当前位置： SCI文献检索 > INTERNATIONAL IMMUNOPHARMACOLOGY期刊下所有文献 > Higenamine promotes M2 macrophage activation and reduces Hmgb1 production through HO-1 induction in a murine model of spinal cord injury.

Higenamine promotes M2 macrophage activation and reduces Hmgb1 production through HO-1 induction in a murine model of spinal cord injury.

Abstract：

:Spinal cord injury (SCI) is considered to be primarily associated with loss of motor function and leads to the activation of diverse cellular mechanisms in the central nervous system to attempt to repair the damaged spinal cord tissue. Higenamine (HG) (1-[(4-hydroxyphenyl) methyl]-1,2,3,4-tetrahydroisoquinoline-6,7-diol), an active ingredient of Aconiti Lateralis Radix Praeparata, has been traditionally used as a heart stimulant and anti-inflammatory agent in oriental countries. However, the function and related mechanism of HG on SCI have never been investigated. In our current study, HG treatment displayed increased myelin sparring and enhanced spinal cord repair process. The numbers of CD4(+) T cells, CD8(+) T cells, Ly6G(+) neutrophils and CD11b(+) macrophages were all significantly lower in the HG-treated group than that in the control group after SCI. HG administration increased the expression of IL-4 and IL-10 and promoted M2 macrophage activation. Significantly reduced Hmgb1 expression was also observed in HG-treated mice with SCI. Furthermore, HG treatment promoted HO-1 production. The increased number of M2 macrophages, decreased expression of Hmgb1 and promoted locomotor recovery induced by HG were all reversed with additional HO-1 inhibitor treatment. In conclusion, HG promotes M2 macrophage activation and reduces Hmgb1 expression dependent on HO-1 induction and then promotes locomotor function after SCI.

journal_name

Int Immunopharmacol

journal_title

International immunopharmacology

authors

Zhang Z,Li M,Wang Y,Wu J,Li J

doi

10.1016/j.intimp.2014.10.022

subject

Has Abstract

pub_date

2014-12-01 00:00:00

pages

681-7

issue

2

eissn

1567-5769

issn

1878-1705

pii

S1567-5769(14)00404-4

journal_volume

23

pub_type

杂志文章

相关文献

INTERNATIONAL IMMUNOPHARMACOLOGY文献大全
  • Semaphorin 4A acts in a feed-forward loop with NF-κB pathway to exacerbate catabolic effect of IL-1β on chondrocytes.

    abstract：:Inflammation is fundamental in osteoarthritis (OA) pathogenesis. Semaphorin 4A (Sema4A) has been implicated in immune-associated diseases, however, its role in OA remains unclear. In this study, we show that Sema4A is upregulated in knee OA articular cartilage as well as in chondrocytes exposed to IL-1β treatment in v...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2019.01.006

    authors： Zhang H,Wei Q,Xiang X,Zhou B,Chen J,Li J,Li Q,Xiong H,Liu F

    更新日期：2019-04-01 00:00:00

  • Complement factor H and hemolytic uremic syndrome.

    abstract：:Factor H is a 150 kDa single chain plasma glycoprotein that plays a pivotal role in the regulation of the alternative pathway of complement. Primary sequence analysis reveals a structural organization of this plasma protein, in 20 homologous units, called Short Consensus Repeats (SCRs), each about 60 amino acids long....

    journal_title：International immunopharmacology

    pub_type： 杂志文章,评审

    doi：10.1016/s1567-5769(00)00047-3

    authors： Zipfel PF,Skerka C,Caprioli J,Manuelian T,Neumann HH,Noris M,Remuzzi G

    更新日期：2001-03-01 00:00:00

  • Depression linked to higher antibodies production against estrogenized insulin in type 1 diabetes.

    abstract：:Depression has been commonly associated with type 1 diabetes (T1D) and insulin covalently modified with catecholestrogens (CEs) was found in serum of these T1D patients. This study aimed to know whether depression link to higher antibodies against estrogenized insulin in T1D. ELISA (direct binding and competition) and...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2020.106712

    authors： Khan WA,Malik A,Khan MWA

    更新日期：2020-09-01 00:00:00

  • Suppression of nuclear factor-kappa B and mitogen-activated protein kinase signalling pathways by goshonoside-F5 extracted from Rubi Fructus.

