Immunomodulation by ethanolic extract of Boerhaavia diffusa roots.

abstract：:Silicosis is a well acknowledged occupational lung disorder with considerable negative impact on the patients' quality of life. Various signaling pathways have been reported to interplay in the pathogenesis of pulmonary fibro-proliferative disorders; of which, P-AKT/mTOR signaling pathway. The current study highlights...

journal_title：International immunopharmacology

authors： Helal MG,Said E

更新日期：2019-05-01 00:00:00

abstract：:A focused library of novel mannosylated glycophospholipids was synthesized employing imidate coupling and H-phosphate phosphorylation methods. All novel glycophospholipids were evaluated for their receptor interactions by molecular docking studies. Docking studies revealed dendritic cell-specific intercellular adhesio...

journal_title：International immunopharmacology

authors： Bonam SR,Bhunia D,Muller S,Nerella SG,Alvala M,Halmuthur Mahabalarao SK

更新日期：2019-09-01 00:00:00

abstract：:Recombinant immunotoxins are chimeric proteins composed of a targeting peptide that binds to a specific tumor antigen and a toxin protein killing target cells. Recombinant immunotoxin exhibits potent cancer inhibiting effects both in vivo and in vitro. However, the non-specific toxicity causes severe syndromes limitin...

journal_title：International immunopharmacology

authors： Wang J,Han L,Chen J,Xie Y,Jiang H,Zhu J

更新日期：2019-01-01 00:00:00

abstract：:Inflammation occurs as a result of acute trauma, invasion of the host by different pathogens, pathogen-associated molecular patterns (PAMPs) or chronic cellular stress generating damage-associated molecular patterns (DAMPs). Thus inflammation may occur under both sterile inflammatory conditions including certain cance...

journal_title：International immunopharmacology

authors： Kumar V

更新日期：2019-08-01 00:00:00

abstract：:Isothiocyanates can inhibit nuclear factor-kappaB (NF-kappaB) activation. Interleukin (IL)-1β activates the NF-kappaB, which in turn activates proteins involved in inflammation. IL-1β is directly associated with caspase-1 activation. We tested the anti-inflammatory effect of allyl isothiocyanate (AITC) in mast cells. ...

journal_title：International immunopharmacology

authors： Han NR,Park W,Um JY,Kim HM,Jeong HJ

更新日期：2011-04-01 00:00:00

abstract：:Cyclosporine A (CsA) is the first immunosuppressant universally used in allotransplantation. However, it has been demonstrated that this drug produces side effects in several organs, particularly in the kidney and in the heart. Since the immunosuppressive therapy induces myocardial toxicity, the aim of this study was ...

journal_title：International immunopharmacology

authors： Bianchi R,Rodella L,Rezzani R

更新日期：2003-03-01 00:00:00

abstract：:Ischemia-reperfusion injury is a common early event in kidney transplantation and contributes to a delay in organ function. Acute tubular necrosis, impaired kidney function and organ leukocyte infiltration are the major findings. The therapeutic potential of stem cells has been the focus of recent research as these ce...

journal_title：International immunopharmacology

authors： da Silva LB,Palma PV,Cury PM,Bueno V

更新日期：2007-12-15 00:00:00

abstract：:Previously it was shown that treatment with mycophenolate mofetil (MMF) attenuated renal inflammation and glomerular injury in a model of diabetes. However, the mechanism involved in the renoprotective effects of MMF in experimental diabetes has not been clearly delineated. Diabetes was induced by injection of strepto...

journal_title：International immunopharmacology

authors： Wu YG,Lin H,Qi XM,Wu GZ,Qian H,Zhao M,Shen JJ,Lin ST

更新日期：2006-03-01 00:00:00

abstract：:Antarctic bacteria are a novel source of polysaccharides which might have potential applications as biological response modifiers (BRM). A heteropolysaccharide (PEP) was isolated from the liquid culture broth of the Antarctic bacterium Pseudoaltermonas sp.S-5. PEP contained Mannose, Glucose, and Galactose in a ratio o...

journal_title：International immunopharmacology

authors： Bai Y,Zhang P,Chen G,Cao J,Huang T,Chen K

更新日期：2012-04-01 00:00:00

abstract：:Chronic low back pain due to lumbar spinal stenosis (LSS) is common, costly, mechanistically complex, and clinically challenging. However, the factors and mechanisms causing and mediating chronic pain induced by cauda equina compression remain unclear. Here, we examined the role of cyclooxygenase (COX)-2 in infiltrate...

journal_title：International immunopharmacology

authors： Lee JY,Choi HY,Park CS,Jang C,Lee KT,Lee JY,Youn I,Yune TY

更新日期：2019-10-01 00:00:00

abstract：BACKGROUND:The pathogenesis of myasthenia gravis (MG) depends upon T and B cells, as well as complement and cytokines. The activation of functional subpopulations of T and B cells is the basis of the immune response. However, the activation levels of T and B cell subsets remain unclear in the pathogenesis of MG. Here, ...

