当前位置： SCI文献检索 > INTERNATIONAL IMMUNOPHARMACOLOGY期刊下所有文献 > COX-2-PGE2 signaling pathway contributes to hippocampal neuronal injury and cognitive impairment in PTZ-kindled epilepsy mice.

COX-2-PGE2 signaling pathway contributes to hippocampal neuronal injury and cognitive impairment in PTZ-kindled epilepsy mice.

Abstract：

:Epilepsy is one of the most common neurological diseases. It adversely affects cognitive function. Neuroinflammation has been widely recognized as an important factor involved in the pathophysiology of epilepsy. Cyclooxygenase (COX) is a type of oxidoreductase enzyme that acts in the metabolic pathway converting arachidonic acid to prostaglandins, which mediate inflammatory reactions. The activation of inducible cyclooxygenase-2 (COX-2) is considered to be a precipitating factor of neuroinflammation in the brain. Neuroinflammatory processes in the brain are known to contribute to the cascade of events leading to neuronal injury, which may consequently cause cognitive decline. Here in this study, we showed that pentylenetetrazole (PTZ)-kindled mice exhibited an increased level of COX-2 and its main product prostaglandin E2 (PGE2) along with neuroinflammation and neuronal injury in the hippocampus. Pharmacological inhibition of COX-2 by celecoxib, however, significantly reduced hippocampal neuroinflammation and neuronal injury. Furthermore, inhibition of COX-2 by celecoxib attenuated cognitive impairment in the PTZ-kindled mice, suggesting that COX-2-PGE2 signaling pathway mediated neuroinflammation and neuronal injury contributes to cognitive dysfunction in the PTZ-kindled epilepsy mice. Targeting COX-2-PGE2 signaling pathway in the epileptic brain appears to be a viable strategy for attenuating neuronal injury and preventing cognitive deficits in epilepsy patients.

journal_name

Int Immunopharmacol

journal_title

International immunopharmacology

authors

Zhu X,Yao Y,Yang J,Zhengxie J,Li X,Hu S,Zhang A,Dong J,Zhang C,Gan G

doi

10.1016/j.intimp.2020.106801

subject

Has Abstract

pub_date

2020-10-01 00:00:00

pages

106801

eissn

1567-5769

issn

1878-1705

pii

S1567-5769(20)31765-3

journal_volume

87

pub_type

杂志文章

相关文献

INTERNATIONAL IMMUNOPHARMACOLOGY文献大全
  • Oncostatin M: A mysterious cytokine in cancers.

    abstract：:Oncostatin M (OSM), as a member of the Interleukin-6 family cytokines, plays a significant role in inflammation, autoimmunity, and cancers. It is mainly secreted by T lymphocytes, neutrophils, and macrophages and was initially introduced as anti-cancer agent. However, in some cases, it promotes cancer progression. Ove...

    journal_title：International immunopharmacology

    pub_type： 杂志文章,评审

    doi：10.1016/j.intimp.2020.107158

    authors： Masjedi A,Hajizadeh F,Beigi Dargani F,Beyzai B,Aksoun M,Hojjat-Farsangi M,Zekiy A,Jadidi-Niaragh F

    更新日期：2021-01-01 00:00:00

  • Immunomodulatory pretreatment with Kalanchoe pinnata extract and its quercitrin flavonoid effectively protects mice against fatal anaphylactic shock.

    abstract：:Previously, we reported the immunosuppressive action of the aqueous extract of Kalanchoe pinnata (Kp) in mice. In the present study, we report on the protective effect of Kp in fatal anaphylactic shock, likewise a Th2-driven immunopathology, and the identification of its active component. Mice daily treated with oral ...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2008.07.006

    authors： Cruz EA,Da-Silva SA,Muzitano MF,Silva PM,Costa SS,Rossi-Bergmann B

    更新日期：2008-12-10 00:00:00

  • Combined exercise training reduces IFN-γ and IL-17 levels in the plasma and the supernatant of peripheral blood mononuclear cells in women with multiple sclerosis.

