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Application of Candida solubilized cell wall beta-glucan in antitumor immunotherapy against P815 mastocytoma in mice.

Abstract：

:This study was designed to evaluate the antitumor activity of CSBG, purified from the cell wall of Candida albicans IFO1385. First, as an effect of CSBG on P815 mastocytoma, significant prolonged survival and suppression of the tumor growth were observed. Second, the transfer of spleen cells from CSBG-sensitized BALB/c mice to CDF1 mice led to further suppression of tumor growth as well as P815-immunized spleen cells. Third, CSBG enhanced antitumor immunity in gene therapy using B7-1-transfected P815 cells. These results strongly suggest that CSBG enhances the host defense response to tumor due in part to an adjuvant effect.

journal_name

Int Immunopharmacol

journal_title

International immunopharmacology

authors

Tokunaka K,Ohno N,Adachi Y,Miura NN,Yadomae T

doi

10.1016/s1567-5769(01)00148-5

keywords:

subject

Has Abstract

pub_date

2002-01-01 00:00:00

pages

59-67

issue

1

eissn

1567-5769

issn

1878-1705

pii

S1567-5769(01)00148-5

journal_volume

2

pub_type

杂志文章

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