Pseudoginsenoside-F11 ameliorates ischemic neuron injury by regulating the polarization of neutrophils and macrophages in vitro.

abstract：OBJECTIVE:Histone deacetylases (HDACs) play an important role in dysregulation of histone acetylation/deacetylation, which is the main driving force of the progression of pulmonary fibrosis. Here we investigated the changes in histone acetylation/deacetylation, and the contribution of specific class I and class II HDAC...

journal_title：International immunopharmacology

authors： Li M,Zheng Y,Yuan H,Liu Y,Wen X

更新日期：2017-11-01 00:00:00

abstract：BACKGROUND:Many studies have shown that ghrelin can down-regulate inflammatory cytokine expression via the inhibition of NF-κB activity and therefore, its administration to septic patients is considered beneficial. However, our knowledge of ghrelin's effects on the upstream activators of the NF-κB pathway, such as NOD2...

journal_title：International immunopharmacology

authors： Peng Z,Zhu Y,Zhang Y,Wilhelmsen K,Jia C,Jin J,Xue Q,Feng X,Zhang F,Yu B

更新日期：2012-08-01 00:00:00

abstract：:β-Caryophyllene (BCP) is a bicyclic sesquiterpene compound that has anti-diabetic activity. However, the effect of BCP on diabetic nephropathy (DN) remains unclear. Here, we aimed to evaluate the potential role of BCP in high glucose (HG)-induced glomerular mesangial cells (MCs). MCs were maintained under HG condition...

journal_title：International immunopharmacology

authors： Li H,Wang D,Chen Y,Yang M

更新日期：2020-07-01 00:00:00

abstract：:Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are responsible for high mortality rates in critical patients. Despite >50 years of intensive research, there is no pharmacologically effective treatment to treat ALI. PPARs agonists, chemically named thiazolidinediones (TZDs) have emerged as poten...

journal_title：International immunopharmacology

authors： Santos LAMD,Rodrigues GB,Mota FVB,França MER,de Souza Barbosa KP,Oliveira WH,Rocha SWS,Lós DB,Silva AKS,Silva TGD,Peixoto CA

更新日期：2018-04-01 00:00:00

abstract：:2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) exposure results in an increased percentage of CD11b(+) (Mac-1(+)) cells in the spleens of mice challenged with P815 tumor cells, coincident with a failure of the mice to generate allospecific CD8(+) CTL activity. Since CD11b(+)Gr-1(+) myeloid suppressor cells (MSC) have been...

journal_title：International immunopharmacology

authors： Choi JY,Oughton JA,Kerkvliet NI

更新日期：2003-04-01 00:00:00

abstract：:Natural killer (NK) cells eliminate cancer cells in a contact-dependent manner. However, how NK cells find cancer cells remain unclear. Here, using time-lapse imaging, we investigated how individual NK cells migrate toward cancer cells. Although naïve B16F10 cancer cells produce low levels of chemokines, IFN-γ-treated...

journal_title：International immunopharmacology

authors： Kim J,Kim JS,Lee HK,Kim HS,Park EJ,Choi JE,Choi YJ,Shin BR,Kim EY,Hong JT,Kim Y,Han SB

更新日期：2018-10-01 00:00:00

abstract：:T lymphocytes play central roles in adaptive immunity. Lycium barbarum L. (L. barbarum), also known as wolfberry, is a Chinese herbal medicine with various biological activities, such as enhancing immunity, protecting liver damage, and reducing the side effects of chemotherapy and radiotherapy. Here, we report that po...

journal_title：International immunopharmacology

authors： Chen Z,Kwong Huat Tan B,Chan SH

更新日期：2008-12-10 00:00:00

abstract：BACKGROUND:The T-cell immunoglobulin and mucin domain-(Tim)-1 molecule and Tim-3 are mainly expressed on activated T helper (Th) 2 and Th1 cells, respectively, and have been implicated in the pathogenesis of some autoimmune diseases. Immune thrombocytopenia (ITP) is a common autoimmune disorder, and the complex dysregu...