    abstract：:Rubi Fructus, a traditional Chinese medicine, was considered as an anti-inflammatory agent in folk medicine. In the present study, we investigated the signalling pathways involved in the anti-inflammatory effects of goshonoside-F5 (GF5), isolated from Rubi Fructus, in peritoneal macrophages and examined its therapeuti...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2014.12.007

    authors： He JM,Chen SC,Li RP,Yuan LX,Bao JM,Guo ML

    更新日期：2015-02-01 00:00:00

  • Molecular validation of the precision-cut kidney slice (PCKS) model of renal fibrosis through assessment of TGF-β1-induced Smad and p38/ERK signaling.

    abstract：BACKGROUND:The precision-cut kidney slice (PCKS) model appears to be a useful ex vivo model of renal fibrosis. However, little in-depth molecular investigation on the PCKS model has been performed. Therefore, the aim of this study will be to investigate and validate the molecular validity of this model. METHODS:The PC...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2016.01.026

    authors： Zhang S,Liu Q,Xiao J,Lei J,Liu Y,Xu H,Hong Z

    更新日期：2016-05-01 00:00:00

  • Upregulation of JHDM1D-AS1 alleviates neuroinflammation and neuronal injury via targeting miR-101-3p-DUSP1 in spinal cord after brachial plexus injury.

    abstract：BACKGROUND:Neuroinflammation in the spinal cord following acute brachial plexus injury (BPI) remains a vital cause that leads to motor dysfunction and neuropathic pain. In this study, we aim to explore the role of long non-coding RNA JHDM1D antisense 1 (JHDM1D-AS1) in mediating BPI-induced neuroinflammation and neurona...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2020.106962

    authors： Liu LP,Zhang J,Pu B,Li WQ,Wang YS

    更新日期：2020-12-01 00:00:00

  • Activation of PPARγ by Curcumin protects mice from ischemia/reperfusion injury induced by orthotopic liver transplantation via modulating polarization of Kupffer cells.

    abstract：:Curcumin shows protective effects on various diseases due to its anti-inflammatory and anti-oxidative functions; however, its effect on organ transplantation has not been fully elucidated. To understand its role in liver ischemia/reperfusion (I/R) injury, we studied its impact on orthotopic liver transplantation (OLT)...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2018.07.013

    authors： Liu Y,Zhang W,Cheng Y,Miao C,Gong J,Wang M

    更新日期：2018-09-01 00:00:00

  • 10-Hydroxydecanoic acid inhibits LPS-induced inflammation by targeting p53 in microglial cells.

    abstract：:Neuroinflammation, characterized by the activation of microglia and astrocytes, is important in the pathogenesis of many neurological disorders, such as Alzheimer's disease. Nonsteroidal anti-inflammatory drugs (NSAIDs), a group of chemically heterogenous medications, are used widely in the treatment of inflammation. ...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2020.106501

    authors： You M,Miao Z,Sienkiewicz O,Jiang X,Zhao X,Hu F

    更新日期：2020-07-01 00:00:00

  • Cyclosporine A up-regulates expression of matrix metalloproteinase 2 and vascular endothelial growth factor in rat heart.

    abstract：:Cyclosporine A (CsA) is the first immunosuppressant universally used in allotransplantation. However, it has been demonstrated that this drug produces side effects in several organs, particularly in the kidney and in the heart. Since the immunosuppressive therapy induces myocardial toxicity, the aim of this study was ...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/S1567-5769(03)00020-1

    authors： Bianchi R,Rodella L,Rezzani R

    更新日期：2003-03-01 00:00:00

  • Up-regulation of phospholipase Cgamma1 and phospholipase D during the differentiation of human monocytes to dendritic cells.

