当前位置： SCI文献检索 > INTERNATIONAL IMMUNOPHARMACOLOGY期刊下所有文献 > Pseudomonas aeruginosa promotes autophagy to suppress macrophage-mediated bacterial eradication.

Pseudomonas aeruginosa promotes autophagy to suppress macrophage-mediated bacterial eradication.

Abstract：

OBJECTIVES:To explore the role of autophagy on macrophage-mediated phagocytosis and intracellular killing of Pseudomonas aeruginosa (PA), a common extracellular bacterium which often causes various opportunistic infections. METHODS:Macrophages were infected with PA or stimulated with zymosan bioparticles. Autophagy was tested by fluorescent microscopy and Western blot for LC3. Phagocytosis and killing efficiency were assessed by plate count assay, flow cytometry or immunofluorescent staining. Phagocytic receptor expression, ROS generation and NO production were examined by PCR, flow cytometry and Griess reaction, respectively. RESULTS:PA infection induced autophagy activation in both mouse and human macrophages. Induction of autophagy by rapamycin or starvation significantly inhibited PA internalization by downregulating phagocytosis receptor expression, and suppressed intracellular killing of PA via reducing ROS and NO production in macrophages. While knockdown of autophagy molecules ATG7 or Beclin1 enhanced macrophage-mediated phagocytosis and intracellular killing of PA. Additionally, confocal microscopy data showed that induction of autophagy reduced the number of phagosomes and phagolysosomes in macrophages after stimulation with zymosan bioparticles. CONCLUSIONS:Our study suggested that PA promotes autophagy to suppress macrophage-mediated bacterial phagocytosis and intracellular killing. These insights demonstrated a novel immune evasion mechanism employed by PA, which may provide potential therapeutic strategies of PA infectious diseases.

journal_name

Int Immunopharmacol

journal_title

International immunopharmacology

authors

Wu Y,Li D,Wang Y,Chen K,Yang K,Huang X,Zhang Y,Wu M

doi

10.1016/j.intimp.2016.04.044

subject

Has Abstract

pub_date

2016-09-01 00:00:00

pages

214-22

eissn

1567-5769

issn

1878-1705

pii

S1567-5769(16)30187-4

journal_volume

38

pub_type

杂志文章

相关文献

INTERNATIONAL IMMUNOPHARMACOLOGY文献大全
  • Protective effect of SKLB010 against D-galactosamine/lipopolysaccharide-induced acute liver failure via nuclear factor-κB signaling pathway in macrophages.

    abstract：:Acute liver failure is characterized by the sudden loss of hepatic function and a high mortality. SKLB010, a derivative of thiazolidinediones, has been proved to be effective in protecting mice from acute liver failure caused by concanavalin A and carbon tetrachloride in our previous work. The purpose of the current s...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2014.05.012

    authors： Xie C,Jingjing W,Li X,Zeng F,Ma L,Li C,Wei Z,Peng A,Chen L

    更新日期：2014-08-01 00:00:00

  • Distinct immunosuppressive effect by Isodon serra extracts.

    abstract：:Distinct effect of ent-Kaurene Diterpenoids from Isodon serra on abnormal proliferation of murine lymphocytes was examined with MTT assay and Flow Cytometry Analyses (FCAS). After choosing the most appropriate monomer from these Diterpenoids, we introduced mouse tumescence model to investigate whether it could impact ...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2005.06.016

    authors： Zhang Y,Liu J,Jia W,Zhao A,Li T

    更新日期：2005-12-01 00:00:00

  • Anandamide prior to sensitization increases cell-mediated immunity in mice.

    abstract：:The endocannabinoid system has become a topic of great interest in pharmacology due to its remarkable distribution in mammal organisms and capacity to play a modulatory role on several physiological systems, including modulation of immunity. Many studies have shown that administration of cannabinoids causes inhibitory...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2009.12.017

    authors： Ribeiro A,Ferraz-de-Paula V,Pinheiro ML,Sakai M,Costa-Pinto FA,Palermo-Neto J

    更新日期：2010-04-01 00:00:00

  • Immunomodulatory activity of analog of muramyl dipeptide and their use as adjunct to chemotherapy of Leishmania donovani in hamster.

