Abstract：
:Macrophages are myeloid immune cells which are strategically positioned throughout the body, where they engulf and degrade debris, dead cells, and foreign substances, and coordinating the inflammatory processes. Macrophages can be divided into two extreme subsets, classical activation (M1), and alternatively activation (M2). The symptoms and signs of rheumatoid arthritis (RA) would exacerbate with the increase in pro-inflammatory cytokines, whereas anti-inflammatory cytokines will alleviate the symptoms and signs of RA. This review, mainly discusses the effects of Notch, JNK and ERK signaling pathways on the regulation of macrophage polarization, and the effects of pro-inflammatory factors and/or anti-inflammatory cytokines produced by polarized macrophages in RA. Also, we will make an attempt to find out the importance of macrophage polarization in RA treatment as a drug target.
journal_name
Int Immunopharmacoljournal_title
International immunopharmacologyauthors
Wang Y,Han CC,Cui D,Li Y,Ma Y,Wei Wdoi
10.1016/j.intimp.2017.07.019subject
Has Abstractpub_date
2017-09-01 00:00:00pages
345-352eissn
1567-5769issn
1878-1705pii
S1567-5769(17)30286-2journal_volume
50pub_type
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journal_title：International immunopharmacology
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abstract：:The changes in molecular structure and anti-inflammatory action of a gamma-irradiated quercetin were examined. Quercetin was gamma-irradiated at doses of 0, 15, 30, 50, 100 and 150kGy, which induced new radiolytic peaks (the highest radiolytic peak at a dose of 30kGy). Treatment of intact- and gamma-irradiated quercet...
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abstract：:Calcineurin (CaN) plays an important role in glomerular hypertrophy and extracellular matrix accumulation in early diabetic nephropathy. Cyclosporine (CSA), a CaN inhibitor, has been shown to reduce renal injury in streptozotocin-induced diabetic rats. We examined whether FK506, which immunosuppressive action was 10-1...
journal_title：International immunopharmacology
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journal_title：International immunopharmacology
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journal_title：International immunopharmacology
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journal_title：International immunopharmacology
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pub_type： 杂志文章
doi：10.1016/j.intimp.2012.11.013
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doi：10.1016/j.intimp.2019.106131
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journal_title：International immunopharmacology
pub_type： 杂志文章
doi：10.1016/j.intimp.2019.01.044
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pub_type： 杂志文章
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journal_title：International immunopharmacology
pub_type： 杂志文章
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pub_type： 杂志文章
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journal_title：International immunopharmacology
pub_type： 杂志文章
doi：10.1016/j.intimp.2009.07.008
更新日期：2009-10-01 00:00:00
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journal_title：International immunopharmacology
pub_type： 杂志文章
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journal_title：International immunopharmacology
pub_type： 杂志文章
doi：10.1016/j.intimp.2014.06.012
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journal_title：International immunopharmacology
pub_type： 杂志文章
doi：10.1016/j.intimp.2016.05.015
更新日期：2016-09-01 00:00:00
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journal_title：International immunopharmacology
pub_type： 杂志文章
doi：10.1016/j.intimp.2018.01.028
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journal_title：International immunopharmacology
pub_type： 杂志文章
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更新日期：2016-05-01 00:00:00
