Angelan isolated from Angelica gigas Nakai induces dendritic cell maturation through toll-like receptor 4.


:During the evolution of neoplastic diseases, dendritic cell (DC) functions are usually attenuated, and this presents a problem to DC-based immunotherapies against cancer. Here, we investigated the effects of angelan, an acidic polysaccharide isolated from Angelica gigas Nakai, on DC maturation. Angelan efficiently increased the maturation of tlr4(+/+) DCs from C57BL/6 and C3H/HeN mice, but not tlr4(-/-) DCs from C3H/HeJ mice. Phenotypic maturation was confirmed by the elevated expressions of CD80, CD86, and MHC-class II molecules, and functional maturation by increased IL-12 production, enhanced allogenic T cell stimulation, and decreased endocytosis. Angelan was found to activate ERK and NF-kappaB, which are signaling molecules down-stream of toll-like receptor-4 (TLR4) receptors. Angelan-treated mature DC more effectively inhibited B16F10 tumor growth than immature DCs in syngenic murine tumor model. These results indicate that angelan induces DC maturation via TLR4 signaling pathways and suggest the possible use of angelan in DC-based immunotherapies.


Int Immunopharmacol


Kim JY,Yoon YD,Ahn JM,Kang JS,Park SK,Lee K,Song KB,Kim HM,Han SB




Has Abstract


2007-01-01 00:00:00














  • The immunosuppressive mechanisms of mesenchymal stem cells are differentially regulated by platelet poor plasma and fetal bovine serum supplemented media.

    abstract:PURPOSE:Mesenchymal Stem Cells (MSCs) can interact with and modulate the functions of all immune cells, suppressing both the innate and adaptive immune responses. Currently, most of the in vitro studies which have led to the description of MSC properties have resulted from MSC culture in the presence of fetal bovine se...

    journal_title:International immunopharmacology

    pub_type: 杂志文章


    authors: Silva-Carvalho AÉ,Neves FAR,Saldanha-Araujo F

    更新日期:2020-02-01 00:00:00

  • Maturation of dendritic cells induced by Candida beta-D-glucan.

    abstract::We investigated whether Candida beta-D-glucan (CSBG) alters the maturation of dendritic cells (DCs). DC phenotypes were analyzed using FACScan. The expression of surface molecules, including major histocompatibility complex (MHC) classes I and II, as well as CD80 and CD86, increased on DCs that were stimulated with li...

    journal_title:International immunopharmacology

    pub_type: 杂志文章


    authors: Kikuchi T,Ohno N,Ohno T

    更新日期:2002-09-01 00:00:00

  • The fungal metabolite, citrinin, inhibits lipopolysaccharide/interferon-γ-induced nitric oxide production in glomerular mesangial cells.

    abstract::The mycotoxin, citrinin (CTN), is a secondary metabolite of the fermented products of Monascus. The mycotoxin can either suppress or stimulate immune responses. In the present study, the immunomodulatory role of CTN in nitric oxide (NO) production, a proinflammatory mediator in the process of inflammation, was investi...

    journal_title:International immunopharmacology

    pub_type: 杂志文章


    authors: Liu BH,Chi JY,Hsiao YW,Tsai KD,Lee YJ,Lin CC,Hsu SC,Yang SM,Lin TH

    更新日期:2010-12-01 00:00:00

  • Regulation of interleukin-10 secretion by histamine in TH2 cells and splenocytes.

    abstract::Interleukin-10 is a potent suppressive factor that down-regulates cellular immune response via inhibition of the production of TH1 cytokines. Histamine shifts the TH1/TH2 balance from TH1 to TH2 cytokines making the effects of histamine on IL-10 secretion an important factor in this switch. This study was designed to ...

    journal_title:International immunopharmacology

    pub_type: 杂志文章


    authors: Osna N,Elliott K,Khan MM

    更新日期:2001-01-01 00:00:00

  • Impact of different mesenchymal stromal cell types on T-cell activation, proliferation and migration.

    abstract::Mesenchymal stromal cells (MSCs) isolated from different tissue sources may present distinct immunomodulatory profiles. As lymphocyte responses are a combination of several distinct steps, we evaluated and compared the impact of MSCs from different sources on the activation, proliferation and migration of T-cells. We ...