    abstract：:In search of a potent immunomodulator to be used as an immunoprophylactic agent and as adjunct to chemotherapy against Leishmania infection, two analogs of muramyl dipeptide, viz. N.Ac-norMur-MeVal-D-isoGln (86/448) and N.AcMur-Acc-D-isoGln (89/729) were evaluated for desired activity. Effect of these peptides on cell...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2004.12.015

    authors： Puri A,Sahai R,Haq W,Zaidi A,Guru PY,Tripathi LM,Srivastava VM

    更新日期：2005-06-01 00:00:00

  • The therapeutic potential of microbial proteasome inhibitors.

    abstract：:The proteasome influences cellular homeostasis through the degradation of regulatory proteins, many of which are also involved in disease pathogenesis. In particular, numerous regulatory proteins associated with tumor growth, such as cyclins, cyclin-dependent kinase inhibitors, tumor suppressors, and NF-κB inhibitors ...

    journal_title：International immunopharmacology

    pub_type： 杂志文章,评审

    doi：10.1016/j.intimp.2015.11.013

    authors： Momose I,Kawada M

    更新日期：2016-08-01 00:00:00

  • Notoginsenoside R1 suppresses wear particle-induced osteolysis and RANKL mediated osteoclastogenesis in vivo and in vitro.

    abstract：:Aseptic periprosthetic osteolysis is a complication induced by wear particles after hip joint replacement, which shortens the service life of prostheses. Although many methods have been applied to prevent this complication, the results were not always successful. In the present study, we explored the prophylactic effe...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2017.03.018

    authors： Zhao S,Yan L,Li X,Zhang Z,Sun Y,Wang J

    更新日期：2017-06-01 00:00:00

  • Follicular regulatory T cells infiltrated the ovarian carcinoma and resulted in CD8 T cell dysfunction dependent on IL-10 pathway.

    abstract：:A high Treg/CD8 T cell ratio in ovarian carcinoma was negatively associated with the prognosis of the patients. The human follicular regulatory T (Tfr) cells are a newly characterized subset of Treg cells with features of both follicular helper T (Tfh) cells (CXCR5+) and canonical Treg cells (CD25+Foxp3+). The role of...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2018.12.051

    authors： Li L,Ma Y,Xu Y

    更新日期：2019-03-01 00:00:00

  • Imiquimod-related dermatitis is mainly mediated by mast cell degranulation via Mas-related G-protein coupled receptor B2.

    abstract：:While imiquimod (IMQ) has been widely used in dermatology, its side effect manifested as dermatitis couldn't be ignored. However, the underlying mechanism has not been fully understood. Considering the clinical features of IMQ-related dermatitis similar to pseudo-allergic reaction and the presence of large numbers of ...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2020.106258

    authors： Hao Y,Peng B,Che D,Zheng Y,Kong S,Liu R,Shi J,Han H,Wang J,Cao J,Zhang Y,Gao J,He L,Geng S

    更新日期：2020-04-01 00:00:00

  • Cannabinoid receptor 2 promotes the intracellular degradation of HMGB1 via the autophagy-lysosome pathway in macrophage.

    abstract：:High mobility group box 1 (HMGB1) is a late phase inflammatory mediator in many inflammatory diseases. Extracellular HMGB1 could bind to many membrane receptors to activate downstream signaling molecules and promote inflammation resulting in cell and tissue damage. In our previous work, we found cannabinoid receptor Ⅱ...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2019.106007

    authors： Zhou H,Du R,Li G,Bai Z,Ma J,Mao C,Wang J,Gui H

    更新日期：2020-01-01 00:00:00

  • Chronic dexamethasone treatment results in hippocampal neurons injury due to activate NLRP1 inflammasome in vitro.

    abstract：:Neuroinflammation mediated by NLRP-1 inflammasome plays an important role in the pathogenesis of neurodegeneration diseases such as Alzheimer's disease (AD). Chronic glucocorticoids (GCs) exposure has deleterious effect on the structure and function of neurons and was found to be correlated with development and progre...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2017.05.039

    authors： Zhang B,Zhang Y,Xu T,Yin Y,Huang R,Wang Y,Zhang J,Huang D,Li W

    更新日期：2017-08-01 00:00:00

  • A prognostic signature based on immune-related genes for cervical squamous cell carcinoma and endocervical adenocarcinoma.

