The fungal metabolite, citrinin, inhibits lipopolysaccharide/interferon-γ-induced nitric oxide production in glomerular mesangial cells.

Abstract:

:The mycotoxin, citrinin (CTN), is a secondary metabolite of the fermented products of Monascus. The mycotoxin can either suppress or stimulate immune responses. In the present study, the immunomodulatory role of CTN in nitric oxide (NO) production, a proinflammatory mediator in the process of inflammation, was investigated. NO is well known as a mediator of immune responses. Overproduction of NO catalyzed by inducible nitric oxide synthase (iNOS) protects host cells against microbial invasion, while aberrant iNOS induction is associated with the pathophysiology of inflammatory events. Herein, we report that CTN significantly suppressed lipopolysaccharide (LPS)/interferon (IFN)-γ-induced NO production in MES-13 cells, a glomerular mesangial cell line. The percentage of NO reduction caused by CTN was far greater than that of the decline in cell viability. CTN decreased iNOS gene and protein expressions in concentration-dependent manners. CTN caused declines in LPS/IFN-γ-induced signal transducer and activator of transcription-1α (STAT-1α) phosphorylation. Furthermore, LPS/IFN-γ's induction of interferon response factor-1 (IRF-1) mRNA expression was inhibited by CTN. Moreover, CTN attenuated IκB-α phosphorylation and reduced NF-κB's translocation to the nuclear fraction. Taken together, our data indicated that CTN significantly suppressed NO and iNOS expressions in MES-13 cells via inhibition of the JAK/STAT-1α and NF-κB signaling pathways.

journal_name

Int Immunopharmacol

authors

Liu BH,Chi JY,Hsiao YW,Tsai KD,Lee YJ,Lin CC,Hsu SC,Yang SM,Lin TH

doi

10.1016/j.intimp.2010.09.017

subject

Has Abstract

pub_date

2010-12-01 00:00:00

pages

1608-15

issue

12

eissn

1567-5769

issn

1878-1705

pii

S1567-5769(10)00309-7

journal_volume

10

pub_type

杂志文章
  • Nicotine modulation of apoptosis in human coronary artery endothelial cells.

    abstract::It has been recently reported that nicotine, the addictive component of tobacco, is an important modulator at the level of immune cell apoptosis or programmed cell death. Apoptosis is a process that helps maintain the homeostasis of the vascular endothelium and vascular smooth muscle cells, and alteration of the apopt...

    journal_title:International immunopharmacology

    pub_type: 杂志文章

    doi:10.1016/s1567-5769(02)00059-0

    authors: Hakki A,Friedman H,Pross S

    更新日期:2002-09-01 00:00:00

  • Serum immunoglobulin G provides early risk prediction in immunoglobulin A nephropathy.

    abstract:BACKGROUND:Immunoglobulin A (IgA) nephropathy (IgAN) is a common primary glomerular disease that potentially leads to renal failure, risk prediction of declining kidney function is crucial for early clinical management. Immunoglobulin G (IgG) is an important constituent of the immune system and serves as the preferred ...

    journal_title:International immunopharmacology

    pub_type: 杂志文章

    doi:10.1016/j.intimp.2018.10.044

    authors: Liu D,You J,Liu Y,Tang X,Tan X,Xia M,Wu L,Chen G,He L,Zhu X,Liu H

    更新日期:2019-01-01 00:00:00

  • Icariin and its derivative, ICT, exert anti-inflammatory, anti-tumor effects, and modulate myeloid derived suppressive cells (MDSCs) functions.

    abstract::3, 5,7-trihydroxy-4'-methoxy-8-(3-hydroxy-3-methylbutyl)-flavone (ICT) is a novel derivative of Icariin (ICA), the major active ingredient of Herba Epimedii, a herb used in traditional Chinese and alternative medicine. We previously demonstrated its anti-inflammatory effect in murine innate immune cells and activated ...

