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In vitro expanded alloantigen-specific CD4+CD25+ regulatory T cell treatment for the induction of donor-specific transplantation tolerance.

Abstract：

:The key goal in clinical transplantation is the induction of donor-specific transplantation tolerance to minimise the morbidity and mortality associated with long-term immunosuppression. Naturally occurring CD4(+)CD25(+) regulatory T cells (Tregs) expressing forkhead transcript factor FoxP3 play a crucial role in the prevention of autoimmunity, and appear to mediate transplantation tolerance, and these cells can have indirect allospecificity for donor antigens. Here we show that self-reactive human CD4(+)CD25(+) Tregs can be subverted into allopeptide-specific cells in vitro and be expanded to large cell numbers, and that similar in vitro expanded murine CD4(+)CD25(+) Tregs with indirect allospecificity were capable of inducing donor-specific experimental transplantation tolerance. These data provide a platform for clinical studies using CD4(+)CD25(+) Tregs with indirect allospecificity as potential reagents for the induction of donor-specific transplantation tolerance.

journal_name

Int Immunopharmacol

journal_title

International immunopharmacology

authors

Jiang S,Golshayan D,Tsang J,Lombardi G,Lechler RI

doi

10.1016/j.intimp.2006.07.025

subject

Has Abstract

pub_date

2006-12-20 00:00:00

pages

1879-82

issue

13-14

eissn

1567-5769

issn

1878-1705

pii

S1567-5769(06)00227-X

journal_volume

6

pub_type

杂志文章

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