    abstract：:Cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC) is the fourth commonest female malignancy worldwide. CESC progresses in immune-microenvironment mainly composed of infiltrating immune and stromal cells. Here, we performed an integrated analysis incorporating the expression profiles from the Canc...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2020.106884

    authors： Liu J,Wu Z,Wang Y,Nie S,Sun R,Yang J,Cheng W

    更新日期：2020-11-01 00:00:00

  • Dihydrofisetin exerts its anti-inflammatory effects associated with suppressing ERK/p38 MAPK and Heme Oxygenase-1 activation in lipopolysaccharide-stimulated RAW 264.7 macrophages and carrageenan-induced mice paw edema.

    abstract：:Dihydrofisetin is a flavanonol derived from some edible wild herbs and traditional Chinese medicines. It has been found to possess many biological activities. However, the anti-inflammatory potential of Dihydrofisetin remains uncharacterized. The aim of the present study was to investigate the anti-inflammatory activi...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2017.11.034

    authors： Li KK,Shen SS,Deng X,Shiu HT,Siu WS,Leung PC,Ko CH,Cheng BH

    更新日期：2018-01-01 00:00:00

  • The impact of a new immunomodulator oxo-quinoline-3-carboxamide on the progression of experimental lupus.

    abstract：:Autoimmune, lupus-prone MRL lpr/lpr mice were treated orally with oxo-quinoline-3-carboxamide (ABR-25757), a newly developed immunomodulator. Treatment was initiated in one set of experiment at the age of 10 weeks, before the onset of clinically apparent disease, and in another set at 15 weeks, after the development o...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2004.07.009

    authors： Carlsten H,Jonsson C,Bokarewa M,Svensson L,Tarkowski A

    更新日期：2004-11-01 00:00:00

  • Severe impairment of anti-cancer effect of lipoteichoic acid-related molecule isolated from a penicillin-killed Streptococcus pyogenes in toll-like receptor 4-deficient mice.

    abstract：:A lipoteichoic acid-related molecule (OK-PSA) isolated from OK-432, a penicillin-killed Streptococcus pyogenes, is a potent inducer of Th1 cytokines, and elicits anti-cancer effect in tumor-bearing mice. Toll-like receptor (TLR) 4 is a member of the recently identified toll-like receptor family of proteins that has be...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/s1567-5769(01)00103-5

    authors： Okamoto M,Oshikawa T,Ohe G,Nishikawa H,Furuichi S,Tano T,Moriya Y,Saito M,Sato M

    更新日期：2001-09-01 00:00:00

  • Exosomes from high glucose-treated macrophages activate macrophages andinduce inflammatory responses via NF-κB signaling pathway in vitro and in vivo.

    abstract：:There is increasing evidence that macrophages play an important role in the development and pathogenesis of diabetic nephropathy (DN) by secreting inflammatory cytokines. Exosomes are a family of extracellular vesicles that are secreted from almost all types of cells and associated with cell-to-cell communications. In...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2020.106551

    authors： Zhu M,Sun X,Qi X,Xia L,Wu Y

    更新日期：2020-07-01 00:00:00

  • Ex vivo induced regulatory T cells regulate inflammatory response of Kupffer cells by TGF-beta and attenuate liver ischemia reperfusion injury.

    abstract：:In the presence of TGF-β, CD4+CD62L+T cells can be induced to CD4+CD25+FoxP3+ regulatory T cells (iTregs). In our previous work, we have shown that adoptive transfer of iTregs promoted liver recovery from ischemia reperfusion injury (IRI). In this study, we examined the molecular mechanism underlying the liver IRI att...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2011.11.010

    authors： Feng M,Wang Q,Zhang F,Lu L

    更新日期：2012-01-01 00:00:00

  • Activation of Nrf2 signaling by salvianolic acid C attenuates NF‑κB mediated inflammatory response both in vivo and in vitro.

