Abstract:
:Salicylic acid (aspirin) is a widely used pharmacological agent with immunodmodulatory properties. Dendritic cells are key regulators of the immune response, and are capable of inducing hyporesponsiveness and regulatory activity in CD4+ T-cells. We have demonstrated that aspirin-treated dendritic cells are effective at antigen processing and presentation, and possess a unique potency for inducing regulatory activity in responder T-cells. Unlike immature dendritic cells, aspirin DCs are resistant to the effects of maturational stimuli, as determined by low levels of CD40, CD80, CD83 and CD86 expression. Aspirin DCs were demonstrated to express high levels of the co-inhibitor of T-cell activation ILT-3. Aspirin DCs themselves produce less IL-10 and more IL-12 than immature DCs, but no specific cytokine is necessary for their tolerogenic capacity. When naïve CD4+ T-cells are exposed to aspirin DCs they produce significant levels of IFNgamma but these same T-cells are hypo-proliferative. Aspirin-treated DCs demonstrate the characteristics of a potential immunotherapy for controlling unwanted immune-responses such as the indirect pathway of allo-recognition that drives chronic allograft rejection.
journal_name
Int Immunopharmacoljournal_title
International immunopharmacologyauthors
Buckland M,Jago C,Fazekesova H,George A,Lechler R,Lombardi Gsubject
Has Abstractpub_date
2006-12-20 00:00:00pages
1895-901issue
13-14eissn
1567-5769issn
1878-1705pii
S1567-5769(06)00209-8journal_volume
6pub_type
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