当前位置： SCI文献检索 > INTERNATIONAL IMMUNOPHARMACOLOGY期刊下所有文献 > Low expression of RGL4 is associated with a poor prognosis and immune infiltration in lung adenocarcinoma patients.

Low expression of RGL4 is associated with a poor prognosis and immune infiltration in lung adenocarcinoma patients.

Abstract：

:Lung adenocarcinoma (LUAD) is a frequently diagnosed histologic subtype with increasing morbidity and mortality. RalGDS-Like 4 (RGL4) has not been reported to be associated with cancer risk, prognosis, immunotherapy or any other treatments. We perform a bioinformatics analysis on data downloaded from the Cancer Genome Atlas (TCGA)-LUAD, and we find that low expression of RGL4 is accompanied by worse outcomes and prognosis in LUAD patients. As a promising predictor, the potential influence and mechanisms of RGL4 on overall survival are worth exploring. Moreover, RGL4 expression is significantly associated with a variety of tumor-infiltrating immune cells (TIICs), particularly memory B cells, CD8+T cells and neutrophils. Subsequently, we evaluated the most notable KEGG pathways, including glycolysis gluconeogenesis, the P53 signaling pathway, RNA degradation, and the B cell receptor signaling pathway, among others. Our findings provide evidence that the decreased expression of RGL4 is significantly associated with poor prognosis and immune cell infiltration in patients with LUAD and highlight the use of RGL4 as a novel predictive biomarker for the prognosis of LUAD and other cancers. RGL4 may also be used in combination with immune checkpoints to identify the benefits of immunotherapy. Subjects: Bioinformatics, Genomics, Oncology, Thoracic surgery.

journal_name

Int Immunopharmacol

journal_title

International immunopharmacology

authors

Sun Y,Zhang Y,Ren S,Li X,Yang P,Zhu J,Lin L,Wang Z,Jia Y

doi

10.1016/j.intimp.2020.106454

subject

Has Abstract

pub_date

2020-06-01 00:00:00

pages

106454

eissn

1567-5769

issn

1878-1705

pii

S1567-5769(20)30344-1

journal_volume

83

pub_type

杂志文章

相关文献

INTERNATIONAL IMMUNOPHARMACOLOGY文献大全
  • Lower levels of vitamin D are associated with SARS-CoV-2 infection and mortality in the Indian population: An observational study.

    abstract：BACKGROUND:The role of vitamin D in the susceptibility and severity of various viral diseases has been well documented. Recently, some reports highlighted the possible importance of vitamin D in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Although India receives adequate sunlight throughout the year, ...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2020.107001

    authors： Padhi S,Suvankar S,Panda VK,Pati A,Panda AK

    更新日期：2020-11-01 00:00:00

  • Anti-brain cholinergic auto antibodies from primary Sjögren syndrome sera modify simultaneously cerebral nitric oxide and prostaglandin biosynthesis.

    abstract：:The presence of circulating antibodies from primary Sjögren Syndrome (pSS) patients enable to interact with rat cerebral frontal cortex by activating muscarinic acetylcholine receptors (mAChR). ELISA assay for PGE2 generation, nitric oxide synthase (NOS) activity was measured in cerebral frontal cortex slices by produ...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2007.07.018

    authors： Orman B,Sterin-Borda L,De Couto Pita A,Reina S,Borda E

    更新日期：2007-12-05 00:00:00

  • The progress and confusion of anti-PD1/PD-L1 immunotherapy for patients with advanced non-small cell lung cancer.

    abstract：:Recently, immunotherapy has evolved into a true treatment modality with the approval of PD-1 and PD-L1 inhibitors as the standard care for first-line treatment in patients with non-small cell lung cancer (NSCLC). Until now, for patients with advanced NSCLC, treatment of targeting immune checkpoints reveals a promising...

    journal_title：International immunopharmacology

    pub_type： 杂志文章,评审

    doi：10.1016/j.intimp.2020.106247

    authors： Zhang S,Bai X,Shan F

    更新日期：2020-03-01 00:00:00

  • Effects of uridine, isomatitol and 4-thiouridine on in vitro cell adhesion and in vivo effects of 4-thiouridine in a lung inflammation model.