    abstract：:Neurodegenerative diseases are closely related to neuroinflammation. Drugs targeting inflammation have been proved to be effective in many animal models. Salvianolic acid C (SalC) is a compound isolated from Salvia miltiorrhiza Bunge, a plant with reported effects of inhibiting inflammation. However, the anti-inflamma...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2018.08.004

    authors： Song J,Zhang W,Wang J,Yang H,Zhao X,Zhou Q,Wang H,Li L,Du G

    更新日期：2018-10-01 00:00:00

  • Influenza virus-like particles composed of conserved influenza proteins and GPI-anchored CCL28/GM-CSF fusion proteins enhance protective immunity against homologous and heterologous viruses.

    abstract：:Influenza viruses cause significant morbidity and mortality and pose a substantial threat to public health. Vaccination represents the principle means of preventing influenza virus infection. Current vaccine approaches are hindered by the need to routinely reformulate vaccine compositions in an effort to account for t...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2018.07.011

    authors： Liu J,Ren Z,Wang H,Zhao Y,Wilker PR,Yu Z,Sun W,Wang T,Feng N,Li Y,Wang H,Ji X,Li N,Yang S,He H,Qin C,Gao Y,Xia X

    更新日期：2018-10-01 00:00:00

  • Genipin inhibits the inflammatory response of rat brain microglial cells.

    abstract：:Microglia are the prime effectors in immune and inflammatory responses of the central nervous system (CNS). Under pathological conditions, the activation of these cells helps restore CNS homeostasis. However, chronic microglial activation endangers neuronal survival through the release of various proinflammatory and n...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2010.01.011

    authors： Nam KN,Choi YS,Jung HJ,Park GH,Park JM,Moon SK,Cho KH,Kang C,Kang I,Oh MS,Lee EH

    更新日期：2010-04-01 00:00:00

  • Efficacy and safety of CTLA-4 inhibitors combined with PD-1 inhibitors or chemotherapy in patients with advanced melanoma.

    abstract：BACKGROUND:Although immune checkpoint inhibitor monotherapy has demonstrated significant efficacy in advanced melanoma, no study has systematically evaluated the efficacy and safety of the combination regimens. In this study, we conduct a comprehensive meta-analysis to explore the efficacy and safety of CTLA-4 inhibito...

    journal_title：International immunopharmacology

    pub_type： 杂志文章,meta分析

    doi：10.1016/j.intimp.2018.12.034

    authors： Zhang B,Zhou YL,Chen X,Wang Z,Wang Q,Ju F,Ren S,Xu R,Xue Q,Wu Q

    更新日期：2019-03-01 00:00:00

  • Relationship between certain T helper cytokines and ANA staining: who is the helper?

    abstract：OBJECTIVE:This study investigated some T helper cytokines' association with different ANA positive sera. METHODS:Sera of 53 ANA-positive subjects (11 were stained of homogeneous pattern, 12 of speckled particle pattern, 9 of nucleolar pattern, 15 of centromere pattern, and 6 of the peripheral nuclear type) were collec...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2014.12.017

    authors： Hu J,Zhang Y,Liu X,Wei L,Zhang D

    更新日期：2015-02-01 00:00:00

  • Fatty acids isolated from royal jelly modulate dendritic cell-mediated immune response in vitro.

    abstract：:Royal jelly (RJ), especially its protein components, has been shown to possess immunomodulatory activity. However, almost nothing is known about the influence of RJ fatty acids on the immune system. In this work we studied the effect of 10-hydroxy-2-decanoic acid (10-HDA) and 3,10-dihydroxy-decanoic acid (3,10-DDA), i...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2007.05.005

    authors： Vucevic D,Melliou E,Vasilijic S,Gasic S,Ivanovski P,Chinou I,Colic M

    更新日期：2007-09-01 00:00:00

  • Oral immunogenicity of the plant proteinase bromelain.

    abstract：:Bromelain is a natural mixture of proteolytic enzymes derived from pineapple stem that has been shown to have anti-inflammatory activity when administered orally. Although most proteins given orally without adjuvant (e.g., food) result in tolerance, we previously reported that long-term oral exposure to bromelain stim...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2006.08.007

    authors： Hale LP,Fitzhugh DJ,Staats HF

    更新日期：2006-12-20 00:00:00

  • Up-regulation of phospholipase Cgamma1 and phospholipase D during the differentiation of human monocytes to dendritic cells.

