当前位置： SCI文献检索 > INTERNATIONAL IMMUNOPHARMACOLOGY期刊下所有文献 > Anti-inflammatory effects of phlorofucofuroeckol B-rich ethyl acetate fraction obtained from Myagropsis myagroides on lipopolysaccharide-stimulated RAW 264.7 cells and mouse edema.

Anti-inflammatory effects of phlorofucofuroeckol B-rich ethyl acetate fraction obtained from Myagropsis myagroides on lipopolysaccharide-stimulated RAW 264.7 cells and mouse edema.

Abstract：

:Myagropsis myagroides has been used as a Chinese medicine and its extract has shown various biological activities, however, its anti-inflammatory mechanism remains unknown. In this study, we investigated the inhibitory effects of the ethyl acetate fraction of M. myagroides (EFM) on the production of inflammatory mediators and pro-inflammatory cytokines in lipopolysaccharides (LPS)-stimulated RAW 264.7 cells. EFM significantly inhibited LPS-induced production of nitric oxide (NO), prostaglandin E(2), and pro-inflammatory cytokines in a dose-dependent manner and suppressed the production of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 in RAW 264.7 cells. Inhibitory effect of EFM on iNOS expression and NO production was further confirmed using LPS-activated mouse peritoneal macrophages. EFM treatment strongly suppressed the activation of nuclear factor-kappa B (NF-κB) by suppressing phosphorylation of Akt and extracellular signal-regulated kinases (ERKs). EFM as well as phlorofucofuroeckol B (PFF-B), a major compound isolated from EFM, reduced ear edema induced by phorbol 12-myristate 13-acetate in mice. These results indicate that the anti-inflammatory effect of EFM, rich in PFF-B, on LPS-stimulated macrophages is regulated by the inhibition of NF-κB pathway through the inhibition of ERKs and Akt phosphorylation in LPS-stimulated macrophage cells.

journal_name

Int Immunopharmacol

journal_title

International immunopharmacology

authors

Joung EJ,Lee MS,Choi JW,Kim JS,Shin T,Jung BM,Kim JI,Kim HR

doi

10.1016/j.intimp.2012.08.021

subject

Has Abstract

pub_date

2012-12-01 00:00:00

pages

471-80

issue

4

eissn

1567-5769

issn

1878-1705

pii

S1567-5769(12)00263-9

journal_volume

14

pub_type

杂志文章

相关文献

INTERNATIONAL IMMUNOPHARMACOLOGY文献大全
  • Inhibition of COX-2 alleviates lumbar spinal stenosis-induced chronic mechanical allodynia in rats.

    abstract：:Chronic low back pain due to lumbar spinal stenosis (LSS) is common, costly, mechanistically complex, and clinically challenging. However, the factors and mechanisms causing and mediating chronic pain induced by cauda equina compression remain unclear. Here, we examined the role of cyclooxygenase (COX)-2 in infiltrate...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2019.105738

    authors： Lee JY,Choi HY,Park CS,Jang C,Lee KT,Lee JY,Youn I,Yune TY

    更新日期：2019-10-01 00:00:00

  • Mechanisms involved in the therapeutic effects of Paeonia lactiflora Pallas in rheumatoid arthritis.

    abstract：:Paeonia lactiflora Pallas, also named Chinese Paeony, is a Chinese herb. A decoction of its root has been used to treat painful or inflammatory disorders in traditional Chinese medicine. A water/ethanol extract of Radix Paeoniae is known as total glycosides of paeony (TGP), of which paeoniflorin is the major active co...

    journal_title：International immunopharmacology

    pub_type： 杂志文章,评审

    doi：10.1016/j.intimp.2012.06.001

    authors： Zhang W,Dai SM

    更新日期：2012-09-01 00:00:00

  • Alkylamides of Echinacea purpurea stimulate alveolar macrophage function in normal rats.

    abstract：:Echinacea plant extract is widely used for the prevention and the treatment of upper respiratory tract infections. However, the active components in the herb, their optimal dosages and their in vivo effects are still undefined. Using male Sprague-Dawley rats (425-475 g), an in vivo study was conducted to examine the i...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/s1567-5769(01)00163-1

    authors： Goel V,Chang C,Slama JV,Barton R,Bauer R,Gahler R,Basu TK

    更新日期：2002-02-01 00:00:00

  • Progesterone as an immunomodulatory molecule.

