflammatory diseases and has a protective effect in mice with DSS-induced colitis. NK1.1- CD4+ NKG2D+ T cells are a subpopulation of regulatory T cells that produce TGF-β1 and IL-10. Whether astilbin directly promotes the induction of NK1.1- CD4+ NKG2D+ T cells and whether these astilbin-stimulated T cells exert an immune-regulatory role remain unclear. Here, we show that astilbin efficiently induces the production of NK1.1- CD4+ NKG2D+ T cells with high expressions of TGF-β1, IL-10, CCR6, and CCR9 in a dose-dependent manner ex vivo. These regulatory T cells also substantially inhibit the activities of CD8+ T cells and macrophages. Intraperitoneal injection of astilbin ameliorates the severity of colitis with an increase in the frequency of NK1.1- CD4+ NKG2D+ T cells in the colon tissue of DSS-treated mice. Moreover, adoptive transfer of NK1.1- CD4+ NKG2D+ T cells induced by astilbin remarkably protects against the onset of DSS-induced colitis. Finally, the PI3K, STAT3, and MAPK signaling pathways are involved in the induction of NK1.1- CD4+ NKG2D+ T cells by astilbin. Taken together, our study elucidates a new immune-regulatory mechanism of astilbin by inducing the regulatory NK1.1- CD4+ NKG2D+ T cells and indicates a potential clinical use of astilbin for patients with inflammatory bowel diseases.


Int Immunopharmacol


Han S,Lin Z,Wen J,Wu K,Xu Y,Zhang Y,Lu G,Xiao W,Ding Y,Jia X,Deng B,Gong W




Has Abstract


2020-04-01 00:00:00












  • 1, 25-dihydroxyvitamin D3 downregulates cytotoxic effector response in pulmonary tuberculosis.

    abstract::1,25-dihydroxyvitaminD3 [1,25(OH)2D3] modulates both the innate and adaptive immunity in tuberculosis. We explored the effect of 1,25(OH)2D3 on cytolytic molecules like perforin, granulysin, and granzyme-B in T-cells and natural killer cells during M. tuberculosis (Mtb) infection. Peripheral blood mononuclear cells (P...

    journal_title:International immunopharmacology

    pub_type: 杂志文章


    authors: Afsal K,Selvaraj P,Harishankar M

    更新日期:2018-09-01 00:00:00

  • Immunogenicity and protective efficacy of multistage vaccine candidates (Mtb8.4-HspX and HspX-Mtb8.4) against Mycobacterium tuberculosis infection in mice.

    abstract::In this study, Mtb8.4 and HspX, which are expressed at proliferating and dormant stages of Mycobacterium tuberculosis (M. tuberculosis), respectively, were chosen to construct two fusion proteins, Mtb8.4-HspX (8.4H) and HspX-Mtb8.4 (H8.4), and we investigated whether the antigen dose and protein sequential order could...

    journal_title:International immunopharmacology

    pub_type: 杂志文章


    authors: Liu W,Li J,Niu H,Lin X,Li R,Wang Y,Xin Q,Yu H,Wu Y,Zhu B,Tan J

    更新日期:2017-12-01 00:00:00

  • Digitalis inhibits and furosemide does not change the in vitro phagocytic function of neutrophils of healthy subjects.

    abstract::This work evaluated the in vitro influence of digitalis and furosemide on the phagocytic function of neutrophils of healthy individuals. Phagocytosis of Saccharomyces cerevisiae by peripheral blood neutrophils of 20 healthy individuals was assessed in the absence or presence of deslanoside or furosemide. The Wilcoxon ...

    journal_title:International immunopharmacology

    pub_type: 杂志文章


    authors: Muniz-Junqueira MI,Mota LM,Aires RB,Junqueira LF Jr

    更新日期:2003-10-01 00:00:00

  • Effect of a topical steroid on gene expressions for chemokines in mice with contact hypersensitivity.

    abstract::Effects of a topical corticosteroid drug, diflucortolone valerate, on the mRNA expressions for four CC- and four CXC-chemokines, which have been reported to be associated with recruitment of different kinds of proinflammatory and inflammatory cells, were investigated by RT-PCR in mice with 2,4,6-trinitrochlorobenzene ...

    journal_title:International immunopharmacology

    pub_type: 杂志文章


    authors: Mitsui G,Hirano T,Niwano Y,Mitsui K,Ohara O,Yanagihara S,Kato M

    更新日期:2004-01-01 00:00:00

  • Gypsophila elegans isoorientin attenuates CCl₄-induced hepatic fibrosis in rats via modulation of NF-κB and TGF-β1/Smad signaling pathways.

    abstract::The hepatoprotective effect of Gypsophila elegans isoorientin (GEI) was evaluated using a hepatic fibrosis model induced by CCl4 in rats. The results revealed that GEI significantly prevented CCl4-induced liver injury and fibrosis, as evidenced by the attenuation of histopathological changes, the decrease in serum ami...

    journal_title:International immunopharmacology

    pub_type: 杂志文章


    authors: Lin X,Chen Y,Lv S,Tan S,Zhang S,Huang R,Zhuo L,Liang S,Lu Z,Huang Q

    更新日期:2015-09-01 00:00:00

  • Maturation of dendritic cells induced by Candida beta-D-glucan.

    abstract::We investigated whether Candida beta-D-glucan (CSBG) alters the maturation of dendritic cells (DCs). DC phenotypes were analyzed using FACScan. The expression of surface molecules, including major histocompatibility complex (MHC) classes I and II, as well as CD80 and CD86, increased on DCs that were stimulated with li...

    journal_title:International immunopharmacology

    pub_type: 杂志文章


    authors: Kikuchi T,Ohno N,Ohno T

    更新日期:2002-09-01 00:00:00

  • American ginseng microbial metabolites attenuate DSS-induced colitis and abdominal pain.

    abstract::Inflammatory bowel disease (IBD) is a significant public health problem in the United States. Abdominal pain is a major complaint among individuals with IBD. Successful IBD management not only controls enteric inflammation, but also reduces abdominal discomfort. Recently, increased attention has been focused on altern...

    journal_title:International immunopharmacology

    pub_type: 杂志文章


    authors: Wang CZ,Yao H,Zhang CF,Chen L,Wan JY,Huang WH,Zeng J,Zhang QH,Liu Z,Yuan J,Bi Y,Sava-Segal C,Du W,Xu M,Yuan CS

    更新日期:2018-11-01 00:00:00

  • Anti-nicotine vaccines: Comparison of adjuvanted CRM197 and Qb-VLP conjugate formulations for immunogenicity and function in non-human primates.

    abstract::Anti-nicotine vaccines comprise nicotine-like haptens conjugated to a carrier protein plus adjuvant(s). Unfortunately, those tested clinically have failed to improve overall long term quit rates. We had shown in mice that carrier, hapten, linker, hapten load (number of haptens per carrier molecule), aggregation and ad...

    journal_title:International immunopharmacology

    pub_type: 杂志文章


    authors: McCluskie MJ,Thorn J,Gervais DP,Stead DR,Zhang N,Benoit M,Cartier J,Kim IJ,Bhattacharya K,Finneman JI,Merson JR,Davis HL

    更新日期:2015-12-01 00:00:00

  • The immunosuppressive mechanisms of mesenchymal stem cells are differentially regulated by platelet poor plasma and fetal bovine serum supplemented media.

    abstract:PURPOSE:Mesenchymal Stem Cells (MSCs) can interact with and modulate the functions of all immune cells, suppressing both the innate and adaptive immune responses. Currently, most of the in vitro studies which have led to the description of MSC properties have resulted from MSC culture in the presence of fetal bovine se...

    journal_title:International immunopharmacology

    pub_type: 杂志文章


    authors: Silva-Carvalho AÉ,Neves FAR,Saldanha-Araujo F

    更新日期:2020-02-01 00:00:00

  • 2,3,5,6-Tetramethylpyrazine of Ephedra sinica regulates melanogenesis and inflammation in a UVA-induced melanoma/keratinocytes co-culture system.

    abstract:BACKGROUND:2,3,5,6-Tetramethylpyrazine (TMP) is known as a composition of Ephedra sinica and it has been used in the treatment of several disorders such as asthma, heart failure, rhinitis, and urinary incontinence. It has been reported that TMP inhibits melanoma metastasis and suppression angiogenesis by VEGF. OBJECTI...

    journal_title:International immunopharmacology

    pub_type: 杂志文章


    authors: Yeom GG,Min S,Kim SY

    更新日期:2014-02-01 00:00:00

  • Tumor associated macrophages in the molecular pathogenesis of ovarian cancer.

    abstract::The tumor microenvironment is a critical factor that enhances cancer progression, drug resistance, and failure of therapeutic approaches. Several cellular and non-cellular factors are involved in cancer promotion. Among the several cell populations in the tumor microenvironment, macrophages, as one of the most abundan...

    journal_title:International immunopharmacology

    pub_type: 杂志文章,评审


    authors: Yousefzadeh Y,Hallaj S,Baghi Moornani M,Asghary A,Azizi G,Hojjat-Farsangi M,Ghalamfarsa G,Jadidi-Niaragh F

    更新日期:2020-07-01 00:00:00

  • Oral immunogenicity of the plant proteinase bromelain.

    abstract::Bromelain is a natural mixture of proteolytic enzymes derived from pineapple stem that has been shown to have anti-inflammatory activity when administered orally. Although most proteins given orally without adjuvant (e.g., food) result in tolerance, we previously reported that long-term oral exposure to bromelain stim...

    journal_title:International immunopharmacology

    pub_type: 杂志文章


    authors: Hale LP,Fitzhugh DJ,Staats HF

    更新日期:2006-12-20 00:00:00

  • Regulation on maturation and function of dendritic cells by Astragalus mongholicus polysaccharides.

    abstract::Astragalus mongholicus polysaccharides(ASP) isolated from one of the Chinese herbs-A. mongholicus which are known to have a variety of immunomodulatory activity. However, little is known about their immunomodulatory effects on murine bone marrow (BM)-derived dendritic cells (DC). DC are professional antigen presenting...

    journal_title:International immunopharmacology

    pub_type: 杂志文章


    authors: Shao P,Zhao LH,Zhi-Chen,Pan JP

    更新日期:2006-07-01 00:00:00

  • 6-Gingerol attenuates ventilator-induced lung injury via anti-inflammation and antioxidative stress by modulating the PPARγ/NF-κBsignalling pathway in rats.

    abstract::Although mechanical ventilation (MV) is indispensable to life-support therapy in critically ill patients, it may promote or aggravatelunginjury known asventilator-inducedlunginjury(VILI). 6-Gingerol is the principal ingredient of ginger with potential anti-inflammatory and antioxidant properties in various diseases. N...

    journal_title:International immunopharmacology

    pub_type: 杂志文章


    authors: Hong W,Zhi FX,Kun TH,Hua FJ,Huan Ling L,Fang F,Wen C,Jie W,Yang LC

    更新日期:2021-01-15 00:00:00

  • BCG-infected adherent mononuclear cells release cytokines that regulate group 1 CD1 molecule expression.

    abstract::Increasing evidence is now available showing that CD1-restricted T cell responses against non-peptide mycobacterial antigens could play a role in the immune resistance against tuberculosis. BCG, widely used in anti-tubercular vaccination, shares various constituents with Mycobacterium tuberculosis, but does not provid...

    journal_title:International immunopharmacology

    pub_type: 杂志文章


    authors: Prete SP,Giuliani A,D'Atri S,Graziani G,Balduzzi A,Oggioni MR,Iona E,Girolomoni G,Bonmassar L,Romani L,Franzese O

    更新日期:2007-03-01 00:00:00

  • Sixteen-year history of rituximab therapy for 1085 pemphigus vulgaris patients: A systematic review.

    abstract::Pemphigus vulgaris (PV) is a rare autoimmune disease due to the production of pathogenic autoantibodies directed against desmoglein 1 and 3, usually affecting both skin and mucous membranes. Recently, rituximab, a chimeric IgG1 monoclonal antibody which targets the CD20 molecules have been regarded as a promising trea...

    journal_title:International immunopharmacology

    pub_type: 杂志文章,评审


    authors: Tavakolpour S,Mahmoudi H,Balighi K,Abedini R,Daneshpazhooh M

    更新日期:2018-01-01 00:00:00

  • Antitumor effects of recombinant human prolactin in human adenocarcinoma-bearing SCID mice with human NK cell xenograft.

    abstract::To survey the immune regulatory function of recombinant human prolactin (rhPRL) and its potential application in adoptive immunotherapy, CB17-SCID mice were loaded with human colon adenocarcinoma HT-29 cells (5 x 10(5) cells/mouse, i.p.) 24 h before adoptive transfer with the purified human NK cells followed by rhPRL ...

