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Interleukin-1β promotes the induction of retinal autoimmune disease.

Abstract：

:Interleukin-1β (IL-1β) is a potent proinflammatory cytokine that plays a critical role in initiating immunoinflammatory responses. In this study, we generated recombinant mouse IL-1β and anti-mouse IL-1β polyclonal antibodies to examine the effect of IL-1β on experimental autoimmune uveoretinitis (EAU), a mouse model for T cell-mediated eye autoimmune disease. Administration of mouse IL-1β by i.p. in the priming phase, but not in the effector phase, of immune response of EAU enhanced disease scores and its related immune responses including DTH, Ag-specific T cell proliferation and the production of IL-17 and IFN-γ. Furthermore, administration of anti-IL-1β antibody in the priming phase reduced EAU scores. These results suggest that IL-1β is an important mediator in the pathogenesis of autoimmune diseases such as uveitis.

journal_name

Int Immunopharmacol

journal_title

International immunopharmacology

authors

Zhao R,Zhou H,Zhang J,Liu X,Su SB

doi

10.1016/j.intimp.2014.06.041

subject

Has Abstract

pub_date

2014-10-01 00:00:00

pages

285-92

issue

2

eissn

1567-5769

issn

1878-1705

pii

S1567-5769(14)00255-0

journal_volume

22

pub_type

杂志文章

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