The pharmacodynamic active components study of Tibetan medicine Gentianopsis paludosa on ulcerative colitis fibrosis.

abstract：:The immunomodulatory effect of metronidazole (MTZ), a nitroimidazole drug used as an antiprotozoal and antibacterial agent, was investigated using Balb/c mice and human peripheral blood lymphocytes. For in vivo studies, mice were divided into six groups, six animals per group, group I received vehicle alone while the ...

journal_title：International immunopharmacology

authors： Fararjeh M,Mohammad MK,Bustanji Y,Alkhatib H,Abdalla S

更新日期：2008-02-01 00:00:00

abstract：:Antrodia camphorata (AC) is a commonly used fungus in folk medicine for the treatment of viral hepatitis and cancer. AC polysaccharides (AC-PS) are reported to possess anti-inflammatory, anti-hepatitis B virus, and anticancer activities. In this study, we tested the in vivo effect of AC-PS on immune function by evalua...

journal_title：International immunopharmacology

authors： Chen YJ,Cheng PC,Lin CN,Liao HF,Chen YY,Chen CC,Lee KM

更新日期：2008-03-01 00:00:00

abstract：:Rheumatoid arthritis (RA) is a high morbidity and disability disease with numerous inflammatory cells infiltrating in interstitial of articular cartilages and bones. As the most abundant inflammatory cells, neutrophil has been reported that their apoptosis changed gradually in the circumstance of RA. Apoptosis, one mo...

journal_title：International immunopharmacology

authors： An Q,Yan W,Zhao Y,Yu K

更新日期：2018-12-01 00:00:00

abstract：:The inner surface of the intestinal tract possesses a large area of mucosal membranes, and the intestinal epithelial cells exist at the interface between an antigen-rich lumen and a lymphocyte-rich lamina propria. The crosstalk that occurs between these compartments serves to maintain intestinal homeostasis, and the c...

journal_title：International immunopharmacology

authors： Matsumoto T,Moriya M,Sakurai MH,Kiyohara H,Tabuchi Y,Yamada H

更新日期：2008-04-01 00:00:00

abstract：:Ulcerative colitis is a chronic nonspecific inflammatory disease of unknown cause. The aim of this study was to evaluate the anti-inflammatory effect of tauroursodeoxycholate in 2, 4, 6-trinitrobenzenesulfonic acid-induced experimental colitis in mice. After the induction of colitis for 24h, the mice were administrate...

journal_title：International immunopharmacology

authors： Yang Y,He J,Suo Y,Zheng Z,Wang J,Lv L,Huo C,Wang Z,Li J,Sun W,Zhang Y

更新日期：2016-07-01 00:00:00

abstract：:Chlorogenic acid (CGA), one of the most abundant dietary polyphenolic compounds, has been reported to exhibit anti-inflammatory ability. However, the hepatoprotective effects and molecular mechanisms of CGA on concanavalin A (Con A)-induced hepatitis have not been explored. In the present study, we found that pretreat...

journal_title：International immunopharmacology

authors： Yuan Y,Gong X,Zhang L,Jiang R,Yang J,Wang B,Wan J

更新日期：2017-03-01 00:00:00

abstract：:Ulcerative colitis (UC), an idiopathic inflammatory bowel disease, not only affects millions of patients worldwide, but also increases the risk of colon cancer. Geniposide is an iridoid glycoside and has many biological activities such as anti-inflammatory and antioxidant. However, its protective efficacy and mechanis...

journal_title：International immunopharmacology

authors： Zhang Z,Li Y,Shen P,Li S,Lu X,Liu J,Cao Y,Liu B,Fu Y,Zhang N

更新日期：2017-08-01 00:00:00

abstract：:The immune system is a very diverse system of the host that evolved during evolution to cope with various pathogens present in the vicinity of environmental surroundings inhabited by multicellular organisms ranging from achordates to chordates (including humans). For example, cells of immune system express various pat...

journal_title：International immunopharmacology

authors： Vijay K

更新日期：2018-06-01 00:00:00

abstract：:The transmembrane activator and calcium modulator and cyclophilin ligand interactor-immunoglobulin (TACI-Ig), a recombinant fusion protein that modulates B and T cells activation by binding and neutralizing B lymphocyte stimulator (BLyS) and a proliferation-inducing ligand (APRIL), has been shown to have a therapeutic...

journal_title：International immunopharmacology

authors： Qin Q,Chang Y,Wang D,Wu Y,Zhang LL,Wei W

更新日期：2011-12-01 00:00:00

abstract：OBJECTIVE:Batroxobin is a medicinal preparation extracted from the venom of the Fer-de-Lance snake, and is used to lower blood viscosity, promote blood fibrinogen decomposition, and inhibit thrombosis. This research is to investigate whether batroxobin can improve the survival of random skin flaps in a rat model. MATE...