    journal_title:International immunopharmacology

    pub_type: 杂志文章


    authors: Zhang J,Sun R,Wei H,Tian Z

    更新日期:2005-02-01 00:00:00

  • Enhanced hematopoietic protection from radiation by the combination of genistein and captopril.

    abstract::The hematopoietic system is sensitive to radiation injury, and mortality can occur due to blood cell deficiency and stem cell loss. Genistein and the angiotensin converting enzyme (ACE) inhibitor captopril are two agents shown to protect the hematopoietic system from radiation injury. In this study we examined the com...

    journal_title:International immunopharmacology

    pub_type: 杂志文章


    authors: Day RM,Davis TA,Barshishat-Kupper M,McCart EA,Tipton AJ,Landauer MR

    更新日期:2013-02-01 00:00:00

  • Efficacy and safety of CTLA-4 inhibitors combined with PD-1 inhibitors or chemotherapy in patients with advanced melanoma.

    abstract:BACKGROUND:Although immune checkpoint inhibitor monotherapy has demonstrated significant efficacy in advanced melanoma, no study has systematically evaluated the efficacy and safety of the combination regimens. In this study, we conduct a comprehensive meta-analysis to explore the efficacy and safety of CTLA-4 inhibito...

    journal_title:International immunopharmacology

    pub_type: 杂志文章,meta分析


    authors: Zhang B,Zhou YL,Chen X,Wang Z,Wang Q,Ju F,Ren S,Xu R,Xue Q,Wu Q

    更新日期:2019-03-01 00:00:00

  • A higher frequency of peripheral blood activated B cells in patients with non-traumatic osteonecrosis of the femoral head.

    abstract:OBJECTIVES:B cells play important roles in inflammatory diseases. This study was aimed at examining the frequency of different subsets of B cells in patients with non-traumatic osteonecrosis of the femoral head (NONFH). METHODS:The percentages of the different subsets of circulating B cells in 28 patients with steroid...

    journal_title:International immunopharmacology

    pub_type: 杂志文章


    authors: Zhang H,Xiao F,Liu Y,Zhao D,Shan Y,Jiang Y

    更新日期:2014-05-01 00:00:00

  • Atractylodin ameliorates lipopolysaccharide and d-galactosamine-induced acute liver failure via the suppression of inflammation and oxidative stress.

    abstract::Atractylodin (ACD) possesses versatile biological and pharmacological activities, including antibacterial, anti-inflammatory and hepatoprotective properties. However, the protective effects of ACD on lipopolysaccharide (LPS) and d-galactosamine (GalN)-induced acute liver failure (ALF) as well as the underlying molecul...

    journal_title:International immunopharmacology

    pub_type: 杂志文章


    authors: Lyu Z,Ji X,Chen G,An B

    更新日期:2019-07-01 00:00:00

  • Differential roles of constitutively activated ERK1/2 and NF-kappa B in cytotoxicity and proliferation by human NK cell lines.

    abstract::Compared with freshly isolated peripheral blood natural killer (NK) cells, the YT and NK-92 cell lines are characterized by elevated cytolytic activity. The molecular mechanisms underlying the rapid proliferation and enhanced lytic activity of NK cell lines are poorly understood. Investigation of these cell lines reve...

    journal_title:International immunopharmacology

    pub_type: 杂志文章


    authors: Liang S,Zhang J,Wei H,Sun R,Tian Z

    更新日期:2005-05-01 00:00:00

  • Chronic dexamethasone treatment results in hippocampal neurons injury due to activate NLRP1 inflammasome in vitro.

    abstract::Neuroinflammation mediated by NLRP-1 inflammasome plays an important role in the pathogenesis of neurodegeneration diseases such as Alzheimer's disease (AD). Chronic glucocorticoids (GCs) exposure has deleterious effect on the structure and function of neurons and was found to be correlated with development and progre...

    journal_title:International immunopharmacology

    pub_type: 杂志文章


    authors: Zhang B,Zhang Y,Xu T,Yin Y,Huang R,Wang Y,Zhang J,Huang D,Li W

    更新日期:2017-08-01 00:00:00

  • Cordycepin negatively modulates lipopolysaccharide-induced cytokine production by up-regulation of heme oxygenase-1.