    abstract：:Multiple sclerosis (MS) is a chronic inflammatory demyelinating disorder in which lymphocytic infiltration mediated mainly by pro-inflammatory cytokines. In this study, we examined the effect of combined exercise training on the levels of IFN-γ, IL-4 and IL-17 in the plasma and the supernatant of peripheral blood lymp...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2010.08.008

    authors： Golzari Z,Shabkhiz F,Soudi S,Kordi MR,Hashemi SM

    更新日期：2010-11-01 00:00:00

  • Elevated plasma BDNF levels are correlated with NK cell activation in patients with traumatic spinal cord injury.

    abstract：BACKGROUND:The precise role of innate immune responses in the early stage of traumatic spinal cord injury (SCI), especially those mediated by natural killer (NK) cells, is poorly understood. METHODS:The frequency and phenotype of NK cells from traumatic SCI patients and healthy controls were assessed by flow cytometry...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2019.105722

    authors： Xu L,Zhang Y,Zhang R,Zhang H,Song P,Ma T,Li Y,Wang X,Hou X,Li Q,Xu J,Gao X,Shen C

    更新日期：2019-09-01 00:00:00

  • Pifithrin-α, a pharmacological inhibitor of p53, downregulates lipopolysaccharide-induced nitric oxide production via impairment of the MyD88-independent pathway.

    abstract：:The effect of pifithrin (PFT)-α, a pharmacological inhibitor of p53, on lipopolysaccharide (LPS)-induced nitric oxide (NO) production in RAW 264.7 macrophage-like cells was examined. PFT-α inhibited the production of NO but not tumor necrosis factor (TNF)-α in response to LPS. PFT-α inhibited LPS-induced NO production...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2013.02.014

    authors： Mendjargal A,Odkhuu E,Koide N,Nagata H,Kurokawa T,Nonami T,Yokochi T

    更新日期：2013-04-01 00:00:00

  • CD5L contributes to the pathogenesis of methicillin-resistant Staphylococcus aureus-induced pneumonia.

    abstract：:Staphylococcus aureus is a major causative microorganism in community- and healthcare-acquired pneumonia. CD5L is an important protein in the control of immune homeostasis. In this study, we found that patients with S. aureus pneumonia displayed increased levels of circulating CD5L. Likewise, mice with S. aureus pneum...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2019.03.057

    authors： Gao X,Yan X,Zhang Q,Yin Y,Cao J

    更新日期：2019-07-01 00:00:00

  • Interleukin-10 delivered by mesenchymal stem cells attenuates experimental autoimmune myocarditis.

    abstract：BACKGROUNDS:Autoimmune myocarditis is characterized by over-activated immune system attacking the cardiomyocytes, resulting in heart function decline. In the current study, we investigated the therapeutic advantages of delivering Interleukin-10 (IL-10) by mesenchymal stem cells (MSCs), both of which had immune suppress...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2020.106212

    authors： Shao M,Wang D,Zhou Y,Du K,Liu W

    更新日期：2020-04-01 00:00:00

  • Chlorophyllin suppresses interleukin-1 beta expression in lipopolysaccharide-activated RAW 264.7 cells.

    abstract：:Our previous findings demonstrated that chlorophyllin (CHL) inhibits inducible nitric oxide gene expression in macrophages. In the present study, we show that CHL inhibited IL-1beta production and its mRNA expression in a lipopolysaccharide (LPS)-stimulated murine macrophage cell-line, RAW 264.7. The inhibitory effect...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2005.08.012

    authors： Yun CH,Jeon YJ,Yang Y,Ju HR,Han SH

    更新日期：2006-02-01 00:00:00

  • Effect of Tinospora cordifolia on the cytokine profile of angiogenesis-induced animals.

    abstract：:The antiangiogenic activity of Tinospora cordifolia was studied using in vivo as well as in vitro models. In vivo antiangiogenic activity was studied using B16F10 melanoma cell-induced capillary formation in animals. Intraperitoneal administration of the extract at a concentration of 20 mg/kg significantly inhibited t...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2004.06.015

    authors： Leyon PV,Kuttan G

    更新日期：2004-12-15 00:00:00

  • Exosomes released from decidual macrophages deliver miR-153-3p, which inhibits trophoblastic biological behavior in unexplained recurrent spontaneous abortion.

