当前位置： SCI文献检索 > INTERNATIONAL IMMUNOPHARMACOLOGY期刊下所有文献 > LXA4 protects against hypoxic-ischemic damage in neonatal rats by reducing the inflammatory response via the IκB/NF-κB pathway.

LXA4 protects against hypoxic-ischemic damage in neonatal rats by reducing the inflammatory response via the IκB/NF-κB pathway.

Abstract：

:Hypoxia and the resultant decreases in cerebral blood flow in the perinatal period can lead to neonatal hypoxic-ischemic (HI) brain injury, which can, in turn, cause severe disability or even death. However, the efficacy of current treatment strategies remains limited. Several studies have demonstrated that lipoxin A4 (LXA4), as one of the earliest types of endogenous lipid mediators, can inhibit the accumulation of neutrophils, arrest inflammation, and promote the resolution of inflammation. However, research on LXA4 in the nervous system has rarely been carried out. In the present study, we sought to investigate the protective effect of LXA4 on HI brain damage in neonatal rats, as well as the underlying mechanisms. Through experiments conducted using an HI animal model, we found that the LXA4 intervention promoted the recovery of neuronal function and tissue structure following brain injury while maintaining the integrity of the blood-brain barrier in addition to reducing cerebral edema, infarct volume, and inflammatory responses. Our results suggest that LXA4 interfered with neuronal oxygen-glucose deprivation insults, reduced the expression of inflammatory factors, inhibited apoptosis, and promoted neuronal survival in vitro. Finally, the LXA4 intervention attenuated HI-induced activation of inhibitor kappa B (IκB) and degradation of nuclear factor-κB (NF-κB). In conclusion, our data suggest that LXA4 exerts a neuroprotective effect against neonatal HI brain damage through the IκB/NF-κB pathway. Our findings will help inform future studies regarding the effects of LXA4 on neuroinflammation, blood-brain barrier integrity, and neuronal apoptosis.

journal_name

Int Immunopharmacol

journal_title

International immunopharmacology

authors

Zhu JJ,Yu BY,Fu CC,He MZ,Zhu JH,Chen BW,Zheng YH,Chen SQ,Fu XQ,Li PJ,Lin ZL

doi

10.1016/j.intimp.2020.107095

subject

Has Abstract

pub_date

2020-12-01 00:00:00

pages

107095

issue

Pt B

eissn

1567-5769

issn

1878-1705

pii

S1567-5769(20)32166-4

journal_volume

89

pub_type

杂志文章

相关文献

INTERNATIONAL IMMUNOPHARMACOLOGY文献大全
  • Dihydroberberine, a hydrogenated derivative of berberine firstly identified in Phellodendri Chinese Cortex, exerts anti-inflammatory effect via dual modulation of NF-κB and MAPK signaling pathways.

    abstract：:Dihydroberberine (DHB), a hydrogenated derivative of berberine (BBR), has been firstly identified in Phellodendri Chinese Cortex (PC) by HPLC-ESI-MS/MS. Nowadays most researches on PC focus on its main components like BBR, however, the role of its naturally-occurring derivatives remains poorly defined heretofore. The ...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2019.105802

    authors： Tan L,Wang Y,Ai G,Luo C,Chen H,Li C,Zeng H,Xie J,Chen J,Su Z

    更新日期：2019-10-01 00:00:00

  • Effects of anti-lymphocytes and anti-thymocytes globulin on human dendritic cells.

    abstract：UNLABELLED:Dendritic cells (DC) were implicated as the mediators of primary stimulation of the immune response against donor antigen. Anti-lymphocytes globulin (ALG) and anti-thymocytes globulin (ATG) antibodies have been widely used as an immunosuppressive agent in the treatment and prevention of rejection after organ...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/s1567-5769(02)00253-9

    authors： Monti P,Allavena P,Di Carlo V,Piemonti L

    更新日期：2003-02-01 00:00:00

  • Association of cytokine gene polymorphisms and the release of cytokines from peripheral blood mononuclear cells treated with methotrexate and dexamethasone.