journal_title：International immunopharmacology

authors： Hu Y,Wang J,Rao J,Xu X,Cheng Y,Yan L,Wu Y,Wu N,Wu X

更新日期：2020-03-01 00:00:00

abstract：PURPOSE:To investigate the effect of miR-200c/PAI-2 on macrophage polarization into M2-type TAMs in TNBC. METHODS AND MATERIALS:PAI-2 expression in MDA-MB-231con, MDA-MB-231miR-200ab and MDA-MB-231miR-200c breast cancer cells was evaluated by RT-PCR and immunofluorescence (IF), while the expression of the TAM marker F...

journal_title：International immunopharmacology

authors： Meng Z,Zhang R,Wang Y,Zhu G,Jin T,Li C,Zhang S

更新日期：2020-04-01 00:00:00

abstract：:This study was designed to evaluate the antitumor activity of CSBG, purified from the cell wall of Candida albicans IFO1385. First, as an effect of CSBG on P815 mastocytoma, significant prolonged survival and suppression of the tumor growth were observed. Second, the transfer of spleen cells from CSBG-sensitized BALB/...

journal_title：International immunopharmacology

authors： Tokunaka K,Ohno N,Adachi Y,Miura NN,Yadomae T

更新日期：2002-01-01 00:00:00

abstract：AIM:Due to the significant increase in the antimicrobial resistance of Acinetobacter baumannii (A. baumannii), new drugs to block the progression of infection are strongly needed. Epigallocatechin-3-gallate (EGCG), a major component of green tea, has exhibited potential activity against A. baumannii in vitro. The aim o...

journal_title：International immunopharmacology

authors： Yan Q,Hao S,Shi F,Zou Y,Song X,Li L,Li Y,Guo H,He R,Zhao L,Ye G,Tang H

更新日期：2021-01-04 00:00:00

abstract：:Acute pancreatitis (AP) is a common acute abdominal disease with local or systemic inflammatory response, caused by abnormal activation of digestive enzymes. Baicalein has been shown to exert anti-inflammatory effects and to attenuate the pathological changes of AP. The aim of the research was to investigate the effec...

journal_title：International immunopharmacology

authors： Pu WL,Bai RY,Zhou K,Peng YF,Zhang MY,Hottiger MO,Li WH,Gao XM,Sun LK

更新日期：2019-07-01 00:00:00

abstract：:Excessive activation of microglial cells has been implicated in various neurodegenerative diseases. Resveratrol, a polyphenolic compound found in grapes and wine, has been reported to reduce the activation of microglia. In the present study, 5-[2-(4-bromothiophen-2-yl)vinyl]benzene-1,3-diol (RV09), a novel resveratrol...

journal_title：International immunopharmacology

authors： Meng XL,Yang JY,Chen GL,Zhang LJ,Wang LH,Li J,Wang JM,Wu CF

更新日期：2008-08-01 00:00:00

abstract：:Joint inflammation is a key player in the pathogenesis of osteoarthritis (OA). Imperatorin, a plant-derived small molecule has been reported to have anti-inflammatory properties; however, its effect on chondrocytes is not known. Here, we investigated the effects of Imperatorin on interleukin-1β (IL-1β) induced express...

journal_title：International immunopharmacology

authors： Ahmad N,Ansari MY,Bano S,Haqqi TM

更新日期：2020-08-01 00:00:00

abstract：BACKGROUNDS:Autoimmune myocarditis is characterized by over-activated immune system attacking the cardiomyocytes, resulting in heart function decline. In the current study, we investigated the therapeutic advantages of delivering Interleukin-10 (IL-10) by mesenchymal stem cells (MSCs), both of which had immune suppress...

journal_title：International immunopharmacology

authors： Shao M,Wang D,Zhou Y,Du K,Liu W

更新日期：2020-04-01 00:00:00

abstract：:For many years, it has been recognized that Mycoplasma infection affects the host's immune system in different ways. In this work, experiments were performed to characterize the influence of Mycoplasma pulmonis infection on various immunological parameters and to follow the kinetics of their variations. A Balb/c mouse...

journal_title：International immunopharmacology

authors： Romero-Rojas A,Ponce-Hernández C,Ciprián A,Estrada-Parra S,Hadden JW

更新日期：2001-09-01 00:00:00

abstract：:The potentiation of the immune system in pregnant rats was performed with Complete Freund's Adjuvant [CFA; 20μl, subcutaneous at gestation day (GD) 18] in experimentally-induced hyperthyroidism by Levo-thyroxine (L-T4; 10μg/100g of b.w., intraperitoneal from GD 2 to 17). The potential effects on the fetal neuroendocri...

