Anti-inflammatory activity of (-)-aptosimon isolated from Daphne genkwa in RAW264.7 cells.

abstract：:Recombinant immunotoxins are chimeric proteins composed of a targeting peptide that binds to a specific tumor antigen and a toxin protein killing target cells. Recombinant immunotoxin exhibits potent cancer inhibiting effects both in vivo and in vitro. However, the non-specific toxicity causes severe syndromes limitin...

journal_title：International immunopharmacology

authors： Wang J,Han L,Chen J,Xie Y,Jiang H,Zhu J

更新日期：2019-01-01 00:00:00

abstract：:We previously demonstrated that decreased expression of miR-140-5p was associated with the progression of multiple sclerosis (MS) and miR-140-5p targeted STAT1 and interfered with the expression of IFN-γ. However, the underlying mechanisms how miR-140-5p regulated the differentiation of encephalomyelitic CD4+T cell re...

journal_title：International immunopharmacology

authors： Zhu S,Zhang X,Guan H,Huang F,Wu L,Hou D,Zheng Z,Yu M,Huang L,Ge L

更新日期：2019-10-01 00:00:00

abstract：:Osteoarthritis (OA) is a degenerative disease characterized by synovium inflammation and articular cartilage damage. The aberrant expression profile of microRNAs (miRNAs) has been implicated in the cartilage of patients with OA. However, how microRNAs carried by exosomes derived from mesenchymal stem cells (MSCs) asso...

journal_title：International immunopharmacology

authors： Jin Z,Ren J,Qi S

更新日期：2020-01-01 00:00:00

abstract：:Dihydrofisetin is a flavanonol derived from some edible wild herbs and traditional Chinese medicines. It has been found to possess many biological activities. However, the anti-inflammatory potential of Dihydrofisetin remains uncharacterized. The aim of the present study was to investigate the anti-inflammatory activi...

journal_title：International immunopharmacology

authors： Li KK,Shen SS,Deng X,Shiu HT,Siu WS,Leung PC,Ko CH,Cheng BH

更新日期：2018-01-01 00:00:00

abstract：:The quaternary ammonium salt, sanguinarine (SG) was reported to possess widespread anti-microbial and anti-inflammatory effects in experimental animals and it has been used to treat many inflammatory diseases. The aim of this study was to evaluate the anti-inflammatory effect and the possible mechanisms underlying the...

journal_title：International immunopharmacology

authors： Li W,Li H,Mu Q,Zhang H,Yao H,Li J,Niu X

更新日期：2014-10-01 00:00:00

abstract：:The polysaccharide PSPP (purified sweet potato polysaccharide), isolated and purified from the roots of Ipomoea batatas, was found to be a glucan with a molecular weight of 53.2 kDa and specific rotation of +115.0 degrees (ca. 0.80, H(2)O). On the basis of methylation analysis, periodate oxidation, Smith degradation, ...

journal_title：International immunopharmacology

authors： Zhao G,Kan J,Li Z,Chen Z

更新日期：2005-08-01 00:00:00

abstract：:Glabridin has multiple pharmacological activities including anti-microbial, anti-atherosclerotic, anti-nephritic, anti-inflammatory and cardiovascular protective activities. In this study, we investigated the effect of glabridin on dendritic cells, which play an essential role in innate and adaptive immune responses. ...

journal_title：International immunopharmacology

authors： Kim JY,Kang JS,Kim HM,Ryu HS,Kim HS,Lee HK,Kim YJ,Hong JT,Kim Y,Han SB

更新日期：2010-10-01 00:00:00

abstract：:Salicylic acid (aspirin) is a widely used pharmacological agent with immunodmodulatory properties. Dendritic cells are key regulators of the immune response, and are capable of inducing hyporesponsiveness and regulatory activity in CD4+ T-cells. We have demonstrated that aspirin-treated dendritic cells are effective a...

journal_title：International immunopharmacology

authors： Buckland M,Jago C,Fazekesova H,George A,Lechler R,Lombardi G

更新日期：2006-12-20 00:00:00

abstract：:Regulatory T cells (Treg), formerly known as suppressor T cells, are essential for maintaining self-tolerance as well as immune homeostasis. Lack of Treg or normal function of Treg often leads to lymphoproliferative syndrome and autoimmunity in human and mouse. The chromatin remodeling BAF complex regulates gene expre...

journal_title：International immunopharmacology

authors： Jani A,Chi T,Wan YY

更新日期：2009-05-01 00:00:00

abstract：:Lipopolysaccharide (LPS) plays an important role in Gram-negative bacteria-induced sepsis and multiple organ dysfunction syndrome, which are still the leading cause of high mortality in intensive care units. Although paeoniflorin (Pae) has reportedly exhibited anti-inflammatory effect and protection against immunologi...

