Batimastat reduces Mycobacterium tuberculosis-induced apoptosis in macrophages.

abstract：:γδ T cells account for approximately 5% of peripheral blood T cells but are more abundant in mucosal tissue. Based on the recognized ligands and their general lack of MHC restriction, γδ T cells are considered as unconventional T cells that link innate and adaptive immunity. γδ T cells produce a diverse range of cytok...

journal_title：International immunopharmacology

authors： Kabelitz D,Peters C,Wesch D,Oberg HH

更新日期：2013-07-01 00:00:00

abstract：:Aseptic periprosthetic osteolysis is a complication induced by wear particles after hip joint replacement, which shortens the service life of prostheses. Although many methods have been applied to prevent this complication, the results were not always successful. In the present study, we explored the prophylactic effe...

journal_title：International immunopharmacology

authors： Zhao S,Yan L,Li X,Zhang Z,Sun Y,Wang J

更新日期：2017-06-01 00:00:00

abstract：:Increasing evidence is now available showing that CD1-restricted T cell responses against non-peptide mycobacterial antigens could play a role in the immune resistance against tuberculosis. BCG, widely used in anti-tubercular vaccination, shares various constituents with Mycobacterium tuberculosis, but does not provid...

journal_title：International immunopharmacology

authors： Prete SP,Giuliani A,D'Atri S,Graziani G,Balduzzi A,Oggioni MR,Iona E,Girolomoni G,Bonmassar L,Romani L,Franzese O

更新日期：2007-03-01 00:00:00

abstract：BACKGROUND:COVID-19 is considered the most critical health pandemic of 21st century. Due to extremely high transmission rate, people are more susceptible to viral infection. COVID-19 patients having chronic type-2 asthma prevails a major risk as it may aggravate the disease and morbidities. OBJECTIVE:The present revie...

journal_title：International immunopharmacology

authors： Ghosh S,Das S,Mondal R,Abdullah S,Sultana S,Singh S,Sehgal A,Behl T

更新日期：2021-02-01 00:00:00

abstract：:Brucellosis is the most common zoonotic disease worldwide and still there is no vaccine for human use. The commercial animal vaccines also have major problems that limit their use. Therefore, there is a need for an effective Brucella vaccine which is multivalent and produces a good protective immunity with minimal dis...

journal_title：International immunopharmacology

authors： Golshani M,Amani M,Amirzadeh F,Nazeri E,Davar Siadat S,Nejati-Moheimani M,Arsang A,Bouzari S

更新日期：2020-07-01 00:00:00

abstract：:Melatonin is a free radical scavenger and broad-spectrum antioxidant with immunomodulatory effects. The objective of the study is to investigate the effects of melatonin in hepatic ischemia/reperfusion (I/R) induced lung injury and explore its underlying mechanisms. Hepatic I/R injury was induced via portal vein and h...

journal_title：International immunopharmacology

authors： Zhou L,Zhao D,An H,Zhang H,Jiang C,Yang B

更新日期：2015-12-01 00:00:00

abstract：:Analgesic and anti-inflammatory applications for non-peptide bradykinin (BK) B2 receptor antagonists have been documented in rats. However, very large species differences in affinity were also noted within this class of drugs, making the preclinical development of relevant drugs difficult. Bradyzide is a potent antago...

journal_title：International immunopharmacology

authors： Marceau F,Fortin JP,Morissette G,Dziadulewicz EK

更新日期：2003-10-01 00:00:00

abstract：:Acute lung injury (ALI) is linked with considerable morbidity and mortality. ALI can be caused by various agents, one of them being sepsis. ALI is characterized by injury to vascular endothelium and alveolar epithelium that results in edema, pulmonary immune cells infiltration and hypoxemia. Neutrophils and T cells pa...

journal_title：International immunopharmacology

authors： Nadeem A,Al-Harbi NO,Ahmad SF,Al-Harbi MM,Alhamed AS,Alfardan AS,Assiri MA,Ibrahim KE,Albassam H

更新日期：2020-06-01 00:00:00

abstract：BACKGROUND:Acute exacerbation of idiopathic pulmonary fibrosis (AE-IPF) is attracting considerable attention due to disease acceleration and substantial mortality. Macrophages are known to regulate the fibrotic process in idiopathic pulmonary fibrosis. OBJECTIVE:We investigated if two new macrophage-specific serum bio...

journal_title：International immunopharmacology

authors： Zou R,Gui X,Zhang J,Tian Y,Liu X,Tian M,Chen T,Wu H,Chen J,Dai J,Cai H

更新日期：2020-09-01 00:00:00

abstract：:Stephanoside E (STE) and its aglycone Stephanthraniline A (STA) isolated from the stems of Stephanotis mucronata (Blanco) Merr. were evaluated for their suppressive potentials on Th1 and Th2 immune responses in vitro, and the effects of the C-3 sugar chains on their activities were discussed. STE and STA significantly...