journal_title：International immunopharmacology

authors： Ahmed RG,Abdel-Latif M,Mahdi EA,El-Nesr KA

更新日期：2015-12-01 00:00:00

abstract：:Factor H is a 150 kDa single chain plasma glycoprotein that plays a pivotal role in the regulation of the alternative pathway of complement. Primary sequence analysis reveals a structural organization of this plasma protein, in 20 homologous units, called Short Consensus Repeats (SCRs), each about 60 amino acids long....

journal_title：International immunopharmacology

authors： Zipfel PF,Skerka C,Caprioli J,Manuelian T,Neumann HH,Noris M,Remuzzi G

更新日期：2001-03-01 00:00:00

abstract：OBJECTIVES:Various studies have researched the serum levels of leptin, adiponectin and resistin in patients with ankylosing spondylitis (AS), but the results were inconclusive. The purpose of this study was to systematically evaluate the correlations between serum levels of these adipokines and AS. METHODS:Electronic ...

journal_title：International immunopharmacology

authors： Yang J,Zhang X,Ma Y,Wu M,Hu X,Han R,Yuan Y,Wang M,Chen M,Jiang S,Tong J,Xu S,Xu J,Shuai Z,Zou Y,Pan F

更新日期：2017-11-01 00:00:00

abstract：:Endotoxin, also known as lipopolysaccharide (LPS), is the major mediator of septic shock due to Gram-negative bacterial infections. Recently, much attention has been focused on cationic peptides which possess the potential to detoxify LPS. Limulus anti-LPS factor (LALF), a protein found in the horseshoe crab (Limulus ...

journal_title：International immunopharmacology

authors： Ren JD,Gu JS,Gao HF,Xia PY,Xiao GX

更新日期：2008-06-01 00:00:00

abstract：:The present study was conducted to determine if selected events in glucocorticoid receptor (GR) signaling that have been identified using mostly in vitro approaches with synthetic glucocorticoids also occur in mature T cells exposed to relevant levels of corticosterone in vivo. In contrast to effects reported in vitro...

journal_title：International immunopharmacology

authors： Pruett SB,Fan R,Zheng Q

更新日期：2003-01-01 00:00:00

abstract：:In a preliminary experiment, it was found that oleanolic acid (OA), which is widely distributed in food and medicinal plants, inhibited interleukin (IL)-6/tumor growth factor beta-induced differentiation of splenic T cells into Th17 cells. Moreover, OA induced the differentiation of splenic T cells into Treg cells. Th...

journal_title：International immunopharmacology

authors： Kang GD,Lim S,Kim DH

更新日期：2015-12-01 00:00:00

abstract：BACKGROUND:Diallyl Trisulfide (DATS) is an organosulfur compound extracted from garlic bulb, and exerts cardioprotective, anti-inflammatory, antioxidant, antimicrobial and anticancer effects. But its role in the pathogenesis of rheumatoid arthritis (RA) is unknown. Here we explored the influence of DATS on human fibrob...

journal_title：International immunopharmacology

authors： Liang JJ,Li HR,Chen Y,Zhang C,Chen DG,Liang ZC,Shi YQ,Zhang LL,Xin L,Zhao DB

更新日期：2019-06-01 00:00:00

abstract：:We previously reported that abnormally down-regulated protein kinase C (PKC) activity is responsible for the impaired cellular function of natural killer cells and polymorphonuclear cells (PMNs), and the giant granule formation in fibroblasts in the beige mouse, an animal model of Chediak-Higashi syndrome. Here, we ex...

journal_title：International immunopharmacology

authors： Morimoto M,Tanabe F,Kasai H,Ito M

更新日期：2007-07-01 00:00:00

abstract：OBJECTIVES:To explore the role of autophagy on macrophage-mediated phagocytosis and intracellular killing of Pseudomonas aeruginosa (PA), a common extracellular bacterium which often causes various opportunistic infections. METHODS:Macrophages were infected with PA or stimulated with zymosan bioparticles. Autophagy wa...

journal_title：International immunopharmacology

authors： Wu Y,Li D,Wang Y,Chen K,Yang K,Huang X,Zhang Y,Wu M

更新日期：2016-09-01 00:00:00

abstract：:Human beta-defensin 2 is an antimicrobial peptide that is produced by several epithelial cells after stimulation with micro-organisms and inflammatory mediators. Gram-negative bacteria, which are typically detected in periodontal pockets in periodontitis, elicit a stronger antibacterial peptide response of human beta-...

journal_title：International immunopharmacology

authors： Rizzo A,Paolillo R,Buommino E,Lanza AG,Guida L,Annunziata M,Carratelli CR

更新日期：2008-09-01 00:00:00

abstract：:Hemorrhagic transformation (HT) is a common and serious complication following ischemic stroke, especially after tissue plasminogen activator (t-PA) thrombolysis, which is associated with increased mortality and disability. Due to the unknown mechanisms and targets of HT, there are no effective therapeutic drugs to de...

journal_title：International immunopharmacology

authors： Ma G,Pan Z,Kong L,Du G

更新日期：2021-01-01 00:00:00