Abstract：
:Osthole has been reported to possess a variety of pharmacological activities, such as antiinflammatory effect. In the present study, we have investigated the effect of osthole on lung inflammation associated with carrageenan-induced pleurisy in rats. The result showed that osthole could inhibit significantly pleural exudates formation and PMNs infiltration. Histological examination revealed osthole could reduce lung inflammation in rats treated with carrageenan. The myeloperoxidase (MPO) level was examined in pleural exudates. The result showed that osthole could attenuate MPO level in pleural exudates. Further studies showed osthole could decrease tumor necrosis factor alpha (TNF-α) and interleukin 1beta (IL-1β) levels in the lungs. Taken together, the present results suggested that osthole could inhibit lung inflammation on carrageenan-induced pleurisy in rats and that could be related to a reduction of PMNs infiltration and release of inflammatory factors.
journal_name
Int Immunopharmacoljournal_title
International immunopharmacologyauthors
Li Z,Ji H,Song X,Hu J,Han N,Chen Ndoi
10.1016/j.intimp.2014.02.013subject
Has Abstractpub_date
2014-05-01 00:00:00pages
33-6issue
1eissn
1567-5769issn
1878-1705pii
S1567-5769(14)00067-8journal_volume
20pub_type
杂志文章abstract：:Leaves of Passiflora alata Curtis were characterized for their antioxidant capacity. Antioxidant analyses of DPPH, FRAP, ABTS, ORAC and phenolic compounds were made in three different extracts: aqueous, methanol/acetone and ethanol. Aqueous extract was found to be the best solvent for recovery of phenolic compounds an...
journal_title：International immunopharmacology
pub_type： 杂志文章
doi：10.1016/j.intimp.2013.11.005
更新日期：2014-01-01 00:00:00
abstract：INTRODUCTION:Idiopathic membranous nephropathy (IMN) is a common cause of nephrotic syndrome in adults and one of the leading causes of end-stage renal disease (ESRD). During recent years, the incidence of IMN has been increasing. The main treatment option for IMN is the use of immunosuppressive (IS) drugs combined wit...
journal_title：International immunopharmacology
pub_type： 杂志文章,meta分析,评审
doi：10.1016/j.intimp.2019.03.002
更新日期：2019-05-01 00:00:00
abstract：:Endotoxin can stimulate inflammatory cytokine release from monocytes/macrophages and result in septic shock. Glycyrrhetinic acid (GA), the main bioactive component of licorice, possesses substantial anti-inflammatory activity. Here, we explored effect of 11-deoxy-18α-glycyrrhetinic acid-30-ethyl ester (DGAEE), a newly...
journal_title：International immunopharmacology
pub_type： 杂志文章
doi：10.1016/j.intimp.2015.09.025
更新日期：2015-12-01 00:00:00
abstract：:It is known that the tissue kallikrein-kinin system is located in the cardiac tissue, and the lack of this system in the cardiac tissue might induce cardiac dysfunctions. In this study, we investigated the potential role of tissue kallikrein and Trasylol, an inhibitor of tissue kallikrein, on survival time with acute ...
journal_title：International immunopharmacology
pub_type： 杂志文章
doi：10.1016/S1567-5769(02)00272-2
更新日期：2003-03-01 00:00:00
abstract：:Visfatin plays an important role in inflammatory and metabolic conditions. In this study, the effects of septic stress on the serum, white-adipose-tissue (WAT), and liver visfatin levels of male and female rats were examined. Both gonadally intact (sham) and ovariectomized (OVX) female rats were used in order to evalu...
journal_title：International immunopharmacology
pub_type： 杂志文章
doi：10.1016/j.intimp.2016.04.002
更新日期：2016-06-01 00:00:00
abstract：:PR domain zinc finger protein 1 (PRDM1)/B lymphocyte-induced maturation protein 1 (BLIMP1) is a transcriptional repressor involved in B and T cell responses which are implicated in chronic hepatitis B virus (HBV) infection and hepatocellular carcinoma (HCC). This study investigated the association of PRDM1 with clinic...