    abstract：BACKGROUND:Spontaneous abortion is a common disease in human pregnancy. Increasing evidence suggests that proper function of trophoblasts and immune balance of the maternal-fetal interface are crucial for successful pregnancy. Macrophages are involved in the maternal-fetal immune microenvironment. However, mechanisms a...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2020.106981

    authors： Ying X,Jin X,Zhu Y,Liang M,Chang X,Zheng L

    更新日期：2020-11-01 00:00:00

  • Regulation of the hepatic multidrug resistance gene expression by endotoxin and inflammatory cytokines in mice.

    abstract：:P-glycoprotein (PGP), an ATP-dependent membrane transporter is found in epithelial tissues of the liver, kidneys, intestine and blood-brain barrier. In tumor cells, PGP is often overexpressed and confers multidrug resistance toward cancer chemotherapeutics. It has been previously shown in rats that induction of an inf...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/s0162-3109(00)00271-x

    authors： Hartmann G,Kim H,Piquette-Miller M

    更新日期：2001-02-01 00:00:00

  • Astilbin promotes the induction of regulatory NK1.1- CD4+ NKG2D+ T cells through the PI3K, STAT3, and MAPK signaling pathways.

    abstract：:Astilbin is a potential agent for autoimmune and inflammatory diseases and has a protective effect in mice with DSS-induced colitis. NK1.1- CD4+ NKG2D+ T cells are a subpopulation of regulatory T cells that produce TGF-β1 and IL-10. Whether astilbin directly promotes the induction of NK1.1- CD4+ NKG2D+ T cells and whe...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2019.106143

    authors： Han S,Lin Z,Wen J,Wu K,Xu Y,Zhang Y,Lu G,Xiao W,Ding Y,Jia X,Deng B,Gong W

    更新日期：2020-04-01 00:00:00

  • Identification of myeloid-derived suppressor cells and T regulatory cells in lung microenvironment after Urethane-induced lung tumor.

    abstract：:Tumor growth occurs by the imbalance between cells with effector function and cells with suppressor/regulatory functions. To investigate this scenario we administered the chemical carcinogen Urethane in BALB/c mice and followed these animals during 120 days to observe lung tumor development. In another set of experime...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2010.12.025

    authors： Rosin FC,Pedregosa JF,de Almeida JS,Bueno V

    更新日期：2011-07-01 00:00:00

  • In vivo thymulin treatments enhance avian lung natural killer cell cytotoxicity in response to infectious bronchitis virus.

    abstract：:Previous work has shown that in vitro thymulin treatments have the ability to enhance natural killer (NK) cell cytotoxicity. The purpose of the experiments presented here was to examine the in vivo effects of thymulin on avian NK cell activity in response to a viral infection. Five and a half-week-old K-strain chicken...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/s1567-5769(02)00236-9

    authors： Oliver MA,Marsh JA

    更新日期：2003-01-01 00:00:00

  • Polydeoxyribonucleotide ameliorates lipopolysaccharide-induced acute lung injury via modulation of the MAPK/NF-κB signaling pathway in rats.

    abstract：:Acute lung injury (ALI) is characterized by disruption of the alveolar-capillary membrane resulting in pulmonary edema and accumulation of associated proteinaceous alveolar exudate. Initiation of ALI upregulates tumor necrosis factor-α (TNF-α), which activates nuclear factor-kappa B (NF-κB) and mitogen-activated prote...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2020.106444

    authors： Ko IG,Hwang JJ,Chang BS,Kim SH,Jin JJ,Hwang L,Kim CJ,Choi CW

    更新日期：2020-06-01 00:00:00

  • Modulation of constitutive and delayed apoptosis by brefeldin A in human neutrophils.

    abstract：:Neutrophil apoptosis is a constitutive process that can be enhanced or delayed by various stimuli. In this study, the effect of brefeldin A (BFA), which affects the biological process of secretion, on constitutive and delayed apoptosis of neutrophils was investigated. Neutrophil apoptosis was determined after culturin...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/S1567-5769(03)00052-3

    authors： Lee MJ,Park JY,Lee SY,Lee JS,Jung DK,Bae YS,Kwak JY

    更新日期：2003-06-01 00:00:00

  • Effects of propolis from different areas on mast cell degranulation and identification of the effective components in propolis.