journal_title：International immunopharmacology

authors： Fang MJ,Qi CY,Chen XY,Hu PY,Wang JW,Xu PF,Jin YZ,Lin DS

更新日期：2019-07-01 00:00:00

abstract：:Stephanoside E (STE) and its aglycone Stephanthraniline A (STA) isolated from the stems of Stephanotis mucronata (Blanco) Merr. were evaluated for their suppressive potentials on Th1 and Th2 immune responses in vitro, and the effects of the C-3 sugar chains on their activities were discussed. STE and STA significantly...

journal_title：International immunopharmacology

authors： Chen F,Ni Y,Ye Y,Sun H,Li X,Xu S

更新日期：2010-10-01 00:00:00

abstract：:Psoriasis is an autoimmune skin disease caused by interactions between keratinocytes and immune cells, such as macrophages. CD200 is expressed on the surface of various cell types, and its receptor, CD200R1, belongs to a family of immunosuppressive receptors that are mainly expressed on myeloid cells. CD200/CD200R1 si...

journal_title：International immunopharmacology

authors： Li D,Wang Y,Tang L,Jin X,Xia C,Xu H,Hu J

更新日期：2020-01-01 00:00:00

abstract：:Tumor necrosis factor-alpha (TNF-alpha) is a vital component of the inflammatory process and its aberrant over-expression has been linked to numerous disease states. New treatment strategies have sought to reduce circulating TNF-alpha, either with neutralizing anti-TNF-alpha binding proteins such as etanercept or via ...

journal_title：International immunopharmacology

authors： Grattendick KJ,Nakashima JM,Feng L,Giri SN,Margolin SB

更新日期：2008-05-01 00:00:00

abstract：:The aims of this study were to elucidate the immunomodulatory effects of glycyrrhizin (GL) on CD4(+)T cell responses during liver fibrogenesis. To obtain in vivo evidence about the effects of GL on CD4(+)T cells in livers and spleens of concanavalin A (ConA)-induced mouse model, mice were administrated with ConA toget...

journal_title：International immunopharmacology

authors： Tu CT,Li J,Wang FP,Li L,Wang JY,Jiang W

更新日期：2012-12-01 00:00:00

abstract：:Cladribine (Cd) is a purine nucleoside analogue which in an oral formulation is approved for treatment of patients with multiple sclerosis (MS). It is known to mediate the effect through a short-term selective reduction of lymphocytes with minimal effect on the innate immune system. However, a few studies have emerged...

journal_title：International immunopharmacology

authors： Mathiesen CBK,Rudjord-Levann AM,Gad M,Larsen J,Sellebjerg F,Pedersen AE

更新日期：2021-02-01 00:00:00

abstract：:The possible onset of Cytokine Release Syndrome (CRS) is an important consideration in the development of monoclonal antibody (mAb) therapeutics. In this study, several machine learning approaches are used to analyze CRS data. The analyzed data come from a human blood in vitro assay which was used to assess the potent...

journal_title：International immunopharmacology

authors： Xiong F,Janko M,Walker M,Makropoulos D,Weinstock D,Kam M,Hrebien L

更新日期：2014-10-01 00:00:00

abstract：BACKGROUNDS:C1q tumor necrosis factor-related protein 9 (CTRP9) has been suggested to exert an atheroprotective effect by modulating the inflammation, foam cell formation, endothelia and smooth muscle cell function via Adenosine Monophosphate Activated Protein Kinase (AMPK) pathway. On the other hand, the NLR Family Py...

journal_title：International immunopharmacology

authors： Zhang H,Gong X,Ni S,Wang Y,Zhu L,Ji N

更新日期：2019-12-01 00:00:00

abstract：:In recent years, using genetic engineering and bioengineering techniques, Bifidobacterium as a carrier to express specific functions of the protein or polypeptide, has become a new treatment for disease. Ulcerative colitis (UC) is a type of inflammatory bowel diseases (IBD). Although the cause of this inflammatory dis...

journal_title：International immunopharmacology

authors： Liu M,Li S,Zhang Q,Xu Z,Wang J,Sun H

更新日期：2018-04-01 00:00:00

abstract：:Hypoxia and the resultant decreases in cerebral blood flow in the perinatal period can lead to neonatal hypoxic-ischemic (HI) brain injury, which can, in turn, cause severe disability or even death. However, the efficacy of current treatment strategies remains limited. Several studies have demonstrated that lipoxin A4...

journal_title：International immunopharmacology

authors： Zhu JJ,Yu BY,Fu CC,He MZ,Zhu JH,Chen BW,Zheng YH,Chen SQ,Fu XQ,Li PJ,Lin ZL

更新日期：2020-12-01 00:00:00

abstract：BACKGROUND:Acute exacerbation of idiopathic pulmonary fibrosis (AE-IPF) is attracting considerable attention due to disease acceleration and substantial mortality. Macrophages are known to regulate the fibrotic process in idiopathic pulmonary fibrosis. OBJECTIVE:We investigated if two new macrophage-specific serum bio...

journal_title：International immunopharmacology

authors： Zou R,Gui X,Zhang J,Tian Y,Liu X,Tian M,Chen T,Wu H,Chen J,Dai J,Cai H

更新日期：2020-09-01 00:00:00

abstract：:We had reported that in the ischemic heart, locally formed bradykinin (BK) and angiotensin II (Ang II) activate B2- and AT1-receptors on sympathetic nerve terminals (SNE), promoting reversal of the norepinephrine (NE) transporter in an outward direction (i.e., carrier-mediated NE release). Although both BK and Ang II ...

