Abstract:
:Astilbin is a potential agent for autoimmune and inflammatory diseases and has a protective effect in mice with DSS-induced colitis. NK1.1- CD4+ NKG2D+ T cells are a subpopulation of regulatory T cells that produce TGF-β1 and IL-10. Whether astilbin directly promotes the induction of NK1.1- CD4+ NKG2D+ T cells and whether these astilbin-stimulated T cells exert an immune-regulatory role remain unclear. Here, we show that astilbin efficiently induces the production of NK1.1- CD4+ NKG2D+ T cells with high expressions of TGF-β1, IL-10, CCR6, and CCR9 in a dose-dependent manner ex vivo. These regulatory T cells also substantially inhibit the activities of CD8+ T cells and macrophages. Intraperitoneal injection of astilbin ameliorates the severity of colitis with an increase in the frequency of NK1.1- CD4+ NKG2D+ T cells in the colon tissue of DSS-treated mice. Moreover, adoptive transfer of NK1.1- CD4+ NKG2D+ T cells induced by astilbin remarkably protects against the onset of DSS-induced colitis. Finally, the PI3K, STAT3, and MAPK signaling pathways are involved in the induction of NK1.1- CD4+ NKG2D+ T cells by astilbin. Taken together, our study elucidates a new immune-regulatory mechanism of astilbin by inducing the regulatory NK1.1- CD4+ NKG2D+ T cells and indicates a potential clinical use of astilbin for patients with inflammatory bowel diseases.
journal_name
Int Immunopharmacoljournal_title
International immunopharmacologyauthors
Han S,Lin Z,Wen J,Wu K,Xu Y,Zhang Y,Lu G,Xiao W,Ding Y,Jia X,Deng B,Gong Wdoi
10.1016/j.intimp.2019.106143subject
Has Abstractpub_date
2020-04-01 00:00:00pages
106143eissn
1567-5769issn
1878-1705pii
S1567-5769(19)32152-6journal_volume
81pub_type
杂志文章abstract:BACKGROUNDS:Autoimmune myocarditis is characterized by over-activated immune system attacking the cardiomyocytes, resulting in heart function decline. In the current study, we investigated the therapeutic advantages of delivering Interleukin-10 (IL-10) by mesenchymal stem cells (MSCs), both of which had immune suppress...
journal_title:International immunopharmacology
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abstract::Flavonoids are a class of compounds that exist in nature with the structure of 2-phenyl-chromone. In Chinese traditional medicine, herbal drugs containing flavonoids are widely used for the treatment of inflammation, cardiovascular disease, tumor and so on. In this study, we investigated the anti-inflammatory effect a...
journal_title:International immunopharmacology
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journal_title:International immunopharmacology
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journal_title:International immunopharmacology
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pub_type: 杂志文章,meta分析,评审
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pub_type: 杂志文章,meta分析
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journal_title:International immunopharmacology
pub_type: 杂志文章
doi:10.1016/j.intimp.2009.06.003
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journal_title:International immunopharmacology
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doi:10.1016/j.intimp.2020.106994
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journal_title:International immunopharmacology
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doi:10.1016/j.intimp.2019.05.034
更新日期:2019-09-01 00:00:00
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journal_title:International immunopharmacology
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doi:10.1016/j.intimp.2019.106046
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journal_title:International immunopharmacology
pub_type: 杂志文章
doi:10.1016/j.intimp.2015.11.009
更新日期:2016-01-01 00:00:00
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journal_title:International immunopharmacology
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doi:10.1016/j.intimp.2014.12.007
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journal_title:International immunopharmacology
pub_type: 杂志文章
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pub_type: 杂志文章,meta分析
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journal_title:International immunopharmacology
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journal_title:International immunopharmacology
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更新日期:2018-02-01 00:00:00
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journal_title:International immunopharmacology
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journal_title:International immunopharmacology
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journal_title:International immunopharmacology
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journal_title:International immunopharmacology
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journal_title:International immunopharmacology
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journal_title:International immunopharmacology
pub_type: 杂志文章
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