    abstract：:Immunosuppressive drugs are widely used in the therapy of autoimmune disorders to suppress autoreactive T cells. The immune system is regulated by the release of cytokines. Cytokine are potent immunomodulatory molecules that act as mediators of inflammation and the immune response. Primarily secreted by T cell and mac...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2005.08.019

    authors： Pawlik A,Baskiewicz-Masiuk M,Machalinski B,Gawronska-Szklarz B

    更新日期：2006-03-01 00:00:00

  • Functional alterations in CD11b(+)Gr-1(+) cells in mice injected with allogeneic tumor cells and treated with 2,3,7,8-tetrachlorodibenzo-p-dioxin.

    abstract：:2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) exposure results in an increased percentage of CD11b(+) (Mac-1(+)) cells in the spleens of mice challenged with P815 tumor cells, coincident with a failure of the mice to generate allospecific CD8(+) CTL activity. Since CD11b(+)Gr-1(+) myeloid suppressor cells (MSC) have been...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/S1567-5769(03)00046-8

    authors： Choi JY,Oughton JA,Kerkvliet NI

    更新日期：2003-04-01 00:00:00

  • Low DNA damage in peripheral lymphocytes of healthy elderly individuals with inverted CD4:CD8 ratio.

    abstract：:The aim of this study was to evaluate the DNA damage in peripheral lymphocytes and the frequencies of CD8+ T cells expressing CD25, CD28 and CD45ro in aged individuals with inverted CD4:CD8 ratio. Blood samples of elderly individuals (aged >65) with normal CD4:CD8 ratio (n = 8) and inverted CD4:CD8 ratio (n = 8) were ...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2018.12.060

    authors： Dorneles GP,Heuser V,de Andrade VM,Vilela TC,da Silva J,Dalberto D,Chies JA,Peres A

    更新日期：2019-02-01 00:00:00

  • Blockade of TNF-α-induced NF-κB signaling pathway and anti-cancer therapeutic response of dihydrotanshinone I.

    abstract：:The nuclear factor-κB (NF-κB) transcription factors control many physiological processes including inflammation, immunity, apoptosis, and angiogenesis. We identified dihydrotanshinone I as an inhibitor of NF-κB activation through our research on Salvia miltiorrhiza Bunge. In this study, we found that dihydrotanshinone...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2015.08.003

    authors： Wang F,Ma J,Wang KS,Mi C,Lee JJ,Jin X

    更新日期：2015-09-01 00:00:00

  • The progress and confusion of anti-PD1/PD-L1 immunotherapy for patients with advanced non-small cell lung cancer.

    abstract：:Recently, immunotherapy has evolved into a true treatment modality with the approval of PD-1 and PD-L1 inhibitors as the standard care for first-line treatment in patients with non-small cell lung cancer (NSCLC). Until now, for patients with advanced NSCLC, treatment of targeting immune checkpoints reveals a promising...

    journal_title：International immunopharmacology

    pub_type： 杂志文章,评审

    doi：10.1016/j.intimp.2020.106247

    authors： Zhang S,Bai X,Shan F

    更新日期：2020-03-01 00:00:00

  • A prognostic signature based on immune-related genes for cervical squamous cell carcinoma and endocervical adenocarcinoma.

    abstract：:Cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC) is the fourth commonest female malignancy worldwide. CESC progresses in immune-microenvironment mainly composed of infiltrating immune and stromal cells. Here, we performed an integrated analysis incorporating the expression profiles from the Canc...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2020.106884

    authors： Liu J,Wu Z,Wang Y,Nie S,Sun R,Yang J,Cheng W

    更新日期：2020-11-01 00:00:00

  • Identification and verification of an immune-related lncRNA signature for predicting the prognosis of patients with bladder cancer.

    abstract：BACKGROUND:Recent studies have revealed the significant roles of immune-related long noncoding RNAs (lncRNAs) in cancer development and progression. The identification of biomarkers that contribute to early detection and risk stratification provides significant benefits for bladder cancer (BC) patients. The current stu...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2020.107146

    authors： Wang J,Shen C,Dong D,Zhong X,Wang Y,Yang X

    更新日期：2021-01-01 00:00:00

  • Function of follicular helper T cell is impaired and correlates with survival time in non-small cell lung cancer.

