当前位置： SCI文献检索 > INTERNATIONAL IMMUNOPHARMACOLOGY期刊下所有文献 > Receptors for chemotactic formyl peptides as pharmacological targets.

Receptors for chemotactic formyl peptides as pharmacological targets.

Abstract：

:Leukocytes accumulate at sites of inflammation and immunological reaction in response to locally existing chemotactic mediators. N-formyl peptides, such as fMet-Leu-Phe (fMLF), are some of the first identified and most potent chemoattractants for phagocytic leukocytes. In addition to the bacterial peptide fMLF and the putative endogenously produced formylated peptides, a number of novel peptide agonists have recently been identified that selectively activate the high-affinity fMLF receptor FPR and/or its low-affinity variant FPRL1, both of which belong to the seven-transmembrane (STM), G protein-coupled receptor (GPCR) superfamily. These agonists include peptide domains derived from the envelope proteins of human immunodeficiency virus type 1 (HIV-1) and at least three amyloidogenic polypeptides, the human acute phase protein serum amyloid A, the 42 amino acid form of beta amyloid peptide and a 21 amino acid fragment of human prion. Furthermore, a cleavage fragment of neutrophil granule-derived bactericidal cathelicidin, LL-37, is also a chemotactic agonist for FPRL1. Activation of formyl peptide receptors results in increased cell migration, phagocytosis, release of proinflammatory mediators, and the signaling cascade culminates in heterologous desensitization of other STM receptors including chemokine receptors CCR5 and CXCR4, two coreceptors for HIV-1. Thus, by interacting with a variety of exogenous and host-derived agonists, formyl peptide receptors may play important roles in proinflammatory and immunological diseases and constitute a novel group of pharmacological targets.

journal_name

Int Immunopharmacol

journal_title

International immunopharmacology

authors

Le Y,Yang Y,Cui Y,Yazawa H,Gong W,Qiu C,Wang JM

doi

10.1016/s1567-5769(01)00150-3

keywords:

subject

Has Abstract

pub_date

2002-01-01 00:00:00

pages

1-13

issue

1

eissn

1567-5769

issn

1878-1705

pii

S1567-5769(01)00150-3

journal_volume

2

pub_type

杂志文章,评审

相关文献

INTERNATIONAL IMMUNOPHARMACOLOGY文献大全
  • Molecular mechanisms of IgE mediated food allergy.

    abstract：:The purpose of this review is to collate current knowledge and recent advances in molecular mechanism behind the immediate type hypersensitivity of foods. Food allergy is a growing concern of human health in developed as well as developing countries now days. Food allergic reactions are mostly IgE mediated and also kn...

    journal_title：International immunopharmacology

    pub_type： 杂志文章,评审

    doi：10.1016/j.intimp.2012.05.018

    authors： Kumar S,Verma AK,Das M,Dwivedi PD

    更新日期：2012-08-01 00:00:00

  • Isodeoxyelephantopin, a sesquiterpene lactone from Elephantopus scaber Linn., inhibits pro-inflammatory mediators' production through both NF-κB and AP-1 pathways in LPS-activated macrophages.

    abstract：:Isodeoxyelephantopin (IDET) has been identified as an anti-tumor natural constituent whose anti-tumor activity and mechanism have been widely investigated. Since the occurrence and development of cancer usually accompany with inflammation, and tumor signaling shares many components with inflammation signaling, the age...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2020.106528

    authors： Han Y,Li X,Zhang X,Gao Y,Qi R,Cai R,Qi Y

    更新日期：2020-07-01 00:00:00

  • Effects of propolis from different areas on mast cell degranulation and identification of the effective components in propolis.

    abstract：:Propolis is considered to down-regulate type I allergy, but the effective components of propolis remain unknown. In addition, propolis components vary depending on the area from which they are collected due to variations among wild plants in an area. Therefore, we compared the effects of water and ethanol extracts of ...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2010.06.013

    authors： Nakamura R,Nakamura R,Watanabe K,Oka K,Ohta S,Mishima S,Teshima R

    更新日期：2010-09-01 00:00:00

  • Osteoclasts in arthritis and Th17 cell development.