    abstract：:Phospholipase C (PLC)gamma and phospholipase D (PLD) play pivotal roles in the signal transduction required for various cellular responses, including cell proliferation and differentiation. Dendritic cells (DCs), which are professional antigen-presenting cells, can be generated from human monocytes by stimulating the ...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2004.04.001

    authors： Kang HK,Lee HY,Lee YN,Jo EJ,Kim JI,Kim GY,Park YM,Min DS,Yano A,Kwak JY,Bae YS

    更新日期：2004-07-01 00:00:00

  • The effects of H1-antihistamines on the nitric oxide production by RAW 264.7 cells with respect to their lipophilicity.

    abstract：:H1-antihistamines are known to be important modulators of inflammatory response. However, the information about the influence of these drugs on reactive nitrogen species generation is still controversial. The main aim of the present study was to investigate the effects of selected H1-antihistamines on nitric oxide pro...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2009.04.005

    authors： Králová J,Racková L,Pekarová M,Kubala L,Nosál R,Jancinová V,Cíz M,Lojek A

    更新日期：2009-07-01 00:00:00

  • Dynamic analysis of tumor-associated immune cells in DEN-induced rat hepatocellular carcinoma.

    abstract：:Hepatocellular carcinoma (HCC) is an aggressive disease with poor prognosis and limited methods to predict patient survival. Immune cells infiltrating tumors are known to impact tumor progression. Here, we analyzed the phenotype and function of dendritic cells (DCs), and the frequency of IL-10-producing regulatory B c...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2014.07.007

    authors： Song S,Yuan P,Li P,Wu H,Lu J,Wei W

    更新日期：2014-10-01 00:00:00

  • Enhanced neutrophil autophagy and increased concentrations of IL-6, IL-8, IL-10 and MCP-1 in rheumatoid arthritis.

    abstract：:Rheumatoid arthritis (RA) is a high morbidity and disability disease with numerous inflammatory cells infiltrating in interstitial of articular cartilages and bones. As the most abundant inflammatory cells, neutrophil has been reported that their apoptosis changed gradually in the circumstance of RA. Apoptosis, one mo...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2018.09.011

    authors： An Q,Yan W,Zhao Y,Yu K

    更新日期：2018-12-01 00:00:00

  • Melatonin prevents lung injury induced by hepatic ischemia-reperfusion through anti-inflammatory and anti-apoptosis effects.

    abstract：:Melatonin is a free radical scavenger and broad-spectrum antioxidant with immunomodulatory effects. The objective of the study is to investigate the effects of melatonin in hepatic ischemia/reperfusion (I/R) induced lung injury and explore its underlying mechanisms. Hepatic I/R injury was induced via portal vein and h...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2015.10.012

    authors： Zhou L,Zhao D,An H,Zhang H,Jiang C,Yang B

    更新日期：2015-12-01 00:00:00

  • Inhibition of hematopoietic progenitor cell growth by Tyr-MIF, an endogenous opiate modulator, and its degradation products.

    abstract：:There is increasing evidence that neuronal factors can affect hematopoietic cell proliferation. Endogenous opioids with specificity for several opioid receptor classes were tested for their ability to inhibit murine and human hematopoietic progenitor cell proliferation. Tyr-MIF, an opioid tetrapeptide (H-Tyr-Pro-Leu-G...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/s1567-5769(02)00007-3

    authors： Horowitz D,Callahan JF,Pelus LM,Fukuda S,King AG

    更新日期：2002-04-01 00:00:00

  • Immunomodulatory pretreatment with Kalanchoe pinnata extract and its quercitrin flavonoid effectively protects mice against fatal anaphylactic shock.

    abstract：:Previously, we reported the immunosuppressive action of the aqueous extract of Kalanchoe pinnata (Kp) in mice. In the present study, we report on the protective effect of Kp in fatal anaphylactic shock, likewise a Th2-driven immunopathology, and the identification of its active component. Mice daily treated with oral ...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2008.07.006

    authors： Cruz EA,Da-Silva SA,Muzitano MF,Silva PM,Costa SS,Rossi-Bergmann B

    更新日期：2008-12-10 00:00:00

  • A model based on tumor-infiltrating immune cells for predicting the relapse rates of patients with testicular germ cell tumors.