    abstract：:Increased progesterone sensitivity of pregnancy lymphocytes is due to activation-induced appearance of progesterone binding sites in the lymphocytes. Following recognition of fetally derived antigens gamma/delta TCR+ cells develop progesterone receptors. Progesterone binding results in the synthesis of a mediator prot...

    journal_title：International immunopharmacology

    pub_type： 杂志文章,评审

    doi：10.1016/s1567-5769(01)00035-2

    authors： Szekeres-Bartho J,Barakonyi A,Par G,Polgar B,Palkovics T,Szereday L

    更新日期：2001-06-01 00:00:00

  • Baicalein attenuates the neuroinflammation in LPS-activated BV-2 microglial cells through suppression of pro-inflammatory cytokines, COX2/NF-κB expressions and regulation of metabolic abnormality.

    abstract：:Baicalein (5,6,7-trihydroxyflavone), isolated from the root of traditional Chinese herb Scutellaria baicalensis Georgi, has anti-inflammatory and anti-oxidative activities. This study explored the protective and modulatory mechanisms of baicalein on neuroinflammation, oxidative stress and metabolic abnormality in lipo...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2019.106092

    authors： Yan JJ,Du GH,Qin XM,Gao L

    更新日期：2020-02-01 00:00:00

  • Characterization of the molecular structure, expression and bioactivity of the TNFSF13B (BAFF) gene of the South African clawed frog, Xenopus laevis.

    abstract：:B cell activating factor (BAFF), a member of the tumor necrosis factor family, is critical to B cell survival, proliferation, maturation, and immunoglobulin secretion and to T cell activation. In the present study, the full-length cDNA of BAFF from the South African clawed frog (Xenopus laevis, designated xlBAFF) was ...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2013.02.006

    authors： Yang L,Zhou L,Zong X,Cao X,Ji X,Gu W,Zhang S

    更新日期：2013-03-01 00:00:00

  • Preventive effect of Diallyl Trisulfide on cutaneous toxicities induced by EGFR inhibitor.

    abstract：:Cutaneous toxicities are the commonest side effects in patients with cancer treated using epidermal growth factor receptor inhibitors such as erlotinib. For patients with such toxicities, there is a lack of safe, effective pharmacological agents. Here we established a skin toxicity model and investigated the preventiv...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2019.01.023

    authors： Liu Y,Jiang X,Gu Y,Chen Y

    更新日期：2019-04-01 00:00:00

  • Suppression of NLRP3 and NF-κB signaling pathways by α-Cyperone via activating SIRT1 contributes to attenuation of LPS-induced acute lung injury in mice.

    abstract：:α-Cyperone is the volatile oil component in Cyperus rotundus L. The previous reports had shown the inhibition of α-Cyperone on NF-κB signaling in LPS-stimulated RAW264.7 cells. However, it is still unclear whether α-Cyperone could suppress inflammatory response in acute lung injury (ALI) induced by LPS. The aim of thi...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2019.105886

    authors： Liu X,Jin X,Yu D,Liu G

    更新日期：2019-11-01 00:00:00

  • Stimulatory effect of antidepressants on the production of IL-6.

    abstract：:A body of evidence indicates that the therapeutic activity of antidepressants is connected with their modulatory effect on the inflammatory response system and cell-mediated immunity. The present study was carried out to examine the effects of antidepressant agents, such as imipramne, venlafaxine, l-5-hydroxytryptopha...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2003.11.006

    authors： Kubera M,Kenis G,Bosmans E,Kajta M,Basta-Kaim A,Scharpe S,Budziszewska B,Maes M

    更新日期：2004-02-01 00:00:00

  • TLR2 and TLR4 expression after kidney ischemia and reperfusion injury in mice treated with FTY720.