    abstract:AIMS:The present study is to investigate the effect of cordycepin on the expression of heme oxygenase-1 (HO-1) in lipopolysaccharide (LPS)-activated microphages, as well as its mechanism of action. METHODS:Mouse RAW264.7 cells were treated with different concentrations of cordycepin for 0-16h. Western blotting was use...

    journal_title:International immunopharmacology

    pub_type: 杂志文章


    authors: Qing R,Huang Z,Tang Y,Xiang Q,Yang F

    更新日期:2017-06-01 00:00:00

  • Key regulators in bee venom-induced apoptosis are Bcl-2 and caspase-3 in human leukemic U937 cells through downregulation of ERK and Akt.

    abstract::Bee venom (BV) has been known to inhibit proliferation and induce apoptosis in cancer cells. However, the molecular mechanisms involved in BV-induced apoptosis are still uncharacterized in human leukemic cells. In the present study, we report that BV induces apoptosis in leukemic U937 cells through downregulation of E...

    journal_title:International immunopharmacology

    pub_type: 杂志文章


    authors: Moon DO,Park SY,Heo MS,Kim KC,Park C,Ko WS,Choi YH,Kim GY

    更新日期:2006-12-05 00:00:00

  • Effects of dynamic changes in histone acetylation and deacetylase activity on pulmonary fibrosis.

    abstract:OBJECTIVE:Histone deacetylases (HDACs) play an important role in dysregulation of histone acetylation/deacetylation, which is the main driving force of the progression of pulmonary fibrosis. Here we investigated the changes in histone acetylation/deacetylation, and the contribution of specific class I and class II HDAC...

    journal_title:International immunopharmacology

    pub_type: 杂志文章


    authors: Li M,Zheng Y,Yuan H,Liu Y,Wen X

    更新日期:2017-11-01 00:00:00

  • Immunoglobulin replacement therapy in primary and secondary antibody deficiency: The correct clinical approach.

    abstract::Immunoglobulin therapy is the administration of human polyvalent IgG and represents the most effective treatment to prevent recurrent infections in antibody deficiency patients. Primary antibody deficiency represents the main indication of immunoglobulin replacement therapy and includes a wide range of disorders chara...

    journal_title:International immunopharmacology

    pub_type: 杂志文章,评审


    authors: Pecoraro A,Crescenzi L,Granata F,Genovese A,Spadaro G

    更新日期:2017-11-01 00:00:00

  • Long-term inhibition of dipeptidyl-peptidase 4 reduces islet infiltration and downregulates IL-1β and IL-12 in NOD mice.

    abstract::Dipeptidyl-peptidase 4 (DPP-4) inhibitor (sitagliptin) is a novel anti-hyperglycemia drug in the treatment of type 2 diabetes. However, its potential in type 1 diabetes is still unclear. Recent studies show that increased infection, especially respiratory tract infection, is significantly associated with DPP-4 inhibit...

    journal_title:International immunopharmacology

    pub_type: 杂志文章


    authors: He X,Li W,Xie Y,Zhao Y

    更新日期:2020-11-01 00:00:00

  • A promising therapeutic target for psoriasis: Neuropeptides in human skin.

    abstract::Psoriasis is a chronic inflammatory skin disease featured by excessive proliferation of keratinocytes, clearly defined round erythema and dry, scaly plaques, long-term inflammatory cells infiltration in skin lesions. However, the physiopathological mechanism of psoriasis is still not clearly understood. Neuropeptides,...

    journal_title:International immunopharmacology

    pub_type: 杂志文章,评审


    authors: Zhang Y,Zhang H,Jiang B,Yan S,Lu J

    更新日期:2020-10-01 00:00:00

  • Ocimum gratissimum Linn. and rosmarinic acid, attenuate eosinophilic airway inflammation in an experimental model of respiratory allergy to Blomia tropicalis.

    abstract::Allergic asthma has emerged as an important public health problem of urban populations in developed countries. Very often herbal medicine is used to treat this widespread disease, due to the lack of efficacy and the important side effects related to the classical drugs in use. Along this line, Ocimum gratissimum (Og) ...

    journal_title:International immunopharmacology

    pub_type: 杂志文章


    authors: Costa RS,Carneiro TC,Cerqueira-Lima AT,Queiroz NV,Alcântara-Neves NM,Pontes-de-Carvalho LC,Velozo Eda S,Oliveira EJ,Figueiredo CA

    更新日期:2012-05-01 00:00:00