journal_title：International immunopharmacology

authors： Chen F,Ni Y,Ye Y,Sun H,Li X,Xu S

更新日期：2010-10-01 00:00:00

abstract：:Visfatin plays an important role in inflammatory and metabolic conditions. In this study, the effects of septic stress on the serum, white-adipose-tissue (WAT), and liver visfatin levels of male and female rats were examined. Both gonadally intact (sham) and ovariectomized (OVX) female rats were used in order to evalu...

journal_title：International immunopharmacology

authors： Iwasa T,Matsuzaki T,Matsui S,Tungalagsuvd A,Munkhzaya M,Takiguchi E,Kawakita T,Kuwahara A,Yasui T,Irahara M

更新日期：2016-06-01 00:00:00

abstract：:The melanoma differentiation associated gene-7 (mda-7) cDNA was isolated by virtue of being induced during melanoma differentiation. Initial gene transfer studies convincingly demonstrated potent antitumor effects of mda-7. Further studies showed that the mechanism of antitumor activity was due to induction of apoptos...

journal_title：International immunopharmacology

authors： Chada S,Sutton RB,Ekmekcioglu S,Ellerhorst J,Mumm JB,Leitner WW,Yang HY,Sahin AA,Hunt KK,Fuson KL,Poìndexter N,Roth JA,Ramesh R,Grimm EA,Mhashilkar AM

更新日期：2004-05-01 00:00:00

abstract：:Over-activation of microglia disrupts the physiological homeostasis of the brain, and induces inflammatory response and other processes which are implicated in neurodegenerative diseases. Therefore, theoretically, suppression of neuroinflammation would slow the progression of neurodegenerative disease. In this study, ...

journal_title：International immunopharmacology

authors： Bao Y,Chen Q,Xie Y,Tao Z,Jin K,Chen S,Bai Y,Yang J,Shan S

更新日期：2019-12-01 00:00:00

abstract：:It is recognized that macrophages in peripheral tissues often proliferate under pathological conditions such as tumors, inflammation and atherosclerosis. Because the growth state of macrophages is believed to be a factor regulating the pathological process of the diseases, substances that regulate macrophage growth or...

journal_title：International immunopharmacology

authors： Yui S,Ubukata K,Hodono K,Kitahara M,Mimaki Y,Kuroda M,Sashida Y,Yamazaki M

更新日期：2001-10-01 00:00:00

abstract：:Pseudoginsenoside-F11 (PF11), an ocotillol-type saponin, has neuroprotective effects on permanent and transient cerebral ischemia in rats by alleviating autophagic/lysosomal defects and repressing calcium overload, respectively. Ischemic stroke triggers peripheral innate immune cells, mainly neutrophils and macrophage...

journal_title：International immunopharmacology

authors： Hou Y,Yang D,Zhang Q,Wang X,Yang J,Wu C

更新日期：2020-08-01 00:00:00

abstract：:Leaves of Passiflora alata Curtis were characterized for their antioxidant capacity. Antioxidant analyses of DPPH, FRAP, ABTS, ORAC and phenolic compounds were made in three different extracts: aqueous, methanol/acetone and ethanol. Aqueous extract was found to be the best solvent for recovery of phenolic compounds an...

journal_title：International immunopharmacology

authors： Colomeu TC,Figueiredo D,Cazarin CB,Schumacher NS,Maróstica MR Jr,Meletti LM,Zollner RL

更新日期：2014-01-01 00:00:00

abstract：PURPOSE:The molecular mechanism responsible for the immunomodulatory effect of 1,25-dihydroxyvitamin D3 (Vit-D) is still not well elucidated. Unavoidable systemic toxicity of Vit-D has encouraged to develop more potent and less toxic Vit-D analogs, such as 1,25-dihydroxyvitamin D3-3-bromoacetate (BE). Our aim was to ex...

journal_title：International immunopharmacology

authors： Datta-Mitra A,Mitra A,Ray R,Raychaudhuri SP,Kundu-Raychaudhuri S

更新日期：2013-11-01 00:00:00

abstract：:Sepsis is a serious and life-threatening medical condition with a higher rate of patients' morbidity and mortality and with complications such as acute kidney injury (AKI). S-allyl cysteine (SAC) is the active constituent of the medicinal plant garlic (Allium sativum) with multiple beneficial effects including anti-in...

journal_title：International immunopharmacology

authors： Khajevand-Khazaei MR,Azimi S,Sedighnejad L,Salari S,Ghorbanpour A,Baluchnejadmojarad T,Mohseni-Moghaddam P,Khamse S,Roghani M

更新日期：2019-04-01 00:00:00

abstract：:Glucocorticoids (GCs) have been considered to regulate immune cell systems through induction of apoptosis in thymocytes and mature peripheral-blood lymphocytes. Here we report that apoptosis induced by cortisol in mitogen-activated peripheral-blood mononuclear cells (PBMC) is suppressed by cortisone, an oxidized metab...

journal_title：International immunopharmacology

authors： Hirano T,Horigome A,Takatani M,Oka K

更新日期：2001-11-01 00:00:00

abstract：:High amounts of nitric oxide (NO) production following the induction of inducible NO synthase (iNOS) gene expression has been implicated in the pathogenesis of inflammatory diseases. Capsaicin, a vanilloid receptor agonist, is known to have an inhibitory effect on NO production in macrophages. In the present study, we...