    abstract：:Non-small cell lung cancer (NSCLC) represents one of the most common and aggressive cancers worldwide. The PD-1/PD-L1 interaction plays important roles in cancer immunology, and expression of PD-L1 has been discovered in NSCLC tumor cells. Since follicular helper T (Tfh) cells have characteristic high PD-1 expression,...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2016.10.014

    authors： Ma QY,Huang DY,Zhang HJ,Chen J,Miller W,Chen XF

    更新日期：2016-12-01 00:00:00

  • CD200-CD200R1 signalling attenuates imiquimod-induced psoriatic inflammation by inhibiting the activation of skin inflammatory macrophages.

    abstract：:Psoriasis is an autoimmune skin disease caused by interactions between keratinocytes and immune cells, such as macrophages. CD200 is expressed on the surface of various cell types, and its receptor, CD200R1, belongs to a family of immunosuppressive receptors that are mainly expressed on myeloid cells. CD200/CD200R1 si...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2019.106046

    authors： Li D,Wang Y,Tang L,Jin X,Xia C,Xu H,Hu J

    更新日期：2020-01-01 00:00:00

  • Ocimum gratissimum Linn. and rosmarinic acid, attenuate eosinophilic airway inflammation in an experimental model of respiratory allergy to Blomia tropicalis.

    abstract：:Allergic asthma has emerged as an important public health problem of urban populations in developed countries. Very often herbal medicine is used to treat this widespread disease, due to the lack of efficacy and the important side effects related to the classical drugs in use. Along this line, Ocimum gratissimum (Og) ...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2012.03.012

    authors： Costa RS,Carneiro TC,Cerqueira-Lima AT,Queiroz NV,Alcântara-Neves NM,Pontes-de-Carvalho LC,Velozo Eda S,Oliveira EJ,Figueiredo CA

    更新日期：2012-05-01 00:00:00

  • Ulinastatin inhibits unilateral ureteral obstruction-induced renal interstitial fibrosis in rats via transforming growth factor β (TGF-β)/Smad signalling pathways.

    abstract：:This study aims to explore the protective effects and mechanisms of ulinastatin (UTI), which is a urinary trypsin inhibitor, of the renal interstitial fibrosis of rats subjected to unilateral ureteral obstruction (UUO). A total of 36 male Wistar rats were divided in random into three groups, namely, the sham operation...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2012.12.019

    authors： Ning XH,Ge XF,Cui Y,An HX

    更新日期：2013-02-01 00:00:00

  • Up-regulation of phospholipase Cgamma1 and phospholipase D during the differentiation of human monocytes to dendritic cells.

    abstract：:Phospholipase C (PLC)gamma and phospholipase D (PLD) play pivotal roles in the signal transduction required for various cellular responses, including cell proliferation and differentiation. Dendritic cells (DCs), which are professional antigen-presenting cells, can be generated from human monocytes by stimulating the ...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2004.04.001

    authors： Kang HK,Lee HY,Lee YN,Jo EJ,Kim JI,Kim GY,Park YM,Min DS,Yano A,Kwak JY,Bae YS

    更新日期：2004-07-01 00:00:00

  • Tiron ameliorates oxidative stress and inflammation in a murine model of airway remodeling.

    abstract：:Airway remodeling includes lung structural changes that have a role in the irreversibility of pulmonary dysfunction shown in chronic bronchial asthmatics. The current experiment investigated the effect of the mitochondrial antioxidant, tiron in comparison with dexamethasone (DEXA) on airway remodeling in chronic asthm...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2016.07.025

    authors： El-Sherbeeny NA,Hassan ZA,Ateyya H

    更新日期：2016-10-01 00:00:00

  • Survivin expression and its potential clinical significance in gastrointestinal stromal sarcoma.

    abstract：:This study was designed to determine the level of survivin expression and its clinical significance as a prognostic factor in gastrointestinal stromal sarcoma (GIST). Twenty patients (12 males and 8 females) ranging in age from 25 to 72, with a median age of 53 were evaluated. Failure of TKI treatment was higher in th...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2011.10.005

    authors： Baykara M,Akkus M,Yildiz R,Gonul II,Dursun A,Coskun U,Benekli M,Sevinc A,Dane F,Buyukberber S

    更新日期：2011-12-01 00:00:00

  • Natural helper cells contribute to pulmonary eosinophilia by producing IL-13 via IL-33/ST2 pathway in a murine model of respiratory syncytial virus infection.

