Abstract：
:Acute lung injury (ALI) is one of the severe complications in patients with traumatic brain injury (TBI), contributing to the high mortality. Ghrelin has protective effects against various inflammatory diseases, but the effects of Ghrelin on TBI-induced ALI and its mechanisms remain unknown. In this study, Ghrelin administration was performed on the mice with TBI, then histological change in cortex and lung tissues, lung vascular permeability and macrophage number in bronchoalveolar lavage fluid (BALF) were examined, respectively. Simultaneously, the alterations of proinflammatory factors and pyroptosis-related proteins in lung tissues were detected. As a result, TBI-induced ALI was ameliorated after Ghrelin treatment, which was demonstrated by improved histology, reduced lung vascular permeability, and peripheral macrophage number. Furthermore, Ghrelin decreased the mRNA levels of proinflammatory factors (IL-1β, IL-6, TNF-α and IL-18), the protein levels of pyroptosis-related proteins (NLRP3, Caspase1-P20, HMGB1 and Gasdermin D), and the phosphorylation levels of NF-κB in lung tissues. These results showed that Ghrelin attenuating TBI-induced ALI might be via ameliorating inflammasome-induced pyroptosis by blocking NF-κB signal, which are important for the prevention and treatment of TBI-induced ALI.
journal_name
Int Immunopharmacoljournal_title
International immunopharmacologyauthors
Shao XF,Li B,Shen J,Wang QF,Chen SS,Jiang XC,Qiang Ddoi
10.1016/j.intimp.2019.106175subject
Has Abstractpub_date
2020-02-01 00:00:00pages
106175eissn
1567-5769issn
1878-1705pii
S1567-5769(19)32437-3journal_volume
79pub_type
杂志文章abstract：:There is increasing evidence that neuronal factors can affect hematopoietic cell proliferation. Endogenous opioids with specificity for several opioid receptor classes were tested for their ability to inhibit murine and human hematopoietic progenitor cell proliferation. Tyr-MIF, an opioid tetrapeptide (H-Tyr-Pro-Leu-G...
journal_title：International immunopharmacology
pub_type： 杂志文章
doi：10.1016/s1567-5769(02)00007-3
更新日期：2002-04-01 00:00:00
abstract：BACKGROUND:There is no vaccine or specific antiviral treatment for HCoVs infection. The use of type I interferons for coronavirus is still under great debate in clinical practice. MATERIALS AND METHODS:A literature search of all relevant studies published on PubMed, Cochrane library, Web of Science database, Science D...
journal_title：International immunopharmacology
pub_type： 杂志文章,meta分析
doi：10.1016/j.intimp.2020.106740
更新日期：2020-09-01 00:00:00
abstract：BACKGROUND:Astragaloside IV (AS-IV), the major active triterpenoid in Radix Astragali, has shown anti-tumorigenic properties in certain cancers; however, its role in breast cancer remains unclear. The present study investigated the effects of AS-IV on breast cancer in vitro and in vivo and examined the underlying mecha...
journal_title：International immunopharmacology
pub_type： 杂志文章
doi：10.1016/j.intimp.2016.10.001
更新日期：2017-01-01 00:00:00
abstract：:The present study was conducted to determine if selected events in glucocorticoid receptor (GR) signaling that have been identified using mostly in vitro approaches with synthetic glucocorticoids also occur in mature T cells exposed to relevant levels of corticosterone in vivo. In contrast to effects reported in vitro...
journal_title：International immunopharmacology
pub_type： 杂志文章
doi：10.1016/s1567-5769(02)00081-4
更新日期：2003-01-01 00:00:00
abstract：:Inflammation occurs as a result of acute trauma, invasion of the host by different pathogens, pathogen-associated molecular patterns (PAMPs) or chronic cellular stress generating damage-associated molecular patterns (DAMPs). Thus inflammation may occur under both sterile inflammatory conditions including certain cance...