    abstract：:Ischemia and reperfusion injury (IR) is an antigen independent inflammatory process that causes tissue damage. After IR, kidneys up-regulate leukocyte adhesion molecules and toll-like receptors (TLRs). Moreover, injured kidneys can also secrete factors (i.e. heat shock protein) which bind to TLRs and trigger intracell...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2011.04.014

    authors： Pedregosa JF,Haidar AA,Hirata AE,Franco M,Gomes GN,Bueno V

    更新日期：2011-09-01 00:00:00

  • Identification of integrative molecular and clinical profiles of Fibrinogen-like protein 2 in gliomas using 1323 samples.

    abstract：BACKGROUND:Fibrinogen-like protein 2 (FGL2), a member of the fibrinogen superfamily, has been described to augment immunosuppression in gliomas. However, the precise clinical molecular features and the prognostic relevance of FGL2 in gliomas remain unclear. Therefore, a comprehensive analysis of the role of FGL2 in gli...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2020.106894

    authors： Song Z,Wang Y,Du Y,Zhang Z,Yuan Y

    更新日期：2020-11-01 00:00:00

  • The effects of H1-antihistamines on the nitric oxide production by RAW 264.7 cells with respect to their lipophilicity.

    abstract：:H1-antihistamines are known to be important modulators of inflammatory response. However, the information about the influence of these drugs on reactive nitrogen species generation is still controversial. The main aim of the present study was to investigate the effects of selected H1-antihistamines on nitric oxide pro...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2009.04.005

    authors： Králová J,Racková L,Pekarová M,Kubala L,Nosál R,Jancinová V,Cíz M,Lojek A

    更新日期：2009-07-01 00:00:00

  • Accelerated differentiation of bone marrow-derived dendritic cells in atopic prone mice.

    abstract：:NC/Nga mice are atopic prone mice that can be an animal model for human atopic dermatitis (AD). Dendritic cells (DC) as professional antigen-presenting cells (APC) are the most capable inducers of immune responses. The present study using BALB/c, C57BL/6J, and NC/Nga male mice investigated whether differentiation and ...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2008.08.006

    authors： Koike E,Takano H,Inoue K,Yanagisawa R

    更新日期：2008-12-20 00:00:00

  • Risperidone modulates the cytokine and chemokine release of dendritic cells and induces TNF-α-directed cell apoptosis in neutrophils.

    abstract：:Antipsychotic drugs (APDs) that bind mainly to the dopamine D2 receptor or the type II 5-HT receptor have been used to ease the symptoms of schizophrenia. Several studies have reported that APDs can also regulate the immune response. Dendritic cells (DCs) are the major antigen-presenting cells in the immune system. DC...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2011.11.011

    authors： Chen ML,Tsai TC,Wang LK,Lin YY,Tsai YM,Lee MC,Tsai FM

    更新日期：2012-01-01 00:00:00

  • Characterization and immunostimulatory activity of an (1-->6)-a-D-glucan from the root of Ipomoea batatas.

    abstract：:The polysaccharide PSPP (purified sweet potato polysaccharide), isolated and purified from the roots of Ipomoea batatas, was found to be a glucan with a molecular weight of 53.2 kDa and specific rotation of +115.0 degrees (ca. 0.80, H(2)O). On the basis of methylation analysis, periodate oxidation, Smith degradation, ...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2005.03.012

    authors： Zhao G,Kan J,Li Z,Chen Z

    更新日期：2005-08-01 00:00:00

  • Albizia lebbeck suppresses histamine signaling by the inhibition of histamine H1 receptor and histidine decarboxylase gene transcriptions.

    abstract：:Histamine plays major roles in allergic diseases and its action is mediated mainly by histamine H(1) receptor (H1R). We have demonstrated that histamine signaling-related H1R and histidine decarboxylase (HDC) genes are allergic diseases sensitive genes and their expression level affects severity of the allergic sympto...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2011.07.003

    authors： Nurul IM,Mizuguchi H,Shahriar M,Venkatesh P,Maeyama K,Mukherjee PK,Hattori M,Choudhuri MS,Takeda N,Fukui H

    更新日期：2011-11-01 00:00:00

  • Changes in maternal and fetal nicotine distribution after maternal administration of monoclonal nicotine-specific antibody to rats.

