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Anti-tumor activity of ex vivo expanded cytokine-induced killer cells against human hepatocellular carcinoma.

Abstract：

:Cytokine-induced killer (CIK) cells are ex vivo expanded T cells with natural killer cell phenotypes and functions. In this study, the anti-tumor activity of CIK cells against hepatocellular carcinoma was evaluated in vitro and in vivo. In the presence of anti-CD3 antibody and IL-2 for 14 days, human peripheral blood mononuclear cell population changed to heterogeneous CIK cell population, which comprised 96% CD3(+), 3% CD3( inverted exclamation mark(c))CD56(+), 32% CD3(+)CD56(+), 11% CD4(+), 75% CD8(+), and 30% CD8(+)CD56(+). CIK cells produced significant amounts of IFN-gamma and TNF-alpha; however, produced only slight amounts of IL-2, IL-4, and IL-5. At an effector-target cell ratio of 30:1, CIK cells destroyed 33% of SNU-354 human hepatocellular carcinoma cells, which was determined by the (51)Cr-release assay. In addition, a dose of 1x10(6) CIK cells per mouse inhibited 60% of SNU-354 tumor growth in irradiated nude mice. This study suggests that CIK cells may be used as an adoptive immunotherapy for patients with hepatocellular carcinoma.

journal_name

Int Immunopharmacol

journal_title

International immunopharmacology

authors

Kim HM,Lim J,Yoon YD,Ahn JM,Kang JS,Lee K,Park SK,Jeong YJ,Kim JM,Han G,Yang KH,Kim YJ,Kim Y,Han SB

doi

10.1016/j.intimp.2007.08.007

subject

Has Abstract

pub_date

2007-12-15 00:00:00

pages

1793-801

issue

13

eissn

1567-5769

issn

1878-1705

pii

S1567-5769(07)00246-9

journal_volume

7

pub_type

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