Abstract:
:The inner surface of the intestinal tract possesses a large area of mucosal membranes, and the intestinal epithelial cells exist at the interface between an antigen-rich lumen and a lymphocyte-rich lamina propria. The crosstalk that occurs between these compartments serves to maintain intestinal homeostasis, and the cytokine network plays an important role in the crosstalk. In this study, the effect of a pectic polysaccharide, bupleuran 2IIc from Bupleurum falcatum L., on cytokine secretion of intestinal epithelial cells was investigated in vitro. When murine normal colonic epithelial cell line MCE301 cells were stimulated with bupleuran 2IIc, the contents of granulocyte colony-stimulating factor (G-CSF) in the conditioned medium were significantly increased in dose- and time-dependent manners. The enhanced G-CSF gene transcription in MCE301 cells by the stimulation of bupleuran 2IIc was observed by RT-PCR. The enhanced G-CSF secretion by bupleuran 2IIc was also observed in C3H/HeJ mice derived primary cultured colonic epithelial cells. Bupleuran 2IIc was digested with endo-(1-->4)-alpha-D-polygalacturonase, and the resulting bupleuran 2IIc/PG-1 ("ramified" region) showed potent G-CSF secretion enhancing activity. The activity of bupleuran 2IIc/PG-1 disappeared after the removal of arabinosyl residues from bupleuran 2IIc/PG-1 by endo-(1-->5)-alpha-L-arabinanase digestion. These results suggest that the "ramified" region (bupleuran 2IIc/PG-1) is the active site for the G-CSF secretion enhancing activity of bupleuran 2IIc, and the arabinan moiety of bupleuran 2IIc/PG-1 plays an important role in expression of the activity.
journal_name
Int Immunopharmacoljournal_title
International immunopharmacologyauthors
Matsumoto T,Moriya M,Sakurai MH,Kiyohara H,Tabuchi Y,Yamada Hdoi
10.1016/j.intimp.2008.01.006subject
Has Abstractpub_date
2008-04-01 00:00:00pages
581-8issue
4eissn
1567-5769issn
1878-1705pii
S1567-5769(08)00012-Xjournal_volume
8pub_type
杂志文章abstract::Streptococcus pneumoniae is a primary cause of invasive bacterial infection and pneumonia and is one of the leading causes of death worldwide. In prior studies we showed that pre-treating mice with 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), a potent agonist of the aryl hydrocarbon receptor (AhR), protects against S. ...
journal_title:International immunopharmacology
pub_type: 杂志文章
doi:10.1016/j.intimp.2012.05.008
更新日期:2012-08-01 00:00:00
abstract::Plasma osteopontin (OPN) levels are elevated in tuberculosis patients and may involve granuloma formation. New inhibitors using brefelamide, an aromatic amide isolated from Dictyostelium cellular slime molds that may inhibit OPN transcription in A549 cells at 1 μM concentration, were synthesized as compounds C, D, and...
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journal_title:International immunopharmacology
pub_type: 杂志文章
doi:10.1016/j.intimp.2017.03.018
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journal_title:International immunopharmacology
pub_type: 杂志文章
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journal_title:International immunopharmacology
pub_type: 杂志文章
doi:10.1016/j.intimp.2019.02.034
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journal_title:International immunopharmacology
pub_type: 杂志文章
doi:10.1016/j.intimp.2017.07.004
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journal_title:International immunopharmacology
pub_type: 杂志文章
doi:10.1016/j.intimp.2017.02.020
更新日期:2017-05-01 00:00:00
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journal_title:International immunopharmacology
pub_type: 杂志文章
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journal_title:International immunopharmacology
pub_type: 杂志文章
doi:10.1016/j.intimp.2015.09.026
更新日期:2015-12-01 00:00:00
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journal_title:International immunopharmacology
pub_type: 杂志文章
doi:10.1016/j.intimp.2017.08.001
更新日期:2017-10-01 00:00:00
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journal_title:International immunopharmacology
pub_type: 杂志文章
doi:10.1016/j.intimp.2021.107413
更新日期:2021-01-29 00:00:00
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journal_title:International immunopharmacology
pub_type: 杂志文章
doi:10.1016/j.intimp.2020.106362
更新日期:2020-02-29 00:00:00
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journal_title:International immunopharmacology
pub_type: 杂志文章
doi:10.1016/j.intimp.2018.11.004
更新日期:2019-01-01 00:00:00
abstract::The immune system is a very diverse system of the host that evolved during evolution to cope with various pathogens present in the vicinity of environmental surroundings inhabited by multicellular organisms ranging from achordates to chordates (including humans). For example, cells of immune system express various pat...
journal_title:International immunopharmacology
pub_type: 杂志文章,评审
doi:10.1016/j.intimp.2018.03.002
更新日期:2018-06-01 00:00:00
abstract:BACKGROUND:The precision-cut kidney slice (PCKS) model appears to be a useful ex vivo model of renal fibrosis. However, little in-depth molecular investigation on the PCKS model has been performed. Therefore, the aim of this study will be to investigate and validate the molecular validity of this model. METHODS:The PC...
journal_title:International immunopharmacology
pub_type: 杂志文章
doi:10.1016/j.intimp.2016.01.026
更新日期:2016-05-01 00:00:00
abstract::Pemphigus vulgaris (PV) is a rare autoimmune disease due to the production of pathogenic autoantibodies directed against desmoglein 1 and 3, usually affecting both skin and mucous membranes. Recently, rituximab, a chimeric IgG1 monoclonal antibody which targets the CD20 molecules have been regarded as a promising trea...
journal_title:International immunopharmacology
pub_type: 杂志文章,评审
doi:10.1016/j.intimp.2017.11.005
更新日期:2018-01-01 00:00:00
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journal_title:International immunopharmacology
pub_type: 杂志文章
doi:10.1016/j.intimp.2019.01.044
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journal_title:International immunopharmacology
pub_type: 杂志文章
doi:10.1016/j.intimp.2018.06.036
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journal_title:International immunopharmacology
pub_type: 临床试验,杂志文章
doi:10.1016/j.intimp.2006.09.013
更新日期:2006-12-20 00:00:00
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journal_title:International immunopharmacology
pub_type: 杂志文章
doi:10.1016/j.intimp.2009.01.025
更新日期:2009-05-01 00:00:00
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journal_title:International immunopharmacology
pub_type: 杂志文章
doi:10.1016/j.intimp.2014.06.003
更新日期:2014-09-01 00:00:00
abstract::Resveratrol is an anticancer phytochemical polyphenol isolated from a natural origin, without any significant side effects. