当前位置： SCI文献检索 > INTERNATIONAL IMMUNOPHARMACOLOGY期刊下所有文献 > Scorpion venom activates natural killer cells in hepatocellular carcinoma via the NKG2D-MICA pathway.

Scorpion venom activates natural killer cells in hepatocellular carcinoma via the NKG2D-MICA pathway.

Abstract：

:Previous studies have demonstrated that polypeptides extracted from scorpion venom (PESV) inhibited cell proliferation in several tumors, however, the effect on dysfunctional and exhausted natural killer cells which contribute to tumor escape from immune surveillance remain to be elucidated. In this study, we determined the effect of PESV on NK infiltration into H22 cells orthotopic transplantation tumors and on the expression of MHC class I chain-related proteins A (MICA) in HepG2 cells. We found that tumor growth in mice was significantly inhibited by PESV and the survival time of tumor-bearing mice treated with PESV was significantly prolonged. Moreover, levels of tumor-infiltrating NK cells, NKG2D protein, perforin and granzyme B mRNA were significantly increased in the group treated with PESV compared with the tumor-bearing control group. In addition, In addition, up-regulation of MICA by PESV enhances the susceptibility of HepG2 cells to NK lysis in vitro. These results indicate that the inhibitory effects of PESV on hepatic carcinoma are likely mediated by up-regulation of NK cell activity via the MICA-NKG2D pathway.

journal_name

Int Immunopharmacol

journal_title

International immunopharmacology

authors

Chen H,Zhidan W,Xia R,Zhaoxia W,Qing J,Qiang G,Haipeng Y,Hengxiao W

doi

10.1016/j.intimp.2016.03.045

subject

Has Abstract

pub_date

2016-06-01 00:00:00

pages

307-314

eissn

1567-5769

issn

1878-1705

pii

S1567-5769(16)30118-7

journal_volume

35

pub_type

杂志文章

相关文献

INTERNATIONAL IMMUNOPHARMACOLOGY文献大全
  • Kinin system in lupus nephritis.

    abstract：:There are few studies regarding the evaluation of the kinin system in patients with systemic lupus erythematosus (SLE). In this study, we evaluated the plasma levels of high-molecular weight kininogen (HKg), low-molecular weight kininogen (LKg) and plasma kallikrein; the plasma activity of tissue kallikrein and kinina...

    journal_title：International immunopharmacology

    pub_type： 临床试验,杂志文章

    doi：10.1016/s1567-5769(01)00109-6

    authors： Dellalibera-Joviliano R,Reis ML,Donadi EA

    更新日期：2001-09-01 00:00:00

  • Lower levels of vitamin D are associated with SARS-CoV-2 infection and mortality in the Indian population: An observational study.

    abstract：BACKGROUND:The role of vitamin D in the susceptibility and severity of various viral diseases has been well documented. Recently, some reports highlighted the possible importance of vitamin D in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Although India receives adequate sunlight throughout the year, ...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2020.107001

    authors： Padhi S,Suvankar S,Panda VK,Pati A,Panda AK

    更新日期：2020-11-01 00:00:00

  • Increased expression of TTC21A in lung adenocarcinoma infers favorable prognosis and high immune infiltrating level.

    abstract：BACKGROUND:Lung adenocarcinoma (LUAD) is a crucial pathological type of lung cancer. Immune-infiltration of the tumor microenvironment positively associated with overall survival in LUAD. TTC21A is a gene has not reported in cancer, and the mechanism behind it is still unclear. Our study assesses TTC21A role in LUAD, v...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2019.106077

    authors： Wang W,Ren S,Wang Z,Zhang C,Huang J

    更新日期：2020-01-01 00:00:00

  • Low-affinity IgE receptor (FcepsilonRII)-mediated activation of human monocytes by both monomeric IgE and IgE/anti-IgE immune complex.

    abstract：:Monocytes and macrophages of individuals with allergic diseases express increased levels of the low-affinity IgE receptors (FcepsilonRII or CD23) on their surfaces. The cross-linking of CD23-bound IgE antibody by allergen activates the cells to release inflammatory mediators. In mast cells, the binding of IgE to the h...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2009.05.009

    authors： Ezeamuzie CI,Al-Attiyah R,Shihab PK,Al-Radwan R

    更新日期：2009-08-01 00:00:00

  • Ulinastatin- and thymosin α1-based immunomodulatory strategy for sepsis: A meta-analysis.

