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Emodin inhibits LPS-induced inflammatory response by activating PPAR-γ in mouse mammary epithelial cells.

Abstract：

:Emodin, an anthraquinone derivative isolated from the rhizomes of Rheum palmatum, has been reported to have a protective effect against lipopolysaccharide (LPS)-induced mastitis. However, the underlying molecular mechanisms are not well understood. The aim of this study was to investigate the molecular mechanisms of emodin in modifying lipopolysaccharide (LPS)-induced signaling pathways in mouse mammary epithelial cells (MEC). The pro-inflammatory cytokines were determined by ELISA. Nuclear factor-κB (NF-κB), inhibitory kappa B (IκBα) protein, p38, extracellular signal-regulated kinase (ERK), c-Jun N-terminal kinase (JNK) and PPAR-γ were determined by Western blotting. The results showed that emodin suppressed tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), iNOS and COX-2 expression. We also found that emodin inhibited LPS-induced NF-κB activation, IκBα degradation, phosphorylation of ERK, JNK and P38. Furthermore, emodin could activate PPAR-γ and the anti-inflammatory effects of emodin can be reversed by GW9662, a specific antagonist for PPAR-γ. In conclusion, our results demonstrate that emodin activates PPAR-γ, thereby attenuating LPS-induced inflammatory response.

journal_name

Int Immunopharmacol

journal_title

International immunopharmacology

authors

Yang Z,Zhou E,Wei D,Li D,Wei Z,Zhang W,Zhang X

doi

10.1016/j.intimp.2014.05.019

subject

Has Abstract

pub_date

2014-08-01 00:00:00

pages

354-60

issue

2

eissn

1567-5769

issn

1878-1705

pii

S1567-5769(14)00191-X

journal_volume

21

pub_type

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