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Angelan isolated from Angelica gigas Nakai induces dendritic cell maturation through toll-like receptor 4.

Abstract：

:During the evolution of neoplastic diseases, dendritic cell (DC) functions are usually attenuated, and this presents a problem to DC-based immunotherapies against cancer. Here, we investigated the effects of angelan, an acidic polysaccharide isolated from Angelica gigas Nakai, on DC maturation. Angelan efficiently increased the maturation of tlr4(+/+) DCs from C57BL/6 and C3H/HeN mice, but not tlr4(-/-) DCs from C3H/HeJ mice. Phenotypic maturation was confirmed by the elevated expressions of CD80, CD86, and MHC-class II molecules, and functional maturation by increased IL-12 production, enhanced allogenic T cell stimulation, and decreased endocytosis. Angelan was found to activate ERK and NF-kappaB, which are signaling molecules down-stream of toll-like receptor-4 (TLR4) receptors. Angelan-treated mature DC more effectively inhibited B16F10 tumor growth than immature DCs in syngenic murine tumor model. These results indicate that angelan induces DC maturation via TLR4 signaling pathways and suggest the possible use of angelan in DC-based immunotherapies.

journal_name

Int Immunopharmacol

journal_title

International immunopharmacology

authors

Kim JY,Yoon YD,Ahn JM,Kang JS,Park SK,Lee K,Song KB,Kim HM,Han SB

doi

10.1016/j.intimp.2006.08.017

subject

Has Abstract

pub_date

2007-01-01 00:00:00

pages

78-87

issue

1

eissn

1567-5769

issn

1878-1705

pii

S1567-5769(06)00274-8

journal_volume

7

pub_type

杂志文章

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