Abstract：
:The immune system is the body's natural defense system against invading pathogens. It protects the body from infection and works to communicate an individual's well-being through a complex network of interconnected cells and cytokines. This system is an associated host defense. An uncontrolled immune system has the potential to trigger negative complications in the host. Type 1 diabetes results from the destruction of pancreatic β-cells by a β-cell-specific autoimmune process. Examples of β-cell autoantigens are insulin, glutamic acid decarboxylase, tyrosine phosphatase, and insulinoma antigen. There are many autoimmune diseases, but type 1 diabetes mellitus is one of the well-characterized autoimmune diseases. The mechanisms involved in the β-cell destruction are still not clear; it is generally believed that β-cell autoantigens, macrophages, dendritic cells, B lymphocytes, and T lymphocytes are involved in the β-cell-specific autoimmune process. It is necessary to determine what exact factors are causing the immune system to become unregulated in such a manner as to promote an autoimmune response.
journal_name
Int Immunopharmacoljournal_title
International immunopharmacologyauthors
Szablewski Ldoi
10.1016/j.intimp.2014.06.033subject
Has Abstractpub_date
2014-09-01 00:00:00pages
182-91issue
1eissn
1567-5769issn
1878-1705pii
S1567-5769(14)00247-1journal_volume
22pub_type
杂志文章,评审abstract：:The aim of this study was to evaluate the involvement of both B1 and B2 kinins receptors (B1R and B2R) in the fibroblast proliferation induced by the cytokine tumour necrosis factor (TNF) attempting to establish an in vitro model of wound healing. Murine fibroblasts L-929 were cultivated in 24 wells plaque until total...
journal_title：International immunopharmacology
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journal_title：International immunopharmacology
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abstract：BACKGROUND:Th17/Treg imbalance and the levels of related cytokines are essential in the pathogenesis of autoimmune and infectious diseases. The aim of the current study was to assess the Treg/Th17 balance and the levels of related cytokines associated with various degrees of liver injury in patients with chronic hepati...
journal_title：International immunopharmacology
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doi：10.1016/j.intimp.2017.02.019
更新日期：2017-05-01 00:00:00
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journal_title：International immunopharmacology
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abstract：:Liver fibrosis has been emphasized as a serious threat to human health. There is currently no effective clinical drug treatment. Although mogrosides (MGs) have extensive pharmacological effects with minimal toxicity, their effects on liver function, inflammation, matrix metalloproteinases and hepatic stellate cell (HS...
journal_title：International immunopharmacology
pub_type： 杂志文章
doi：10.1016/j.intimp.2017.12.023
更新日期：2018-02-01 00:00:00
abstract：:Triggered by the successful administration of the proteasome inhibitor bortezomib in kidney transplant recipients with acute or chronic antibody-mediated rejection, we evaluated the effect of the proteasome inhibitor CEP-18770 and of the selective immunoproteasome inhibitor ONX-0914 on cellular and humoral alloimmunit...
journal_title：International immunopharmacology
pub_type： 杂志文章
doi：10.1016/j.intimp.2017.06.009
更新日期：2017-09-01 00:00:00
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journal_title：International immunopharmacology
pub_type： 杂志文章,评审
doi：10.1016/s1567-5769(00)00047-3
更新日期：2001-03-01 00:00:00
abstract：:Staphylococcus aureus is a major causative microorganism in community- and healthcare-acquired pneumonia. CD5L is an important protein in the control of immune homeostasis. In this study, we found that patients with S. aureus pneumonia displayed increased levels of circulating CD5L. Likewise, mice with S. aureus pneum...
journal_title：International immunopharmacology
pub_type： 杂志文章
doi：10.1016/j.intimp.2019.03.057
更新日期：2019-07-01 00:00:00
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journal_title：International immunopharmacology
pub_type： 杂志文章
doi：10.1016/j.intimp.2019.105901
更新日期：2020-02-01 00:00:00
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journal_title：International immunopharmacology
pub_type： 杂志文章
doi：10.1016/j.intimp.2019.05.017
更新日期：2019-08-01 00:00:00
abstract：:The presence of thrombin-cleaved form of osteopontin well correlated with various inflammatory disease activities in not only rodents, but also humans. We previously demonstrated that the blocking of the interaction of a cryptic epitope within osteopontin, which is exposed by thrombin cleavage, with its integrins by s...
journal_title：International immunopharmacology
pub_type： 杂志文章
doi：10.1016/j.intimp.2007.06.009
更新日期：2007-11-01 00:00:00
abstract：:Macrophages are myeloid immune cells which are strategically positioned throughout the body, where they engulf and degrade debris, dead cells, and foreign substances, and coordinating the inflammatory processes. Macrophages can be divided into two extreme subsets, classical activation (M1), and alternatively activatio...
journal_title：International immunopharmacology
pub_type： 杂志文章,评审
doi：10.1016/j.intimp.2017.07.019
更新日期：2017-09-01 00:00:00
abstract：:Bone erosion is a central feature of rheumatoid arthritis (RA) that is characterized by the infiltration of the synovial lining by osteoclasts and lymphocytes. In the present study, swertiamarin a major secoiridoid glycoside was evaluated for anti-osteoclastogenic property to prevent bone erosion in Freund's complete ...