    abstract：:Since leukocyte adhesion to endothelial cells is crucial for extravasation of leukocytes to sites of inflammation, inhibition of cell-cell adhesion has been suggested as a means to achieve selective modulation of the immune system. We have, using a static in vitro adhesion assay involving adhesion of granulocytes to t...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2004.04.016

    authors： Uppugunduri S,Gautam C

    更新日期：2004-09-01 00:00:00

  • Tanshinone IIA ameliorates the bleomycin-induced endothelial-to-mesenchymal transition via the Akt/mTOR/p70S6K pathway in a murine model of systemic sclerosis.

    abstract：:Systemic sclerosis (SSc) is an autoimmune inflammatory and vascular disorder leading to progressive tissue fibrosis. Tanshinone IIA (Tan IIA) is a phytochemical extracted from the Chinese herb Salvia miltiorrhiza that exhibits diverse activities. In this study, we attempted to evaluate the potential impact of Tan IIA ...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2019.105968

    authors： Jiang Y,Hu F,Li Q,Shen C,Yang J,Li M

    更新日期：2019-12-01 00:00:00

  • Activation of Nrf2 signaling by salvianolic acid C attenuates NF‑κB mediated inflammatory response both in vivo and in vitro.

    abstract：:Neurodegenerative diseases are closely related to neuroinflammation. Drugs targeting inflammation have been proved to be effective in many animal models. Salvianolic acid C (SalC) is a compound isolated from Salvia miltiorrhiza Bunge, a plant with reported effects of inhibiting inflammation. However, the anti-inflamma...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2018.08.004

    authors： Song J,Zhang W,Wang J,Yang H,Zhao X,Zhou Q,Wang H,Li L,Du G

    更新日期：2018-10-01 00:00:00

  • Neutralizing antibody production against Rebif® and ReciGen® in Relapsing-Remitting Multiple Sclerosis (RRMS) patients and its association with patient's disability.

    abstract：INTRODUCTION:Human recombinant interferon beta (IFN-β) is one of the first line treatments for Relapsing-Remitting Multiple Sclerosis (RRMS). However, the production of neutralizing antibodies (NAb) can impair its function. The aim of this study was to investigate the production of neutralizing antibodies against Rebif...

    journal_title：International immunopharmacology

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.intimp.2018.06.032

    authors： Shokrollahi Barough M,Ashtari F,Sadat Akhavi M,Asghari N,Mosayebi G,Mirmohammadkhani M,Kokhaei N,Bahraminia F,Ajami A,Kokhaei P

    更新日期：2018-09-01 00:00:00

  • Allergenicity assessment of Buchanania lanzan protein extract in Balb/c mice.

    abstract：:Tree nuts are among "Big Eight" and have been reported globally for causing allergy. Buchanania lanzan (Bl) is one of the major tree nuts consumed by Indian population. However, very little is known about B. lanzan's induced allergic manifestation. Therefore, evaluation of it's allergenic potential was undertaken. Bl-...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2018.07.039

    authors： Kumar S,Sharma A,Gupta RK,Verma AK,Dwivedi PD

    更新日期：2018-10-01 00:00:00

  • TLR2 and TLR4 expression after kidney ischemia and reperfusion injury in mice treated with FTY720.

    abstract：:Ischemia and reperfusion injury (IR) is an antigen independent inflammatory process that causes tissue damage. After IR, kidneys up-regulate leukocyte adhesion molecules and toll-like receptors (TLRs). Moreover, injured kidneys can also secrete factors (i.e. heat shock protein) which bind to TLRs and trigger intracell...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2011.04.014

    authors： Pedregosa JF,Haidar AA,Hirata AE,Franco M,Gomes GN,Bueno V

    更新日期：2011-09-01 00:00:00

  • Osteopontin exacerbates the progression of experimental autoimmune myasthenia gravis by affecting the differentiation of T cell subsets.

    abstract：:Osteopontin (OPN) is a multifunctional extracellular matrix phosphoprotein that has a specific and complicated structure, and contributes to numerous physiological and pathological activities. The mechanism of OPN in many diseases has been confirmed; however, the role of OPN in myasthenia gravis (MG) remains unclear. ...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2020.106335

    authors： Zhao J,Jing J,Zhao W,Li X,Hou L,Zheng C,Kong Q,Li W,Yao X,Chang L,Li H,Mu L,Wang G,Wang J

    更新日期：2020-02-25 00:00:00

  • TanshinoneIIA ameliorates inflammatory microenvironment of colon cancer cells via repression of microRNA-155.

    abstract：:TanshinoneIIA, an active component derived from a traditional Chinese medicine, has anti-inflammatory and anti-cancer effect. However, the mechanisms underlying the interaction between anti-inflammation and anti-cancer of TanshinoneIIA remain elusive. In the present study, a cell model of inflammation between macropha...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2012.08.015

    authors： Tu J,Xing Y,Guo Y,Tang F,Guo L,Xi T

    更新日期：2012-12-01 00:00:00

  • Nordihydroguaiaretic acid ameliorates cisplatin induced nephrotoxicity and potentiates its anti-tumor activity in DMBA induced breast cancer in female Sprague-Dawley rats.

    abstract：:Cisplatin is a widely used antineoplastic drug, but its clinical usefulness is limited due to dose dependent nephrotoxicity. Nordihydroguaiaretic acid (NDGA) is a natural compound with broad pharmacological properties like antioxidant, anti-inflammatory and anticancer activity. The present study was undertaken to eval...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2015.07.016

    authors： Mundhe NA,Kumar P,Ahmed S,Jamdade V,Mundhe S,Lahkar M

    更新日期：2015-09-01 00:00:00

  • 1,4-Dithiothreitol treatment ameliorates hematopoietic and intestinal injury in irradiated mice: Potential application of a treatment for acute radiation syndrome.

    abstract：:Radiation exposure poses a significant threat to public health, which can lead to acute hematopoietic system and intestinal system injuries due to their higher radiation sensitivity. Hence, antioxidants and thiol-reducing agents could have a potential protective effect against this complication. The dithiol compound 1...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2019.105913

    authors： Li K,Zhang J,Cao J,Li X,Tian H

    更新日期：2019-11-01 00:00:00

  • Keratinocyte nicotinic acetylcholine receptor activation modulates early TLR2-mediated wound healing responses.

    abstract：:The cholinergic anti-inflammatory pathway spans several macro- and micro-environments to control inflammation via α7 nicotinic acetylcholine receptors (nAChRs). Physiologic inflammation is necessary for normal wound repair and is triggered, in part, via Toll-like receptors (TLRs). Here, we demonstrate that keratinocyt...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2015.05.047

    authors： Kishibe M,Griffin TM,Radek KA

    更新日期：2015-11-01 00:00:00

  • Herpesviral Fcgamma receptors: culprits attenuating antiviral IgG?

    abstract：:Production of IgG in response to virus infection is central to antiviral immune effector functions and a hallmark of B cell memory. Antiviral antibodies (Abs) recognising viral glycoproteins or protein antigen displayed on the surface of virions or virus-infected cells are crucial in rendering the virus noninfectious ...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2004.05.020

    authors： Budt M,Reinhard H,Bigl A,Hengel H

    更新日期：2004-09-01 00:00:00

  • Sixteen-year history of rituximab therapy for 1085 pemphigus vulgaris patients: A systematic review.

    abstract：:Pemphigus vulgaris (PV) is a rare autoimmune disease due to the production of pathogenic autoantibodies directed against desmoglein 1 and 3, usually affecting both skin and mucous membranes. Recently, rituximab, a chimeric IgG1 monoclonal antibody which targets the CD20 molecules have been regarded as a promising trea...

    journal_title：International immunopharmacology

    pub_type： 杂志文章,评审

    doi：10.1016/j.intimp.2017.11.005

    authors： Tavakolpour S,Mahmoudi H,Balighi K,Abedini R,Daneshpazhooh M

    更新日期：2018-01-01 00:00:00

  • TRIP6 accelerates the proliferation and migration of fetal airway smooth muscle cells by enhancing YAP activation.

    abstract：:The thyroid receptor interactor protein 6 (TRIP6) has emerged as a key regulator for the proliferation and migration of various cells. However, whether TRIP6 is involved in regulating the proliferation and migration of airway smooth muscle (ASM) cells in the progression of pediatric asthma remains undetermined. The pr...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2020.106366

    authors： Wei F,Hao Y

    更新日期：2020-03-06 00:00:00

  • CXCR3-deficient natural killer cells fail to migrate to B16F10 melanoma cells.

    abstract：:Natural killer (NK) cells eliminate cancer cells in a contact-dependent manner. However, how NK cells find cancer cells remain unclear. Here, using time-lapse imaging, we investigated how individual NK cells migrate toward cancer cells. Although naïve B16F10 cancer cells produce low levels of chemokines, IFN-γ-treated...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2018.07.026

    authors： Kim J,Kim JS,Lee HK,Kim HS,Park EJ,Choi JE,Choi YJ,Shin BR,Kim EY,Hong JT,Kim Y,Han SB

    更新日期：2018-10-01 00:00:00

  • Long-term intake of Korean red ginseng in HIV-1-infected patients: development of resistance mutation to zidovudine is delayed.

    abstract：:We have observed that CD4+ T cell counts in human immunodeficiency virus (HIV)-1-infected patients treated with only Korean red ginseng (KRG) are maintained or even increased for a prolonged period. In the present study, we investigated whether the development of resistance mutations in reverse transcriptase (RT) to z...

    journal_title：International immunopharmacology

    pub_type： 临床试验,杂志文章

    doi：10.1016/s1567-5769(01)00061-3

    authors： Cho YK,Sung H,Lee HJ,Joo CH,Cho GJ

    更新日期：2001-07-01 00:00:00

  • Recombinant human ulinastatin improves immune dysfunction of dendritic cells in septic mice by inhibiting endoplasmic reticulum stress-related apoptosis.

    abstract：:Urinary trypsin inhibitor (UTI), also known as ulinastatin, has been reported to protect multiple organs against inflammation- and/or injury-induced dysfunction. In the present study, we aimed to investigate the immunomodulation effects of a recombinant human ulinastatin (urinary trypsin inhibitor, UTI) (rhUTI) on spl...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2020.106643

    authors： Qi AL,Wu Y,Dong N,Chai YF,Zhu XM,Yao YM

    更新日期：2020-08-01 00:00:00

  • NFAT-1 hyper-activation by methionine enkephalin (MENK) significantly induces cell apoptosis of rats C6 glioma in vivo and in vitro.

    abstract：:The aim of the work was to investigate the effect and possible mechanism of MENK on the growth of rat C6 glioma in vivo or in vitro. Our findings showed that MENK could inhibit the growth of rat C6 glioma, prolong median survival times in tumor-bearing rats, and induce glioma cell apoptosis. Moreover, MENK could incre...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2018.01.005

    authors： Lu WC,Xie H,Tie XX,Wang R,Wu AH,Shan FP

    更新日期：2018-03-01 00:00:00

  • Bradykinin receptors: Agonists, antagonists, expression, signaling, and adaptation to sustained stimulation.

    abstract：:Bradykinin-related peptides, the kinins, are blood-derived peptides that stimulate 2 G protein-coupled receptors, the B1 and B2 receptors (B1R, B2R). The pharmacologic and molecular identities of these 2 receptor subtypes will be succinctly reviewed herein, with emphasis on drug development, receptor expression, signa...

    journal_title：International immunopharmacology

    pub_type： 杂志文章,评审

    doi：10.1016/j.intimp.2020.106305

    authors： Marceau F,Bachelard H,Bouthillier J,Fortin JP,Morissette G,Bawolak MT,Charest-Morin X,Gera L

    更新日期：2020-02-24 00:00:00

  • Immunomodulatory effect of caffeic acid phenethyl ester in Balb/c mice.

    abstract：:Caffeic acid phenethyl ester (CAPE), an the active component of propolis, is known to have anticarcinogenic, antiviral and various biological activities; however, the effect of CAPE on the immunomodulatory activity in vivo remains unknown. We have investigated the effect of CAPE on the immune system in female Balb/c m...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2004.01.013

    authors： Park JH,Lee JK,Kim HS,Chung ST,Eom JH,Kim KA,Chung SJ,Paik SY,Oh HY

    更新日期：2004-03-01 00:00:00

  • New thiazolidinedione LPSF/GQ-2 inhibits NFκB and MAPK activation in LPS-induced acute lung inflammation.