    journal_title:International immunopharmacology

    pub_type: 杂志文章

    doi:10.1016/j.intimp.2011.01.007

    authors: Zhou J,Wu J,Chen X,Fortenbery N,Eksioglu E,Kodumudi KN,Pk EB,Dong J,Djeu JY,Wei S

    更新日期:2011-07-01 00:00:00

  • Chromatin remodeling complex in Treg function.

    abstract::Regulatory T cells (Treg), formerly known as suppressor T cells, are essential for maintaining self-tolerance as well as immune homeostasis. Lack of Treg or normal function of Treg often leads to lymphoproliferative syndrome and autoimmunity in human and mouse. The chromatin remodeling BAF complex regulates gene expre...

    journal_title:International immunopharmacology

    pub_type: 杂志文章,评审

    doi:10.1016/j.intimp.2009.01.019

    authors: Jani A,Chi T,Wan YY

    更新日期:2009-05-01 00:00:00

  • Th17/Treg imbalance and increased interleukin-21 are associated with liver injury in patients with chronic severe hepatitis B.

    abstract:BACKGROUND:Th17/Treg imbalance and the levels of related cytokines are essential in the pathogenesis of autoimmune and infectious diseases. The aim of the current study was to assess the Treg/Th17 balance and the levels of related cytokines associated with various degrees of liver injury in patients with chronic hepati...

    journal_title:International immunopharmacology

    pub_type: 杂志文章

    doi:10.1016/j.intimp.2017.02.019

    authors: Liu B,Gao W,Zhang L,Wang J,Chen M,Peng M,Ren H,Hu P

    更新日期:2017-05-01 00:00:00

  • Use of IGIV in the treatment of atopic dermatitis, urticaria, scleromyxedema, pyoderma gangrenosum, psoriasis, and pretibial myxedema.

    abstract::There has been a rapid expansion in the use of IGIV for an ever-growing number of conditions. It is a product with an excellent safety record without the side effects of steroids or other immunosuppressive agents. There have been numerous recent advances in our understanding of the mechanisms of action of IGIV in many...

    journal_title:International immunopharmacology

    pub_type: 杂志文章,评审

    doi:10.1016/j.intimp.2005.11.017

    authors: Jolles S,Hughes J

    更新日期:2006-04-01 00:00:00

  • Anti-neuroinflammatory effect of aurantiamide acetate from the marine fungus Aspergillus sp. SF-5921: inhibition of NF-κB and MAPK pathways in lipopolysaccharide-induced mouse BV2 microglial cells.

    abstract::In the course of a search for anti-neuroinflammatory metabolites from marine fungi, aurantiamide acetate (1) was isolated from marine-derived Aspergillus sp. as an anti-neuroinflammatory component. Compound 1 dose-dependently inhibited the production of nitric oxide (NO) and prostaglandin E2 (PGE2) in BV2 microglial c...

    journal_title:International immunopharmacology

    pub_type: 杂志文章

    doi:10.1016/j.intimp.2014.10.006

    authors: Yoon CS,Kim DC,Lee DS,Kim KS,Ko W,Sohn JH,Yim JH,Kim YC,Oh H

    更新日期:2014-12-01 00:00:00

  • Heparin changes the conformation of high-mobility group protein 1 and decreases its affinity toward receptor for advanced glycation endproducts in vitro.

    abstract::High-mobility group protein 1 (HMGB1) has been identified as a late-acting mediator of inflammation. The receptor for advanced glycation end products (RAGE) is the main receptor and mediates the cytokine activity of HMGB1. Since HMGB1 also exhibits heparin-binding activity, we investigated whether heparin interferes w...

    journal_title:International immunopharmacology

    pub_type: 杂志文章

    doi:10.1016/j.intimp.2010.11.014

    authors: Ling Y,Yang ZY,Yin T,Li L,Yuan WW,Wu HS,Wang CY

    更新日期:2011-02-01 00:00:00

  • Taishan Pinus massoniana pollen polysaccharides promote immune responses of recombinant Bordetella avium ompA in BALB/c mice.

