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TanshinoneIIA ameliorates inflammatory microenvironment of colon cancer cells via repression of microRNA-155.

Abstract：

:TanshinoneIIA, an active component derived from a traditional Chinese medicine, has anti-inflammatory and anti-cancer effect. However, the mechanisms underlying the interaction between anti-inflammation and anti-cancer of TanshinoneIIA remain elusive. In the present study, a cell model of inflammation between macrophages and colon cancer cells was used. The results showed that TanshinoneIIA inhibited the proliferation of inflammation-related colon cancer cells HCT116 and HT-29 by decreasing the production of inflammatory cytokines tumor necrosis factor α (TNF-α) and interleukin 6 (IL-6), which generated by macrophage RAW264.7 cell line. We identified Phosphatidylinositol-3, 4, 5-trisphosphate 5-phosphatase 1 (SHIP1) was a bona fide target of miR-155. TanshinoneIIA restored the down-regulated level of SHIP1 protein after lipopolysaccharide (LPS)-stimulation in RAW264.7 cells. MicroRNA-155 (miR-155) was up-regulated in macrophages, possibly due to the concomitant increase of PU.1, a transcriptional activator of miR-155, accounting for decreased SHIP1. Treatment with TanshinoneIIA prevented increased PU.1 and hence increased miR-155, whereas aspirin could not. These findings support that the interruption of signal conduction between activated macrophages and colon cancer cells could be considered as a new therapeutic strategy and miR-155 could be a potential target for the prevention of inflammation-related cancer.

journal_name

Int Immunopharmacol

journal_title

International immunopharmacology

authors

Tu J,Xing Y,Guo Y,Tang F,Guo L,Xi T

doi

10.1016/j.intimp.2012.08.015

subject

Has Abstract

pub_date

2012-12-01 00:00:00

pages

353-61

issue

4

eissn

1567-5769

issn

1878-1705

pii

S1567-5769(12)00257-3

journal_volume

14

pub_type

杂志文章

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