journal_title：International immunopharmacology

authors： Cao W,Zhang W,Liu J,Wang Y,Peng X,Lu D,Qi R,Wang Y,Wang H

更新日期：2011-02-01 00:00:00

abstract：:Endomorphin-1 is a recently isolated endogenous opioid peptide, and potent and selective high affinity mu-opioid receptor agonist. We evaluate the role of endomorphin-1 on macrophage functions. Endomorphin-1 potentiated macrophage adhesion and the expression of adhesion molecule Mac-1 on macrophages. However, endomorp...

journal_title：International immunopharmacology

authors： Inui Y,Azuma Y,Ohura K

更新日期：2002-07-01 00:00:00

abstract：:Suberoylanilide hydroxamic acid (SAHA), a histone deacetylase inhibitor, has been proven to be an anti-cancer agent. Its anti-inflammatory activities have recently been observed both in in vitro and in vivo models. Yet its action on lymphocytes and the underlying mechanism are still not well known. In this study, in o...

journal_title：International immunopharmacology

authors： Shi ZJ,Ouyang DY,Zhu JS,Xu LH,He XH

更新日期：2012-04-01 00:00:00

abstract：:Calea uniflora Less. (family Asteraceae), also named "arnica" and "erva-de-lagarto", is a native plant to the South and Southeast of Brazil. This species was used to treat rheumatism, respiratory diseases, and digestive problems in Brazilian folk medicine. In vitro studies have shown the important biological effects o...

journal_title：International immunopharmacology

authors： da Rosa JS,de Mello SV,Vicente G,Moon YJ,Daltoé FP,Lima TC,de Jesus Souza R,Biavatti MW,Fröde TS

更新日期：2017-01-01 00:00:00

abstract：:The tumor microenvironment is a critical factor that enhances cancer progression, drug resistance, and failure of therapeutic approaches. Several cellular and non-cellular factors are involved in cancer promotion. Among the several cell populations in the tumor microenvironment, macrophages, as one of the most abundan...

journal_title：International immunopharmacology

authors： Yousefzadeh Y,Hallaj S,Baghi Moornani M,Asghary A,Azizi G,Hojjat-Farsangi M,Ghalamfarsa G,Jadidi-Niaragh F

更新日期：2020-07-01 00:00:00

abstract：:A body of evidence indicates that the therapeutic activity of antidepressants is connected with their modulatory effect on the inflammatory response system and cell-mediated immunity. The present study was carried out to examine the effects of antidepressant agents, such as imipramne, venlafaxine, l-5-hydroxytryptopha...

journal_title：International immunopharmacology

authors： Kubera M,Kenis G,Bosmans E,Kajta M,Basta-Kaim A,Scharpe S,Budziszewska B,Maes M

更新日期：2004-02-01 00:00:00

abstract：:Astilbin is a potential agent for autoimmune and inflammatory diseases and has a protective effect in mice with DSS-induced colitis. NK1.1- CD4+ NKG2D+ T cells are a subpopulation of regulatory T cells that produce TGF-β1 and IL-10. Whether astilbin directly promotes the induction of NK1.1- CD4+ NKG2D+ T cells and whe...

journal_title：International immunopharmacology

authors： Han S,Lin Z,Wen J,Wu K,Xu Y,Zhang Y,Lu G,Xiao W,Ding Y,Jia X,Deng B,Gong W

更新日期：2020-04-01 00:00:00

abstract：OBJECTIVE:Batroxobin is a medicinal preparation extracted from the venom of the Fer-de-Lance snake, and is used to lower blood viscosity, promote blood fibrinogen decomposition, and inhibit thrombosis. This research is to investigate whether batroxobin can improve the survival of random skin flaps in a rat model. MATE...

journal_title：International immunopharmacology

authors： Fang MJ,Qi CY,Chen XY,Hu PY,Wang JW,Xu PF,Jin YZ,Lin DS

更新日期：2019-07-01 00:00:00

abstract：:High mobility group box protein 1 (HMGB1) and receptor for the advanced glycation end product (RAGE) play important roles in the development of sepsis-induced acute lung injury (ALI). Ketamine is considered to confer protective effects on ALI during sepsis. In this study, we investigated the effects of ketamine on HMG...

journal_title：International immunopharmacology

authors： Li K,Yang J,Han X

更新日期：2016-05-01 00:00:00

abstract：:It has been recently reported that nicotine, the addictive component of tobacco, is an important modulator at the level of immune cell apoptosis or programmed cell death. Apoptosis is a process that helps maintain the homeostasis of the vascular endothelium and vascular smooth muscle cells, and alteration of the apopt...

journal_title：International immunopharmacology

authors： Hakki A,Friedman H,Pross S

更新日期：2002-09-01 00:00:00

abstract：:Inflammation is fundamental in osteoarthritis (OA) pathogenesis. Semaphorin 4A (Sema4A) has been implicated in immune-associated diseases, however, its role in OA remains unclear. In this study, we show that Sema4A is upregulated in knee OA articular cartilage as well as in chondrocytes exposed to IL-1β treatment in v...

