Novel trisaccharide based phospholipids as immunomodulators.

abstract：:Here, we report the immunomodulating potential of N-palmitoyl-amino-ethyl-rigin amide (PR) and N-cholestanyl-amino-ethyl-rigin amide (CR), the two new structural analogs of rigin (an IgG-derived tetrapeptide). Their activity profiles are compared with native tuftsin (NT) and/or N-palmitoyl-amino-ethyl-tuftsin amide (P...

journal_title：International immunopharmacology

authors： Dutta RC,Puri A,Anand N

更新日期：2001-05-01 00:00:00

abstract：:Neurodegenerative diseases are closely related to neuroinflammation. Drugs targeting inflammation have been proved to be effective in many animal models. Salvianolic acid C (SalC) is a compound isolated from Salvia miltiorrhiza Bunge, a plant with reported effects of inhibiting inflammation. However, the anti-inflamma...

journal_title：International immunopharmacology

authors： Song J,Zhang W,Wang J,Yang H,Zhao X,Zhou Q,Wang H,Li L,Du G

更新日期：2018-10-01 00:00:00

abstract：:Oxidative stress, inflammation, and foam cell formation in vascular smooth muscle cells (VSMCs) are considered to play crucial roles in the pathogenesis of atherosclerosis. Poria cocos polysaccharides (PCP) has been shown to possess anti-inflammatory, antitumor and anti-oxidative properties. In this study we explored ...

journal_title：International immunopharmacology

authors： Zhao J,Niu X,Yu J,Xiao X,Li W,Zang L,Hu Z,Siu-Po Ip P,Li W

更新日期：2020-03-01 00:00:00

abstract：:IL-36 cytokines (IL-36Ra, IL-36α, IL-36β and IL-36γ) belong to the IL-1 family and have been linked to several autoimmune diseases. However, little is known about the relationships between systemic lupus erythematosus (SLE) and IL-36 cytokines. In this study, serum IL-36 cytokine levels were determined by enzyme-linke...

journal_title：International immunopharmacology

authors： Mai SZ,Li CJ,Xie XY,Xiong H,Xu M,Zeng FQ,Guo Q,Han YF

更新日期：2018-05-01 00:00:00

abstract：:Acute liver failure is characterized by the sudden loss of hepatic function and a high mortality. SKLB010, a derivative of thiazolidinediones, has been proved to be effective in protecting mice from acute liver failure caused by concanavalin A and carbon tetrachloride in our previous work. The purpose of the current s...

journal_title：International immunopharmacology

authors： Xie C,Jingjing W,Li X,Zeng F,Ma L,Li C,Wei Z,Peng A,Chen L

更新日期：2014-08-01 00:00:00

abstract：:Tree nuts are among "Big Eight" and have been reported globally for causing allergy. Buchanania lanzan (Bl) is one of the major tree nuts consumed by Indian population. However, very little is known about B. lanzan's induced allergic manifestation. Therefore, evaluation of it's allergenic potential was undertaken. Bl-...

journal_title：International immunopharmacology

authors： Kumar S,Sharma A,Gupta RK,Verma AK,Dwivedi PD

更新日期：2018-10-01 00:00:00

abstract：:To evaluate the effects of pirfenidone in the treatment of HUVEC using an in vitro model and on rat corneal wound healing, edema, cornea neovascularization (CNV) and inflammation after alkali burn in vivo model. In vitro, CCK-8 assay was used to detect the effect of pirfenidone on the viability of HUVECs. The effects ...

journal_title：International immunopharmacology

authors： Jiang N,Ma M,Li Y,Su T,Zhou XZ,Ye L,Yuan Q,Zhu P,Min Y,Shi W,Xu X,Lv J,Shao Y

更新日期：2018-11-01 00:00:00

abstract：:Ischemia and reperfusion injury (IR) is an antigen independent inflammatory process that causes tissue damage. After IR, kidneys up-regulate leukocyte adhesion molecules and toll-like receptors (TLRs). Moreover, injured kidneys can also secrete factors (i.e. heat shock protein) which bind to TLRs and trigger intracell...

journal_title：International immunopharmacology

authors： Pedregosa JF,Haidar AA,Hirata AE,Franco M,Gomes GN,Bueno V

更新日期：2011-09-01 00:00:00

abstract：:Over-activation of microglia disrupts the physiological homeostasis of the brain, and induces inflammatory response and other processes which are implicated in neurodegenerative diseases. Therefore, theoretically, suppression of neuroinflammation would slow the progression of neurodegenerative disease. In this study, ...

journal_title：International immunopharmacology

authors： Bao Y,Chen Q,Xie Y,Tao Z,Jin K,Chen S,Bai Y,Yang J,Shan S

更新日期：2019-12-01 00:00:00

abstract：INTRODUCTION:Idiopathic membranous nephropathy (IMN) is a common cause of nephrotic syndrome in adults and one of the leading causes of end-stage renal disease (ESRD). During recent years, the incidence of IMN has been increasing. The main treatment option for IMN is the use of immunosuppressive (IS) drugs combined wit...