    abstract：OBJECTIVE:This meta-analysis was performed to evaluate the efficacy of ulinastatin (UTI) and thymosin α1 (Tα1) based immunomodulatory strategy in sepsis patients. METHODS:A systematic search was made of MEDLINE, Cochrane, ISI Web of Science and SCOPUS databases. Randomized clinical trials on treatment of sepsis with t...

    journal_title：International immunopharmacology

    pub_type： 杂志文章,meta分析,评审

    doi：10.1016/j.intimp.2015.10.026

    authors： Han D,Shang W,Wang G,Sun L,Zhang Y,Wen H,Xu L

    更新日期：2015-12-01 00:00:00

  • Fructose-1,6-diphosphate attenuates acute lung injury induced by lipopolysaccharide in mice.

    abstract：:Fructose-1,6-diphosphate (FDP), a high-energy glycolytic pathway intermediate, is reported to have a salutary effect in endotoxic shock and sepsis, but its underlying mechanism of action in inflammation is incompletely understood. In this study, our aim was to examine the function of FDP on acute lung injury (ALI) ind...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2008.09.004

    authors： Yin H,Jin XB,Gong Q,Yang H,Hu LY,Gong FL,Zhu JY

    更新日期：2008-12-20 00:00:00

  • Sirtuin 1 activation alleviates primary biliary cholangitis via the blocking of the NF-κB signaling pathway.

    abstract：:This report sought to establish the mechanistic role of sirtuin-1 (Sirt1), a NAD+-dependent deacetylase in the modulation of primary biliary cholangitis (PBC) pathogenesis. 64 PBC patients (diagnosed based on practice guidelines for American Association for the Study of Liver Diseases) and 60 healthy controls were inc...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2020.106386

    authors： Li Y,Xi Y,Tao G,Xu G,Yang Z,Fu X,Liang Y,Qian J,Cui Y,Jiang T

    更新日期：2020-06-01 00:00:00

  • Chronic opioid treatment of the mouse thymoma cell lines R1.G1 and R1EGO leads to down-regulation of the kappa opioid receptor without desensitization of adenylyl cyclase activity.

    abstract：:Kappa opioid agonists alter some immune functions of macrophages, and T- and B-lymphocytes. The mouse thymoma cell lines R1.G1 and R1EGO express only kappa-opioid receptors and these kappa-opioid receptors are coupled to an inhibitory GTP-binding regulatory protein. Binding of kappa-opioid agonists to the opioid recep...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/s1567-5769(00)00011-4

    authors： Martin-Kleiner I,Bidlack JM

    更新日期：2001-01-01 00:00:00

  • Chondroprotective effects and multi-target mechanisms of Icariin in IL-1 beta-induced human SW 1353 chondrosarcoma cells and a rat osteoarthritis model.

    abstract：:Cartilage degradation is the most predominant pathological change during osteoarthritis (OA). Furthermore, accumulating evidence suggests that an excess of matrix metalloproteinase-13 (MMP-13) plays a critical role in the breakdown of cartilage. Here, the effects of Icariin on the expression of MMP-13 in IL-1β-induced...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2013.11.021

    authors： Zeng L,Wang W,Rong XF,Zhong Y,Jia P,Zhou GQ,Li RH

    更新日期：2014-01-01 00:00:00

  • Generation of two high affinity anti-mouse FcRn antibodies: Inhibition of IgG recycling in wild type mice and effect in a mouse model of immune thrombocytopenia.

    abstract：:Primary immune thrombocytopenia (ITP) is an autoimmune disease characterized by pathogenic immunoglobulin G (IgG) autoantibodies that bind to platelets, causing their phagocytic removal and leading to reductions in platelet number. The neonatal Fc receptor (FcRn) selectively salvages and recycles IgG, including pathog...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2018.11.040

    authors： Smith B,Christodoulou L,Clargo A,Eddleston A,Greenslade K,Lightwood D,Shock A,Tyson K,Brennan FR

