当前位置： SCI文献检索 > INTERNATIONAL IMMUNOPHARMACOLOGY期刊下所有文献 > Overview of the current promising approaches for the development of an effective severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine.

Overview of the current promising approaches for the development of an effective severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine.

Abstract：

:Coronavirus disease 2019 (COVID-19) is a pandemic infectious disease caused by the novel coronavirus called SARS-CoV-2. There is a gap in our understanding regarding the immunopathogenesis of COVID-19. However, many clinical trials are underway across the world for screening effective drugs against COVID-19. Nevertheless, currently, no proven effective therapies for this virus exists. The vaccines are deemed as a significant part of disease prevention for emerging viral diseases, since, in several cases, other therapeutic choices are limited or non-existent, or that diseases result in such an accelerated clinical worsening that the efficacy of treatments is restricted. Therefore, effective vaccines against COVID-19 are urgently required to overcome the tremendous burden of mortality and morbidity correlated with SARS-CoV-2. In this review, we will describe the latest evidence regarding outstanding vaccine approaches and the challenges for vaccine production.

journal_name

Int Immunopharmacol

journal_title

International immunopharmacology

authors

Mirzaei R,Mohammadzadeh R,Mahdavi F,Badrzadeh F,Kazemi S,Ebrahimi M,Soltani F,Kazemi S,Jeda AS,Darvishmotevalli M,Yousefimashouf R,Keyvani H,Karampoor S

doi

10.1016/j.intimp.2020.106928

subject

Has Abstract

pub_date

2020-11-01 00:00:00

pages

106928

eissn

1567-5769

issn

1878-1705

pii

S1567-5769(20)32046-4

journal_volume

88

pub_type

杂志文章,评审

相关文献

INTERNATIONAL IMMUNOPHARMACOLOGY文献大全
  • STAT1 phosphorylation and cleavage is regulated by the histamine (H4) receptor in human atopic and non-atopic lymphocytes.

    abstract：:Histamine can modulate the balance between T helper lymphocytes 1 and 2 (Th1 and Th2), and there is evidence that allergic reactions can be associated with excessive histamine production causing shifts toward Th2 responses. As signal transduction in Th-cells is specifically correlated to signal transducer and activato...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2006.06.005

    authors： Horr B,Borck H,Thurmond R,Grösch S,Diel F

    更新日期：2006-10-01 00:00:00

  • Quercetin protects against perfluorooctanoic acid-induced liver injury by attenuating oxidative stress and inflammatory response in mice.

    abstract：:The aim of the present study was to investigate the protective effect of quercetin (Que) against perfluorooctanoic acid (PFOA)-induced liver injury in mice and its possible mechanisms of action. Mice were intragastrically administered PFOA (10mg/kg/day) alone or in combination with Que (75 mg/kg/day) for 14 consecutiv...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2015.05.043

    authors： Zou W,Liu W,Yang B,Wu L,Yang J,Zou T,Liu F,Xia L,Zhang D

    更新日期：2015-09-01 00:00:00

  • Icaritin exhibits anti-inflammatory effects in the mouse peritoneal macrophages and peritonitis model.

    abstract：:Icaritin, an intestinal metabolite of prenylflavonoids from Herba Epimedii, has been known to regulate many cellular processes. The purpose of this study was to investigate the protective effects of icaritin on inflammation in lipopolysaccharide (LPS) stimulated mouse peritoneal macrophages in vitro and zymosan induce...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2013.03.025

    authors： Lai X,Ye Y,Sun C,Huang X,Tang X,Zeng X,Yin P,Zeng Y

    更新日期：2013-05-01 00:00:00

  • Activation of a renin-angiotensin system in ischemic cardiac sympathetic nerve endings and its association with norepinephrine release.

    abstract：:We had reported that in the ischemic heart, locally formed bradykinin (BK) and angiotensin II (Ang II) activate B2- and AT1-receptors on sympathetic nerve terminals (SNE), promoting reversal of the norepinephrine (NE) transporter in an outward direction (i.e., carrier-mediated NE release). Although both BK and Ang II ...