    journal_title:International immunopharmacology

    pub_type: 杂志文章


    authors: Najar M,Raicevic G,Fayyad-Kazan H,De Bruyn C,Bron D,Toungouz M,Lagneaux L

    更新日期:2013-04-01 00:00:00

  • IL-6 promotes collagen-induced arthritis by activating the NLRP3 inflammasome through the cathepsin B/S100A9-mediated pathway.

    abstract::Rheumatoid arthritis (RA) is an inflammatory disease with symmetric polyarthritis. IL-6 and NLRP3 inflammasome in macrophages contribute to the pathogenesis of RA. This study aimed to investigate the relationship between IL-6 and the NLRP3 inflammasome in RA. Here, we found that IL-6 inhibition reduced NLRP3 inflammas...

    journal_title:International immunopharmacology

    pub_type: 杂志文章


    authors: Wang H,Wang Z,Wang L,Sun L,Liu W,Li Q,Wang J

    更新日期:2020-11-01 00:00:00

  • Privigen® has similar pharmacokinetic properties in primary and secondary immune deficiency.

    abstract:PURPOSE:Primary (PID) and secondary immune deficiencies (SID) represent diverse groups of diagnoses, yet both can be effectively treated with intravenous immunoglobulin (IVIG) replacement therapy. Guidelines for the use of IVIG in SID vary due to the paucity of data. The objective was to analyze available IVIG Privigen...

    journal_title:International immunopharmacology

    pub_type: 杂志文章


    authors: Tortorici MA,Lawo JP,Weide R,Jochems J,Puli S,Hofmann J,Pfruender D,Rojavin MA

    更新日期:2019-01-01 00:00:00

  • Regulatory functions of γδ T cells.

    abstract::γδ T cells account for approximately 5% of peripheral blood T cells but are more abundant in mucosal tissue. Based on the recognized ligands and their general lack of MHC restriction, γδ T cells are considered as unconventional T cells that link innate and adaptive immunity. γδ T cells produce a diverse range of cytok...

    journal_title:International immunopharmacology

    pub_type: 杂志文章,评审


    authors: Kabelitz D,Peters C,Wesch D,Oberg HH

    更新日期:2013-07-01 00:00:00

  • Enhancement of IL-2 and IFN-gamma expression and NK cells activity involved in the anti-tumor effect of ganoderic acid Me in vivo.

    abstract::Ganoderic acid Me (GA-Me) is a lanostane triterpenoid purified from Ganoderma lucidum mycelia, one of the most widely used herbs for cancer treatment and prevention in east Asia. In the present study, it was demonstrated that GA-Me could inhibit both tumor growth and lung metastasis of Lewis lung carcinoma in C57BL/6 ...

    journal_title:International immunopharmacology

    pub_type: 杂志文章


    authors: Wang G,Zhao J,Liu J,Huang Y,Zhong JJ,Tang W

    更新日期:2007-06-01 00:00:00

  • Chemotherapy in combination with cytokine-induced killer cell transfusion: An effective therapeutic option for patients with extensive stage small cell lung cancer.

    abstract:BACKGROUND AND AIMS:In the past decade of clinical studies, the combination of chemotherapy with cytokine induced killer (CIK) cell transfusion has confirmed a promised efficacy in several types of cancer. CIK cells are a mixture of T lymphocytes, generated from peripheral blood mononuclear cells induced by multiple cy...

    journal_title:International immunopharmacology

    pub_type: 杂志文章


    authors: Huang J,Kan Q,Lan,Zhao X,Zhang Z,Yang S,Li H,Wang L,Xu L,Cheng Z,Zhang Y

    更新日期:2017-05-01 00:00:00

  • Effect of gut microbiota on LPS-induced acute lung injury by regulating the TLR4/NF-kB signaling pathway.

    abstract::Acute lung injury (ALI) is a common acute respiratory disease treated in the clinic. Intestinal microflora disorder affect lung diseases through the gut-lung axis. In this study, we explored the regulatory mechanism of the gut flora in the host defense against lipopolysaccharide (LPS)-induced ALI through the TLR4/NF-k...

    journal_title:International immunopharmacology

    pub_type: 杂志文章


    authors: Tang J,Xu L,Zeng Y,Gong F

    更新日期:2021-02-01 00:00:00

  • A promising therapeutic target for psoriasis: Neuropeptides in human skin.