    abstract：:It has been reported that natural helper cells, which are a non-T, non-B innate lymphoid cell type expressing c-Kit and ST2, mediate influenza-induced airway hyper-reactivity by producing substantial IL-13. However, little is known about natural helper cells for the development of RSV-induced airway inflammation, part...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2015.05.035

    authors： Liu J,Wu J,Qi F,Zeng S,Xu L,Hu H,Wang D,Liu B

    更新日期：2015-09-01 00:00:00

  • Effect of a thiol proteinase inhibitor, E-64-d, on susceptibility to infection with Staphylococcus aureus in Chediak-Higashi syndrome (beige) mice.

    abstract：:We previously reported that abnormally down-regulated protein kinase C (PKC) activity is responsible for the impaired cellular function of natural killer cells and polymorphonuclear cells (PMNs), and the giant granule formation in fibroblasts in the beige mouse, an animal model of Chediak-Higashi syndrome. Here, we ex...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2007.03.004

    authors： Morimoto M,Tanabe F,Kasai H,Ito M

    更新日期：2007-07-01 00:00:00

  • TRIP6 accelerates the proliferation and migration of fetal airway smooth muscle cells by enhancing YAP activation.

    abstract：:The thyroid receptor interactor protein 6 (TRIP6) has emerged as a key regulator for the proliferation and migration of various cells. However, whether TRIP6 is involved in regulating the proliferation and migration of airway smooth muscle (ASM) cells in the progression of pediatric asthma remains undetermined. The pr...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2020.106366

    authors： Wei F,Hao Y

    更新日期：2020-03-06 00:00:00

  • Carvedilol attenuates experimentally induced silicosis in rats via modulation of P-AKT/mTOR/TGFβ1 signaling.

    abstract：:Silicosis is a well acknowledged occupational lung disorder with considerable negative impact on the patients' quality of life. Various signaling pathways have been reported to interplay in the pathogenesis of pulmonary fibro-proliferative disorders; of which, P-AKT/mTOR signaling pathway. The current study highlights...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2019.02.011

    authors： Helal MG,Said E

    更新日期：2019-05-01 00:00:00

  • American ginseng microbial metabolites attenuate DSS-induced colitis and abdominal pain.

    abstract：:Inflammatory bowel disease (IBD) is a significant public health problem in the United States. Abdominal pain is a major complaint among individuals with IBD. Successful IBD management not only controls enteric inflammation, but also reduces abdominal discomfort. Recently, increased attention has been focused on altern...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2018.09.005

    authors： Wang CZ,Yao H,Zhang CF,Chen L,Wan JY,Huang WH,Zeng J,Zhang QH,Liu Z,Yuan J,Bi Y,Sava-Segal C,Du W,Xu M,Yuan CS

    更新日期：2018-11-01 00:00:00

  • Baicalein attenuates the neuroinflammation in LPS-activated BV-2 microglial cells through suppression of pro-inflammatory cytokines, COX2/NF-κB expressions and regulation of metabolic abnormality.

    abstract：:Baicalein (5,6,7-trihydroxyflavone), isolated from the root of traditional Chinese herb Scutellaria baicalensis Georgi, has anti-inflammatory and anti-oxidative activities. This study explored the protective and modulatory mechanisms of baicalein on neuroinflammation, oxidative stress and metabolic abnormality in lipo...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2019.106092

    authors： Yan JJ,Du GH,Qin XM,Gao L

    更新日期：2020-02-01 00:00:00

  • Artin M enhances TNF-α production and phagocytosis of Candida albicans mediated by dectin-1 and mannose receptors.

    abstract：:The activities of dectin-1 and mannose receptors on phagocytosis of Candida albicans and the production of TNF-α by macrophages from mice pretreated for 3 days with extract of Artocarpus intergrifolia seeds (jack extract), Artin M or jacalin were studied. Macrophages from these mice were coincubated with C. albicans C...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2011.12.010

    authors： Loyola W,Custodio LA,Felipe I,Conchon-Costa I,Carvalho PG,Quirino GF,Silva LF,Gaziri LC

    更新日期：2012-02-01 00:00:00

  • A signature of 29 immune-related genes pairs to predict prognosis in patients with neuroblastoma.