    abstract：OBJECTIVE:The activities of tumor-infiltrating immune cells (TIICs) play an important role in the outcomes of many types of cancers. Here, we sought to describe the landscape of TIICs in testicular germ cell tumors (TGCT) and to develop a prognostic model based on this information. METHODS:The Cell-type Identification...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2020.106710

    authors： Wang Y,Ji C,Liu J,Wang Y,Song N,Cao P

    更新日期：2020-09-01 00:00:00

  • GABA-mediated activated microglia induce neuroinflammation in the hippocampus of mice following cold exposure through the NLRP3 inflammasome and NF-κB signaling pathways.

    abstract：:Chronic cold stress has long-term dramatic effects on the animal immune and neuroendocrine systems. As one of the important regions of the brain, the hippocampus is the main region involved in response to stressors. Nevertheless, the impact to the hippocampus following cold exposure and the underlying mechanism involv...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2020.106908

    authors： Lang L,Xu B,Yuan J,Li S,Lian S,Chen Y,Guo J,Yang H

    更新日期：2020-12-01 00:00:00

  • Regulation of interleukin-10 secretion by histamine in TH2 cells and splenocytes.

    abstract：:Interleukin-10 is a potent suppressive factor that down-regulates cellular immune response via inhibition of the production of TH1 cytokines. Histamine shifts the TH1/TH2 balance from TH1 to TH2 cytokines making the effects of histamine on IL-10 secretion an important factor in this switch. This study was designed to ...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/s0162-3109(00)00268-x

    authors： Osna N,Elliott K,Khan MM

    更新日期：2001-01-01 00:00:00

  • Macrophage activation and nitric oxide production by water soluble components of Hericium erinaceum.

    abstract：:Hericium erinaceum is a medicinal and edible mushroom with anti-microbial and anti-cancer activities. To evaluate the immunoregulatory functions of H. erinaceum, we prepared water extract from H. erinaceum (WEHE) and investigated its ability to activate macrophages and to induce nitric oxide (NO) production in macroph...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2006.03.005

    authors： Son CG,Shin JW,Cho JH,Cho CK,Yun CH,Chung W,Han SH

    更新日期：2006-08-01 00:00:00

  • Epigallocatechin-3-gallate reduces liver and immune system damage in Acinetobacter baumannii-loaded mice with restraint stress.

    abstract：AIM:Due to the significant increase in the antimicrobial resistance of Acinetobacter baumannii (A. baumannii), new drugs to block the progression of infection are strongly needed. Epigallocatechin-3-gallate (EGCG), a major component of green tea, has exhibited potential activity against A. baumannii in vitro. The aim o...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2020.107346

    authors： Yan Q,Hao S,Shi F,Zou Y,Song X,Li L,Li Y,Guo H,He R,Zhao L,Ye G,Tang H

    更新日期：2021-01-04 00:00:00

  • Inhibitory effect of chaga mushroom extract on compound 48/80-induced anaphylactic shock and IgE production in mice.

    abstract：:Chaga mushrooms (Inonotus obliquus) are hypothesised to exhibit general immune-potentiating, anti-inflammatory, and antitumor properties, but their anti-allergic activities are not fully understood. Therefore, this study investigated whether a chaga mushroom extract (C-HE) might have anti-allergic activity. This activ...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2013.03.015

    authors： Yoon TJ,Lee SJ,Kim EY,Cho EH,Kang TB,Yu KW,Suh HJ

    更新日期：2013-04-01 00:00:00

  • Oral immunogenicity of the plant proteinase bromelain.

    abstract：:Bromelain is a natural mixture of proteolytic enzymes derived from pineapple stem that has been shown to have anti-inflammatory activity when administered orally. Although most proteins given orally without adjuvant (e.g., food) result in tolerance, we previously reported that long-term oral exposure to bromelain stim...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2006.08.007

    authors： Hale LP,Fitzhugh DJ,Staats HF

    更新日期：2006-12-20 00:00:00

  • Coupling pathogen recognition to innate immunity through glycan-dependent mechanisms.

