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A higher frequency of peripheral blood activated B cells in patients with non-traumatic osteonecrosis of the femoral head.

Abstract：

OBJECTIVES:B cells play important roles in inflammatory diseases. This study was aimed at examining the frequency of different subsets of B cells in patients with non-traumatic osteonecrosis of the femoral head (NONFH). METHODS:The percentages of the different subsets of circulating B cells in 28 patients with steroid-related, alcohol-related, or idiopathic NONFH and 10 healthy controls (HC) were examined by flow cytometry. The concentrations of serum C-reactive protein (CRP), fibrinogen (FIB), immunoglobulins, cytokines and blood erythrocyte sedimentation rate (ESR) were measured. RESULTS:In comparison with those in the HC, significantly higher percentages of CD27-, CD86+, CD95+, and CD27+CD95+CD19+ but lower CD27+CD19+ B cells were detected in the patients. The percentages of CD86+, CD95+, and CD27+CD95+CD19+ B cells in each group of the patients were significantly higher than those in the HC. The levels of serum IL-17A and IFN-γ in steroid group and serum TNF-α in alcoholic group were significantly higher than those in the HC. The percentages of CD86+CD19+ B cells were positively associated with the degrees of femoral head collapse in both steroid and alcoholic groups of patients and the levels of serum TNF-α were positively associated with the degrees of femoral head collapse in the alcoholic NONFH patients. CONCLUSIONS:These data suggest a higher frequency of CD86+CD19+ activated B cells and elevated levels of serum TNF-α may be associated with the development of NONFH.

journal_name

Int Immunopharmacol

journal_title

International immunopharmacology

authors

Zhang H,Xiao F,Liu Y,Zhao D,Shan Y,Jiang Y

doi

10.1016/j.intimp.2014.02.016

subject

Has Abstract

pub_date

2014-05-01 00:00:00

pages

95-100

issue

1

eissn

1567-5769

issn

1878-1705

pii

S1567-5769(14)00070-8

journal_volume

20

pub_type

杂志文章

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