    abstract：:Propolis is considered to down-regulate type I allergy, but the effective components of propolis remain unknown. In addition, propolis components vary depending on the area from which they are collected due to variations among wild plants in an area. Therefore, we compared the effects of water and ethanol extracts of ...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2010.06.013

    authors： Nakamura R,Nakamura R,Watanabe K,Oka K,Ohta S,Mishima S,Teshima R

    更新日期：2010-09-01 00:00:00

  • Nordihydroguaiaretic acid ameliorates cisplatin induced nephrotoxicity and potentiates its anti-tumor activity in DMBA induced breast cancer in female Sprague-Dawley rats.

    abstract：:Cisplatin is a widely used antineoplastic drug, but its clinical usefulness is limited due to dose dependent nephrotoxicity. Nordihydroguaiaretic acid (NDGA) is a natural compound with broad pharmacological properties like antioxidant, anti-inflammatory and anticancer activity. The present study was undertaken to eval...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2015.07.016

    authors： Mundhe NA,Kumar P,Ahmed S,Jamdade V,Mundhe S,Lahkar M

    更新日期：2015-09-01 00:00:00

  • Ex vivo induced regulatory T cells regulate inflammatory response of Kupffer cells by TGF-beta and attenuate liver ischemia reperfusion injury.

    abstract：:In the presence of TGF-β, CD4+CD62L+T cells can be induced to CD4+CD25+FoxP3+ regulatory T cells (iTregs). In our previous work, we have shown that adoptive transfer of iTregs promoted liver recovery from ischemia reperfusion injury (IRI). In this study, we examined the molecular mechanism underlying the liver IRI att...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2011.11.010

    authors： Feng M,Wang Q,Zhang F,Lu L

    更新日期：2012-01-01 00:00:00

  • Neutrophils: Cinderella of innate immune system.

    abstract：:Neutrophils are the first line of innate immune defense against infectious diseases. However, since their discovery by Elie Metchnikoff, they have always been considered tissue-destructive cells responsible for inflammatory tissue damage occurring during acute infections. Now, extensive research in the field of neutro...

    journal_title：International immunopharmacology

    pub_type： 杂志文章,评审

    doi：10.1016/j.intimp.2010.08.012

    authors： Kumar V,Sharma A

    更新日期：2010-11-01 00:00:00

  • Accelerated differentiation of bone marrow-derived dendritic cells in atopic prone mice.

    abstract：:NC/Nga mice are atopic prone mice that can be an animal model for human atopic dermatitis (AD). Dendritic cells (DC) as professional antigen-presenting cells (APC) are the most capable inducers of immune responses. The present study using BALB/c, C57BL/6J, and NC/Nga male mice investigated whether differentiation and ...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2008.08.006

    authors： Koike E,Takano H,Inoue K,Yanagisawa R

    更新日期：2008-12-20 00:00:00

  • Application of Candida solubilized cell wall beta-glucan in antitumor immunotherapy against P815 mastocytoma in mice.

    abstract：:This study was designed to evaluate the antitumor activity of CSBG, purified from the cell wall of Candida albicans IFO1385. First, as an effect of CSBG on P815 mastocytoma, significant prolonged survival and suppression of the tumor growth were observed. Second, the transfer of spleen cells from CSBG-sensitized BALB/...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/s1567-5769(01)00148-5

    authors： Tokunaka K,Ohno N,Adachi Y,Miura NN,Yadomae T

    更新日期：2002-01-01 00:00:00

  • A soy diet accelerates renal damage in autoimmune MRL/Mp-lpr/lpr mice.

    abstract：:Isoflavones, which are phytoestrogens present in large quantities in soy and soy-derived products, have estrogenic activity, inhibit protein tyrosine kinase, and exert other effects in the human body. Thus, the recent spread of soy consumption in Western populations emphasizes the need to more fully understand the pot...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2005.04.011

    authors： Zhao JH,Sun SJ,Horiguchi H,Arao Y,Kanamori N,Kikuchi A,Oguma E,Kayama F

    更新日期：2005-10-01 00:00:00

  • Icariin attenuates glucocorticoid insensitivity mediated by repeated psychosocial stress on an ovalbumin-induced murine model of asthma.