    abstract：:Bone destruction associated with rheumatoid arthritis (RA) is mainly attributed to the abnormal activation of osteoclasts, which are terminally differentiated cells of monocyte/macrophage lineage that resorb bone matrix. Studies on the immune regulation of osteoclasts in RA have promoted the new research field of "ost...

    journal_title：International immunopharmacology

    pub_type： 杂志文章,评审

    doi：10.1016/j.intimp.2010.11.010

    authors： Okamoto K,Takayanagi H

    更新日期：2011-05-01 00:00:00

  • 1,25‑Dihydroxyvitamin D regulates macrophage polarization and ameliorates experimental inflammatory bowel disease by suppressing miR-125b.

    abstract：:Macrophages are highly plastic cells. Depending on stimulation, macrophages rapidly polarize to functionally distinct phenotypes that are involved in the pathogenesis of inflammatory bowel disease (IBD). 1,25‑Dihydroxyvitamin D (1,25(OH)2D3) has immunomodulatory activity, and 1,25(OH)2D3 deficiency is correlated with ...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2018.12.015

    authors： Zhu X,Zhu Y,Li C,Yu J,Ren D,Qiu S,Nie Y,Yu X,Xu X,Zhu W

    更新日期：2019-02-01 00:00:00

  • Dihydrofisetin exerts its anti-inflammatory effects associated with suppressing ERK/p38 MAPK and Heme Oxygenase-1 activation in lipopolysaccharide-stimulated RAW 264.7 macrophages and carrageenan-induced mice paw edema.

    abstract：:Dihydrofisetin is a flavanonol derived from some edible wild herbs and traditional Chinese medicines. It has been found to possess many biological activities. However, the anti-inflammatory potential of Dihydrofisetin remains uncharacterized. The aim of the present study was to investigate the anti-inflammatory activi...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2017.11.034

    authors： Li KK,Shen SS,Deng X,Shiu HT,Siu WS,Leung PC,Ko CH,Cheng BH

    更新日期：2018-01-01 00:00:00

  • A synthetic peptide derived from bactericidal/permeability-increasing protein neutralizes endotoxin in vitro and in vivo.

    abstract：:Lipopolysaccharide (LPS [endotoxin]), a structural component of gram-negative bacteria, is implicated in the pathogenesis of septic shock. Lipid A is an evolutionarily conserved region of LPS that has been identified as the toxic component of LPS. Therapeutic strategies for the treatment of septic shock in humans are ...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2004.02.004

    authors： Jiang Z,Hong Z,Guo W,Xiaoyun G,Gengfa L,Yongning L,Guangxia X

    更新日期：2004-04-01 00:00:00

  • FK506 ameliorates renal injury in early experimental diabetic rats induced by streptozotocin.

    abstract：:Calcineurin (CaN) plays an important role in glomerular hypertrophy and extracellular matrix accumulation in early diabetic nephropathy. Cyclosporine (CSA), a CaN inhibitor, has been shown to reduce renal injury in streptozotocin-induced diabetic rats. We examined whether FK506, which immunosuppressive action was 10-1...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2011.05.023

    authors： Qi XM,Wu YG,Liang C,Zhang P,Dong J,Ren KJ,Zhang W,Fang F,Shen JJ

    更新日期：2011-10-01 00:00:00

  • Inflammation research sails through the sea of immunology to reach immunometabolism.

    abstract：:Inflammation occurs as a result of acute trauma, invasion of the host by different pathogens, pathogen-associated molecular patterns (PAMPs) or chronic cellular stress generating damage-associated molecular patterns (DAMPs). Thus inflammation may occur under both sterile inflammatory conditions including certain cance...

    journal_title：International immunopharmacology

    pub_type： 杂志文章,评审

    doi：10.1016/j.intimp.2019.05.002

    authors： Kumar V

    更新日期：2019-08-01 00:00:00

  • The roles of a novel inflammatory neopterin in subjects with coronary atherosclerotic heart disease.

    abstract：:Coronary atherosclerotic heart disease (CHD) is currently regarded as a chronic inflammatory disease. The inflammatory cytokine neopterin (NP) is a new predictor of the stable type of atherosclerotic plaque, and this study focused on the relationship between neopterin, Gensini score and high-sensitivity C-reactive pro...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2014.11.013

    authors： Lyu Y,Jiang X,Dai W

    更新日期：2015-02-01 00:00:00

  • Quantitative in vivo comparisons of the Fc gamma receptor-dependent agonist activities of different fucosylation variants of an immunoglobulin G antibody.