journal_title：International immunopharmacology
pub_type： 杂志文章
doi：10.1016/j.intimp.2019.05.012
更新日期：2019-08-01 00:00:00
abstract：:Regulatory T cells (Treg), formerly known as suppressor T cells, are essential for maintaining self-tolerance as well as immune homeostasis. Lack of Treg or normal function of Treg often leads to lymphoproliferative syndrome and autoimmunity in human and mouse. The chromatin remodeling BAF complex regulates gene expre...
journal_title：International immunopharmacology
pub_type： 杂志文章,评审
doi：10.1016/j.intimp.2009.01.019
更新日期：2009-05-01 00:00:00
abstract：OBJECTIVE:Ankylosing spondylitis (AS) is a disease characterized by inflammation of the sacroiliac joint and the attachment point of the spine. This study aimed to investigate the effect of microRNA (miR)-204-targeted GSDMD on fibroblast-like synoviocytes (FLSs) in AS. METHODS:miR-204, GSDMD, pyrolysis-related genes (...
journal_title：International immunopharmacology
pub_type： 杂志文章
doi：10.1016/j.intimp.2020.107227
更新日期：2021-02-01 00:00:00
abstract：:Atractylodin (ACD) possesses versatile biological and pharmacological activities, including antibacterial, anti-inflammatory and hepatoprotective properties. However, the protective effects of ACD on lipopolysaccharide (LPS) and d-galactosamine (GalN)-induced acute liver failure (ALF) as well as the underlying molecul...
journal_title：International immunopharmacology
pub_type： 杂志文章
doi：10.1016/j.intimp.2019.04.005
更新日期：2019-07-01 00:00:00
abstract：BACKGROUND:Development of agents that specifically kill cancer cells and simultaneously elicit antitumor immune response is a step forward in cancer therapy. In the present study, we investigated whether the administration of artemether contributes to the augmentation of antitumor immunity and the regression of tumor t...
journal_title：International immunopharmacology
pub_type： 杂志文章
doi：10.1016/j.intimp.2011.07.008
更新日期：2011-11-01 00:00:00
abstract：:Bronchial asthma is characterized by chronic lung inflammation, airway hyperresponsiveness (AHR), and airway remodeling. Astilbic acid, extracted from the medicinal herb Astilbe chinensis, is used as a headache remedy in traditional medicine and has anti-pyretic and analgesic effects. However, the effect of astilbic a...
journal_title：International immunopharmacology
pub_type： 杂志文章
doi：10.1016/j.intimp.2010.12.002
更新日期：2011-02-01 00:00:00
abstract：:The potentiation of the immune system in pregnant rats was performed with Complete Freund's Adjuvant [CFA; 20μl, subcutaneous at gestation day (GD) 18] in experimentally-induced hyperthyroidism by Levo-thyroxine (L-T4; 10μg/100g of b.w., intraperitoneal from GD 2 to 17). The potential effects on the fetal neuroendocri...
journal_title：International immunopharmacology
pub_type： 杂志文章
doi：10.1016/j.intimp.2015.09.004
更新日期：2015-12-01 00:00:00
abstract：:Endothelial cell (EC) activation and dysfunction have been linked to a wide variety of vascular inflammatory diseases. However, the role of microRNAs in EC activation and inflammation remains largely unknown. In this study, we found that miR-130b was significantly decreased in human umbilical vein endothelial cells (H...
journal_title：International immunopharmacology
pub_type： 杂志文章
doi：10.1016/j.intimp.2017.07.020
更新日期：2017-10-01 00:00:00
abstract：:To survey the immune regulatory function of recombinant human prolactin (rhPRL) and its potential application in adoptive immunotherapy, CB17-SCID mice were loaded with human colon adenocarcinoma HT-29 cells (5 x 10(5) cells/mouse, i.p.) 24 h before adoptive transfer with the purified human NK cells followed by rhPRL ...