    abstract::Psoriasis is a chronic inflammatory skin disease featured by excessive proliferation of keratinocytes, clearly defined round erythema and dry, scaly plaques, long-term inflammatory cells infiltration in skin lesions. However, the physiopathological mechanism of psoriasis is still not clearly understood. Neuropeptides,...

    journal_title:International immunopharmacology

    pub_type: 杂志文章,评审


    authors: Zhang Y,Zhang H,Jiang B,Yan S,Lu J

    更新日期:2020-10-01 00:00:00

  • Impact of culture medium on CD4(+) CD25(high)CD127(lo/neg) Treg expansion for the purpose of clinical application.

    abstract::A recently discovered population of lymphocytes, called T regulatory cells (Tregs), is characterized by expression of transcription factor Forkhead box P3 (FoxP3). These cells have been successfully used as therapeutic treatments and prophylaxis for graft-versus-host disease (GVHD) and diabetes and might become an att...

    journal_title:International immunopharmacology

    pub_type: 杂志文章


    authors: Gołąb K,Krzystyniak A,Marek-Trzonkowska N,Misawa R,Wang LJ,Wang X,Cochet O,Tibudan M,Langa P,Millis JM,Trzonkowski P,Witkowski P

    更新日期:2013-07-01 00:00:00

  • Tear and serum MMP-9 and serum TIMPs levels in the severe sulfur mustard eye injured exposed patients.

    abstract:INTRODUCTION:Sulfur mustard (SM) intoxication produces local and systemic changes in the human body. In this study, the relationship between tear and serum matrix metalloproteinase (MMP)-9 and serum tissue inhibitors of metalloproteinases (TIMPs) are assessed in serious eye-injured SM-exposed casualties. METHODS:A gro...

    journal_title:International immunopharmacology

    pub_type: 杂志文章


    authors: Ghasemi H,Yaraee R,Faghihzadeh S,Ghassemi-Broumand M,Mahmoudi M,Babaei M,Naderi M,Safavi M,Ghazanfari Z,Rastin M,Zamani S,Tabasi N,Faghihzadeh E,Gharebaghi R,Hassan ZM,Mirsharif ES,Ghazanfari T

    更新日期:2019-12-01 00:00:00

  • Induction of MLR-Bf and protection of fetal loss: a current double blind randomized trial of paternal lymphocyte immunization for women with recurrent spontaneous abortion.

    abstract::The present study was conducted to evaluate the efficacy of paternal lymphocyte (PL) immunotherapy and its relation with the development of mixed lymphocyte reaction blocking antibodies (MLR-Bf) and the success of pregnancy outcome in women with recurrent spontaneous abortion (RSA). A total of 124 women with unknown c...

    journal_title:International immunopharmacology

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Pandey MK,Agrawal S

    更新日期:2004-02-01 00:00:00

  • ELISA measurement of specific antibodies to phosphorylated tau in intravenous immunoglobulin products.

    abstract::The therapeutic effects of intravenous immunoglobulin (IVIG) products were recently studied in Alzheimer's disease (AD) patients. Pilot studies produced encouraging results but phase II and III trials gave disappointing results; a further study is in progress. IVIG products contain antibodies to tau protein, the main ...

    journal_title:International immunopharmacology

    pub_type: 杂志文章


    authors: Loeffler DA,Klaver AC,Coffey MP

    更新日期:2015-10-01 00:00:00

  • Combined immunotherapy with dendritic cells and cytokine-induced killer cells for malignant tumors: a systematic review and meta-analysis.

    abstract:PURPOSE:A new strategy of adoptive and passive immunotherapy involves combining dendritic cells (DCs) with a subset of natural killer T lymphocytes termed cytokine-induced killer (CIK) cells. The objective of this systematic review and meta-analysis was to evaluate the safety and efficacy of DC-CIK therapy vs. placebo,...

    journal_title:International immunopharmacology

    pub_type: 杂志文章,meta分析,评审


    authors: Chen R,Deng X,Wu H,Peng P,Wen B,Li F,Li F

    更新日期:2014-10-01 00:00:00

  • Inhibition of inflammatory-molecule synthesis in THP-1 cells stimulated with phorbol 12-myristate 13-acetate by brefelamide derivatives.