journal_title：International immunopharmacology

authors： Liu D,Yang Y,Kuang F,Qing S,Hu B,Yu X

更新日期：2019-05-01 00:00:00

abstract：:Mastitis is a postpartum disease in both humans and animals. Staphylococcus aureus (S. aureus) can induce mastitis by infection of the lactiferous ducts. There is no efficacious treatment for S. aureus-induced mastitis. Betulin has been confirmed to have multiple biological activities, including anti-inflammatory prop...

journal_title：International immunopharmacology

authors： Guo MY,Li WY,Zhang Z,Qiu C,Li C,Deng G

更新日期：2015-12-01 00:00:00

abstract：:Understanding of oligodendrocyte precursor cells and their role in the generation of oligodendrocytes in developing and adult rodents has been considered, particularly much less is known about aged-rodent oligodendrocyte precursor cells and their cell lineage. In this present study, we have developed oligodendrocyte c...

journal_title：International immunopharmacology

authors： Kobayashi J,Seiwa C,Sakai T,Gotoh M,Komatsu Y,Yamamoto M,Fukutake M,Matsuno K,Sakurai Y,Kawano Y,Asou H

更新日期：2003-07-01 00:00:00

abstract：:Salicylic acid (aspirin) is a widely used pharmacological agent with immunodmodulatory properties. Dendritic cells are key regulators of the immune response, and are capable of inducing hyporesponsiveness and regulatory activity in CD4+ T-cells. We have demonstrated that aspirin-treated dendritic cells are effective a...

journal_title：International immunopharmacology

authors： Buckland M,Jago C,Fazekesova H,George A,Lechler R,Lombardi G

更新日期：2006-12-20 00:00:00

abstract：:The discovery of microRNAs (miRNAs) provides a new and powerful tool for studying the mechanisms, diagnosis and treatments of cancer. In this study, we employed AFFX miRNA expression chips to search for miRNAs that may be aberrantly expressed in gastric cancer tissues and to investigate the potential roles that miRNAs...

journal_title：International immunopharmacology

authors： Su Y,Ni Z,Wang G,Cui J,Wei C,Wang J,Yang Q,Xu Y,Li F

更新日期：2012-08-01 00:00:00

abstract：BACKGROUND:Activation of nuclear factor-kappa B (NF-κB), which controls transcription of various pro-inflammatory cytokine genes, has been shown to play a critical role in the pathogenesis of ulcerative colitis (UC). Parthenolide, a sesquiterpene lactone compound isolated from extracts of the herb Feverfew (Tanacetum p...

journal_title：International immunopharmacology

authors： Zhao ZJ,Xiang JY,Liu L,Huang XL,Gan HT

更新日期：2012-01-01 00:00:00

abstract：:Chlorogenic acid (CGA), one of the most abundant dietary polyphenolic compounds, has been reported to exhibit anti-inflammatory ability. However, the hepatoprotective effects and molecular mechanisms of CGA on concanavalin A (Con A)-induced hepatitis have not been explored. In the present study, we found that pretreat...

journal_title：International immunopharmacology

authors： Yuan Y,Gong X,Zhang L,Jiang R,Yang J,Wang B,Wan J

更新日期：2017-03-01 00:00:00

abstract：:Myagropsis myagroides has been used as a Chinese medicine and its extract has shown various biological activities, however, its anti-inflammatory mechanism remains unknown. In this study, we investigated the inhibitory effects of the ethyl acetate fraction of M. myagroides (EFM) on the production of inflammatory media...

journal_title：International immunopharmacology

authors： Joung EJ,Lee MS,Choi JW,Kim JS,Shin T,Jung BM,Kim JI,Kim HR

更新日期：2012-12-01 00:00:00

abstract：:An emerging role is postulated for IL-17-producing thymocytes, which in their majority consist of IL-17-producing CD4(+) cells. For these, a specific role in the immediate defense against infectious pathogens is suggested, independent from the development of an adaptive immune response in the immune periphery. Immune ...

journal_title：International immunopharmacology

authors： Weber A,Zimmermann C,Mausberg AK,Kieseier BC,Hartung HP,Hofstetter HH

更新日期：2013-10-01 00:00:00

abstract：BACKGROUND:Ischaemic stroke is a lethal cerebrovascular disease that occurs worldwide. Astilbin is a natural flavonoid compound with various physiological activities. The purpose of this study was to investigate the neuroprotective effects of Astilbin after cerebral ischaemia reperfusion (I/R) injury. METHODS:The oxyg...

journal_title：International immunopharmacology

authors： Li Y,Wang R,Xue L,Yang Y,Zhi F

更新日期：2020-07-01 00:00:00

abstract：:A procedure was developed for the determination of low levels of the anthraquinones aloe-emodin and aloin A (barbalin) in aloe products based on gas chromatography/mass spectrometry (GC/MS) of the trimethyl silyl (TMS) derivatives of these analytes in the presence of Chrysophanol used as internal standard. The method ...

journal_title：International immunopharmacology

authors： ElSohly MA,Gul W,Murphy TP

更新日期：2004-12-20 00:00:00

abstract：BACKGROUNDS:C1q tumor necrosis factor-related protein 9 (CTRP9) has been suggested to exert an atheroprotective effect by modulating the inflammation, foam cell formation, endothelia and smooth muscle cell function via Adenosine Monophosphate Activated Protein Kinase (AMPK) pathway. On the other hand, the NLR Family Py...