    abstract：:Phospholipase C (PLC)gamma and phospholipase D (PLD) play pivotal roles in the signal transduction required for various cellular responses, including cell proliferation and differentiation. Dendritic cells (DCs), which are professional antigen-presenting cells, can be generated from human monocytes by stimulating the ...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2004.04.001

    authors： Kang HK,Lee HY,Lee YN,Jo EJ,Kim JI,Kim GY,Park YM,Min DS,Yano A,Kwak JY,Bae YS

    更新日期：2004-07-01 00:00:00

  • CD5L contributes to the pathogenesis of methicillin-resistant Staphylococcus aureus-induced pneumonia.

    abstract：:Staphylococcus aureus is a major causative microorganism in community- and healthcare-acquired pneumonia. CD5L is an important protein in the control of immune homeostasis. In this study, we found that patients with S. aureus pneumonia displayed increased levels of circulating CD5L. Likewise, mice with S. aureus pneum...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2019.03.057

    authors： Gao X,Yan X,Zhang Q,Yin Y,Cao J

    更新日期：2019-07-01 00:00:00

  • Inhibitory effects of eicosapentaenoic acid on lipopolysaccharide-induced activation in BV2 microglia.

    abstract：:Upon activation, microglia release proinflammatory mediators that play important roles in eliciting neuroinflammatory responses associated with neurodegenerative diseases. The anti-inflammatory properties of eicosapentaenoic acid (EPA) have been known, however, the effects responsible for lipopolysaccharide (LPS)-indu...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2006.10.001

    authors： Moon DO,Kim KC,Jin CY,Han MH,Park C,Lee KJ,Park YM,Choi YH,Kim GY

    更新日期：2007-02-01 00:00:00

  • A review on the effect of COVID-19 in type 2 asthma and its management.

    abstract：BACKGROUND:COVID-19 is considered the most critical health pandemic of 21st century. Due to extremely high transmission rate, people are more susceptible to viral infection. COVID-19 patients having chronic type-2 asthma prevails a major risk as it may aggravate the disease and morbidities. OBJECTIVE:The present revie...

    journal_title：International immunopharmacology

    pub_type： 杂志文章,评审

    doi：10.1016/j.intimp.2020.107309

    authors： Ghosh S,Das S,Mondal R,Abdullah S,Sultana S,Singh S,Sehgal A,Behl T

    更新日期：2021-02-01 00:00:00

  • Glycyrrhizin regulates CD4+T cell response during liver fibrogenesis via JNK, ERK and PI3K/AKT pathway.

    abstract：:The aims of this study were to elucidate the immunomodulatory effects of glycyrrhizin (GL) on CD4(+)T cell responses during liver fibrogenesis. To obtain in vivo evidence about the effects of GL on CD4(+)T cells in livers and spleens of concanavalin A (ConA)-induced mouse model, mice were administrated with ConA toget...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2012.08.013

    authors： Tu CT,Li J,Wang FP,Li L,Wang JY,Jiang W

    更新日期：2012-12-01 00:00:00

  • Macrophage activation and nitric oxide production by water soluble components of Hericium erinaceum.

    abstract：:Hericium erinaceum is a medicinal and edible mushroom with anti-microbial and anti-cancer activities. To evaluate the immunoregulatory functions of H. erinaceum, we prepared water extract from H. erinaceum (WEHE) and investigated its ability to activate macrophages and to induce nitric oxide (NO) production in macroph...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2006.03.005

    authors： Son CG,Shin JW,Cho JH,Cho CK,Yun CH,Chung W,Han SH

    更新日期：2006-08-01 00:00:00

  • Tristetraprolin exerts tumor suppressive functions on the tumorigenesis of glioma by targeting IL-13.

    abstract：:The RNA-binding protein tristetraprolin (TTP) is an adenine/uridine (AU)-rich elements (AREs)-binding protein that can induce the decay of AREs containing mRNAs. In this study, we demonstrated that TTP is significantly down-regulated in human glioma tissue samples and cell lines. It is also associated with diminished ...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2016.07.001

    authors： Zeng B,Zhu D,Su Z,Li Z,Yu Z

    更新日期：2016-10-01 00:00:00