    abstract：:Although it has been shown that functions of immunoglobulin G (IgG) antibodies (Abs) that depend on binding to certain Fc gamma receptors (Fc gamma R) can be influenced by Fc glycan fucosylation, quantitative in vivo analyses comparing the effects of different levels of fucose are still lacking. We used a simple mouse...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2007.01.014

    authors： Scallon B,McCarthy S,Radewonuk J,Cai A,Naso M,Raju TS,Capocasale R

    更新日期：2007-06-01 00:00:00

  • Altered gene expression profiles associated with enhanced skin inflammation induced by 12-O-tetradecanoylphorbol-13-acetate in streptozotocin-diabetic mice.

    abstract：:To examine the mechanisms of diabetes-enhanced inflammation, ear inflammation was induced by 12-O-tetradecanoylphorbol-13-acetate (TPA) in streptozotocin (STZ)-injected diabetic and control mice. The inflammatory response was determined from ear thickness and histology. The mRNA expression of several inflammation-rela...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2013.01.007

    authors： Iba Y,Watanabe K,Ozaki K,Aozasa O,Ishizawa K,Matsuura T,Oyama H,Masukawa T

    更新日期：2013-03-01 00:00:00

  • Enhanced neutrophil autophagy and increased concentrations of IL-6, IL-8, IL-10 and MCP-1 in rheumatoid arthritis.

    abstract：:Rheumatoid arthritis (RA) is a high morbidity and disability disease with numerous inflammatory cells infiltrating in interstitial of articular cartilages and bones. As the most abundant inflammatory cells, neutrophil has been reported that their apoptosis changed gradually in the circumstance of RA. Apoptosis, one mo...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2018.09.011

    authors： An Q,Yan W,Zhao Y,Yu K

    更新日期：2018-12-01 00:00:00

  • The sensitivity of adipose tissue visfatin mRNA expression to lipopolysaccharide-induced endotoxemia is increased by ovariectomy in female rats.

    abstract：:Visfatin plays an important role in inflammatory and metabolic conditions. In this study, the effects of septic stress on the serum, white-adipose-tissue (WAT), and liver visfatin levels of male and female rats were examined. Both gonadally intact (sham) and ovariectomized (OVX) female rats were used in order to evalu...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2016.04.002

    authors： Iwasa T,Matsuzaki T,Matsui S,Tungalagsuvd A,Munkhzaya M,Takiguchi E,Kawakita T,Kuwahara A,Yasui T,Irahara M

    更新日期：2016-06-01 00:00:00

  • Anti-allergic potential of oligomannose-coated liposome-entrapped Cry j 1 as immunotherapy for Japanese cedar pollinosis in mice.

    abstract：:Administration of oligomannose-coated liposomes (OMLs) in mice can induce Th1 immune responses against antigens entrapped in the OMLs. In the present study, we investigated the anti-allergic effect of treatment with oligomannose-coated liposomes (OMLs) with entrapped Cry j 1, a major allergen of Japanese cedar pollen ...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2010.06.003

    authors： Ishii M,Koyama A,Iseki H,Narumi H,Yokoyama N,Kojima N

    更新日期：2010-09-01 00:00:00

  • Comprehensive analysis of elastase-induced pulmonary emphysema in mice: effects of ambient existing particulate matters.

    abstract：:Pulmonary exposure of rodents to porcine pancreatic elastase (PPE) induces lesions that morphologically resemble human panacinar emphysema. However, there has been little work on the comprehensive analysis of this model. The present study was designed to extensively examine the biological effects of PPE on inflammatio...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2010.07.016

    authors： Inoue K,Koike E,Takano H

    更新日期：2010-11-01 00:00:00

  • Oridonin inhibits LPS-induced inflammation in human gingival fibroblasts by activating PPARγ.