journal_title：International immunopharmacology
pub_type： 杂志文章,评审
doi：10.1016/j.intimp.2019.05.002
更新日期：2019-08-01 00:00:00
abstract：:In this study, we investigated the preventive effects of curcumin using dextran sulfate sodium (DSS)-induced colitis and the potential role of curcumin in regulation of anti-inflammation through S-nitrosylation. After curcumin treatment for 6days, the body weight and disease activity index of DSS-induced mice was alle...
journal_title：International immunopharmacology
pub_type： 杂志文章
doi：10.1016/j.intimp.2016.05.015
更新日期：2016-09-01 00:00:00
abstract：:γδ T cells account for approximately 5% of peripheral blood T cells but are more abundant in mucosal tissue. Based on the recognized ligands and their general lack of MHC restriction, γδ T cells are considered as unconventional T cells that link innate and adaptive immunity. γδ T cells produce a diverse range of cytok...
journal_title：International immunopharmacology
pub_type： 杂志文章,评审
doi：10.1016/j.intimp.2013.01.022
更新日期：2013-07-01 00:00:00
abstract：OBJECTIVE:Acute exacerbation of idiopathic pulmonary fibrosis (AE-IPF) is of concern because of its propensity for rapid deterioration and high mortality. Its aetiology and mechanism are still unclear. The aims of this study were to clarify the pathophysiology differences between AE-IPF and stable IPF (S-IPF) by compar...
journal_title：International immunopharmacology
pub_type： 杂志文章
doi：10.1016/j.intimp.2019.02.039
更新日期：2019-05-01 00:00:00
abstract：:We studied the suitability of our murine model for the treatment trials of atopic dermatitis (AD). In this model topical application of ovalbumin (OVA) together with bacterial superantigen, staphylococcal enterotoxin B (SEB) induces a cutaneous disease resembling AD. Injured mouse skin was treated with three different...
journal_title：International immunopharmacology
pub_type： 杂志文章
doi：10.1016/j.intimp.2010.01.001
更新日期：2010-04-01 00:00:00
abstract：:Lipopolysaccharide (LPS) plays an important role in Gram-negative bacteria-induced sepsis and multiple organ dysfunction syndrome, which are still the leading cause of high mortality in intensive care units. Although paeoniflorin (Pae) has reportedly exhibited anti-inflammatory effect and protection against immunologi...
journal_title：International immunopharmacology
pub_type： 杂志文章
doi：10.1016/j.intimp.2010.11.012
更新日期：2011-02-01 00:00:00
abstract：:Ischemia and reperfusion injury (IR) is an antigen independent inflammatory process that causes tissue damage. After IR, kidneys up-regulate leukocyte adhesion molecules and toll-like receptors (TLRs). Moreover, injured kidneys can also secrete factors (i.e. heat shock protein) which bind to TLRs and trigger intracell...
journal_title：International immunopharmacology
pub_type： 杂志文章
doi：10.1016/j.intimp.2011.04.014
更新日期：2011-09-01 00:00:00
abstract：:The proteasome influences cellular homeostasis through the degradation of regulatory proteins, many of which are also involved in disease pathogenesis. In particular, numerous regulatory proteins associated with tumor growth, such as cyclins, cyclin-dependent kinase inhibitors, tumor suppressors, and NF-κB inhibitors ...
journal_title：International immunopharmacology
pub_type： 杂志文章,评审
doi：10.1016/j.intimp.2015.11.013
更新日期：2016-08-01 00:00:00
abstract：PURPOSE:A new strategy of adoptive and passive immunotherapy involves combining dendritic cells (DCs) with a subset of natural killer T lymphocytes termed cytokine-induced killer (CIK) cells. The objective of this systematic review and meta-analysis was to evaluate the safety and efficacy of DC-CIK therapy vs. placebo,...
journal_title：International immunopharmacology
pub_type： 杂志文章,meta分析,评审
doi：10.1016/j.intimp.2014.07.019
更新日期：2014-10-01 00:00:00
abstract：:Although it has been shown that functions of immunoglobulin G (IgG) antibodies (Abs) that depend on binding to certain Fc gamma receptors (Fc gamma R) can be influenced by Fc glycan fucosylation, quantitative in vivo analyses comparing the effects of different levels of fucose are still lacking. We used a simple mouse...
