Abstract：
BACKGROUND:The precise role of innate immune responses in the early stage of traumatic spinal cord injury (SCI), especially those mediated by natural killer (NK) cells, is poorly understood. METHODS:The frequency and phenotype of NK cells from traumatic SCI patients and healthy controls were assessed by flow cytometry. ELISA assay was used to detect the production of a series of cytokines, neurotrophins, and neurohormones in plasma samples. In vitro cell culture was performed to observe brain-derived neurotrophic factor (BDNF)-induced NK cell activation. RESULTS:A significant increase in the NK cell frequency and the presence of NK cells with the activated phenotype was observed, as reflected by the enhanced expression of CD69, HLA-DR, NKG2D, and NKp30 on the NK cells, in traumatic SCI patients within 24 h of injury, compared to case for the healthy controls. Meanwhile, a higher level of BDNF, a member of the neurotrophin family, was observed in the plasma samples of the SCI patients; the elevated level of BDNF was strongly and positively correlated with the percentage of NK cells during the early stage of traumatic SCI. Furthermore, the expression of CD69 and NKp30 on the NK cells increased following stimulation with BDNF for 24 h in vitro, which is consistent with the in vivo observation in SCI patients. CONCLUSION:Collectively, our findings demonstrate the activation of NK cells within 24 h after traumatic SCI, and reveal a novel role of BDNF in regulating NK cell activation.
journal_name
Int Immunopharmacoljournal_title
International immunopharmacologyauthors
Xu L,Zhang Y,Zhang R,Zhang H,Song P,Ma T,Li Y,Wang X,Hou X,Li Q,Xu J,Gao X,Shen Cdoi
10.1016/j.intimp.2019.105722subject
Has Abstractpub_date
2019-09-01 00:00:00pages
105722eissn
1567-5769issn
1878-1705pii
S1567-5769(19)30920-8journal_volume
74pub_type
杂志文章abstract：OBJECTIVES:Various studies have researched the serum levels of leptin, adiponectin and resistin in patients with ankylosing spondylitis (AS), but the results were inconclusive. The purpose of this study was to systematically evaluate the correlations between serum levels of these adipokines and AS. METHODS:Electronic ...
journal_title：International immunopharmacology
pub_type： 杂志文章,meta分析,评审
doi：10.1016/j.intimp.2017.09.029
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abstract：:Mannan-binding lectin (MBL) constitutes an important part of the innate immune defence by effecting the deposition of complement on microbial surfaces. MBL deficiency is among the most common primary immunodeficiencies and is associated with recurrent infections and symptoms of poor immune complex clearance. Plasma-de...
journal_title：International immunopharmacology
pub_type： 杂志文章
doi：10.1016/s1567-5769(00)00052-7
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abstract：:Suberoylanilide hydroxamic acid (SAHA), a histone deacetylase inhibitor, has been proven to be an anti-cancer agent. Its anti-inflammatory activities have recently been observed both in in vitro and in vivo models. Yet its action on lymphocytes and the underlying mechanism are still not well known. In this study, in o...
journal_title：International immunopharmacology
pub_type： 杂志文章
doi：10.1016/j.intimp.2012.02.005
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abstract：:Bone destruction associated with rheumatoid arthritis (RA) is mainly attributed to the abnormal activation of osteoclasts, which are terminally differentiated cells of monocyte/macrophage lineage that resorb bone matrix. Studies on the immune regulation of osteoclasts in RA have promoted the new research field of "ost...
journal_title：International immunopharmacology
pub_type： 杂志文章,评审
doi：10.1016/j.intimp.2010.11.010
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abstract：:Problem due to disc degeneration is frequently found in the aging population. However, severe pain and accompanying end plate inflammation is only found in a small subset of patients, who can be of a younger age than most people with severe disc degeneration, with no apparent cause. We hypothesized that deficiencies i...
journal_title：International immunopharmacology
pub_type： 杂志文章
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journal_title：International immunopharmacology
pub_type： 杂志文章
doi：10.1016/j.intimp.2004.07.029
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journal_title：International immunopharmacology
pub_type： 杂志文章
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abstract：:An expansion of regulatory T cells (Tregs) in ankylosing spondylitis (AS) was observed. However, AS patients continue to exhibit aberrant inflammation. In this study, we collected PBMCs from 26 AS patients and 26 healthy controls, and investigated the functional capacity of Treg cells from these subjects. In AS patien...
journal_title：International immunopharmacology
pub_type： 杂志文章
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更新日期：2018-06-01 00:00:00
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journal_title：International immunopharmacology
pub_type： 杂志文章
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pub_type： 杂志文章,评审
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journal_title：International immunopharmacology
pub_type： 杂志文章
doi：10.1016/j.intimp.2014.03.022
更新日期：2014-07-01 00:00:00
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journal_title：International immunopharmacology
pub_type： 杂志文章
doi：10.1016/j.intimp.2015.05.035
更新日期：2015-09-01 00:00:00
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journal_title：International immunopharmacology
pub_type： 杂志文章
doi：10.1016/j.intimp.2004.09.033
更新日期：2005-02-01 00:00:00
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更新日期：2006-08-01 00:00:00
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journal_title：International immunopharmacology
pub_type： 杂志文章
doi：10.1016/j.intimp.2020.107270
更新日期：2021-02-01 00:00:00
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journal_title：International immunopharmacology
pub_type： 杂志文章
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journal_title：International immunopharmacology
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journal_title：International immunopharmacology
pub_type： 杂志文章
doi：10.1016/j.intimp.2007.08.007
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journal_title：International immunopharmacology
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journal_title：International immunopharmacology
pub_type： 杂志文章
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更新日期：2003-12-01 00:00:00
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pub_type： 杂志文章
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更新日期：2020-07-01 00:00:00
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journal_title：International immunopharmacology
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更新日期：2018-10-01 00:00:00
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journal_title：International immunopharmacology
pub_type： 杂志文章
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更新日期：2005-04-01 00:00:00
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pub_type： 杂志文章
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pub_type： 杂志文章,meta分析
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更新日期：2016-11-01 00:00:00