    abstract::Plasma osteopontin (OPN) levels are elevated in tuberculosis patients and may involve granuloma formation. New inhibitors using brefelamide, an aromatic amide isolated from Dictyostelium cellular slime molds that may inhibit OPN transcription in A549 cells at 1 μM concentration, were synthesized as compounds C, D, and...

    journal_title:International immunopharmacology

    pub_type: 杂志文章


    authors: Bai G,Matsuba T,Kikuchi H,Chagan-Yasutan H,Motoda H,Ozuru R,Yamada O,Oshima Y,Hattori T

    更新日期:2019-10-01 00:00:00

  • Exosomes from high glucose-treated macrophages activate macrophages andinduce inflammatory responses via NF-κB signaling pathway in vitro and in vivo.

    abstract::There is increasing evidence that macrophages play an important role in the development and pathogenesis of diabetic nephropathy (DN) by secreting inflammatory cytokines. Exosomes are a family of extracellular vesicles that are secreted from almost all types of cells and associated with cell-to-cell communications. In...

    journal_title:International immunopharmacology

    pub_type: 杂志文章


    authors: Zhu M,Sun X,Qi X,Xia L,Wu Y

    更新日期:2020-07-01 00:00:00

  • Gene expression profiling of bovine mammary gland epithelial cells stimulated with lipoteichoic acid plus peptidoglycan from Staphylococcus aureus.

    abstract::A Gram-positive bacterium, Staphylococcus aureus is known to be one of the major pathogenic bacteria responsible for causing bovine mastitis. Among the various cell wall components of S. aureus, lipoteichoic acid (LTA) and peptidoglycan (PGN) are closely associated with inflammatory responses. However, the role of LTA...

    journal_title:International immunopharmacology

    pub_type: 杂志文章


    authors: Im J,Lee T,Jeon JH,Baik JE,Kim KW,Kang SS,Yun CH,Kim H,Han SH

    更新日期:2014-07-01 00:00:00

  • Immunological and protective effects of Bordetella bronchiseptica subunit vaccines based on the recombinant N-terminal domain of dermonecrotic toxin.

    abstract::Dermonecrotic toxin (DNT) produced by Bordetella bronchiseptica (B. bronchiseptica) can cause clinical turbinate atrophy in swine and induce dermonecrotic lesions in model mice. We know that the N-terminal of DNT molecule contains the receptor-binding domain, which facilitates binding to the target cells. However, we ...

    journal_title:International immunopharmacology

    pub_type: 杂志文章


    authors: Wang C,Liu L,Zhang Z,Yan Z,Yu C,Shao M,Jiang X,Chi S,Wei K,Zhu R

    更新日期:2015-10-01 00:00:00

  • Trans sodium crocetinate alleviates ischemia/reperfusion-induced myocardial oxidative stress and apoptosis via the SIRT3/FOXO3a/SOD2 signaling pathway.

    abstract::Trans sodium crocetinate (TSC) has been reported to exert a protective effect against cerebral ischemia/reperfusion (I/R) injury. However, whether TSC protects against myocardial ischemia/reperfusion (MI/R) injury remains unknown. Herein, we found that TSC treatment reduced myocardial infract size and elevated serum L...

    journal_title:International immunopharmacology

    pub_type: 杂志文章


    authors: Chang G,Chen Y,Zhang H,Zhou W

    更新日期:2019-06-01 00:00:00

  • Is macrophage polarization important in rheumatoid arthritis?

    abstract::Macrophages are myeloid immune cells which are strategically positioned throughout the body, where they engulf and degrade debris, dead cells, and foreign substances, and coordinating the inflammatory processes. Macrophages can be divided into two extreme subsets, classical activation (M1), and alternatively activatio...

    journal_title:International immunopharmacology

    pub_type: 杂志文章,评审


    authors: Wang Y,Han CC,Cui D,Li Y,Ma Y,Wei W

    更新日期:2017-09-01 00:00:00

  • Macrophage immunomodulatory activity of extracellular polysaccharide (PEP) of Antarctic bacterium Pseudoaltermonas sp.S-5.

    abstract::Antarctic bacteria are a novel source of polysaccharides which might have potential applications as biological response modifiers (BRM). A heteropolysaccharide (PEP) was isolated from the liquid culture broth of the Antarctic bacterium Pseudoaltermonas sp.S-5. PEP contained Mannose, Glucose, and Galactose in a ratio o...