journal_title：International immunopharmacology
pub_type： 杂志文章
doi：10.1016/j.intimp.2007.01.014
更新日期：2007-06-01 00:00:00
abstract：:We have observed that CD4+ T cell counts in human immunodeficiency virus (HIV)-1-infected patients treated with only Korean red ginseng (KRG) are maintained or even increased for a prolonged period. In the present study, we investigated whether the development of resistance mutations in reverse transcriptase (RT) to z...
journal_title：International immunopharmacology
pub_type： 临床试验,杂志文章
doi：10.1016/s1567-5769(01)00061-3
更新日期：2001-07-01 00:00:00
abstract：:Fructose-1,6-diphosphate (FDP), a high-energy glycolytic pathway intermediate, is reported to have a salutary effect in endotoxic shock and sepsis, but its underlying mechanism of action in inflammation is incompletely understood. In this study, our aim was to examine the function of FDP on acute lung injury (ALI) ind...
journal_title：International immunopharmacology
pub_type： 杂志文章
doi：10.1016/j.intimp.2008.09.004
更新日期：2008-12-20 00:00:00
abstract：BACKGROUND:Although available evidence from clinical trials has shown that immune checkpoint inhibitors (ICIs) combination therapy can lead to a series of immune-related adverse events (irAEs), the overall risk of irAEs on combination therapy has yet not been systematically reported. Therefore, we performed a meta-anal...
journal_title：International immunopharmacology
pub_type： 杂志文章,meta分析,评审
doi：10.1016/j.intimp.2018.08.014
更新日期：2018-10-01 00:00:00
abstract：:Tumor necrosis factor-alpha (TNF-alpha) is a vital component of the inflammatory process and its aberrant over-expression has been linked to numerous disease states. New treatment strategies have sought to reduce circulating TNF-alpha, either with neutralizing anti-TNF-alpha binding proteins such as etanercept or via ...
journal_title：International immunopharmacology
pub_type： 杂志文章
doi：10.1016/j.intimp.2008.01.013
更新日期：2008-05-01 00:00:00
abstract：:Bradykinin B1 and B2 receptors, members of the G-protein coupled receptor superfamily, are involved in inflammation and pain. Chinese hamster ovary (CHO) cells stably expressing the human B2 bradykinin receptor (CHO-B2) were used to characterize the signal transduction pathways associated with this receptor and its re...
journal_title：International immunopharmacology
pub_type： 杂志文章
doi：10.1016/s1567-5769(01)00032-7
更新日期：2001-05-01 00:00:00
abstract：:Radiation exposure poses a significant threat to public health, which can lead to acute hematopoietic system and intestinal system injuries due to their higher radiation sensitivity. Hence, antioxidants and thiol-reducing agents could have a potential protective effect against this complication. The dithiol compound 1...
journal_title：International immunopharmacology
pub_type： 杂志文章
doi：10.1016/j.intimp.2019.105913
更新日期：2019-11-01 00:00:00
abstract：:Increasing evidence suggests that inflammation is related to the pathophysiology of depression. Curcumin (CUR), which is a natural component extracted from the rhizome of Curcuma longa, seems to be efficacious in depression treatment. Hence, the present study aims to explore whether the anti-depressive effect of curcu...
journal_title：International immunopharmacology
pub_type： 杂志文章
doi：10.1016/j.intimp.2018.12.012
更新日期：2019-02-01 00:00:00
abstract：:Transmembrane protein 16A (TMEM16A), a channel underlying the calcium-activated chloride channel (CaCC) currents, has been shown to be a key regulator of mucus overproduction in airway epithelial cells. However, the precise molecular mechanism involved in the TMEM16A-mediated mucus secretion remains unclear. In the pr...