journal_title：International immunopharmacology
pub_type： 杂志文章
doi：10.1016/j.intimp.2004.10.008
更新日期：2005-02-01 00:00:00
abstract：:The melanoma differentiation associated gene-7 (mda-7) cDNA was isolated by virtue of being induced during melanoma differentiation. Initial gene transfer studies convincingly demonstrated potent antitumor effects of mda-7. Further studies showed that the mechanism of antitumor activity was due to induction of apoptos...
journal_title：International immunopharmacology
pub_type： 杂志文章,评审
doi：10.1016/j.intimp.2004.01.017
更新日期：2004-05-01 00:00:00
abstract：:Thalidomide has been used in inflammatory and autoimmune disorders due to its anti-inflammatory activity. Paraquat (PQ) poisoning causes severe lung injury. PQ-induced pulmonary inflammation and fibrosis are due to its ability to induce oxidative stress, inflammatory and fibrotic reactions. This study was designed to ...
journal_title：International immunopharmacology
pub_type： 杂志文章
doi：10.1016/j.intimp.2013.06.005
更新日期：2013-10-01 00:00:00
abstract：:Interleukin 17 (IL-17) is a proinflammatory cytokine that acts as an immune checkpoint for several autoimmune diseases. Therapeutic neutralizing antibodies that target this cytokine have demonstrated clinical efficacy in psoriasis. However, biologics have limitations such as their high cost and their lack of oral bioa...
journal_title：International immunopharmacology
pub_type： 杂志文章
doi：10.1016/j.intimp.2020.107026
更新日期：2020-12-01 00:00:00
abstract：:The microbial community in the mucosal surfaces is involved in the development of human cancers, including gastric cancer and colorectal cancer. The respiratory tract in the lung also hosts a distinctive microbial community, but the correlation between this community and lung cancer is largely unknown. Here, we examin...
journal_title：International immunopharmacology
pub_type： 杂志文章
doi：10.1016/j.intimp.2017.09.024
更新日期：2017-11-01 00:00:00
abstract：:The present study reports the anti-mycobacterial activity of 2-hydroxy-3-(3-methyl-2-butenyl)-1,4-naphthoquinone (lapachol) as well as its influence on macrophage functions. Lapachol (L) did not induce apoptosis/necrosis of THP-1 macrophages at ≤32 μg/mL. Mycobacterium avium liquid growth was arrested by ≥32 μg/mL and...
journal_title：International immunopharmacology
pub_type： 杂志文章
doi：10.1016/j.intimp.2010.08.023
更新日期：2010-11-01 00:00:00
abstract：:Neutrophil apoptosis is a constitutive process that can be enhanced or delayed by various stimuli. In this study, the effect of brefeldin A (BFA), which affects the biological process of secretion, on constitutive and delayed apoptosis of neutrophils was investigated. Neutrophil apoptosis was determined after culturin...
journal_title：International immunopharmacology
pub_type： 杂志文章
doi：10.1016/S1567-5769(03)00052-3
更新日期：2003-06-01 00:00:00
abstract：:Cutaneous toxicities are the commonest side effects in patients with cancer treated using epidermal growth factor receptor inhibitors such as erlotinib. For patients with such toxicities, there is a lack of safe, effective pharmacological agents. Here we established a skin toxicity model and investigated the preventiv...
journal_title：International immunopharmacology
pub_type： 杂志文章
doi：10.1016/j.intimp.2019.01.023
更新日期：2019-04-01 00:00:00
abstract：:This study investigated apoptotic mechanisms of down-expression vascular endothelial growth factor (VEGF) by short interfering RNA (siRNA) in human breast cancer MCF-7 cells. Human breast cancer cells were evaluated for the expression of VEGF and VEGF receptor 2 (VEGFR-2). siRNA targeting VEGF mRNA were chemically syn...
