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Oncostatin M: A mysterious cytokine in cancers.

Abstract：

:Oncostatin M (OSM), as a member of the Interleukin-6 family cytokines, plays a significant role in inflammation, autoimmunity, and cancers. It is mainly secreted by T lymphocytes, neutrophils, and macrophages and was initially introduced as anti-cancer agent. However, in some cases, it promotes cancer progression. Overexpression of OSM and OSM receptor has been detected in various cancers including colon cancer, breast cancer, pancreatic cancer, myeloma, brain tumors, chronic lymphocytic leukemia, and hepatoblastoma. STAT3 is the main downstream signaling molecule of OSM, which operates the leading role in modifications of cancer cells and enhancing cell growth, invasion, survival, and all other hallmarks of cancer cells. However, due to the presence of multiple signaling pathways, it can act contradictory in some cancers. In this review, we will discuss the emerging roles of OSM in cancer and elucidate its function in tumor control or progression and finally discuss therapeutic approaches designed to manipulate this cytokine in cancer.

journal_name

Int Immunopharmacol

journal_title

International immunopharmacology

authors

Masjedi A,Hajizadeh F,Beigi Dargani F,Beyzai B,Aksoun M,Hojjat-Farsangi M,Zekiy A,Jadidi-Niaragh F

doi

10.1016/j.intimp.2020.107158

subject

Has Abstract

pub_date

2021-01-01 00:00:00

pages

107158

eissn

1567-5769

issn

1878-1705

pii

S1567-5769(20)33625-0

journal_volume

90

pub_type

杂志文章,评审

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