Abstract:
:The aim of this study was to evaluate possible association between ophthalmic complications in sulfur mustard (SM) exposed patients with mild ocular injuries and serum soluble adhesion molecules. Serum levels of sICAM-1, sL-selectin, sP-selectin and sE-selectin in 367 SM-exposed individuals with or without eye injuries were checked and compared with 128 unexposed controls. All participants underwent ocular examinations. Serum sICAM-1 level in SM exposed with blurred vision, was significantly (p=0.021) higher than in SM exposed with no blurred vision. Serum sL-selectin level was significantly (p=0.024) higher in SM exposed with photophobia than SM exposed with no photophobia. Serum P-selectin level in exposed without any slit lamp findings was significantly (p=0.003) lower than the matched control groups. Similar finding was seen in exposed group without ocular problem compared with the control groups. Serum sE-selectin level in exposed with normal ocular condition except for photophobia and blurred vision was significantly (p<0.05) higher than the matched controls. Serum E-selectin level in exposed with photophobia condition was significantly (p=0.047) higher than the control group with photophobia. In conclusion it seems that the changes in the E- and P-selectins is a regulatory mechanism for inhibition of SM induced ocular problems, although the local levels are more important and further investigations required in more severe ocular problems in SM exposed patients.
journal_name
Int Immunopharmacoljournal_title
International immunopharmacologyauthors
Ghasemi H,Yaraee R,Hassan ZM,Faghihzadeh S,Soroush MR,Pourfarzam S,Ebtekar M,Babaei M,Moaiedmohseni S,Naghizadeh MM,Askari N,Ghazanfari Tdoi
10.1016/j.intimp.2012.12.014subject
Has Abstractpub_date
2013-11-01 00:00:00pages
980-5issue
3eissn
1567-5769issn
1878-1705pii
S1567-5769(12)00392-Xjournal_volume
17pub_type
杂志文章abstract::Our previous work showed that SEP, a novel glucan isolated from the eggs of sea urchins, Strongylocentrotus nudus, had remarkable anti-tumor activity. To elucidate the mechanism of the anti-tumor activity, the immunomodulatory activity of SEP was investigated. The in vivo experiment results showed that SEP remarkably ...
journal_title:International immunopharmacology
pub_type: 杂志文章
doi:10.1016/j.intimp.2008.09.005
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abstract:OBJECTIVE:To compare anti-malondialdehyde-acetaldehyde (MAA) antibody concentrations between rheumatoid arthritis (RA) patients and healthy and rheumatic disease controls. METHODS:Anti-MAA antibody (IgA, IgM, IgG) was measured using ELISA and banked serum from patients with RA (n = 284), osteoarthritis (OA, n = 330), ...
journal_title:International immunopharmacology
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journal_title:International immunopharmacology
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journal_title:International immunopharmacology
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journal_title:International immunopharmacology
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journal_title:International immunopharmacology
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journal_title:International immunopharmacology
pub_type: 杂志文章
doi:10.1016/j.intimp.2003.11.006
更新日期:2004-02-01 00:00:00
abstract:BACKGROUNDS:C1q tumor necrosis factor-related protein 9 (CTRP9) has been suggested to exert an atheroprotective effect by modulating the inflammation, foam cell formation, endothelia and smooth muscle cell function via Adenosine Monophosphate Activated Protein Kinase (AMPK) pathway. On the other hand, the NLR Family Py...
journal_title:International immunopharmacology
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journal_title:International immunopharmacology
pub_type: 杂志文章
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journal_title:International immunopharmacology
pub_type: 杂志文章
doi:10.1016/j.intimp.2014.10.022
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journal_title:International immunopharmacology
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更新日期:2020-12-01 00:00:00
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journal_title:International immunopharmacology
pub_type: 杂志文章
doi:10.1016/j.intimp.2016.03.045
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abstract::Red cell-derived microparticles (RMPs) are potential mediators of transfusion-related acute lung injury (TRALI). The aim of this study was to investigate the effects of microparticles present in red cell concentrates (RCC) on polymorphonuclear neutrophil (PMN) respiratory burst and acute lung injury (ALI) in mice. Mic...
journal_title:International immunopharmacology
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journal_title:International immunopharmacology
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journal_title:International immunopharmacology
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doi:10.1016/j.intimp.2019.105760
更新日期:2019-10-01 00:00:00
abstract::Isoflavones, which are phytoestrogens present in large quantities in soy and soy-derived products, have estrogenic activity, inhibit protein tyrosine kinase, and exert other effects in the human body. Thus, the recent spread of soy consumption in Western populations emphasizes the need to more fully understand the pot...
journal_title:International immunopharmacology
pub_type: 杂志文章
doi:10.1016/j.intimp.2005.04.011
更新日期:2005-10-01 00:00:00
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journal_title:International immunopharmacology
pub_type: 杂志文章,评审
doi:10.1016/j.intimp.2020.107196
更新日期:2021-01-01 00:00:00
abstract::In a preliminary experiment, it was found that oleanolic acid (OA), which is widely distributed in food and medicinal plants, inhibited interleukin (IL)-6/tumor growth factor beta-induced differentiation of splenic T cells into Th17 cells. Moreover, OA induced the differentiation of splenic T cells into Treg cells. Th...
journal_title:International immunopharmacology
pub_type: 杂志文章
doi:10.1016/j.intimp.2015.10.024
更新日期:2015-12-01 00:00:00
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journal_title:International immunopharmacology
pub_type: 杂志文章,评审
doi:10.1016/j.intimp.2012.04.015
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journal_title:International immunopharmacology
pub_type: 杂志文章
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更新日期:2006-12-05 00:00:00
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journal_title:International immunopharmacology
pub_type: 杂志文章
doi:10.1016/j.intimp.2018.08.017
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journal_title:International immunopharmacology
pub_type: 临床试验,杂志文章
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journal_title:International immunopharmacology
pub_type: 杂志文章
doi:10.1016/j.intimp.2015.09.026
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