    更新日期：2019-01-01 00:00:00

  • Enhanced neutrophil autophagy and increased concentrations of IL-6, IL-8, IL-10 and MCP-1 in rheumatoid arthritis.

    abstract：:Rheumatoid arthritis (RA) is a high morbidity and disability disease with numerous inflammatory cells infiltrating in interstitial of articular cartilages and bones. As the most abundant inflammatory cells, neutrophil has been reported that their apoptosis changed gradually in the circumstance of RA. Apoptosis, one mo...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2018.09.011

    authors： An Q,Yan W,Zhao Y,Yu K

    更新日期：2018-12-01 00:00:00

  • Vaccination with IL-6 analogues induces autoantibodies to IL-6 and influences experimentally induced inflammation.

    abstract：:IL-6 is involved in inflammation and a therapeutic target. 0.1% of Danish blood donors have nanomolar plasma concentrations of polyclonal, picomolar affinity and in vitro as well as in vivo neutralizing IgG autoantibodies to IL-6 (aAb-IL-6). Such donors are assumed to be severely IL-6 deficient; yet they appear health...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2007.08.026

    authors： Galle P,Jensen L,Andersson C,Cuzzocrea S,Di Paola R,Nicoletti F,Svenson M,Bendtzen K,Thomsen AR,Hansen MB

    更新日期：2007-12-15 00:00:00

  • Dulaglutide mitigates inflammatory response in fibroblast-like synoviocytes.

    abstract：:Rheumatoid arthritis is a common autoimmune disease primarily characterized by chronic inflammation, the formation of an invasive pannus, and destruction of the joints. In the present study, we employed real-time PCR and western blot analysis to investigate the role of dulaglutide in human fibroblast-like synoviocytes...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2019.05.034

    authors： Zheng W,Pan H,Wei L,Gao F,Lin X

    更新日期：2019-09-01 00:00:00

  • Pleurotus citrinopileatus polysaccharide induces activation of human dendritic cells through multiple pathways.

    abstract：:Many edible mushrooms have become attractive as "health foods" and as source materials for immunomodulators. To increase our insight in the immune-modulatory properties of a polysaccharide of the oyster mushroom Pleurotus citrinopileatus, PCPS, we analyzed its effects on the function of human dendritic cells (DCs). We...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2016.08.034

    authors： Minato KI,Laan LC,Ohara A,van Die I

    更新日期：2016-11-01 00:00:00

  • Influenza virus-like particles composed of conserved influenza proteins and GPI-anchored CCL28/GM-CSF fusion proteins enhance protective immunity against homologous and heterologous viruses.

    abstract：:Influenza viruses cause significant morbidity and mortality and pose a substantial threat to public health. Vaccination represents the principle means of preventing influenza virus infection. Current vaccine approaches are hindered by the need to routinely reformulate vaccine compositions in an effort to account for t...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2018.07.011

    authors： Liu J,Ren Z,Wang H,Zhao Y,Wilker PR,Yu Z,Sun W,Wang T,Feng N,Li Y,Wang H,Ji X,Li N,Yang S,He H,Qin C,Gao Y,Xia X

    更新日期：2018-10-01 00:00:00

  • Low expression of RGL4 is associated with a poor prognosis and immune infiltration in lung adenocarcinoma patients.

    abstract：:Lung adenocarcinoma (LUAD) is a frequently diagnosed histologic subtype with increasing morbidity and mortality. RalGDS-Like 4 (RGL4) has not been reported to be associated with cancer risk, prognosis, immunotherapy or any other treatments. We perform a bioinformatics analysis on data downloaded from the Cancer Genome...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2020.106454

    authors： Sun Y,Zhang Y,Ren S,Li X,Yang P,Zhu J,Lin L,Wang Z,Jia Y

    更新日期：2020-06-01 00:00:00

  • Big Potassium (BK) ion channels in biology, disease and possible targets for cancer immunotherapy.

    abstract：:The Big Potassium (BK) ion channel is commonly known by a variety of names (Maxi-K, KCNMA1, slo, stretch-activated potassium channel, KCa1.1). Each name reflects a different physical property displayed by this single ion channel. This transmembrane channel is found on nearly every cell type of the body and has its own...