    abstract：:Vaccination against nicotine to elicit the production of nicotine-specific antibodies is a potential treatment for tobacco addiction which reduces nicotine distribution from serum to brain. Vaccination of pregnant rats also reduces the distribution of maternally-administered nicotine to the fetal brain. Whether this i...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2006.06.013

    authors： Keyler DE,Lesage MG,Dufek MB,Pentel PR

    更新日期：2006-11-01 00:00:00

  • Administration of a vaccine composed of dendritic cells pulsed with premalignant oral lesion lysate to mice bearing carcinogen-induced premalignant oral lesions stimulates a protective immune response.

    abstract：:The use of dendritic cell (DC) vaccines as treatment for malignancy is complicated by immune evasion tactics often employed by carcinomas such as head and neck squamous cell carcinoma (HNSCC). The present study aims to determine if an immune response can be elicited by administering a DC vaccine during the premalignan...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2012.05.004

    authors： De Costa AM,Justis DN,Schuyler CA,Young MR

    更新日期：2012-07-01 00:00:00

  • Immunomodulatory activity of analog of muramyl dipeptide and their use as adjunct to chemotherapy of Leishmania donovani in hamster.

    abstract：:In search of a potent immunomodulator to be used as an immunoprophylactic agent and as adjunct to chemotherapy against Leishmania infection, two analogs of muramyl dipeptide, viz. N.Ac-norMur-MeVal-D-isoGln (86/448) and N.AcMur-Acc-D-isoGln (89/729) were evaluated for desired activity. Effect of these peptides on cell...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2004.12.015

    authors： Puri A,Sahai R,Haq W,Zaidi A,Guru PY,Tripathi LM,Srivastava VM

    更新日期：2005-06-01 00:00:00

  • Nicotine modulation of apoptosis in human coronary artery endothelial cells.

    abstract：:It has been recently reported that nicotine, the addictive component of tobacco, is an important modulator at the level of immune cell apoptosis or programmed cell death. Apoptosis is a process that helps maintain the homeostasis of the vascular endothelium and vascular smooth muscle cells, and alteration of the apopt...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/s1567-5769(02)00059-0

    authors： Hakki A,Friedman H,Pross S

    更新日期：2002-09-01 00:00:00

  • Anti-inflammatory effects of novel barbituric acid derivatives in T lymphocytes.

    abstract：:We have used a high throughput small molecule screen, using a fission yeast-based assay, to identify novel phosphodiesterase 7 (PDE7) inhibitors. One of the most effective hit compounds was BC12, a barbituric acid-based molecule that exhibits unusually potent immunosuppressive and immunomodulatory actions on T lymphoc...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2016.06.004

    authors： Xu C,Wyman AR,Alaamery MA,Argueta SA,Ivey FD,Meyers JA,Lerner A,Burdo TH,Connolly T,Hoffman CS,Chiles TC

    更新日期：2016-09-01 00:00:00

  • Metformin attenuated endotoxin-induced acute myocarditis via activating AMPK.

    abstract：:Metformin is a widely used anti-diabetic drug and increasing evidence suggests that metformin have profound cardioprotective effects under both diabetic and non-diabetic situations. The protective benefits of metformin have been proved in diabetic patients with cardiovascular complications and in experimental animals ...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2017.04.002

    authors： Liu G,Wu K,Zhang L,Dai J,Huang W,Lin L,Ge P,Luo F,Lei H

    更新日期：2017-06-01 00:00:00

  • Inhibitory effect of chaga mushroom extract on compound 48/80-induced anaphylactic shock and IgE production in mice.

    abstract：:Chaga mushrooms (Inonotus obliquus) are hypothesised to exhibit general immune-potentiating, anti-inflammatory, and antitumor properties, but their anti-allergic activities are not fully understood. Therefore, this study investigated whether a chaga mushroom extract (C-HE) might have anti-allergic activity. This activ...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2013.03.015

    authors： Yoon TJ,Lee SJ,Kim EY,Cho EH,Kang TB,Yu KW,Suh HJ

    更新日期：2013-04-01 00:00:00

  • Pinocembrin attenuates allergic airway inflammation via inhibition of NF-κB pathway in mice.