journal_title：International immunopharmacology

authors： Zhang H,Wei Q,Xiang X,Zhou B,Chen J,Li J,Li Q,Xiong H,Liu F

更新日期：2019-04-01 00:00:00

abstract：:The proteasome influences cellular homeostasis through the degradation of regulatory proteins, many of which are also involved in disease pathogenesis. In particular, numerous regulatory proteins associated with tumor growth, such as cyclins, cyclin-dependent kinase inhibitors, tumor suppressors, and NF-κB inhibitors ...

journal_title：International immunopharmacology

authors： Momose I,Kawada M

更新日期：2016-08-01 00:00:00

abstract：:Red cell-derived microparticles (RMPs) are potential mediators of transfusion-related acute lung injury (TRALI). The aim of this study was to investigate the effects of microparticles present in red cell concentrates (RCC) on polymorphonuclear neutrophil (PMN) respiratory burst and acute lung injury (ALI) in mice. Mic...

journal_title：International immunopharmacology

authors： Xie R,Yang Y,Zhu Y,Gao L,Jiang X,Sun J,Bian M,Yang J

更新日期：2018-02-01 00:00:00

abstract：:In the pathogenesis of acute respiratory distress syndrome (ARDS), an increase in vascular endothelial permeability may trigger pulmonary edema and ultimately lead to respiratory failure. Endothelial glycocalyx damage is an important factor that causes an increase in vascular endothelial permeability. Berberine (BBR) ...

journal_title：International immunopharmacology

authors： Huang L,Zhang X,Ma X,Zhang D,Li D,Feng J,Pan X,Lü J,Wang X,Liu X

更新日期：2018-12-01 00:00:00

abstract：:Osteopontin (OPN) is a multifunctional extracellular matrix phosphoprotein that has a specific and complicated structure, and contributes to numerous physiological and pathological activities. The mechanism of OPN in many diseases has been confirmed; however, the role of OPN in myasthenia gravis (MG) remains unclear. ...

journal_title：International immunopharmacology

authors： Zhao J,Jing J,Zhao W,Li X,Hou L,Zheng C,Kong Q,Li W,Yao X,Chang L,Li H,Mu L,Wang G,Wang J

更新日期：2020-02-25 00:00:00

abstract：:Lipopolysaccharide (LPS)-induced TLR4-NF-(K)B signaling plays an important role in the development of prostatic tumors from chronic bacterial prostatic infection. Although many studies support the role of selenium in protecting against the development of prostate cancer secondary to chronic prostatitis, the mechanism ...

journal_title：International immunopharmacology

authors： Pei Z,Li H,Guo Y,Jin Y,Lin D

更新日期：2010-01-01 00:00:00

abstract：:The anti-inflammatory effects of glycyrol, a benzofuran coumarin isolated from Glycyrrhizae Radix, were studied. Glycyrol of 5, 25 and 50 microM dose-dependently inhibited nitric oxide (NO) production by down-regulating inducible nitric oxide synthase (iNOS), and alleviated cyclooxygenase-2 (COX-2) expression in LPS-s...

journal_title：International immunopharmacology

authors： Shin EM,Zhou HY,Guo LY,Kim JA,Lee SH,Merfort I,Kang SS,Kim HS,Kim S,Kim YS

更新日期：2008-11-01 00:00:00

abstract：:Myocardial fibrosis plays a central role in the development of heart failure. It has been shown that recurrent exposure to subclinical lipopolysaccharide (LPS) increases mortality and induces cardiac fibrosis in mice, which is not mediated by the common renin-angiotensin system. LPS increased NADPH oxidase2 (NOX2) in ...

journal_title：International immunopharmacology

authors： Huang L,Zhu J,Zheng M,Zou R,Zhou Y,Zhu M

更新日期：2018-07-01 00:00:00

abstract：:The immune system is a very diverse system of the host that evolved during evolution to cope with various pathogens present in the vicinity of environmental surroundings inhabited by multicellular organisms ranging from achordates to chordates (including humans). For example, cells of immune system express various pat...

journal_title：International immunopharmacology

authors： Vijay K

更新日期：2018-06-01 00:00:00

abstract：:There is increasing evidence that neuronal factors can affect hematopoietic cell proliferation. Endogenous opioids with specificity for several opioid receptor classes were tested for their ability to inhibit murine and human hematopoietic progenitor cell proliferation. Tyr-MIF, an opioid tetrapeptide (H-Tyr-Pro-Leu-G...

journal_title：International immunopharmacology

authors： Horowitz D,Callahan JF,Pelus LM,Fukuda S,King AG

更新日期：2002-04-01 00:00:00

abstract：:Silicosis is a well acknowledged occupational lung disorder with considerable negative impact on the patients' quality of life. Various signaling pathways have been reported to interplay in the pathogenesis of pulmonary fibro-proliferative disorders; of which, P-AKT/mTOR signaling pathway. The current study highlights...

journal_title：International immunopharmacology

authors： Helal MG,Said E

更新日期：2019-05-01 00:00:00