    journal_title：International immunopharmacology

    pub_type： 杂志文章,评审

    doi：10.1016/s1567-5769(02)00148-0

    authors： Levi R,Silver RB,Mackins CJ,Seyedi N,Koyama M

    更新日期：2002-12-01 00:00:00

  • Neutralizing antibody production against Rebif® and ReciGen® in Relapsing-Remitting Multiple Sclerosis (RRMS) patients and its association with patient's disability.

    abstract：INTRODUCTION:Human recombinant interferon beta (IFN-β) is one of the first line treatments for Relapsing-Remitting Multiple Sclerosis (RRMS). However, the production of neutralizing antibodies (NAb) can impair its function. The aim of this study was to investigate the production of neutralizing antibodies against Rebif...

    journal_title：International immunopharmacology

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.intimp.2018.06.032

    authors： Shokrollahi Barough M,Ashtari F,Sadat Akhavi M,Asghari N,Mosayebi G,Mirmohammadkhani M,Kokhaei N,Bahraminia F,Ajami A,Kokhaei P

    更新日期：2018-09-01 00:00:00

  • Imbalanced expression of human Tim-1 and Tim-3 in peripheral blood mononuclear cells from immune thrombocytopenia patients.

    abstract：BACKGROUND:The T-cell immunoglobulin and mucin domain-(Tim)-1 molecule and Tim-3 are mainly expressed on activated T helper (Th) 2 and Th1 cells, respectively, and have been implicated in the pathogenesis of some autoimmune diseases. Immune thrombocytopenia (ITP) is a common autoimmune disorder, and the complex dysregu...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2013.12.025

    authors： Zhang XM,Shan NN,Sun M,Wang X,Feng XM,Liu X,Li Y,Yuan D,Ding M

    更新日期：2014-03-01 00:00:00

  • A novel chrysin thiazole derivative polarizes macrophages to an M1 phenotype via targeting TLR4.

    abstract：:Tumor-associated macrophages (TAMs) are an important cause of tumorigenesis and tumor development. M2 macrophages can promote tumor growth while M1 macrophages kill tumor cells, therefore, polarizing macrophages to achieve a functional M1 phenotype could effectively play its anti-tumor role. In the current study, we s...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2020.106986

    authors： Feng X,Yu W,Cao L,Meng F,Cong M

    更新日期：2020-11-01 00:00:00

  • Botulinum toxin as a novel addition to anti-arthritis armamentarium: an experimental study in rabbits.

    abstract：OBJECTIVE:This study aims to investigate the effects of intra-articular botulinum toxin. METHODS:Osteoarthritis was induced in both knees of 20 rabbits by transecting the anterior cruciate ligament under intramuscular anesthesia with ketamine and xylazine. Botulinum toxin, at a dose of 2.5 microg/ml (0.6 ml) and physi...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2006.07.020

    authors： Namazi H

    更新日期：2006-11-01 00:00:00

  • Analysis of cytokine release assay data using machine learning approaches.

    abstract：:The possible onset of Cytokine Release Syndrome (CRS) is an important consideration in the development of monoclonal antibody (mAb) therapeutics. In this study, several machine learning approaches are used to analyze CRS data. The analyzed data come from a human blood in vitro assay which was used to assess the potent...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2014.07.024

    authors： Xiong F,Janko M,Walker M,Makropoulos D,Weinstock D,Kam M,Hrebien L

    更新日期：2014-10-01 00:00:00

  • Cord blood-derived cytokine-induced killer cells biotherapy combined with second-line chemotherapy in the treatment of advanced solid malignancies.

    abstract：:This study investigated the efficacy of cord blood-derived cytokine-induced killer (CB-CIK) biotherapy combined with second-line chemotherapy in treating advanced solid malignancies after first-line chemotherapy failure. Forty patients with advanced solid malignancies after first-line chemotherapy failure were divided...

    journal_title：International immunopharmacology

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.intimp.2010.12.014

    authors： Niu Q,Wang W,Li Y,Qin S,Wang Y,Wan G,Guan J,Zhu W

    更新日期：2011-04-01 00:00:00

  • Ca2+ signalling of kinins in cells expressing rat, mouse and human B1/B2-receptor.