    abstract：BACKGROUND:Neuroblastoma (NB) is one of the most common childhood tumors that is associated with a poor prognosis. Recently, immunotherapy has been recognized as an effective strategy in the treatment of NB patients. In this study, an immune-related gene pair (IRGP) signature was established for predicting the prognosi...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2020.106994

    authors： Song J,Zhao Q,Xu Y,Zhu L

    更新日期：2020-11-01 00:00:00

  • miR-140-5p regulates T cell differentiation and attenuates experimental autoimmune encephalomyelitis by affecting CD4+T cell metabolism and DNA methylation.

    abstract：:We previously demonstrated that decreased expression of miR-140-5p was associated with the progression of multiple sclerosis (MS) and miR-140-5p targeted STAT1 and interfered with the expression of IFN-γ. However, the underlying mechanisms how miR-140-5p regulated the differentiation of encephalomyelitic CD4+T cell re...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2019.105778

    authors： Zhu S,Zhang X,Guan H,Huang F,Wu L,Hou D,Zheng Z,Yu M,Huang L,Ge L

    更新日期：2019-10-01 00:00:00

  • Amelioration of experimental autoimmune encephalomyelitis by curcumin treatment through inhibition of IL-17 production.

    abstract：:Experimental autoimmune encephalomylitis (EAE), an animal mode of multiple sclerosis (MS), was previously considered that be mediated by Th1 cells. However, a number of recent studies provided strong evidence that T helper cells that produce IL-17 play a dominant role in the pathogenesis of EAE. Curcumin (1,7-Bis 94-h...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2009.01.025

    authors： Xie L,Li XK,Funeshima-Fuji N,Kimura H,Matsumoto Y,Isaka Y,Takahara S

    更新日期：2009-05-01 00:00:00

  • Sodium selenite inhibits the expression of VEGF, TGFbeta(1) and IL-6 induced by LPS in human PC3 cells via TLR4-NF-(K)B signaling blockage.

    abstract：:Lipopolysaccharide (LPS)-induced TLR4-NF-(K)B signaling plays an important role in the development of prostatic tumors from chronic bacterial prostatic infection. Although many studies support the role of selenium in protecting against the development of prostate cancer secondary to chronic prostatitis, the mechanism ...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2009.09.020

    authors： Pei Z,Li H,Guo Y,Jin Y,Lin D

    更新日期：2010-01-01 00:00:00

  • Immunomodulating activities of acidic sulphated polysaccharides obtained from the seaweed Ulva rigida C. Agardh.

    abstract：:Water-soluble acidic polysaccharides from the cell walls of Ulva rigida are mainly composed of disaccharides that contain glucuronic acid and sulphated rhamnose. The structure of disaccharides resembles that of glycosaminoglycans (GAGs) as they both contain glucuronic acid and sulphated sugars. Glycosaminoglycans occu...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2007.02.007

    authors： Leiro JM,Castro R,Arranz JA,Lamas J

    更新日期：2007-07-01 00:00:00

  • Stimulatory effect of a pectic polysaccharide from a medicinal herb, the roots of Bupleurum falcatum L., on G-CSF secretion from intestinal epithelial cells.

    abstract：:The inner surface of the intestinal tract possesses a large area of mucosal membranes, and the intestinal epithelial cells exist at the interface between an antigen-rich lumen and a lymphocyte-rich lamina propria. The crosstalk that occurs between these compartments serves to maintain intestinal homeostasis, and the c...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2008.01.006

    authors： Matsumoto T,Moriya M,Sakurai MH,Kiyohara H,Tabuchi Y,Yamada H

    更新日期：2008-04-01 00:00:00

  • Recombinant expression of human mannan-binding lectin.

    abstract：:Mannan-binding lectin (MBL) constitutes an important part of the innate immune defence by effecting the deposition of complement on microbial surfaces. MBL deficiency is among the most common primary immunodeficiencies and is associated with recurrent infections and symptoms of poor immune complex clearance. Plasma-de...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/s1567-5769(00)00052-7

    authors： Vorup-Jensen T,Sørensen ES,Jensen UB,Schwaeble W,Kawasaki T,Ma Y,Uemura K,Wakamiya N,Suzuki Y,Jensen TG,Takahashi K,Ezekowitz RA,Thiel S,Jensenius JC

    更新日期：2001-04-01 00:00:00