    abstract::To study the effects of Taishan Pinus massoniana pollen polysaccharides (TPPPS) on Bordetella avium outer membrane protein A (ompA) recombinant protein vaccine, ompA was expressed, confirmed by Western blotting and mixed with TPPPS. Female BALB/c mice were randomly divided into six groups (I-VI). Groups I, II, and III...

    journal_title:International immunopharmacology

    pub_type: 杂志文章

    doi:10.1016/j.intimp.2013.09.008

    authors: Zhao X,Liang M,Yang P,Guo F,Pan D,Huang X,Li Y,Wu C,Qu T,Zhu R

    更新日期:2013-11-01 00:00:00

  • Altered gene expression profiles associated with enhanced skin inflammation induced by 12-O-tetradecanoylphorbol-13-acetate in streptozotocin-diabetic mice.

    abstract::To examine the mechanisms of diabetes-enhanced inflammation, ear inflammation was induced by 12-O-tetradecanoylphorbol-13-acetate (TPA) in streptozotocin (STZ)-injected diabetic and control mice. The inflammatory response was determined from ear thickness and histology. The mRNA expression of several inflammation-rela...

    journal_title:International immunopharmacology

    pub_type: 杂志文章

    doi:10.1016/j.intimp.2013.01.007

    authors: Iba Y,Watanabe K,Ozaki K,Aozasa O,Ishizawa K,Matsuura T,Oyama H,Masukawa T

    更新日期:2013-03-01 00:00:00

  • Receptors for chemotactic formyl peptides as pharmacological targets.

    abstract::Leukocytes accumulate at sites of inflammation and immunological reaction in response to locally existing chemotactic mediators. N-formyl peptides, such as fMet-Leu-Phe (fMLF), are some of the first identified and most potent chemoattractants for phagocytic leukocytes. In addition to the bacterial peptide fMLF and the...

    journal_title:International immunopharmacology

    pub_type: 杂志文章,评审

    doi:10.1016/s1567-5769(01)00150-3

    authors: Le Y,Yang Y,Cui Y,Yazawa H,Gong W,Qiu C,Wang JM

    更新日期:2002-01-01 00:00:00

  • Regulatory functions of γδ T cells.

    abstract::γδ T cells account for approximately 5% of peripheral blood T cells but are more abundant in mucosal tissue. Based on the recognized ligands and their general lack of MHC restriction, γδ T cells are considered as unconventional T cells that link innate and adaptive immunity. γδ T cells produce a diverse range of cytok...

    journal_title:International immunopharmacology

    pub_type: 杂志文章,评审

    doi:10.1016/j.intimp.2013.01.022

    authors: Kabelitz D,Peters C,Wesch D,Oberg HH

    更新日期:2013-07-01 00:00:00

  • Resveratrol inhibits nitric oxide and TNF-alpha production by lipopolysaccharide-activated microglia.

    abstract::Upon activation, brain macrophages, the microglia, release proinflammatory mediators that play important roles in eliciting neuroinflammatory responses associated with neurodegenerative diseases. As resveratrol, an antioxidant component of grape, has been reported to exert anti-inflammatory activities on macrophages, ...

    journal_title:International immunopharmacology

    pub_type: 杂志文章

    doi:10.1016/j.intimp.2004.08.008

    authors: Bi XL,Yang JY,Dong YX,Wang JM,Cui YH,Ikeshima T,Zhao YQ,Wu CF

    更新日期:2005-01-01 00:00:00

  • Ginkgo terpene component has an anti-inflammatory effect on Candida albicans-caused arthritic inflammation.

    abstract::The Ginkgo biloba extract, EGb 761, contains flavonoid glycosides and unique terpene lactones as major active components. In this study, we determined the anti-inflammatory effect of the water-soluble portion (GH415) of the EGb 761 on the inflammation caused by Candida albicans, a major ethiological agent that causes ...

