Cord blood-derived cytokine-induced killer cells biotherapy combined with second-line chemotherapy in the treatment of advanced solid malignancies.

abstract：:Microglial inflammation induced by ischemic stroke aggravates brain damage. MicroRNAs (miRNAs) have emerged as pivotal regulators in ischemic stroke-induced inflammation in microglial cells. miR-665-3p has been reported as a critical inflammation-associated miRNA. However, whether miR-665-3p participates in regulating...

journal_title：International immunopharmacology

authors： Zhang X,Feng Y,Li J,Zheng L,Shao Y,Zhu F,Sun X

更新日期：2020-08-01 00:00:00

abstract：BACKGROUNDS:Autoimmune myocarditis is characterized by over-activated immune system attacking the cardiomyocytes, resulting in heart function decline. In the current study, we investigated the therapeutic advantages of delivering Interleukin-10 (IL-10) by mesenchymal stem cells (MSCs), both of which had immune suppress...

journal_title：International immunopharmacology

authors： Shao M,Wang D,Zhou Y,Du K,Liu W

更新日期：2020-04-01 00:00:00

abstract：:Rubi Fructus, a traditional Chinese medicine, was considered as an anti-inflammatory agent in folk medicine. In the present study, we investigated the signalling pathways involved in the anti-inflammatory effects of goshonoside-F5 (GF5), isolated from Rubi Fructus, in peritoneal macrophages and examined its therapeuti...

journal_title：International immunopharmacology

authors： He JM,Chen SC,Li RP,Yuan LX,Bao JM,Guo ML

更新日期：2015-02-01 00:00:00

abstract：:We studied the suitability of our murine model for the treatment trials of atopic dermatitis (AD). In this model topical application of ovalbumin (OVA) together with bacterial superantigen, staphylococcal enterotoxin B (SEB) induces a cutaneous disease resembling AD. Injured mouse skin was treated with three different...

journal_title：International immunopharmacology

authors： Lehto M,Savinko T,Wolff H,Kvist PH,Kemp K,Lauerma A,Alenius H

更新日期：2010-04-01 00:00:00

abstract：OBJECTIVE:The activities of tumor-infiltrating immune cells (TIICs) play an important role in the outcomes of many types of cancers. Here, we sought to describe the landscape of TIICs in testicular germ cell tumors (TGCT) and to develop a prognostic model based on this information. METHODS:The Cell-type Identification...

journal_title：International immunopharmacology

authors： Wang Y,Ji C,Liu J,Wang Y,Song N,Cao P

更新日期：2020-09-01 00:00:00

abstract：:We can now declare that the clinical goal of immune intervention as a therapeutic strategy for neoplastic, infectious, autoimmune and inflammatory diseases, has been achieved and in many instances obtained regulatory approval. Although, interest in and optimism for this approach has fluctuated, in the last 20years, im...

journal_title：International immunopharmacology

authors： Talmadge JE

更新日期：2016-08-01 00:00:00

abstract：:Phospholipase C (PLC)gamma and phospholipase D (PLD) play pivotal roles in the signal transduction required for various cellular responses, including cell proliferation and differentiation. Dendritic cells (DCs), which are professional antigen-presenting cells, can be generated from human monocytes by stimulating the ...

journal_title：International immunopharmacology

authors： Kang HK,Lee HY,Lee YN,Jo EJ,Kim JI,Kim GY,Park YM,Min DS,Yano A,Kwak JY,Bae YS

更新日期：2004-07-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is an aggressive disease with poor prognosis and limited methods to predict patient survival. Immune cells infiltrating tumors are known to impact tumor progression. Here, we analyzed the phenotype and function of dendritic cells (DCs), and the frequency of IL-10-producing regulatory B c...

journal_title：International immunopharmacology

authors： Song S,Yuan P,Li P,Wu H,Lu J,Wei W

更新日期：2014-10-01 00:00:00

abstract：:Oxidative stress, inflammation, and foam cell formation in vascular smooth muscle cells (VSMCs) are considered to play crucial roles in the pathogenesis of atherosclerosis. Poria cocos polysaccharides (PCP) has been shown to possess anti-inflammatory, antitumor and anti-oxidative properties. In this study we explored ...

journal_title：International immunopharmacology

authors： Zhao J,Niu X,Yu J,Xiao X,Li W,Zang L,Hu Z,Siu-Po Ip P,Li W

更新日期：2020-03-01 00:00:00

abstract：:Myagropsis myagroides has been used as a Chinese medicine and its extract has shown various biological activities, however, its anti-inflammatory mechanism remains unknown. In this study, we investigated the inhibitory effects of the ethyl acetate fraction of M. myagroides (EFM) on the production of inflammatory media...

journal_title：International immunopharmacology

authors： Joung EJ,Lee MS,Choi JW,Kim JS,Shin T,Jung BM,Kim JI,Kim HR

更新日期：2012-12-01 00:00:00

abstract：:We investigated whether Candida beta-D-glucan (CSBG) alters the maturation of dendritic cells (DCs). DC phenotypes were analyzed using FACScan. The expression of surface molecules, including major histocompatibility complex (MHC) classes I and II, as well as CD80 and CD86, increased on DCs that were stimulated with li...