journal_title：International immunopharmacology

authors： Zhang XM,Shan NN,Sun M,Wang X,Feng XM,Liu X,Li Y,Yuan D,Ding M

更新日期：2014-03-01 00:00:00

abstract：:The global panic of the novel coronavirus disease 2019 (COVID-19) triggered by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has led to an urgent requirement for effective therapy. COVID-19 infection, especially in severely ill patients, is likely to be associated with immune dysregulation, promptin...

journal_title：International immunopharmacology

authors： Razmi M,Hashemi F,Gheytanchi E,Dehghan Manshadi M,Ghods R,Madjd Z

更新日期：2020-11-01 00:00:00

abstract：:We had reported that in the ischemic heart, locally formed bradykinin (BK) and angiotensin II (Ang II) activate B2- and AT1-receptors on sympathetic nerve terminals (SNE), promoting reversal of the norepinephrine (NE) transporter in an outward direction (i.e., carrier-mediated NE release). Although both BK and Ang II ...

journal_title：International immunopharmacology

authors： Levi R,Silver RB,Mackins CJ,Seyedi N,Koyama M

更新日期：2002-12-01 00:00:00

abstract：:Understanding of oligodendrocyte precursor cells and their role in the generation of oligodendrocytes in developing and adult rodents has been considered, particularly much less is known about aged-rodent oligodendrocyte precursor cells and their cell lineage. In this present study, we have developed oligodendrocyte c...

journal_title：International immunopharmacology

authors： Kobayashi J,Seiwa C,Sakai T,Gotoh M,Komatsu Y,Yamamoto M,Fukutake M,Matsuno K,Sakurai Y,Kawano Y,Asou H

更新日期：2003-07-01 00:00:00

abstract：:Coronavirus disease 2019 (COVID-19) is a pandemic infectious disease caused by the novel coronavirus called SARS-CoV-2. There is a gap in our understanding regarding the immunopathogenesis of COVID-19. However, many clinical trials are underway across the world for screening effective drugs against COVID-19. Neverthel...

journal_title：International immunopharmacology

authors： Mirzaei R,Mohammadzadeh R,Mahdavi F,Badrzadeh F,Kazemi S,Ebrahimi M,Soltani F,Kazemi S,Jeda AS,Darvishmotevalli M,Yousefimashouf R,Keyvani H,Karampoor S

更新日期：2020-11-01 00:00:00

abstract：BACKGROUND:Spontaneous abortion is a common disease in human pregnancy. Increasing evidence suggests that proper function of trophoblasts and immune balance of the maternal-fetal interface are crucial for successful pregnancy. Macrophages are involved in the maternal-fetal immune microenvironment. However, mechanisms a...

journal_title：International immunopharmacology

authors： Ying X,Jin X,Zhu Y,Liang M,Chang X,Zheng L

更新日期：2020-11-01 00:00:00

abstract：:Antrodia camphorata (AC) is a commonly used fungus in folk medicine for the treatment of viral hepatitis and cancer. AC polysaccharides (AC-PS) are reported to possess anti-inflammatory, anti-hepatitis B virus, and anticancer activities. In this study, we tested the in vivo effect of AC-PS on immune function by evalua...

journal_title：International immunopharmacology

authors： Chen YJ,Cheng PC,Lin CN,Liao HF,Chen YY,Chen CC,Lee KM

更新日期：2008-03-01 00:00:00

abstract：BACKGROUND:Regulatory T cells (Tregs) are thought to play a modulatory role in immune responses and to improve outcomes after ischemic stroke. Thus, various strategies for increasing Tregs in animal models of ischemic stroke have yielded successful results. The aim of this study was to examine the potential effect of p...