journal_title：International immunopharmacology

authors： Levi R,Silver RB,Mackins CJ,Seyedi N,Koyama M

更新日期：2002-12-01 00:00:00

abstract：:New strategies that stimulate cell-mediated immunity (CMI) against tumors and inhibit regulatory T cells are needed to improve the outcome of cancer immunotherapy. The aim of this study was to enhance the anti-tumor immunity of gp96 vaccine through naloxone administration. Therefore, we used BALB/c mouse model of fibr...

journal_title：International immunopharmacology

authors： Molla Hassan AT,Hassan ZM,Moazzeni SM,Mostafaie A,Shahabi S,Ebtekar M,Hashemi SM

更新日期：2009-11-01 00:00:00

abstract：:Macrophage migration inhibitory factor (MIF) has a multitude of biological activity and is associated with a number of inflammatory and immune diseases, including rheumatoid arthritis (RA). The increased serum levels of MIF in patients not only suggest this protein as a marker for disease progression, but also as a po...

journal_title：International immunopharmacology

authors： Li S,Zhang R,Li P,Yi W,Zhang Z,Chen S,Su S,Zhao L,Hu C

更新日期：2008-06-01 00:00:00

abstract：:This study was designed to determine the level of survivin expression and its clinical significance as a prognostic factor in gastrointestinal stromal sarcoma (GIST). Twenty patients (12 males and 8 females) ranging in age from 25 to 72, with a median age of 53 were evaluated. Failure of TKI treatment was higher in th...

journal_title：International immunopharmacology

authors： Baykara M,Akkus M,Yildiz R,Gonul II,Dursun A,Coskun U,Benekli M,Sevinc A,Dane F,Buyukberber S

更新日期：2011-12-01 00:00:00

abstract：:Increased progesterone sensitivity of pregnancy lymphocytes is due to activation-induced appearance of progesterone binding sites in the lymphocytes. Following recognition of fetally derived antigens gamma/delta TCR+ cells develop progesterone receptors. Progesterone binding results in the synthesis of a mediator prot...

journal_title：International immunopharmacology

authors： Szekeres-Bartho J,Barakonyi A,Par G,Polgar B,Palkovics T,Szereday L

更新日期：2001-06-01 00:00:00

abstract：:The activities of dectin-1 and mannose receptors on phagocytosis of Candida albicans and the production of TNF-α by macrophages from mice pretreated for 3 days with extract of Artocarpus intergrifolia seeds (jack extract), Artin M or jacalin were studied. Macrophages from these mice were coincubated with C. albicans C...

journal_title：International immunopharmacology

authors： Loyola W,Custodio LA,Felipe I,Conchon-Costa I,Carvalho PG,Quirino GF,Silva LF,Gaziri LC

更新日期：2012-02-01 00:00:00

abstract：:Asthma is an inflammatory disorder of the airways dominated by a Th2-type pattern. Recently, an emerging interest arises whether transient receptor potential ankyrin 1 (TRPA1) plays a potential role in the adaptive immune response. In this study, the role of TRPA1 in the development and exacerbation of asthma was expl...

journal_title：International immunopharmacology

authors： Li M,Fan X,Yue Q,Hu F,Zhang Y,Zhu C

更新日期：2020-09-01 00:00:00

abstract：BACKGROUND:Growing evidence points to the pivotal role of inflammation in the pathogenesis of diabetic kidney disease (DKD). However, as an inflammation-based prognostic score, the significance of platelet-to-lymphocyte ratio (PLR) in biopsy-proven DKD remains uncertain. Therefore, the current study aimed to evaluate t...

journal_title：International immunopharmacology

authors： Duan S,Sun L,Zhang C,Wu L,Nie G,Huang Z,Xing C,Zhang B,Yuan Y

更新日期：2021-01-29 00:00:00

abstract：:A Gram-positive bacterium, Staphylococcus aureus is known to be one of the major pathogenic bacteria responsible for causing bovine mastitis. Among the various cell wall components of S. aureus, lipoteichoic acid (LTA) and peptidoglycan (PGN) are closely associated with inflammatory responses. However, the role of LTA...

journal_title：International immunopharmacology

authors： Im J,Lee T,Jeon JH,Baik JE,Kim KW,Kang SS,Yun CH,Kim H,Han SH

更新日期：2014-07-01 00:00:00

abstract：:Increasing evidence is now available showing that CD1-restricted T cell responses against non-peptide mycobacterial antigens could play a role in the immune resistance against tuberculosis. BCG, widely used in anti-tubercular vaccination, shares various constituents with Mycobacterium tuberculosis, but does not provid...

journal_title：International immunopharmacology

authors： Prete SP,Giuliani A,D'Atri S,Graziani G,Balduzzi A,Oggioni MR,Iona E,Girolomoni G,Bonmassar L,Romani L,Franzese O

更新日期：2007-03-01 00:00:00