    abstract：:Evidence shows that psychosocial stress exacerbates asthma, but there is little intervention to alleviate negative effects of psychosocial stress on asthma. We investigated the role of icariin in anti-inflammation and anti-anxiety potential in a murine model combined psychosocial stress with allergic exposure. The res...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2014.01.009

    authors： Li B,Duan X,Xu C,Wu J,Liu B,Du Y,Luo Q,Jin H,Gong W,Dong J

    更新日期：2014-04-01 00:00:00

  • Carvedilol can attenuate histamine-induced paw edema and formaldehyde-induced arthritis in rats without risk of gastric irritation.

    abstract：BACKGROUND AND AIM:Rheumatoid arthritis treatment aims to control joint damage and any associated complications such as cardiovascular disease. Most anti-inflammatory drugs have a high tendency to cause gastro-intestinal irritation. The present study is designed to investigate the anti-inflammatory effect of carvedilol...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2017.07.004

    authors： Osman AS,Labib DA,Kamel MM

    更新日期：2017-09-01 00:00:00

  • Association of cytokine gene polymorphisms and the release of cytokines from peripheral blood mononuclear cells treated with methotrexate and dexamethasone.

    abstract：:Immunosuppressive drugs are widely used in the therapy of autoimmune disorders to suppress autoreactive T cells. The immune system is regulated by the release of cytokines. Cytokine are potent immunomodulatory molecules that act as mediators of inflammation and the immune response. Primarily secreted by T cell and mac...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2005.08.019

    authors： Pawlik A,Baskiewicz-Masiuk M,Machalinski B,Gawronska-Szklarz B

    更新日期：2006-03-01 00:00:00

  • Poria cocos polysaccharides attenuated ox-LDL-induced inflammation and oxidative stress via ERK activated Nrf2/HO-1 signaling pathway and inhibited foam cell formation in VSMCs.

    abstract：:Oxidative stress, inflammation, and foam cell formation in vascular smooth muscle cells (VSMCs) are considered to play crucial roles in the pathogenesis of atherosclerosis. Poria cocos polysaccharides (PCP) has been shown to possess anti-inflammatory, antitumor and anti-oxidative properties. In this study we explored ...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2019.106173

    authors： Zhao J,Niu X,Yu J,Xiao X,Li W,Zang L,Hu Z,Siu-Po Ip P,Li W

    更新日期：2020-03-01 00:00:00

  • The immunosuppressive mechanisms of mesenchymal stem cells are differentially regulated by platelet poor plasma and fetal bovine serum supplemented media.

    abstract：PURPOSE:Mesenchymal Stem Cells (MSCs) can interact with and modulate the functions of all immune cells, suppressing both the innate and adaptive immune responses. Currently, most of the in vitro studies which have led to the description of MSC properties have resulted from MSC culture in the presence of fetal bovine se...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2019.106172

    authors： Silva-Carvalho AÉ,Neves FAR,Saldanha-Araujo F

    更新日期：2020-02-01 00:00:00

  • Immunological evaluation of colonic delivered Hepatitis B surface antigen loaded TLR-4 agonist modified solid fat nanoparticles.

    abstract：:Hepatitis B is one of the leading liver diseases and remains a major global health problem. Currently available vaccines provide protection but often results in weaker/minimal mucosal immunity. Thus the present study is devoted to the development and in-vivo exploration of the colonically delivered biomimetic nanopart...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2016.08.007

    authors： Sahu KK,Pandey RS

    更新日期：2016-10-01 00:00:00

  • Preventive effect of Diallyl Trisulfide on cutaneous toxicities induced by EGFR inhibitor.

    abstract：:Cutaneous toxicities are the commonest side effects in patients with cancer treated using epidermal growth factor receptor inhibitors such as erlotinib. For patients with such toxicities, there is a lack of safe, effective pharmacological agents. Here we established a skin toxicity model and investigated the preventiv...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2019.01.023

    authors： Liu Y,Jiang X,Gu Y,Chen Y

    更新日期：2019-04-01 00:00:00