    abstract：:Innate immune cells have evolved to sense microbial pathogens through pattern recognition receptors (PRRs), which interact with conserved pathogen-associated molecular patterns (PAMPs) to convey microbial information into immune cell signaling and activation events. PRRs also recognize endogenous damage-associated mol...

    journal_title：International immunopharmacology

    pub_type： 杂志文章,评审

    doi：10.1016/j.intimp.2011.05.002

    authors： Davicino RC,Eliçabe RJ,Di Genaro MS,Rabinovich GA

    更新日期：2011-10-01 00:00:00

  • Interleukin-35 stimulates tumor necrosis factor-α activated osteoblasts differentiation through Wnt/β-catenin signaling pathway in rheumatoid arthritis.

    abstract：:Interleukin (IL)-35 plays an important role in the pathogenesis of rheumatoid arthritis (RA), which is characterized by tumor necrosis factor (TNF)-α activated bone loss beginning early and persisting over time. The aim of this study was to explore the effects and signaling pathway of IL-35 on osteoblasts differentiat...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2019.105810

    authors： Li Y,Yuan L,Jiang S,Liu S,Xia L,Shen H,Lu J

    更新日期：2019-10-01 00:00:00

  • Function of follicular helper T cell is impaired and correlates with survival time in non-small cell lung cancer.

    abstract：:Non-small cell lung cancer (NSCLC) represents one of the most common and aggressive cancers worldwide. The PD-1/PD-L1 interaction plays important roles in cancer immunology, and expression of PD-L1 has been discovered in NSCLC tumor cells. Since follicular helper T (Tfh) cells have characteristic high PD-1 expression,...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2016.10.014

    authors： Ma QY,Huang DY,Zhang HJ,Chen J,Miller W,Chen XF

    更新日期：2016-12-01 00:00:00

  • Dysregulation of the expression of HLA-DR, costimulatory molecule, and chemokine receptors on immune cells in children with autism.

    abstract：:Autism spectrum disorder (ASD) is a heterogeneous disorder diagnosed based on the severity of abnormalities in social skills. Several studies have acknowledged the presence of abnormal immune functions among individuals diagnosed with ASD. HLA-DR (human leukocyte antigen-antigen D related) has been shown to play a sig...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2018.10.027

    authors： Ahmad SF,Ansari MA,Nadeem A,Bakheet SA,Al-Ayadhi LY,Alotaibi MR,Alhoshani AR,Al-Hosaini KA,Attia SM

    更新日期：2018-12-01 00:00:00

  • Assembly, activation, and physiologic influence of the plasma kallikrein/kinin system.

    abstract：:The plasma kallikrein/kinin system that consists of the proteins factor XII, prekallikrein, and high molecular weight kininogen was first recognized as a surface-activated coagulation system arising when blood or plasma interacts with artificial surfaces. Although surface-activated contact activation occurs in vivo wh...

    journal_title：International immunopharmacology

    pub_type： 杂志文章,评审

    doi：10.1016/j.intimp.2007.08.022

    authors： Schmaier AH

    更新日期：2008-02-01 00:00:00

  • Accelerated differentiation of bone marrow-derived dendritic cells in atopic prone mice.

    abstract：:NC/Nga mice are atopic prone mice that can be an animal model for human atopic dermatitis (AD). Dendritic cells (DC) as professional antigen-presenting cells (APC) are the most capable inducers of immune responses. The present study using BALB/c, C57BL/6J, and NC/Nga male mice investigated whether differentiation and ...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2008.08.006

    authors： Koike E,Takano H,Inoue K,Yanagisawa R

    更新日期：2008-12-20 00:00:00

  • Herpesviral Fcgamma receptors: culprits attenuating antiviral IgG?

    abstract：:Production of IgG in response to virus infection is central to antiviral immune effector functions and a hallmark of B cell memory. Antiviral antibodies (Abs) recognising viral glycoproteins or protein antigen displayed on the surface of virions or virus-infected cells are crucial in rendering the virus noninfectious ...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2004.05.020

    authors： Budt M,Reinhard H,Bigl A,Hengel H

    更新日期：2004-09-01 00:00:00