    journal_title:International immunopharmacology

    pub_type: 杂志文章

    doi:10.1016/j.intimp.2005.02.002

    authors: Han Y

    更新日期:2005-06-01 00:00:00

  • Progesterone suppresses Aβ42-induced neuroinflammation by enhancing autophagy in astrocytes.

    abstract::Autophagy is an intracellular catabolic mechanism essential for recycling intracellular unfolding protein and eliminating toxic protein aggregates. Several studies have shown that deficient autophagy is implicated in the development of Alzheimer's disease (AD) progression. To date, rapidly emerging evidence suggests t...

    journal_title:International immunopharmacology

    pub_type: 杂志文章

    doi:10.1016/j.intimp.2017.11.044

    authors: Hong Y,Liu Y,Zhang G,Wu H,Hou Y

    更新日期:2018-01-01 00:00:00

  • Methionine enkephalin, its role in immunoregulation and cancer therapy.

    abstract::Methionine enkephalin (MENK), an endogenous neuropeptide has a crucial role in both neuroendocrine and immune systems. MENK is believed to have an immunoregulatory activity to have cancer biotherapy activity by binding to the opioid receptors on immune and cancer cells. Clinical trial studies in cancer patients have s...

    journal_title:International immunopharmacology

    pub_type: 杂志文章

    doi:10.1016/j.intimp.2016.02.015

    authors: Zhao D,Plotnikoff N,Griffin N,Song T,Shan F

    更新日期:2016-08-01 00:00:00

  • Metformin attenuated endotoxin-induced acute myocarditis via activating AMPK.

    abstract::Metformin is a widely used anti-diabetic drug and increasing evidence suggests that metformin have profound cardioprotective effects under both diabetic and non-diabetic situations. The protective benefits of metformin have been proved in diabetic patients with cardiovascular complications and in experimental animals ...

    journal_title:International immunopharmacology

    pub_type: 杂志文章

    doi:10.1016/j.intimp.2017.04.002

    authors: Liu G,Wu K,Zhang L,Dai J,Huang W,Lin L,Ge P,Luo F,Lei H

    更新日期:2017-06-01 00:00:00

  • Immunogenic cross-reaction among outer membrane proteins of Gram-negative bacteria.

    abstract::In the present study, antigenic cross-reactivity of OMPs was investigated in several species of bacterial pathogens. Heterogeneous mouse or fish antisera were used to ascertain OMPs with cross-reactivity and cluster analysis was performed to analyze the distribution of cross-antigenic OMPs in diverse bacterial strains...

    journal_title:International immunopharmacology

    pub_type: 杂志文章

    doi:10.1016/j.intimp.2005.02.008

    authors: Xu C,Wang S,Zhaoxia Z,Peng X

    更新日期:2005-07-01 00:00:00

  • MDA-7/IL-24 is a unique cytokine--tumor suppressor in the IL-10 family.

    abstract::The melanoma differentiation associated gene-7 (mda-7) cDNA was isolated by virtue of being induced during melanoma differentiation. Initial gene transfer studies convincingly demonstrated potent antitumor effects of mda-7. Further studies showed that the mechanism of antitumor activity was due to induction of apoptos...

    journal_title:International immunopharmacology

    pub_type: 杂志文章,评审

    doi:10.1016/j.intimp.2004.01.017

    authors: Chada S,Sutton RB,Ekmekcioglu S,Ellerhorst J,Mumm JB,Leitner WW,Yang HY,Sahin AA,Hunt KK,Fuson KL,Poìndexter N,Roth JA,Ramesh R,Grimm EA,Mhashilkar AM

    更新日期:2004-05-01 00:00:00

  • Berberine suppresses IL-33-induced inflammatory responses in mast cells by inactivating NF-κB and p38 signaling.

    abstract::Berberine (BBR) possesses many pharmacological characteristics including anti-inflammation, anti-allergy, anti-angiogenesis and anti-tumor. However, the effects and mechanisms of BBR on IL-33-induced mast cell inflammatory responses are kept unknown. To investigate these, rat peritoneal mast cells (RPMCs) were isolate...