journal_title：International immunopharmacology

authors： Noh MY,Lee WM,Lee SJ,Kim HY,Kim SH,Kim YS

更新日期：2018-07-01 00:00:00

abstract：:During the evolution of neoplastic diseases, dendritic cell (DC) functions are usually attenuated, and this presents a problem to DC-based immunotherapies against cancer. Here, we investigated the effects of angelan, an acidic polysaccharide isolated from Angelica gigas Nakai, on DC maturation. Angelan efficiently inc...

journal_title：International immunopharmacology

authors： Kim JY,Yoon YD,Ahn JM,Kang JS,Park SK,Lee K,Song KB,Kim HM,Han SB

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND:Allergic rhinitis (AR) is characterized by a Th2 polarized immune response and soluble HLA (sHLA) molecules play an immunomodulatory role in this response. Previously, it has been reported that these molecules are increased in sera of patients with pollen-induced allergic rhinitis studied outside the pollen ...

journal_title：International immunopharmacology

authors： Ciprandi G,Contini P,Murdaca G,DeAmici M,Gallina AM,Puppo F

更新日期：2009-08-01 00:00:00

abstract：:Treatment of asthma with corticosteroids results in downregulation of eosinophilic airway inflammation. We evaluated in vitro the activity of an "inhaled" corticosteroid, mometasone furoate (MF), and of a "systemic" corticosteroid, dexamethasone (DEX), on eosinophil functions, i.e. adhesion molecule expression and cel...

journal_title：International immunopharmacology

authors： Sale R,Sabatini F,Silvestri M,Serpero L,Petecchia L,Rossi GA

更新日期：2004-12-15 00:00:00

abstract：:Bothrops snake venoms contain biologically active components, including L-amino acid oxidases (LAAO) that induce significant leukocyte accumulation at inflammatory sites characterized by early neutrophil infiltration. As it remains unclear how snake venoms modulate neutrophil activation and chemokine production, here ...

journal_title：International immunopharmacology

authors： Pereira-Crott LS,Casare-Ogasawara TM,Ambrosio L,Chaim LFP,de Morais FR,Cintra ACO,Canicoba NC,Tucci LFF,Torqueti MR,Sampaio SV,Marzocchi-Machado CM,Castro FA

更新日期：2020-03-01 00:00:00

abstract：:It has been reported that natural helper cells, which are a non-T, non-B innate lymphoid cell type expressing c-Kit and ST2, mediate influenza-induced airway hyper-reactivity by producing substantial IL-13. However, little is known about natural helper cells for the development of RSV-induced airway inflammation, part...

journal_title：International immunopharmacology

authors： Liu J,Wu J,Qi F,Zeng S,Xu L,Hu H,Wang D,Liu B

更新日期：2015-09-01 00:00:00

abstract：:Acetylcholine (ACh) acts as a local cellular signaling molecule and is widely expressed in nature, including mammalian cells and embryonic stem cells. The murine embryonic stem cell line CGR8 synthesizes and releases substantial amounts of ACh. Particularly during early differentiation - a period associated with multi...

journal_title：International immunopharmacology

authors： Michel-Schmidt R,Kirkpatrick CJ,Wessler I

更新日期：2015-11-01 00:00:00

abstract：:Acute lung injury (ALI), induced by intestinal ischemia reperfusion (II/R) injury, is characterized by pulmonary edema and inflammation. Aquaporin 4 (AQP4), has been pointed out recently involving in edema development. Previous studies have shown that p38 mitogen activated protein kinase (MAPK) activation resulted in ...

journal_title：International immunopharmacology

authors： Xiong LL,Tan Y,Ma HY,Dai P,Qin YX,Yang RA,Xu YY,Deng Z,Zhao W,Xia QJ,Wang TH,Zhang YH