journal_title：International immunopharmacology
pub_type： 杂志文章
doi：10.1016/j.intimp.2017.10.022
更新日期：2017-12-01 00:00:00
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journal_title：International immunopharmacology
pub_type： 杂志文章
doi：10.1016/j.intimp.2008.07.006
更新日期：2008-12-10 00:00:00
abstract：:Oncostatin M (OSM), as a member of the Interleukin-6 family cytokines, plays a significant role in inflammation, autoimmunity, and cancers. It is mainly secreted by T lymphocytes, neutrophils, and macrophages and was initially introduced as anti-cancer agent. However, in some cases, it promotes cancer progression. Ove...
journal_title：International immunopharmacology
pub_type： 杂志文章,评审
doi：10.1016/j.intimp.2020.107158
更新日期：2021-01-01 00:00:00
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journal_title：International immunopharmacology
pub_type： 杂志文章
doi：10.1016/j.intimp.2013.12.021
更新日期：2014-02-01 00:00:00
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journal_title：International immunopharmacology
pub_type： 杂志文章
doi：10.1016/s1567-5769(00)00026-6
更新日期：2001-02-01 00:00:00
abstract：:Oxidative stress, inflammation, and foam cell formation in vascular smooth muscle cells (VSMCs) are considered to play crucial roles in the pathogenesis of atherosclerosis. Poria cocos polysaccharides (PCP) has been shown to possess anti-inflammatory, antitumor and anti-oxidative properties. In this study we explored ...
journal_title：International immunopharmacology
pub_type： 杂志文章
doi：10.1016/j.intimp.2019.106173
更新日期：2020-03-01 00:00:00
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journal_title：International immunopharmacology
pub_type： 杂志文章
doi：10.1016/j.intimp.2018.07.039
更新日期：2018-10-01 00:00:00
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journal_title：International immunopharmacology
pub_type： 杂志文章
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journal_title：International immunopharmacology
pub_type： 杂志文章
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更新日期：2019-12-01 00:00:00
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journal_title：International immunopharmacology
pub_type： 杂志文章
doi：10.1016/j.intimp.2008.03.011
更新日期：2008-08-01 00:00:00
abstract：:Neutrophils are the first line of innate immune defense against infectious diseases. However, since their discovery by Elie Metchnikoff, they have always been considered tissue-destructive cells responsible for inflammatory tissue damage occurring during acute infections. Now, extensive research in the field of neutro...
journal_title：International immunopharmacology
pub_type： 杂志文章,评审
doi：10.1016/j.intimp.2010.08.012
更新日期：2010-11-01 00:00:00
abstract：:The effects of TGF-β on dendritic cells (DCs) in the tumor microenvironment are not well-understood. In this study, we investigated the effect of TGF-β on the induction of programmed death ligand-1 (PD-L1) expression in DCs and the underlying mechanism, and we further investigated the influence of the DCs with PD-L1 e...
journal_title：International immunopharmacology
pub_type： 杂志文章
doi：10.1016/j.intimp.2014.02.027
更新日期：2014-05-01 00:00:00
abstract：OBJECTIVES:B cells play important roles in inflammatory diseases. This study was aimed at examining the frequency of different subsets of B cells in patients with non-traumatic osteonecrosis of the femoral head (NONFH). METHODS:The percentages of the different subsets of circulating B cells in 28 patients with steroid...
journal_title：International immunopharmacology
pub_type： 杂志文章
doi：10.1016/j.intimp.2014.02.016
更新日期：2014-05-01 00:00:00
abstract：:Cutaneous toxicities are the commonest side effects in patients with cancer treated using epidermal growth factor receptor inhibitors such as erlotinib. For patients with such toxicities, there is a lack of safe, effective pharmacological agents. Here we established a skin toxicity model and investigated the preventiv...
journal_title：International immunopharmacology
pub_type： 杂志文章
doi：10.1016/j.intimp.2019.01.023
更新日期：2019-04-01 00:00:00
abstract：:The activities of dectin-1 and mannose receptors on phagocytosis of Candida albicans and the production of TNF-α by macrophages from mice pretreated for 3 days with extract of Artocarpus intergrifolia seeds (jack extract), Artin M or jacalin were studied. Macrophages from these mice were coincubated with C. albicans C...
journal_title：International immunopharmacology
pub_type： 杂志文章
doi：10.1016/j.intimp.2011.12.010
更新日期：2012-02-01 00:00:00
abstract：:Acute lung injury (ALI) is an excessive and uncontrolled inflammatory response in lung, of which remains the leading cause of morbidity and mortality in worldwide. Chikusetsusaponin V (CsV), a bioactive compounds derived from Panacis Japonica, has been reported to have anti-inflammatory effects. However, it is still u...
journal_title：International immunopharmacology
pub_type： 杂志文章
doi：10.1016/j.intimp.2019.02.023
更新日期：2019-05-01 00:00:00
abstract：:Psoriasis is a chronic inflammatory skin disease featured by excessive proliferation of keratinocytes, clearly defined round erythema and dry, scaly plaques, long-term inflammatory cells infiltration in skin lesions. However, the physiopathological mechanism of psoriasis is still not clearly understood. Neuropeptides,...
journal_title：International immunopharmacology
pub_type： 杂志文章,评审
doi：10.1016/j.intimp.2020.106755
更新日期：2020-10-01 00:00:00
abstract：:Autoimmune, lupus-prone MRL lpr/lpr mice were treated orally with oxo-quinoline-3-carboxamide (ABR-25757), a newly developed immunomodulator. Treatment was initiated in one set of experiment at the age of 10 weeks, before the onset of clinically apparent disease, and in another set at 15 weeks, after the development o...
journal_title：International immunopharmacology
pub_type： 杂志文章
doi：10.1016/j.intimp.2004.07.009
更新日期：2004-11-01 00:00:00
