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Molecular mechanisms of IgE mediated food allergy.

Abstract：

:The purpose of this review is to collate current knowledge and recent advances in molecular mechanism behind the immediate type hypersensitivity of foods. Food allergy is a growing concern of human health in developed as well as developing countries now days. Food allergic reactions are mostly IgE mediated and also known as immediate type hypersensitivity or type I reaction. This review encompasses a wide range of molecular events during IgE mediated reactions like primary exposure of allergens, processing of allergens by antigen presenting cells, role of transcription factors like GATA-3, STAT-6, NF-AT, c-maf, c-kit and NF-κB, Treg cells, toll like receptors, cytokines and chemokines, class switch to IgE, FcεR1 receptor, priming of IgE on mast cells or basophils, signaling events followed by secondary exposure of allergens, degranulation and release of mediators like leukotrienes, histamines, prostaglandins, β-hexosaminidase and ultimately anaphylaxis. This review may be helpful to beginners as well as experts working in the field of allergy and immunology because of the stepwise explanations of molecular mechanisms involved in IgE mediated reactions.

journal_name

Int Immunopharmacol

journal_title

International immunopharmacology

authors

Kumar S,Verma AK,Das M,Dwivedi PD

doi

10.1016/j.intimp.2012.05.018

subject

Has Abstract

pub_date

2012-08-01 00:00:00

pages

432-9

issue

4

eissn

1567-5769

issn

1878-1705

pii

S1567-5769(12)00156-7

journal_volume

13

pub_type

杂志文章,评审

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