更新日期：2016-09-01 00:00:00

abstract：:Our previous work showed that SEP, a novel glucan isolated from the eggs of sea urchins, Strongylocentrotus nudus, had remarkable anti-tumor activity. To elucidate the mechanism of the anti-tumor activity, the immunomodulatory activity of SEP was investigated. The in vivo experiment results showed that SEP remarkably ...

journal_title：International immunopharmacology

authors： Liu C,Xi T,Lin Q,Xing Y,Ye L,Luo X,Wang F

更新日期：2008-12-20 00:00:00

abstract：:A Gram-positive bacterium, Staphylococcus aureus is known to be one of the major pathogenic bacteria responsible for causing bovine mastitis. Among the various cell wall components of S. aureus, lipoteichoic acid (LTA) and peptidoglycan (PGN) are closely associated with inflammatory responses. However, the role of LTA...

journal_title：International immunopharmacology

authors： Im J,Lee T,Jeon JH,Baik JE,Kim KW,Kang SS,Yun CH,Kim H,Han SH

更新日期：2014-07-01 00:00:00

abstract：:Many edible mushrooms have become attractive as "health foods" and as source materials for immunomodulators. To increase our insight in the immune-modulatory properties of a polysaccharide of the oyster mushroom Pleurotus citrinopileatus, PCPS, we analyzed its effects on the function of human dendritic cells (DCs). We...

journal_title：International immunopharmacology

authors： Minato KI,Laan LC,Ohara A,van Die I

更新日期：2016-11-01 00:00:00

abstract：:Interleukin 17 (IL-17) is a proinflammatory cytokine that acts as an immune checkpoint for several autoimmune diseases. Therapeutic neutralizing antibodies that target this cytokine have demonstrated clinical efficacy in psoriasis. However, biologics have limitations such as their high cost and their lack of oral bioa...

journal_title：International immunopharmacology

authors： Álvarez-Coiradas E,Munteanu CR,Díaz-Sáez L,Pazos A,Huber KVM,Loza MI,Domínguez E

更新日期：2020-12-01 00:00:00

abstract：:Our previous findings demonstrated that chlorophyllin (CHL) inhibits inducible nitric oxide gene expression in macrophages. In the present study, we show that CHL inhibited IL-1beta production and its mRNA expression in a lipopolysaccharide (LPS)-stimulated murine macrophage cell-line, RAW 264.7. The inhibitory effect...

journal_title：International immunopharmacology

authors： Yun CH,Jeon YJ,Yang Y,Ju HR,Han SH

更新日期：2006-02-01 00:00:00

abstract：:Acute lung injury (ALI) is an excessive and uncontrolled inflammatory response in lung, of which remains the leading cause of morbidity and mortality in worldwide. Chikusetsusaponin V (CsV), a bioactive compounds derived from Panacis Japonica, has been reported to have anti-inflammatory effects. However, it is still u...

journal_title：International immunopharmacology

authors： Su K,Zhang G,Zhang X,Jiang W

更新日期：2019-05-01 00:00:00

abstract：:Lung adenocarcinoma (LUAD) is a frequently diagnosed histologic subtype with increasing morbidity and mortality. RalGDS-Like 4 (RGL4) has not been reported to be associated with cancer risk, prognosis, immunotherapy or any other treatments. We perform a bioinformatics analysis on data downloaded from the Cancer Genome...

journal_title：International immunopharmacology

authors： Sun Y,Zhang Y,Ren S,Li X,Yang P,Zhu J,Lin L,Wang Z,Jia Y

更新日期：2020-06-01 00:00:00

abstract：:Tuberculosis (TB) remains as a global health problem. The prevalence of this infection is related to the association with other diseases, such as HIV, neglect treatment and misuse of antibiotics. Hence, the identification of new drugs is required to eradicate TB. Possible alternatives to existing antibiotics include p...

journal_title：International immunopharmacology

authors： Guzmán-Beltrán S,Rubio-Badillo MÁ,Juárez E,Hernández-Sánchez F,Torres M

更新日期：2016-02-01 00:00:00