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Effects of Astragalus polysaccharides (APS) on the expression of immune response genes in head kidney, gill and spleen of the common carp, Cyprinus carpio L.

Abstract：

:For fish immune defences, cytokines and anti-microbial peptides (lysozyme) in circulating system play important roles. In the present study, the effects of Astragalus polysaccharides (APS) injection on gene expression of interleukin 1beta (IL-1beta), tumor necrosis factoralpha (TNF-alpha) and lysozyme-C in the head kidney, gill and spleen of common carp were determined using semi-quantitative reverse transcription-polymerase chain reaction (RT-PCR). After injection of APS, IL-1beta mRNA level increased in a dose-dependent manner in the head kidney, while no significant changes were found in the gill and spleen. High dose of APS up regulated TNF-alpha transcription in the gill and spleen, while TNF-alpha mRNA level decreased significantly in the head kidney of low dose of APS. Lysozyme-C mRNA levels were up regulated in the gill of low dose of APS and spleen of middle dose of APS. No effect of the APS on lysozyme-C expression was observed in head kidney. These results constitute a first step toward the understanding of APS effect on cytokines and immune-related gene expression in different organs of common carp.

journal_name

Int Immunopharmacol

journal_title

International immunopharmacology

authors

Yuan C,Pan X,Gong Y,Xia A,Wu G,Tang J,Han X

doi

10.1016/j.intimp.2007.10.009

subject

Has Abstract

pub_date

2008-01-01 00:00:00

pages

51-8

issue

1

eissn

1567-5769

issn

1878-1705

pii

S1567-5769(07)00318-9

journal_volume

8

pub_type

杂志文章

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