    journal_title：International immunopharmacology

    pub_type： 杂志文章,评审

    doi：10.1016/j.intimp.2014.06.040

    authors： Ge L,Hoa NT,Wilson Z,Arismendi-Morillo G,Kong XT,Tajhya RB,Beeton C,Jadus MR

    更新日期：2014-10-01 00:00:00

  • Is neuroimmunomodulation a future therapeutic approach for sepsis?

    abstract：:Sepsis is considered as a disease of profoundly and uncontrollably activated innate immune response against bacterial infection or their products. Thus, regulation of innate immune response plays a critical role in controlling exaggerated systemic inflammation responsible for sepsis development. However, treatment of ...

    journal_title：International immunopharmacology

    pub_type： 杂志文章,评审

    doi：10.1016/j.intimp.2009.10.003

    authors： Kumar V,Sharma A

    更新日期：2010-01-01 00:00:00

  • Upregulation of JHDM1D-AS1 alleviates neuroinflammation and neuronal injury via targeting miR-101-3p-DUSP1 in spinal cord after brachial plexus injury.

    abstract：BACKGROUND:Neuroinflammation in the spinal cord following acute brachial plexus injury (BPI) remains a vital cause that leads to motor dysfunction and neuropathic pain. In this study, we aim to explore the role of long non-coding RNA JHDM1D antisense 1 (JHDM1D-AS1) in mediating BPI-induced neuroinflammation and neurona...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2020.106962

    authors： Liu LP,Zhang J,Pu B,Li WQ,Wang YS

    更新日期：2020-12-01 00:00:00

  • Immunomodulatory activity of polysaccharides isolated from Strongylocentrotus nudus eggs.

    abstract：:Our previous work showed that SEP, a novel glucan isolated from the eggs of sea urchins, Strongylocentrotus nudus, had remarkable anti-tumor activity. To elucidate the mechanism of the anti-tumor activity, the immunomodulatory activity of SEP was investigated. The in vivo experiment results showed that SEP remarkably ...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2008.09.005

    authors： Liu C,Xi T,Lin Q,Xing Y,Ye L,Luo X,Wang F

    更新日期：2008-12-20 00:00:00

  • Polysaccharides from Antrodia camphorata mycelia extracts possess immunomodulatory activity and inhibits infection of Schistosoma mansoni.

    abstract：:Antrodia camphorata (AC) is a commonly used fungus in folk medicine for the treatment of viral hepatitis and cancer. AC polysaccharides (AC-PS) are reported to possess anti-inflammatory, anti-hepatitis B virus, and anticancer activities. In this study, we tested the in vivo effect of AC-PS on immune function by evalua...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2007.11.008

    authors： Chen YJ,Cheng PC,Lin CN,Liao HF,Chen YY,Chen CC,Lee KM

    更新日期：2008-03-01 00:00:00

  • Sodium selenite inhibits the expression of VEGF, TGFbeta(1) and IL-6 induced by LPS in human PC3 cells via TLR4-NF-(K)B signaling blockage.

    abstract：:Lipopolysaccharide (LPS)-induced TLR4-NF-(K)B signaling plays an important role in the development of prostatic tumors from chronic bacterial prostatic infection. Although many studies support the role of selenium in protecting against the development of prostate cancer secondary to chronic prostatitis, the mechanism ...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2009.09.020

    authors： Pei Z,Li H,Guo Y,Jin Y,Lin D

    更新日期：2010-01-01 00:00:00

  • Scutellarin suppresses cartilage destruction in osteoarthritis mouse model by inhibiting the NF-κB and PI3K/AKT signaling pathways.

    abstract：:Osteoarthritis (OA), a common and severe disease, is predominantly characterized by cartilage destruction, which results in the degeneration of joint surfaces. Nowadays, it is accepted that TNFα plays a critical role in OA. Scutellarin, the main bioactive flavonoid glycoside extracted form Erigeron breviscapus, has be...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2019.105928

    authors： Wang W,Li J,Li F,Peng J,Xu M,Shangguan Y,Li Y,Zhao Y,Qiu C,Qu R,Li W,Zhang C,Zhang T

    更新日期：2019-12-01 00:00:00

  • The pharmacodynamic active components study of Tibetan medicine Gentianopsis paludosa on ulcerative colitis fibrosis.