    abstract：:With respect to functional aspects, the kallikrein-kinin-system can be divided into a plasma kallikrein-kinin-system and a tissue kallikrein-kinin-system. At least four functional kinin peptides act via two different G-protein-coupled receptors, an inducible B1-receptor and a constitutively expressed B2-receptor. B1R ...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2007.10.001

    authors： Zubakova R,Gille A,Faussner A,Hilgenfeldt U

    更新日期：2008-02-01 00:00:00

  • Ellagic acid protects Lipopolysaccharide/D-galactosamine-induced acute hepatic injury in mice.

    abstract：:Ellagic acid, a natural polyphenol found in certain fruits, nuts and vegetables, has been reported to have anti-inflammatory, anti-tumor, and antioxidant activities. However, the effects of ellagic acid on acute hepatic injury have not been reported. In the present study, we investigated the effects of ellagic acid on...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2014.07.005

    authors： Gu L,Deng WS,Liu Y,Jiang CH,Sun LC,Sun XF,Xu Q,Zhou H

    更新日期：2014-10-01 00:00:00

  • Exosomes released from decidual macrophages deliver miR-153-3p, which inhibits trophoblastic biological behavior in unexplained recurrent spontaneous abortion.

    abstract：BACKGROUND:Spontaneous abortion is a common disease in human pregnancy. Increasing evidence suggests that proper function of trophoblasts and immune balance of the maternal-fetal interface are crucial for successful pregnancy. Macrophages are involved in the maternal-fetal immune microenvironment. However, mechanisms a...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2020.106981

    authors： Ying X,Jin X,Zhu Y,Liang M,Chang X,Zheng L

    更新日期：2020-11-01 00:00:00

  • Inhibitory effects of flavonoids extracted from Nepalese propolis on the LPS signaling pathway.

    abstract：:Flavonoids, particularly those derived from plants, harbor biological effects such as anti-inflammation and the inhibition of cancer progression. In the present study, we investigated the effects of 10 kinds of flavonoids isolated from Nepalese propolis on the LPS signaling pathway in order to clarify their anti-infla...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2016.10.008

    authors： Funakoshi-Tago M,Ohsawa K,Ishikawa T,Nakamura F,Ueda F,Narukawa Y,Kiuchi F,Tamura H,Tago K,Kasahara T

    更新日期：2016-11-01 00:00:00

  • Curcumin represses the activity of inhibitor-κB kinase in dextran sulfate sodium-induced colitis by S-nitrosylation.

    abstract：:In this study, we investigated the preventive effects of curcumin using dextran sulfate sodium (DSS)-induced colitis and the potential role of curcumin in regulation of anti-inflammation through S-nitrosylation. After curcumin treatment for 6days, the body weight and disease activity index of DSS-induced mice was alle...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2016.05.015

    authors： Kao NJ,Hu JY,Wu CS,Kong ZL

    更新日期：2016-09-01 00:00:00

  • Effects of RO27-3225 on neurogenesis, PDGFRβ+ cells and neuroinflammation after cerebral infarction.

    abstract：:Cerebral infarction causes severe social and economic burdens to patients due to its high morbidity and mortality rates, and the available treatments are limited. RO27-3225 is a highly selective melanocortin receptor 4 agonist that alleviates damage in many nervous system diseases, such as cerebral hemorrhage, traumat...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2020.106281

    authors： Zhang Y,Wang J,Zhang D,Lu Z,Man J

    更新日期：2020-04-01 00:00:00

  • Regulation on maturation and function of dendritic cells by Astragalus mongholicus polysaccharides.

    abstract：:Astragalus mongholicus polysaccharides(ASP) isolated from one of the Chinese herbs-A. mongholicus which are known to have a variety of immunomodulatory activity. However, little is known about their immunomodulatory effects on murine bone marrow (BM)-derived dendritic cells (DC). DC are professional antigen presenting...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2006.02.009

    authors： Shao P,Zhao LH,Zhi-Chen,Pan JP

    更新日期：2006-07-01 00:00:00

  • Glycyrrhizin regulates CD4+T cell response during liver fibrogenesis via JNK, ERK and PI3K/AKT pathway.

