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GABA-mediated activated microglia induce neuroinflammation in the hippocampus of mice following cold exposure through the NLRP3 inflammasome and NF-κB signaling pathways.

Abstract：

:Chronic cold stress has long-term dramatic effects on the animal immune and neuroendocrine systems. As one of the important regions of the brain, the hippocampus is the main region involved in response to stressors. Nevertheless, the impact to the hippocampus following cold exposure and the underlying mechanism involved are not clear. To evaluate the response of the hippocampus during chronic cold stress, male C57BL/6 mice were exposed to 4 °C, 3 h per day for 1 week, after which neuroinflammation and the molecular and signaling pathways in the hippocampus response to cold stress were investigated. To confirm the potential mechanism, BV2 cells were treated with γ-aminobutyric acid (GABA) and BAY 11-7082 and MCC950, then the activation of microglia and key proteins involved in the regulation of inflammation were measured. We demonstrated that chronic cold stress induced the activation of microglia, the emergence of neuroinflammation, and the impairment of neurons in the hippocampus, which might be the result of GABA-mediated activation of nod-like receptor protein 3 (NLRP3) inflammasome and the nuclear factor kappa B (NF-κB) signaling pathway.

journal_name

Int Immunopharmacol

journal_title

International immunopharmacology

authors

Lang L,Xu B,Yuan J,Li S,Lian S,Chen Y,Guo J,Yang H

doi

10.1016/j.intimp.2020.106908

subject

Has Abstract

pub_date

2020-12-01 00:00:00

pages

106908

issue

Pt B

eissn

1567-5769

issn

1878-1705

pii

S1567-5769(20)31623-4

journal_volume

89

pub_type

杂志文章

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