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Effect of Brazilian propolis on scratching behavior induced by compound 48/80 and histamine in mice.

Abstract：

:We studied the effect of Brazilian propolis on scratching behavior induced by compound 48/80 and histamine in ICR mice. Propolis granular A.P.C dose-related inhibited scratching behavior induced by compound 48/80 and significant inhibition were observed at 1000 mg/kg. However, histamine-induced scratching behavior was not inhibited by propolis granular A.P.C even at 1000 mg/kg. Propolis ethanol extract at 10 microg/ml or more inhibited histamine release from rat mast cells induced by compound 48/80. In addition, it blocked increased vascular permeability induced by compound 48/80. The inhibitory effect of propolis on scratching behavior induced by compound 48/80 was gradually enhanced by repeated administration, and 500 mg/kg propolis granular A.P.C, which caused no effect through single administration, significantly inhibited scratching behavior after repeated administration for 4 weeks. From these findings, it is assumed that the inhibition of scratching behavior induced by propolis occurs through a mast cell-dependent mechanism.

journal_name

Int Immunopharmacol

journal_title

International immunopharmacology

authors

Shinmei Y,Hossen MA,Okihara K,Sugimoto H,Yamada H,Kamei C

doi

10.1016/j.intimp.2004.06.007

keywords:

subject

Has Abstract

pub_date

2004-10-01 00:00:00

pages

1431-6

issue

10-11

eissn

1567-5769

issn

1878-1705

pii

S1567-5769(04)00195-X

journal_volume

4

pub_type

杂志文章

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