journal_title：International immunopharmacology
pub_type： 杂志文章
doi：10.1016/j.intimp.2008.11.020
更新日期：2009-04-01 00:00:00
abstract：:We recently designed a series of N-[4-(t-amino-yl)-but-2-yn-1-yl] isoindoline-1,3-diones as anti-inflammatory compounds, called ZM compounds. These ZM compounds were categorized according to the nature of the cyclic amino groups into ZM2, ZM3, ZM4, and ZM5 and were shown to reduce carrageenan-induced inflammation, inh...
journal_title：International immunopharmacology
pub_type： 杂志文章
doi：10.1016/j.intimp.2012.07.016
更新日期：2012-11-01 00:00:00
abstract：:Treatment of asthma with corticosteroids results in downregulation of eosinophilic airway inflammation. We evaluated in vitro the activity of an "inhaled" corticosteroid, mometasone furoate (MF), and of a "systemic" corticosteroid, dexamethasone (DEX), on eosinophil functions, i.e. adhesion molecule expression and cel...
journal_title：International immunopharmacology
pub_type： 杂志文章
doi：10.1016/j.intimp.2004.07.029
更新日期：2004-12-15 00:00:00
abstract：:Streptococcus aureus (S. aureus)-induced acute lung injury (ALI) has a high incidence of mortality clinically. Glycyrrhizin (GL) is a traditional Chinese medicine for anti-inflammatory. However, the role of GL in S. aureus-induced ALI has not previously been elucidated. GL (25 mg/kg i.p.) administration exerts potent ...
journal_title：International immunopharmacology
pub_type： 杂志文章
doi：10.1016/j.intimp.2019.02.046
更新日期：2019-05-01 00:00:00
abstract：:Anti-nicotine vaccines comprise nicotine-like haptens conjugated to a carrier protein plus adjuvant(s). Unfortunately, those tested clinically have failed to improve overall long term quit rates. We had shown in mice that carrier, hapten, linker, hapten load (number of haptens per carrier molecule), aggregation and ad...
journal_title：International immunopharmacology
pub_type： 杂志文章
doi：10.1016/j.intimp.2015.09.012
更新日期：2015-12-01 00:00:00
abstract：:Oxidative stress, inflammation, and foam cell formation in vascular smooth muscle cells (VSMCs) are considered to play crucial roles in the pathogenesis of atherosclerosis. Poria cocos polysaccharides (PCP) has been shown to possess anti-inflammatory, antitumor and anti-oxidative properties. In this study we explored ...
journal_title：International immunopharmacology
pub_type： 杂志文章
doi：10.1016/j.intimp.2019.106173
更新日期：2020-03-01 00:00:00
abstract：:Previous studies demonstrated that annonaceous acetogenin (AA) was an antitumor drug with anti-angiogenic activity. However, the effect of AA on ocular neovascular disorders remains unclear. The aim of the present study is to explore the effect of AA092, an annonaceous acetogenin mimetic, on corneal neovascularization...
journal_title：International immunopharmacology
pub_type： 杂志文章
doi：10.1016/j.intimp.2015.08.009
更新日期：2015-10-01 00:00:00
abstract：:Acne is a common inflammatory skin disease with the dysregulation of innate and adaptive immunity. However, the underlying mechanism of acne has not been completely elucidated. In this study, we identified gene signatures and the immune-related regulatory network in acne using integrated bioinformatics methods. Here, ...
journal_title：International immunopharmacology
pub_type： 杂志文章
doi：10.1016/j.intimp.2020.107083
更新日期：2020-12-01 00:00:00
abstract：OBJECTIVE:Bone marrow mesenchymal stem cells (BMSCs)-derived exosomes have been widely applied in disease therapies. However, the role of BMSCs-derived exosomes in depression remains obscure. This study aims to explore the mechanism of BMSCs-derived exosomal microRNA-26a (miR-26a) on hippocampal neuronal injury of depr...
journal_title：International immunopharmacology
pub_type： 杂志文章
doi：10.1016/j.intimp.2020.106285
更新日期：2020-02-20 00:00:00
