Abstract:
:Endomorphin-1 is a recently isolated endogenous opioid peptide, and potent and selective high affinity mu-opioid receptor agonist. We evaluate the role of endomorphin-1 on macrophage functions. Endomorphin-1 potentiated macrophage adhesion and the expression of adhesion molecule Mac-1 on macrophages. However, endomorphin-1 did not alter phagocytosis of Escherichia coli by macrophages. Moreover, endomorphin-1 inhibited macrophage chemotaxis and the production of superoxide anion by macrophages. On the contrary, endomorphin-1 inhibited TNF-alpha production by macrophages stimulated with both LPS and PMA, respectively. Similarly, endomorphin-1 suppressed IL-10 and IL-12 productions in response to LPS. In contrast, endomorphin-1 potentiated IL-1beta production by macrophages stimulated with PMA. These results suggest that endomorphin-1 may alter macrophage functions such as cytokine productions and functions related to natural host defense.
journal_name
Int Immunopharmacoljournal_title
International immunopharmacologyauthors
Inui Y,Azuma Y,Ohura Kdoi
10.1016/s1567-5769(02)00065-6keywords:
subject
Has Abstractpub_date
2002-07-01 00:00:00pages
1133-42issue
8eissn
1567-5769issn
1878-1705pii
S1567-5769(02)00065-6journal_volume
2pub_type
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pub_type: 杂志文章
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