journal_title：International immunopharmacology

authors： Zhang H,Gong X,Ni S,Wang Y,Zhu L,Ji N

更新日期：2019-12-01 00:00:00

abstract：BACKGROUND:Severe acute pancreatitis (SAP) is a common threat to human health. In the present study, we aimed to investigate the underlying mechanisms by which p38α in macrophages contributes to SAP. We used conditional knockout of p38α in macrophages and p38 MAPK inhibitors to understand the effects of p38α in macroph...

journal_title：International immunopharmacology

authors： Fan HN,Chen W,Fan LN,Wu JT,Zhu JS,Zhang J

更新日期：2019-12-01 00:00:00

abstract：PURPOSE:A new strategy of adoptive and passive immunotherapy involves combining dendritic cells (DCs) with a subset of natural killer T lymphocytes termed cytokine-induced killer (CIK) cells. The objective of this systematic review and meta-analysis was to evaluate the safety and efficacy of DC-CIK therapy vs. placebo,...

journal_title：International immunopharmacology

authors： Chen R,Deng X,Wu H,Peng P,Wen B,Li F,Li F

更新日期：2014-10-01 00:00:00

abstract：:Rheumatoid arthritis (RA) is a chronic autoimmune inflammatory disease. Gallium nitrate has been reported to reserve immunosuppressive activities. Therefore, we assessed the therapeutic effects of gallium nitrate in the mouse model of developed type II collagen-induced arthritis (CIA). CIA was induced by bovine type I...

journal_title：International immunopharmacology

authors： Choi JH,Lee JH,Roh KH,Seo SK,Choi IW,Park SG,Lim JG,Lee WJ,Kim MH,Cho KR,Kim YJ

更新日期：2014-05-01 00:00:00

abstract：:Triggered by the successful administration of the proteasome inhibitor bortezomib in kidney transplant recipients with acute or chronic antibody-mediated rejection, we evaluated the effect of the proteasome inhibitor CEP-18770 and of the selective immunoproteasome inhibitor ONX-0914 on cellular and humoral alloimmunit...

journal_title：International immunopharmacology

authors： Eleftheriadis T,Pissas G,Antoniadi G,Liakopoulos V,Stefanidis I

更新日期：2017-09-01 00:00:00

abstract：BACKGROUND:The pathogenesis of myasthenia gravis (MG) depends upon T and B cells, as well as complement and cytokines. The activation of functional subpopulations of T and B cells is the basis of the immune response. However, the activation levels of T and B cell subsets remain unclear in the pathogenesis of MG. Here, ...

journal_title：International immunopharmacology

authors： Hu Y,Wang J,Rao J,Xu X,Cheng Y,Yan L,Wu Y,Wu N,Wu X

更新日期：2020-03-01 00:00:00

abstract：:Coronavirus disease 2019 (COVID-19) is a pandemic infectious disease caused by the novel coronavirus called SARS-CoV-2. There is a gap in our understanding regarding the immunopathogenesis of COVID-19. However, many clinical trials are underway across the world for screening effective drugs against COVID-19. Neverthel...

journal_title：International immunopharmacology

authors： Mirzaei R,Mohammadzadeh R,Mahdavi F,Badrzadeh F,Kazemi S,Ebrahimi M,Soltani F,Kazemi S,Jeda AS,Darvishmotevalli M,Yousefimashouf R,Keyvani H,Karampoor S

更新日期：2020-11-01 00:00:00

abstract：:Leaves of Passiflora alata Curtis were characterized for their antioxidant capacity. Antioxidant analyses of DPPH, FRAP, ABTS, ORAC and phenolic compounds were made in three different extracts: aqueous, methanol/acetone and ethanol. Aqueous extract was found to be the best solvent for recovery of phenolic compounds an...

journal_title：International immunopharmacology

authors： Colomeu TC,Figueiredo D,Cazarin CB,Schumacher NS,Maróstica MR Jr,Meletti LM,Zollner RL

更新日期：2014-01-01 00:00:00

abstract：:Evidence shows that psychosocial stress exacerbates asthma, but there is little intervention to alleviate negative effects of psychosocial stress on asthma. We investigated the role of icariin in anti-inflammation and anti-anxiety potential in a murine model combined psychosocial stress with allergic exposure. The res...

journal_title：International immunopharmacology

authors： Li B,Duan X,Xu C,Wu J,Liu B,Du Y,Luo Q,Jin H,Gong W,Dong J

更新日期：2014-04-01 00:00:00

abstract：:Opioid abuse has been shown to exacerbate the immunosuppressive effects and pathogenesis of HIV infection. The mu opioid receptor (MOR) is present on immune cells, such as macrophages, and mediates the direct immunomodulatory effects of opioids. Through its surface glycoprotein, gp120, HIV-1 binds to surface receptors...

journal_title：International immunopharmacology

authors： Beltran JA,Pallur A,Chang SL

更新日期：2006-09-01 00:00:00