journal_title：International immunopharmacology

authors： Oh GS,Pae HO,Seo WG,Kim NY,Pyun KH,Kim IK,Shin M,Chung HT

更新日期：2001-04-01 00:00:00

abstract：OBJECTIVE:This study aims to investigate the effects of intra-articular botulinum toxin. METHODS:Osteoarthritis was induced in both knees of 20 rabbits by transecting the anterior cruciate ligament under intramuscular anesthesia with ketamine and xylazine. Botulinum toxin, at a dose of 2.5 microg/ml (0.6 ml) and physi...

journal_title：International immunopharmacology

authors： Namazi H

更新日期：2006-11-01 00:00:00

abstract：:Transmembrane protein 16A (TMEM16A), a channel underlying the calcium-activated chloride channel (CaCC) currents, has been shown to be a key regulator of mucus overproduction in airway epithelial cells. However, the precise molecular mechanism involved in the TMEM16A-mediated mucus secretion remains unclear. In the pr...

journal_title：International immunopharmacology

authors： Qin Y,Jiang Y,Sheikh AS,Shen S,Liu J,Jiang D

更新日期：2016-11-01 00:00:00

abstract：AIMS:Immune mediated liver injury includes activation of different immune pathways that requires various modalities to control their consequences. The current study involves evaluation of retinoic acid (RA) modulatory effects on immune responses induced in concanavalin A (ConA) model of acute hepatitis. MAIN METHODS:M...

journal_title：International immunopharmacology

authors： Elshal M,Abu-Elsaad N,El-Karef A,Ibrahim T

更新日期：2019-10-01 00:00:00

abstract：:We have observed that CD4+ T cell counts in human immunodeficiency virus (HIV)-1-infected patients treated with only Korean red ginseng (KRG) are maintained or even increased for a prolonged period. In the present study, we investigated whether the development of resistance mutations in reverse transcriptase (RT) to z...

journal_title：International immunopharmacology

authors： Cho YK,Sung H,Lee HJ,Joo CH,Cho GJ

更新日期：2001-07-01 00:00:00

abstract：:Histamine can modulate the balance between T helper lymphocytes 1 and 2 (Th1 and Th2), and there is evidence that allergic reactions can be associated with excessive histamine production causing shifts toward Th2 responses. As signal transduction in Th-cells is specifically correlated to signal transducer and activato...

journal_title：International immunopharmacology

authors： Horr B,Borck H,Thurmond R,Grösch S,Diel F

更新日期：2006-10-01 00:00:00

abstract：:Hepatitis B is one of the leading liver diseases and remains a major global health problem. Currently available vaccines provide protection but often results in weaker/minimal mucosal immunity. Thus the present study is devoted to the development and in-vivo exploration of the colonically delivered biomimetic nanopart...

journal_title：International immunopharmacology

authors： Sahu KK,Pandey RS

更新日期：2016-10-01 00:00:00

abstract：:Our previous work showed that SEP, a novel glucan isolated from the eggs of sea urchins, Strongylocentrotus nudus, had remarkable anti-tumor activity. To elucidate the mechanism of the anti-tumor activity, the immunomodulatory activity of SEP was investigated. The in vivo experiment results showed that SEP remarkably ...

journal_title：International immunopharmacology

authors： Liu C,Xi T,Lin Q,Xing Y,Ye L,Luo X,Wang F

更新日期：2008-12-20 00:00:00

abstract：:Dendritic cells (DCs) control immune responses and are central to the development of immune memory and tolerance. DCs initiate and orchestrate immune responses in a manner that depends on signals they receive from microbes and cellular environment. Although DCs consist mainly of bone marrow-derived and resident popula...

journal_title：International immunopharmacology

authors： Chen K,Wang JM,Yuan R,Yi X,Li L,Gong W,Yang T,Li L,Su S

更新日期：2016-05-01 00:00:00

abstract：:Chronic low back pain due to lumbar spinal stenosis (LSS) is common, costly, mechanistically complex, and clinically challenging. However, the factors and mechanisms causing and mediating chronic pain induced by cauda equina compression remain unclear. Here, we examined the role of cyclooxygenase (COX)-2 in infiltrate...

journal_title：International immunopharmacology

authors： Lee JY,Choi HY,Park CS,Jang C,Lee KT,Lee JY,Youn I,Yune TY

更新日期：2019-10-01 00:00:00

abstract：:Psoriasis is an autoimmune skin disease caused by interactions between keratinocytes and immune cells, such as macrophages. CD200 is expressed on the surface of various cell types, and its receptor, CD200R1, belongs to a family of immunosuppressive receptors that are mainly expressed on myeloid cells. CD200/CD200R1 si...

journal_title：International immunopharmacology

authors： Li D,Wang Y,Tang L,Jin X,Xia C,Xu H,Hu J

更新日期：2020-01-01 00:00:00