    abstract：:The aims of this study were to elucidate the immunomodulatory effects of glycyrrhizin (GL) on CD4(+)T cell responses during liver fibrogenesis. To obtain in vivo evidence about the effects of GL on CD4(+)T cells in livers and spleens of concanavalin A (ConA)-induced mouse model, mice were administrated with ConA toget...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2012.08.013

    authors： Tu CT,Li J,Wang FP,Li L,Wang JY,Jiang W

    更新日期：2012-12-01 00:00:00

  • Immune responses modulation by curcumin and allergen encapsulated into PLGA nanoparticles in mice model of rhinitis allergic through sublingual immunotherapy.

    abstract：:The purpose of this study was the combination of curcumin and ovalbumin in free form or encapsulated into PLGA NPs (polylactic co-glycolic acid nanoparticles) to enhance their sublingual immunotherapy (SLIT) efficiency in mouse model of rhinitis allergic. PLGA NPs containing curcumin (CUR), ovalbumin (OVA) or both wer...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2020.106525

    authors： Shahgordi S,Sankian M,Yazdani Y,Mashayekhi K,Hasan Ayati S,Sadeghi M,Saeidi M,Hashemi M

    更新日期：2020-07-01 00:00:00

  • Icariin targets Nrf2 signaling to inhibit microglia-mediated neuroinflammation.

    abstract：:Microglia-mediated neuroinflammation is an important contributor to the pathogenesis of neurodegenerative diseases. Inhibition of neuroinflammation has been proved to be effective in neurodegenerative diseases treatment. Nuclear factor erythroid 2 related factor 2 (Nrf2) is a key mediator of endogenous inducible defen...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2019.05.033

    authors： Zheng Y,Zhu G,He J,Wang G,Li D,Zhang F

    更新日期：2019-08-01 00:00:00

  • Osthole attenuates the development of carrageenan-induced lung inflammation in rats.

    abstract：:Osthole has been reported to possess a variety of pharmacological activities, such as antiinflammatory effect. In the present study, we have investigated the effect of osthole on lung inflammation associated with carrageenan-induced pleurisy in rats. The result showed that osthole could inhibit significantly pleural e...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2014.02.013

    authors： Li Z,Ji H,Song X,Hu J,Han N,Chen N

    更新日期：2014-05-01 00:00:00

  • Fosfomycin inhibits neutrophil function via a protein kinase C-dependent signaling pathway.

    abstract：:We investigated effects of fosfomycin (FOM) on neutrophil function, specifically the oxidative burst and adhesion molecule expression (CD11b/CD18, or MAC-1) using flow cytometry assay. Preincubation of polymorphonuclear leukocytes (PMNL) with FOM from 1 to 100 microg/ml prior to stimulation by phorbol 12-myristate 13-...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/s1567-5769(01)00194-1

    authors： Hamada M,Honda J,Yoshimuta T,Fumimori T,Okamoto M,Aizawa H

    更新日期：2002-03-01 00:00:00

  • Anti-inflammatory effects of phlorofucofuroeckol B-rich ethyl acetate fraction obtained from Myagropsis myagroides on lipopolysaccharide-stimulated RAW 264.7 cells and mouse edema.

    abstract：:Myagropsis myagroides has been used as a Chinese medicine and its extract has shown various biological activities, however, its anti-inflammatory mechanism remains unknown. In this study, we investigated the inhibitory effects of the ethyl acetate fraction of M. myagroides (EFM) on the production of inflammatory media...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2012.08.021

    authors： Joung EJ,Lee MS,Choi JW,Kim JS,Shin T,Jung BM,Kim JI,Kim HR

    更新日期：2012-12-01 00:00:00

  • Characterization of (2R, 3S)-2-([[4-(2-butynyloxy)phenyl]sulfonyl]amino)-N,3-dihydroxybutanamide, a potent and selective inhibitor of TNF-alpha converting enzyme.