    abstract：:The current study focused on the pharmacodynamic activity components of Gentianopsis paludosa against ulcerative colitis (UC) fibrosis including symptoms of intestinal diarrhea and inflammatory. Trinitro-benzene-sulfonic acid induced UC model rats were gavaged with gradient polarity extracts respectively from ethanol-...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2017.01.001

    authors： Lu NH,Zhao HQ,Jing M,Liu X,Ren CZ,Liu XF,Liu JJ,Zhang YX

    更新日期：2017-05-01 00:00:00

  • Immunomodulation by ethanolic extract of Boerhaavia diffusa roots.

    abstract：:We have earlier reported that ethanolic extract of Boerhaavia diffusa, a plant used in Indian traditional system of medicine, significantly inhibits the cell proliferation. This led us to evaluate the immunomodulatory properties of this plant extract on various in vitro tests such as human natural killer (NK) cell cyt...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/s1567-5769(02)00031-0

    authors： Mehrotra S,Mishra KP,Maurya R,Srimal RC,Singh VK

    更新日期：2002-06-01 00:00:00

  • Macrophage activation and nitric oxide production by water soluble components of Hericium erinaceum.

    abstract：:Hericium erinaceum is a medicinal and edible mushroom with anti-microbial and anti-cancer activities. To evaluate the immunoregulatory functions of H. erinaceum, we prepared water extract from H. erinaceum (WEHE) and investigated its ability to activate macrophages and to induce nitric oxide (NO) production in macroph...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2006.03.005

    authors： Son CG,Shin JW,Cho JH,Cho CK,Yun CH,Chung W,Han SH

    更新日期：2006-08-01 00:00:00

  • Reduction of non-specific toxicity of immunotoxin by intein mediated reconstitution on target cells.

    abstract：:Recombinant immunotoxins are chimeric proteins composed of a targeting peptide that binds to a specific tumor antigen and a toxin protein killing target cells. Recombinant immunotoxin exhibits potent cancer inhibiting effects both in vivo and in vitro. However, the non-specific toxicity causes severe syndromes limitin...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2018.11.039

    authors： Wang J,Han L,Chen J,Xie Y,Jiang H,Zhu J

    更新日期：2019-01-01 00:00:00

  • The novel non-mitogenic anti-CD3 antibody, mini-yCD3, delivers a partial TCR signal.

    abstract：:Previous studies indicated that a partial T-cell receptor signal delivered by non-mitogenic anti-CD3 antibodies is critical for dampening the activated T-cell response. The mini-yCD3 is a novel non-mitogenic anti-CD3 antibody based on a murine anti-human CD3 antibody yCD3. However, the mechanism by which mini-yCD3 sup...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2009.10.016

    authors： Lv M,Qiao C,Lin Z,Yu M,Hou C,Sun Y,Li Y,Feng J,Shen B

    更新日期：2010-02-01 00:00:00

  • Cord blood-derived cytokine-induced killer cells biotherapy combined with second-line chemotherapy in the treatment of advanced solid malignancies.

    abstract：:This study investigated the efficacy of cord blood-derived cytokine-induced killer (CB-CIK) biotherapy combined with second-line chemotherapy in treating advanced solid malignancies after first-line chemotherapy failure. Forty patients with advanced solid malignancies after first-line chemotherapy failure were divided...

    journal_title：International immunopharmacology

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.intimp.2010.12.014

    authors： Niu Q,Wang W,Li Y,Qin S,Wang Y,Wan G,Guan J,Zhu W

    更新日期：2011-04-01 00:00:00

  • Interleukin-8 prevents oxidative stress-induced human endothelial cell senescence via telomerase activation.

    abstract：:Senescence is an irreversible growth arrest which can be triggered by stresses such as oxidative reaction, telomere shortening, DNA damage, or oncogene signaling. Oxidative stress accelerates vascular endothelial cell senescence, and may promote atherosclerosis in humans. Interleukin-8 (IL-8) has been shown to play an...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2013.04.003

    authors： Shen XH,Xu SJ,Jin CY,Ding F,Zhou YC,Fu GS

    更新日期：2013-06-01 00:00:00