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Macrophage activation and nitric oxide production by water soluble components of Hericium erinaceum.

Abstract：

:Hericium erinaceum is a medicinal and edible mushroom with anti-microbial and anti-cancer activities. To evaluate the immunoregulatory functions of H. erinaceum, we prepared water extract from H. erinaceum (WEHE) and investigated its ability to activate macrophages and to induce nitric oxide (NO) production in macrophages. Rat peritoneal macrophages stimulated with 1 to 100 mug/ml of WEHE for 24, 48, or 72 h produced NO in a time- and dose-dependent manner. Reverse transcription-polymerase chain reaction demonstrated that WEHE augmented the steady-state level of inducible NO synthase (iNOS) mRNA in both the peritoneal macrophages and a murine macrophage cell-line, RAW 264.7. Electrophoretic mobility shift assay showed that WEHE increased DNA binding activity of the transcription factor NF-kappaB, which is responsible for iNOS gene expression. Furthermore, its trans-acting activity was confirmative as determined by in vitro transfection assay using a reporter gene construct, p(NF-kappaB)(3)-CAT, whose expression is solely regulated by the activity of NF-kappaB. Concomitantly with the activation of NF-kappaB, WEHE markedly decreased intracellular IkappaBalpha level as demonstrated by Western blot assay. These results suggested that WEHE induces iNOS gene expression followed by NO production in macrophages via enhancing the activation of transcription factor, NF-kappaB.

journal_name

Int Immunopharmacol

journal_title

International immunopharmacology

authors

Son CG,Shin JW,Cho JH,Cho CK,Yun CH,Chung W,Han SH

doi

10.1016/j.intimp.2006.03.005

subject

Has Abstract

pub_date

2006-08-01 00:00:00

pages

1363-9

issue

8

eissn

1567-5769

issn

1878-1705

pii

S1567-5769(06)00091-9

journal_volume

6

pub_type

杂志文章

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