journal_title：International immunopharmacology

authors： Kikuchi T,Ohno N,Ohno T

更新日期：2002-09-01 00:00:00

abstract：:The opioid peptide methionine-enkephalin (MENK) has significant immunomodulatory ability in addition to its neurotransmitter function. Since neutral endopeptidase (NEP, CD10, enkephalinase EC 3.4.24.11) cleaves opioid peptides, the presence and activity of NEP in neutrophils from different persons might be responsible...

journal_title：International immunopharmacology

authors： Balog T,Marotti T,Abramić M,Beusan-Svoboda I,Sobocanec S,Hrsak I

更新日期：2001-03-01 00:00:00

abstract：:Understanding of oligodendrocyte precursor cells and their role in the generation of oligodendrocytes in developing and adult rodents has been considered, particularly much less is known about aged-rodent oligodendrocyte precursor cells and their cell lineage. In this present study, we have developed oligodendrocyte c...

journal_title：International immunopharmacology

authors： Kobayashi J,Seiwa C,Sakai T,Gotoh M,Komatsu Y,Yamamoto M,Fukutake M,Matsuno K,Sakurai Y,Kawano Y,Asou H

更新日期：2003-07-01 00:00:00

abstract：:A series of nitro substituted benzamide derivatives were synthesized and evaluated for their potential anti-inflammatory activities in vitro. Firstly, all compounds (1-6) were screened for their inhibitory capacity on LPS induced nitric oxide (NO) production in RAW264.7 macrophages. Compounds 5 and 6 demonstrated sign...

journal_title：International immunopharmacology

authors： Tumer TB,Onder FC,Ipek H,Gungor T,Savranoglu S,Tok TT,Celik A,Ay M

更新日期：2017-02-01 00:00:00

abstract：:Suberoylanilide hydroxamic acid (SAHA), a histone deacetylase inhibitor, has been proven to be an anti-cancer agent. Its anti-inflammatory activities have recently been observed both in in vitro and in vivo models. Yet its action on lymphocytes and the underlying mechanism are still not well known. In this study, in o...

journal_title：International immunopharmacology

authors： Shi ZJ,Ouyang DY,Zhu JS,Xu LH,He XH

更新日期：2012-04-01 00:00:00

abstract：:1,25-dihydroxyvitaminD3 [1,25(OH)2D3] modulates both the innate and adaptive immunity in tuberculosis. We explored the effect of 1,25(OH)2D3 on cytolytic molecules like perforin, granulysin, and granzyme-B in T-cells and natural killer cells during M. tuberculosis (Mtb) infection. Peripheral blood mononuclear cells (P...

journal_title：International immunopharmacology

authors： Afsal K,Selvaraj P,Harishankar M

更新日期：2018-09-01 00:00:00

abstract：:NC/Nga mice are atopic prone mice that can be an animal model for human atopic dermatitis (AD). Dendritic cells (DC) as professional antigen-presenting cells (APC) are the most capable inducers of immune responses. The present study using BALB/c, C57BL/6J, and NC/Nga male mice investigated whether differentiation and ...

journal_title：International immunopharmacology

authors： Koike E,Takano H,Inoue K,Yanagisawa R

更新日期：2008-12-20 00:00:00

abstract：:Resveratrol is an anticancer phytochemical polyphenol isolated from a natural origin, without any significant side effects. Resveratrol was investigated in immunocompetent mice with regards to its possible effect on lung cancer metastasis. Cytotoxicity was assessed in three melanoma cell lines (B16F10, B6, and A375) b...

journal_title：International immunopharmacology

authors： Davoodvandi A,Darvish M,Borran S,Nejati M,Mazaheri S,Reza Tamtaji O,Hamblin MR,Masoudian N,Mirzaei H

更新日期：2020-11-01 00:00:00

abstract：:Delvestidine (DLTD) is a monomeric compound isolated from Aconitum leucostomum Worosch, a widely used medicine for local treatment of rheumatoid arthritis (RA). Studies have shown that Aconitum leucostomum Worosch. can inhibit maturation of bone marrow-derived dendritic cells (BMDCs). Further, microRNAs (miRNAs) have ...

journal_title：International immunopharmacology

authors： Wang YY,Liu HZ,Cao M,Wang XL,Cong S,Sun J,Jia BT,Ta-Bu-Shi NE,Bian YH,Luo L

更新日期：2020-11-01 00:00:00

abstract：:Despite the use of increasingly specific immunosuppressive therapy, rejection remains the leading cause of death in cardiac transplant patients. Endomyocardial biopsy (EMB) is the gold standard for early detection and monitoring of cardiac transplant rejection. However, this approach is invasive and not suitable for r...