    abstract：:Pinocembrin, one of the primary flavonoids in propolis, possesses many biological activities, including anti-inflammation, anti-oxidation and immunoregulation. This study aimed to evaluate whether pinocembrin could attenuate ovalbumin (OVA)-induced allergic airway inflammation in mice and to explore the possible mecha...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2017.10.005

    authors： Gu X,Zhang Q,Du Q,Shen H,Zhu Z

    更新日期：2017-12-01 00:00:00

  • Comparison of peripheral blood B cell subset ratios and B cell-related cytokine levels between ocular and generalized myasthenia gravis.

    abstract：BACKGROUND:The pathogenesis of myasthenia gravis (MG) depends upon T and B cells, as well as complement and cytokines. The activation of functional subpopulations of T and B cells is the basis of the immune response. However, the activation levels of T and B cell subsets remain unclear in the pathogenesis of MG. Here, ...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2019.106130

    authors： Hu Y,Wang J,Rao J,Xu X,Cheng Y,Yan L,Wu Y,Wu N,Wu X

    更新日期：2020-03-01 00:00:00

  • Cudratricusxanthone A from Cudrania tricuspidata suppresses pro-inflammatory mediators through expression of anti-inflammatory heme oxygenase-1 in RAW264.7 macrophages.

    abstract：:Cudratricusxanthone A (CTXA), isolated from the roots of Cudrania tricuspidata Bureau (Moraceae) has an isoprenylated xanthone skeleton that is known to exert a variety of biological activities. In the present study, we demonstrated that CTXA inhibited cyclooxygenase-2 (COX-2) and inducible nitric oxide (NO) synthase ...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2008.11.008

    authors： Jeong GS,Lee DS,Kim YC

    更新日期：2009-02-01 00:00:00

  • Suppression of lipopolysaccharide-stimulated inducible nitric oxide synthase (iNOS) expression by a novel humulene derivative in macrophage cells.

    abstract：:In our previous study, we reported the isolation of a novel humulene derivative, 5-hydroxyzerumbone, from Zingiber zerumbet and its inhibitory activity on lipopolysaccharide (LPS)-induced nitric oxide (NO) production in RAW 264.7 mouse macrophage cells. This study was performed to examine its mechanism of action on th...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2009.03.005

    authors： Min HY,Kim MS,Jang DS,Park EJ,Seo EK,Lee SK

    更新日期：2009-07-01 00:00:00

  • Adenovirus-mediated transduction with Histone Deacetylase 4 ameliorates disease progression in an osteoarthritis rat model.

    abstract：BACKGROUND:Downregulation of histone deacetylase-4 (HDAC4) contributes to cartilage degeneration in osteoarthritis (OA) because it promotes upregulation of runt-related transcription factor-2 (Runx-2) and osteoarthritis-related genes. The effect of HDAC4 upregulation on cartilage damage in OA remains unknown. METHODS:...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2019.105752

    authors： Gu XD,Wei L,Li PC,Che XD,Zhao RP,Han PF,Lu JG,Wei XC

    更新日期：2019-10-01 00:00:00

  • IL-7R gene variants are associated with breast cancer susceptibility in Chinese Han women.

    abstract：BACKGROUND:Interleukin 7 receptor (IL-7R) is a member of the type I cytokine receptor family, which affects the occurrence of various tumors by forming a signaling complex with its ligand Interleukin 7 (IL-7). This study aimed to explore the potential relationships of IL-7R polymorphisms with breast cancer susceptibili...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2020.106756

    authors： Wang Z,Wang X,Gao Y,Wang Y,Xu M,Han Q,Zhao X

    更新日期：2020-09-01 00:00:00

  • Human bone mesenchymal stem cells-derived exosomes overexpressing microRNA-26a-5p alleviate osteoarthritis via down-regulation of PTGS2.

    abstract：:Osteoarthritis (OA) is a degenerative disease characterized by synovium inflammation and articular cartilage damage. The aberrant expression profile of microRNAs (miRNAs) has been implicated in the cartilage of patients with OA. However, how microRNAs carried by exosomes derived from mesenchymal stem cells (MSCs) asso...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2019.105946

    authors： Jin Z,Ren J,Qi S

    更新日期：2020-01-01 00:00:00