    journal_title:International immunopharmacology

    pub_type: 杂志文章

    doi:10.1016/j.intimp.2018.11.009

    authors: Li W,Yin N,Tao W,Wang Q,Fan H,Wang Z

    更新日期:2019-01-01 00:00:00

  • Mogroside IVE attenuates experimental liver fibrosis in mice and inhibits HSC activation through downregulating TLR4-mediated pathways.

    abstract::Liver fibrosis has been emphasized as a serious threat to human health. There is currently no effective clinical drug treatment. Although mogrosides (MGs) have extensive pharmacological effects with minimal toxicity, their effects on liver function, inflammation, matrix metalloproteinases and hepatic stellate cell (HS...

    journal_title:International immunopharmacology

    pub_type: 杂志文章

    doi:10.1016/j.intimp.2017.12.023

    authors: Cao F,Zhang Y,Li W,Shimizu K,Xie H,Zhang C

    更新日期:2018-02-01 00:00:00

  • Selective modulation of lymphoproliferation and cytokine production via intracellular signaling targets by α1- and α2-adrenoceptors and estrogen in splenocytes.

    abstract:UNLABELLED:The mechanistic implications of the presence of sympathetic noradrenergic innervation in lymphoid organs in synaptic association with lymphocytes open to the influence of hormonal fluctuations throughout reproductive age in females has not been investigated yet. OBJECTIVES:The aim of the present study is to...

    journal_title:International immunopharmacology

    pub_type: 杂志文章

    doi:10.1016/j.intimp.2013.08.020

    authors: Priyanka HP,ThyagaRajan S

    更新日期:2013-11-01 00:00:00

  • Angiotensin II contributes to intratumoral immunosuppressionvia induction of PD-L1 expression in non-small cell lung carcinoma.

    abstract::The formation of an immunosuppressive microenvironment and up-regulation of PD-L1 protein are the main causes of tumor immune escape. Previous reports suggest that Angiotensin II (Ang II) can modulate the immune status of tumor microenvironment in non-small cell lung cancer (NSCLC), but the underlying mechanism remain...

    journal_title:International immunopharmacology

    pub_type: 杂志文章

    doi:10.1016/j.intimp.2020.106507

    authors: Yang K,Zhou J,Chen Y,Chen Y,Chen L,Zhang P,Ma L,Jiang Z,Bian J,Yin W

    更新日期:2020-07-01 00:00:00

  • A promising therapeutic target for psoriasis: Neuropeptides in human skin.

    abstract::Psoriasis is a chronic inflammatory skin disease featured by excessive proliferation of keratinocytes, clearly defined round erythema and dry, scaly plaques, long-term inflammatory cells infiltration in skin lesions. However, the physiopathological mechanism of psoriasis is still not clearly understood. Neuropeptides,...

    journal_title:International immunopharmacology

    pub_type: 杂志文章,评审

    doi:10.1016/j.intimp.2020.106755

    authors: Zhang Y,Zhang H,Jiang B,Yan S,Lu J

    更新日期:2020-10-01 00:00:00

  • Anti-tumor activity of ex vivo expanded cytokine-induced killer cells against human hepatocellular carcinoma.

    abstract::Cytokine-induced killer (CIK) cells are ex vivo expanded T cells with natural killer cell phenotypes and functions. In this study, the anti-tumor activity of CIK cells against hepatocellular carcinoma was evaluated in vitro and in vivo. In the presence of anti-CD3 antibody and IL-2 for 14 days, human peripheral blood ...

    journal_title:International immunopharmacology

    pub_type: 杂志文章

    doi:10.1016/j.intimp.2007.08.007

    authors: Kim HM,Lim J,Yoon YD,Ahn JM,Kang JS,Lee K,Park SK,Jeong YJ,Kim JM,Han G,Yang KH,Kim YJ,Kim Y,Han SB