    journal_title:International immunopharmacology

    pub_type: 杂志文章


    authors: Bai Y,Zhang P,Chen G,Cao J,Huang T,Chen K

    更新日期:2012-04-01 00:00:00

  • Molecular mechanisms of IgE mediated food allergy.

    abstract::The purpose of this review is to collate current knowledge and recent advances in molecular mechanism behind the immediate type hypersensitivity of foods. Food allergy is a growing concern of human health in developed as well as developing countries now days. Food allergic reactions are mostly IgE mediated and also kn...

    journal_title:International immunopharmacology

    pub_type: 杂志文章,评审


    authors: Kumar S,Verma AK,Das M,Dwivedi PD

    更新日期:2012-08-01 00:00:00

  • Adiponectin inhibits proliferation of vascular endothelial cells induced by Ox-LDL by promoting dephosphorylation of Caveolin-1 and depolymerization of eNOS and up-regulating release of NO.

    abstract::Oxidized low density lipoprotein (ox-LDL) can induce the proliferation and differentiation of endothelial cells, which is one of the important mechanisms of ox-LDL atherosclerosis. Adiponectin is an endogenous bioactive polypeptide secreted by adipocytes, it participates in the metabolism of fat and glucose. It has th...

    journal_title:International immunopharmacology

    pub_type: 杂志文章


    authors: Lu Y,Gao X,Wang R,Sun J,Guo B,Wei R,Jia Y

    更新日期:2019-08-01 00:00:00

  • Role of interleukin-23 as a biomarker in rheumatoid arthritis patients and its correlation with disease activity.

    abstract:BACKGROUND:IL-23 is a pro-inflammatory cytokine belonging to the IL-12 cytokine family. IL-23 is essential for the differentiation of Th17 lymphocytes, a subtype of T lymphocyte implicated in chronic inflammatory/autoimmune mediated diseases. Experimental models of arthritis and clinical indications have highlighted an...

    journal_title:International immunopharmacology

    pub_type: 杂志文章,评审


    authors: Zaky DS,El-Nahrery EM

    更新日期:2016-02-01 00:00:00

  • Naloxone can improve the anti-tumor immunity by reducing the CD4+CD25+Foxp3+ regulatory T cells in BALB/c mice.

    abstract::New strategies that stimulate cell-mediated immunity (CMI) against tumors and inhibit regulatory T cells are needed to improve the outcome of cancer immunotherapy. The aim of this study was to enhance the anti-tumor immunity of gp96 vaccine through naloxone administration. Therefore, we used BALB/c mouse model of fibr...

    journal_title:International immunopharmacology

    pub_type: 杂志文章


    authors: Molla Hassan AT,Hassan ZM,Moazzeni SM,Mostafaie A,Shahabi S,Ebtekar M,Hashemi SM

    更新日期:2009-11-01 00:00:00

  • Gypsophila elegans isoorientin attenuates CCl₄-induced hepatic fibrosis in rats via modulation of NF-κB and TGF-β1/Smad signaling pathways.

    abstract::The hepatoprotective effect of Gypsophila elegans isoorientin (GEI) was evaluated using a hepatic fibrosis model induced by CCl4 in rats. The results revealed that GEI significantly prevented CCl4-induced liver injury and fibrosis, as evidenced by the attenuation of histopathological changes, the decrease in serum ami...

    journal_title:International immunopharmacology

    pub_type: 杂志文章


    authors: Lin X,Chen Y,Lv S,Tan S,Zhang S,Huang R,Zhuo L,Liang S,Lu Z,Huang Q

    更新日期:2015-09-01 00:00:00

  • Interleukin-8 prevents oxidative stress-induced human endothelial cell senescence via telomerase activation.

    abstract::Senescence is an irreversible growth arrest which can be triggered by stresses such as oxidative reaction, telomere shortening, DNA damage, or oncogene signaling. Oxidative stress accelerates vascular endothelial cell senescence, and may promote atherosclerosis in humans. Interleukin-8 (IL-8) has been shown to play an...

    journal_title:International immunopharmacology

    pub_type: 杂志文章


    authors: Shen XH,Xu SJ,Jin CY,Ding F,Zhou YC,Fu GS

    更新日期:2013-06-01 00:00:00