    abstract：:Oridonin, the major terpene isolated from Rabdosia rubescens, has been used as dietary supplement. Recently, it has been known to exhibit anti-inflammatory effect. This study we employed an in vitro model of LPS-stimulated human gingival fibroblasts to investigate the anti-inflammatory effects and mechanism of oridoni...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2019.04.006

    authors： Yu T,Xie W,Sun Y

    更新日期：2019-07-01 00:00:00

  • A specific prebiotic oligosaccharide mixture stimulates delayed-type hypersensitivity in a murine influenza vaccination model.

    abstract：:Analogous to reported immunomodulatory effects of probiotics, this study was performed to analyse the immunomodulatory properties of prebiotic oligosaccharides that share chemical characteristics with human milk oligosaccharides. A mixture containing galacto- and fructo-oligosaccharides (GOS/FOS; ratio 9:1) was tested...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2006.03.010

    authors： Vos AP,Haarman M,Buco A,Govers M,Knol J,Garssen J,Stahl B,Boehm G,M'Rabet L

    更新日期：2006-08-01 00:00:00

  • Anomalin attenuates LPS-induced acute lungs injury through inhibition of AP-1 signaling.

    abstract：:In the present study, the anomalin was investigated to determine the protective effects and underlying mechanism against LPS-induced acute lung injury in mice. Anomalin administration 30 min after the LPS injection, significantly attenuated the mechanical allodynia, decrease body temperature, and improved the histolog...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2019.05.032

    authors： Khan A,Khan S,Ali H,Shah KU,Ali H,Shehzad O,Onder A,Kim YS

    更新日期：2019-08-01 00:00:00

  • Immune stimulation improves endocrine and neural fetal outcomes in a model of maternofetal thyrotoxicosis.

    abstract：:The potentiation of the immune system in pregnant rats was performed with Complete Freund's Adjuvant [CFA; 20μl, subcutaneous at gestation day (GD) 18] in experimentally-induced hyperthyroidism by Levo-thyroxine (L-T4; 10μg/100g of b.w., intraperitoneal from GD 2 to 17). The potential effects on the fetal neuroendocri...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2015.09.004

    authors： Ahmed RG,Abdel-Latif M,Mahdi EA,El-Nesr KA

    更新日期：2015-12-01 00:00:00

  • Effects of hydroxyethyl starch (130 kD) on brain inflammatory response and outcome during normotensive sepsis.

    abstract：BACKGROUND:During sepsis, the dysfunction of blood-brain barrier (BBB) was mediated by inflammation and subsequently caused sepsis-associated encephalopathy. Hydroxyethyl starch (HES, 130/0.4) is most widely used for volume replacement to maintain or improve tissue perfusion in patients with sepsis, trauma, and shock. ...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2010.04.020

    authors： Feng X,Zhang F,Dong R,Wang H,Liu J,Liu X,Li W,Yao J,Xu J,Yu B

    更新日期：2010-08-01 00:00:00

  • Analysis of immune subtypes based on immunogenomic profiling identifies prognostic signature for cutaneous melanoma.

    abstract：:Skin cutaneous melanoma (SKCM) is the most invasive form of skin cancer with poor prognosis. Growing evidence has demonstrated that tumor immune microenvironment plays a key contributing role in tumorigenesis and predicting clinical outcomes. The aim of this study was to recognize immune classification and a reliable ...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2020.107162

    authors： Hu B,Wei Q,Zhou C,Ju M,Wang L,Chen L,Li Z,Wei M,He M,Zhao L

    更新日期：2020-12-01 00:00:00

  • Baccatin III, a precursor for the semisynthesis of paclitaxel, inhibits the accumulation and suppressive activity of myeloid-derived suppressor cells in tumor-bearing mice.

    abstract：:Myeloid-derived suppressor cells (MDSCs) mediate tumor-associated immune suppression in both cancer patients and tumor-bearing animals. Reduction or elimination of MDSCs reduces the rate of tumor progression and improves cancer therapies that employ mechanisms of immunity. Here we show that baccatin III, which is the ...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2014.06.012

    authors： Lee YH,Lee YR,Park CS,Im SA,Song S,Hong JT,Whang BY,Kim K,Lee CK

    更新日期：2014-08-01 00:00:00

  • Paeoniflorin improves survival in LPS-challenged mice through the suppression of TNF-α and IL-1β release and augmentation of IL-10 production.