journal_title：International immunopharmacology
pub_type： 杂志文章
doi：10.1016/j.intimp.2016.08.033
更新日期：2016-11-01 00:00:00
abstract：:Resveratrol is a polyphenol abundantly found in red grape skin and is effective against antiaging and anti-inflammation associated with immune responses. In this study, we have investigated the effect of resveratrol on skin lesion, high mobility group box (HMGB)1 and inflammation pathway in an atopic dermatitis (AD) m...
journal_title：International immunopharmacology
pub_type： 杂志文章
doi：10.1016/j.intimp.2014.10.014
更新日期：2014-12-01 00:00:00
abstract：:The key goal in clinical transplantation is the induction of donor-specific transplantation tolerance to minimise the morbidity and mortality associated with long-term immunosuppression. Naturally occurring CD4(+)CD25(+) regulatory T cells (Tregs) expressing forkhead transcript factor FoxP3 play a crucial role in the ...
journal_title：International immunopharmacology
pub_type： 杂志文章
doi：10.1016/j.intimp.2006.07.025
更新日期：2006-12-20 00:00:00
abstract：:Silicosis is a well acknowledged occupational lung disorder with considerable negative impact on the patients' quality of life. Various signaling pathways have been reported to interplay in the pathogenesis of pulmonary fibro-proliferative disorders; of which, P-AKT/mTOR signaling pathway. The current study highlights...
journal_title：International immunopharmacology
pub_type： 杂志文章
doi：10.1016/j.intimp.2019.02.011
更新日期：2019-05-01 00:00:00
abstract：BACKGROUND:Growing evidence points to the pivotal role of inflammation in the pathogenesis of diabetic kidney disease (DKD). However, as an inflammation-based prognostic score, the significance of platelet-to-lymphocyte ratio (PLR) in biopsy-proven DKD remains uncertain. Therefore, the current study aimed to evaluate t...
journal_title：International immunopharmacology
pub_type： 杂志文章
doi：10.1016/j.intimp.2021.107413
更新日期：2021-01-29 00:00:00
abstract：:Over-activation of microglia disrupts the physiological homeostasis of the brain, and induces inflammatory response and other processes which are implicated in neurodegenerative diseases. Therefore, theoretically, suppression of neuroinflammation would slow the progression of neurodegenerative disease. In this study, ...
journal_title：International immunopharmacology
pub_type： 杂志文章
doi：10.1016/j.intimp.2019.105980
更新日期：2019-12-01 00:00:00
abstract：:Monocytes and macrophages of individuals with allergic diseases express increased levels of the low-affinity IgE receptors (FcepsilonRII or CD23) on their surfaces. The cross-linking of CD23-bound IgE antibody by allergen activates the cells to release inflammatory mediators. In mast cells, the binding of IgE to the h...
journal_title：International immunopharmacology
pub_type： 杂志文章
doi：10.1016/j.intimp.2009.05.009
更新日期：2009-08-01 00:00:00
abstract：AIMS:The present study is to investigate the effect of cordycepin on the expression of heme oxygenase-1 (HO-1) in lipopolysaccharide (LPS)-activated microphages, as well as its mechanism of action. METHODS:Mouse RAW264.7 cells were treated with different concentrations of cordycepin for 0-16h. Western blotting was use...
journal_title：International immunopharmacology
pub_type： 杂志文章
doi：10.1016/j.intimp.2017.03.002
更新日期：2017-06-01 00:00:00
abstract：:The present study reports the anti-mycobacterial activity of 2-hydroxy-3-(3-methyl-2-butenyl)-1,4-naphthoquinone (lapachol) as well as its influence on macrophage functions. Lapachol (L) did not induce apoptosis/necrosis of THP-1 macrophages at ≤32 μg/mL. Mycobacterium avium liquid growth was arrested by ≥32 μg/mL and...
journal_title：International immunopharmacology
pub_type： 杂志文章
doi：10.1016/j.intimp.2010.08.023
更新日期：2010-11-01 00:00:00