    abstract：:TNF-alpha converting enzyme (TACE) is a validated therapeutic target for the development of oral tumor necrosis factor-alpha (TNF-alpha) inhibitors. Here we report the pre-clinical results and characterization of a selective and potent TACE inhibitor, (2R, 3S)-2-([[4-(2-butynyloxy)phenyl]sulfonyl]amino)-N,3-dihydroxyb...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2004.08.003

    authors： Zhang Y,Hegen M,Xu J,Keith JC Jr,Jin G,Du X,Cummons T,Sheppard BJ,Sun L,Zhu Y,Rao VR,Wang Q,Xu W,Cowling R,Nickerson-Nutter CL,Gibbons J,Skotnicki J,Lin LL,Levin J

    更新日期：2004-12-20 00:00:00

  • Stearoyl lysophosphatidylcholine prevents lipopolysaccharide-induced extracellular release of high mobility group box-1 through AMP-activated protein kinase activation.

    abstract：:Previous studies have suggested that stearoyl lysophosphatidlycholine (LPC) protects against lethal experimental sepsis by inhibiting lipopolysaccharide (LPS)-induced extracellular release of high-mobility group box 1 (HMGB1). However, limited information exists on the mechanism by which stearoyl-LPC suppresses the ex...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2015.07.010

    authors： Kim JM,Han HJ,Hur YH,Quan H,Kwak SH,Choi JI,Bae HB

    更新日期：2015-09-01 00:00:00

  • Chlorogenic acid ameliorated concanavalin A-induced hepatitis by suppression of Toll-like receptor 4 signaling in mice.

    abstract：:Chlorogenic acid (CGA), one of the most abundant dietary polyphenolic compounds, has been reported to exhibit anti-inflammatory ability. However, the hepatoprotective effects and molecular mechanisms of CGA on concanavalin A (Con A)-induced hepatitis have not been explored. In the present study, we found that pretreat...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2017.01.017

    authors： Yuan Y,Gong X,Zhang L,Jiang R,Yang J,Wang B,Wan J

    更新日期：2017-03-01 00:00:00

  • Angelan isolated from Angelica gigas Nakai induces dendritic cell maturation through toll-like receptor 4.

    abstract：:During the evolution of neoplastic diseases, dendritic cell (DC) functions are usually attenuated, and this presents a problem to DC-based immunotherapies against cancer. Here, we investigated the effects of angelan, an acidic polysaccharide isolated from Angelica gigas Nakai, on DC maturation. Angelan efficiently inc...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2006.08.017

    authors： Kim JY,Yoon YD,Ahn JM,Kang JS,Park SK,Lee K,Song KB,Kim HM,Han SB

    更新日期：2007-01-01 00:00:00

  • The role of kinins in the proliferation of fibroblast primed with TNF in scratch wound assay: Kinins and cell proliferation.

    abstract：:The aim of this study was to evaluate the involvement of both B1 and B2 kinins receptors (B1R and B2R) in the fibroblast proliferation induced by the cytokine tumour necrosis factor (TNF) attempting to establish an in vitro model of wound healing. Murine fibroblasts L-929 were cultivated in 24 wells plaque until total...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2018.09.036

    authors： França AJVBDV,De Faveri R,Nunes R,Steimbach VMB,Santin JR,Quintão NLM

    更新日期：2018-12-01 00:00:00

  • Morphological and functional analysis of beige (Chèdiak-Higashi syndrome) mouse mast cells with giant granules.

    abstract：:Chèdiak-Higashi syndrome is a rare autosomal recessive disease that causes hypopigmentation, recurrent infections, mild coagulation defects and neurological problems. Beige mice carry a mutation in the lysosome trafficking regulator (LYST) gene and display some of the key characteristics of human Chèdiak-Higashi syndr...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2019.01.053

    authors： Kiyoi T,Liu S,Sahid MNA,Shudou M,Ogasawara M,Mogi M,Maeyama K

    更新日期：2019-04-01 00:00:00

  • Immunological evaluation of colonic delivered Hepatitis B surface antigen loaded TLR-4 agonist modified solid fat nanoparticles.

    abstract：:Hepatitis B is one of the leading liver diseases and remains a major global health problem. Currently available vaccines provide protection but often results in weaker/minimal mucosal immunity. Thus the present study is devoted to the development and in-vivo exploration of the colonically delivered biomimetic nanopart...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2016.08.007

    authors： Sahu KK,Pandey RS

    更新日期：2016-10-01 00:00:00