    abstract：:Lipopolysaccharide (LPS) plays an important role in Gram-negative bacteria-induced sepsis and multiple organ dysfunction syndrome, which are still the leading cause of high mortality in intensive care units. Although paeoniflorin (Pae) has reportedly exhibited anti-inflammatory effect and protection against immunologi...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2010.11.012

    authors： Cao W,Zhang W,Liu J,Wang Y,Peng X,Lu D,Qi R,Wang Y,Wang H

    更新日期：2011-02-01 00:00:00

  • TNF-alpha regulates vascular smooth muscle cell responses in genetic hypertension.

    abstract：:Cellular and molecular events in vascular smooth muscle cells (VSMC) from Wistar-Kyoto rats (WKY) and spontaneously hypertensive rats (SHR) were investigated. SHR-derived VSMC showed increased proliferative capacity and MAP kinase levels in comparison with WKY-derived VSMC. Flow cytometry analysis revealed that progre...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2009.03.010

    authors： Lee SJ,Kim WJ,Moon SK

    更新日期：2009-07-01 00:00:00

  • Anti-tumor activity of ex vivo expanded cytokine-induced killer cells against human hepatocellular carcinoma.

    abstract：:Cytokine-induced killer (CIK) cells are ex vivo expanded T cells with natural killer cell phenotypes and functions. In this study, the anti-tumor activity of CIK cells against hepatocellular carcinoma was evaluated in vitro and in vivo. In the presence of anti-CD3 antibody and IL-2 for 14 days, human peripheral blood ...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2007.08.007

    authors： Kim HM,Lim J,Yoon YD,Ahn JM,Kang JS,Lee K,Park SK,Jeong YJ,Kim JM,Han G,Yang KH,Kim YJ,Kim Y,Han SB

    更新日期：2007-12-15 00:00:00

  • Interleukin-1β promotes the induction of retinal autoimmune disease.

    abstract：:Interleukin-1β (IL-1β) is a potent proinflammatory cytokine that plays a critical role in initiating immunoinflammatory responses. In this study, we generated recombinant mouse IL-1β and anti-mouse IL-1β polyclonal antibodies to examine the effect of IL-1β on experimental autoimmune uveoretinitis (EAU), a mouse model ...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2014.06.041

    authors： Zhao R,Zhou H,Zhang J,Liu X,Su SB

    更新日期：2014-10-01 00:00:00

  • Immunoglobulin replacement therapy in primary and secondary antibody deficiency: The correct clinical approach.

    abstract：:Immunoglobulin therapy is the administration of human polyvalent IgG and represents the most effective treatment to prevent recurrent infections in antibody deficiency patients. Primary antibody deficiency represents the main indication of immunoglobulin replacement therapy and includes a wide range of disorders chara...

    journal_title：International immunopharmacology

    pub_type： 杂志文章,评审

    doi：10.1016/j.intimp.2017.09.005

    authors： Pecoraro A,Crescenzi L,Granata F,Genovese A,Spadaro G

    更新日期：2017-11-01 00:00:00

  • Combination treatment of low dose Anti-Thymocyte Globulin (ATG), Rituximab and high dose Sirolimus as induction agents in immune-conditioned recipients.

    abstract：UNLABELLED:A prospective study was performed to evaluate low dose Anti-Thymocyte Globulin (ATG) and Rituximab along with high dose Sirolimus as induction agents for reducing the incidence of acute rejection in renal transplantation. 66 patients who were to undergo live renal transplantation were divided into the low ri...

    journal_title：International immunopharmacology

    pub_type： 临床试验,杂志文章

    doi：10.1016/j.intimp.2006.09.013

    authors： Ravichandran P,Natrajan T,Jaganathan R

    更新日期：2006-12-20 00:00:00

  • Immunotherapeutic modulation of the suppressive liver and tumor microenvironments.

    abstract：:The liver is an immunologically unique organ, consisting of resident hematopoietic and parenchymal cells which often contribute to a relatively tolerant microenvironment. It is also becoming increasingly clear that tumor-induced immunosuppression occurs via many of the same cellular mechanisms which contribute to the ...

    journal_title：International immunopharmacology

    pub_type： 杂志文章,评审

    doi：10.1016/j.intimp.2010.12.024

    authors： Chan T,Wiltrout RH,Weiss JM

    更新日期：2011-07-01 00:00:00