journal_title：International immunopharmacology

authors： Zupan I,Vrtovec B,Breskvar UD,Gabrijelcic T

更新日期：2005-01-01 00:00:00

abstract：:Lung cancer is the leading reason of cancer-related death from cancer globally for both men and women. Recently, tumor immune heterogeneity has been implicated in cancer clinical outcome. However, this prognostic significance of immune cell types in lung squamous cell carcinoma (LUSC) is unclear and should be systemat...

journal_title：International immunopharmacology

authors： Xu F,Zhang H,Chen J,Lin L,Chen Y

更新日期：2020-04-01 00:00:00

abstract：:Salicylic acid (aspirin) is a widely used pharmacological agent with immunodmodulatory properties. Dendritic cells are key regulators of the immune response, and are capable of inducing hyporesponsiveness and regulatory activity in CD4+ T-cells. We have demonstrated that aspirin-treated dendritic cells are effective a...

journal_title：International immunopharmacology

authors： Buckland M,Jago C,Fazekesova H,George A,Lechler R,Lombardi G

更新日期：2006-12-20 00:00:00

abstract：:We have used a high throughput small molecule screen, using a fission yeast-based assay, to identify novel phosphodiesterase 7 (PDE7) inhibitors. One of the most effective hit compounds was BC12, a barbituric acid-based molecule that exhibits unusually potent immunosuppressive and immunomodulatory actions on T lymphoc...

journal_title：International immunopharmacology

authors： Xu C,Wyman AR,Alaamery MA,Argueta SA,Ivey FD,Meyers JA,Lerner A,Burdo TH,Connolly T,Hoffman CS,Chiles TC

更新日期：2016-09-01 00:00:00

abstract：:Previous studies have demonstrated that polypeptides extracted from scorpion venom (PESV) inhibited cell proliferation in several tumors, however, the effect on dysfunctional and exhausted natural killer cells which contribute to tumor escape from immune surveillance remain to be elucidated. In this study, we determin...

journal_title：International immunopharmacology

authors： Chen H,Zhidan W,Xia R,Zhaoxia W,Qing J,Qiang G,Haipeng Y,Hengxiao W

更新日期：2016-06-01 00:00:00

abstract：:Dihydrofisetin is a flavanonol derived from some edible wild herbs and traditional Chinese medicines. It has been found to possess many biological activities. However, the anti-inflammatory potential of Dihydrofisetin remains uncharacterized. The aim of the present study was to investigate the anti-inflammatory activi...

journal_title：International immunopharmacology

authors： Li KK,Shen SS,Deng X,Shiu HT,Siu WS,Leung PC,Ko CH,Cheng BH

更新日期：2018-01-01 00:00:00

abstract：:Lipoteichoic acid (LTA) is a major virulence factor of Gram-positive bacteria including Staphylococcus aureus. Despite its pivotal role in causing sepsis, the systemic immune responses to LTA in human cells are poorly understood. Here, we produced highly-pure and structurally-intact LTA from S. aureus and examined the...

journal_title：International immunopharmacology

authors： Kang SS,Kim HJ,Jang MS,Moon S,In Lee S,Jeon JH,Baik JE,Park OJ,Son YM,Kim GR,Joo D,Kim H,Han JY,Yun CH,Han SH

更新日期：2012-08-01 00:00:00

abstract：BACKGROUND:Osteoarthritis (OA) is a familiar joint degenerative disease. Long non-coding RNAs (lncRNAs) play vital roles in the pathogenesis of OA. Nevertheless, the regulatory impacts of lncRNA highly up-regulated in liver cancer (lncRNA-HULC) on OA remain dimness. The study tried to probe the protective effect of HUL...

journal_title：International immunopharmacology

authors： Chu P,Wang Q,Wang Z,Gao C

更新日期：2019-07-01 00:00:00

abstract：BACKGROUND:Activation of nuclear factor-kappa B (NF-κB), which controls transcription of various pro-inflammatory cytokine genes, has been shown to play a critical role in the pathogenesis of ulcerative colitis (UC). Parthenolide, a sesquiterpene lactone compound isolated from extracts of the herb Feverfew (Tanacetum p...

journal_title：International immunopharmacology

authors： Zhao ZJ,Xiang JY,Liu L,Huang XL,Gan HT

更新日期：2012-01-01 00:00:00

abstract：:Endotoxin, also known as lipopolysaccharide (LPS), is the major mediator of septic shock due to Gram-negative bacterial infections. Recently, much attention has been focused on cationic peptides which possess the potential to detoxify LPS. Limulus anti-LPS factor (LALF), a protein found in the horseshoe crab (Limulus ...

journal_title：International immunopharmacology

authors： Ren JD,Gu JS,Gao HF,Xia PY,Xiao GX

更新日期：2008-06-01 00:00:00

abstract：:Cathepsin K (Cat K) is the major cysteine protease expressed in osteoclast and is thought to play a key role in matrix degradation during bone resorption. It is shown that the intracellular maturation of Cat K was prevented by the cAMP antagonist, Rp-cAMP, and the protein kinase A (PKA) inhibitors of KT5720 and H89. I...

journal_title：International immunopharmacology

authors： Park YG,Kim YH,Kang SK,Kim CH

更新日期：2006-06-01 00:00:00