    abstract：:Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are responsible for high mortality rates in critical patients. Despite >50 years of intensive research, there is no pharmacologically effective treatment to treat ALI. PPARs agonists, chemically named thiazolidinediones (TZDs) have emerged as poten...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2018.02.011

    authors： Santos LAMD,Rodrigues GB,Mota FVB,França MER,de Souza Barbosa KP,Oliveira WH,Rocha SWS,Lós DB,Silva AKS,Silva TGD,Peixoto CA

    更新日期：2018-04-01 00:00:00

  • Differential alteration of functions of rat peritoneal macrophages responsive to endogenous opioid peptide endomorphin-1.

    abstract：:Endomorphin-1 is a recently isolated endogenous opioid peptide, and potent and selective high affinity mu-opioid receptor agonist. We evaluate the role of endomorphin-1 on macrophage functions. Endomorphin-1 potentiated macrophage adhesion and the expression of adhesion molecule Mac-1 on macrophages. However, endomorp...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/s1567-5769(02)00065-6

    authors： Inui Y,Azuma Y,Ohura K

    更新日期：2002-07-01 00:00:00

  • PRDM1 levels are associated with clinical diseases in chronic HBV infection and survival of patients with HBV-related hepatocellular carcinoma.

    abstract：:PR domain zinc finger protein 1 (PRDM1)/B lymphocyte-induced maturation protein 1 (BLIMP1) is a transcriptional repressor involved in B and T cell responses which are implicated in chronic hepatitis B virus (HBV) infection and hepatocellular carcinoma (HCC). This study investigated the association of PRDM1 with clinic...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2019.05.012

    authors： Li N,Fan X,Wang X,Deng H,Zhang K,Zhang X,Wang Y,Han Q,Lv Y,Liu Z

    更新日期：2019-08-01 00:00:00

  • Artin M enhances TNF-α production and phagocytosis of Candida albicans mediated by dectin-1 and mannose receptors.

    abstract：:The activities of dectin-1 and mannose receptors on phagocytosis of Candida albicans and the production of TNF-α by macrophages from mice pretreated for 3 days with extract of Artocarpus intergrifolia seeds (jack extract), Artin M or jacalin were studied. Macrophages from these mice were coincubated with C. albicans C...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2011.12.010

    authors： Loyola W,Custodio LA,Felipe I,Conchon-Costa I,Carvalho PG,Quirino GF,Silva LF,Gaziri LC

    更新日期：2012-02-01 00:00:00

  • Dietary garlic (Allium sativum) lectins, ASA I and ASA II, are highly stable and immunogenic.

    abstract：:The immunomodulatory proteins present in garlic have recently been shown to be identical to the garlic lectins ASA I and ASA II [Clement F, Pramod SN, Venkatesh YP. Int. Immunopharmacol. 2010; 10: 316-324]. In this study, the stability of garlic lectins as a function of pH, temperature and denaturants has been examine...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2010.06.022

    authors： Clement F,Venkatesh YP

    更新日期：2010-10-01 00:00:00

  • Application of Candida solubilized cell wall beta-glucan in antitumor immunotherapy against P815 mastocytoma in mice.

    abstract：:This study was designed to evaluate the antitumor activity of CSBG, purified from the cell wall of Candida albicans IFO1385. First, as an effect of CSBG on P815 mastocytoma, significant prolonged survival and suppression of the tumor growth were observed. Second, the transfer of spleen cells from CSBG-sensitized BALB/...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/s1567-5769(01)00148-5

    authors： Tokunaka K,Ohno N,Adachi Y,Miura NN,Yadomae T

    更新日期：2002-01-01 00:00:00

  • Follicular regulatory T cells infiltrated the ovarian carcinoma and resulted in CD8 T cell dysfunction dependent on IL-10 pathway.

    abstract：:A high Treg/CD8 T cell ratio in ovarian carcinoma was negatively associated with the prognosis of the patients. The human follicular regulatory T (Tfr) cells are a newly characterized subset of Treg cells with features of both follicular helper T (Tfh) cells (CXCR5+) and canonical Treg cells (CD25+Foxp3+). The role of...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2018.12.051

    authors： Li L,Ma Y,Xu Y

    更新日期：2019-03-01 00:00:00