    更新日期:2007-12-15 00:00:00

  • Comprehensive analysis of CTLA-4 in the tumor immune microenvironment of 33 cancer types.

    abstract::Immunotherapy has recently become a powerful weapon against cancer. Cytotoxic T lymphocyte-associated antigen-4 (CTLA-4) was the first immune checkpoint used for immunotherapy. However, CTLA-4-related mechanisms in various cancers have not been comprehensively investigated. This aim of this study was an in-depth inves...

    journal_title:International immunopharmacology

    pub_type: 杂志文章

    doi:10.1016/j.intimp.2020.106633

    authors: Zhang C,Chen J,Song Q,Sun X,Xue M,Yang Z,Shang J

    更新日期:2020-08-01 00:00:00

  • Sauchinone, a lignan from Saururus chinensis, reduces tumor necrosis factor-alpha production through the inhibition of c-raf/MEK1/2/ERK 1/2 pathway activation.

    abstract::We investigated the anti-inflammatory effects of sauchinone, a lignan isolated from Saururus chinensis, and the underlying mechanism in lipopolysaccharide (LPS)-stimulated RAW264.7 cells. To assess the effects of sauchinone on LPS-induced macrophages activation, we measured the production of tumor necrosis factor (TNF...

    journal_title:International immunopharmacology

    pub_type: 杂志文章

    doi:10.1016/j.intimp.2010.06.001

    authors: Bae HB,Li M,Son JK,Seo CS,Chung SH,Kim SJ,Jeong CW,Lee HG,Kim W,Park HC,Kwak SH

    更新日期:2010-09-01 00:00:00

  • Transplantation of Aire-overexpressing bone marrow-derived dendritic cells delays the onset of type 1 diabetes.

    abstract::Autoimmune regulator (Aire) plays an indispensable role in maintaining central immune tolerance by promoting the ectopic expression of tissue-restricted antigens (TRAs) in medullary thymic epithelial cells (mTECs) and dendritic cells (DCs), which lead to the deletion of autoreactive T cells or the induction of Tregs a...

    journal_title:International immunopharmacology

    pub_type: 杂志文章

    doi:10.1016/j.intimp.2017.05.023

    authors: Li D,Zhao B,Luo Y,Limbara S,Zhao B,Zou X,Yang W,Li Y

    更新日期:2017-08-01 00:00:00

  • Anti-brain cholinergic auto antibodies from primary Sjögren syndrome sera modify simultaneously cerebral nitric oxide and prostaglandin biosynthesis.

    abstract::The presence of circulating antibodies from primary Sjögren Syndrome (pSS) patients enable to interact with rat cerebral frontal cortex by activating muscarinic acetylcholine receptors (mAChR). ELISA assay for PGE2 generation, nitric oxide synthase (NOS) activity was measured in cerebral frontal cortex slices by produ...

    journal_title:International immunopharmacology

    pub_type: 杂志文章

    doi:10.1016/j.intimp.2007.07.018

    authors: Orman B,Sterin-Borda L,De Couto Pita A,Reina S,Borda E

    更新日期:2007-12-05 00:00:00

  • Indirubin-3'-monoxime prevents aberrant activation of GSK-3β/NF-κB and alleviates high fat-high fructose induced Aβ-aggregation, gliosis and apoptosis in mice brain.

    abstract::Deciphering the molecular mechanisms of amyloid pathology and glial cell-mediated neuroinflammation, offers a novel avenue for therapeutic intervention against neurodegeneration. Recent findings demonstrate a crucial link between activation of glycogen synthase kinase-3β (GSK-3β), amyloid deposition and a neuroinflamm...

    journal_title:International immunopharmacology

    pub_type: 杂志文章

    doi:10.1016/j.intimp.2019.02.053

    authors: Sathiya Priya C,Vidhya R,Kalpana K,Anuradha CV

    更新日期:2019-05-01 00:00:00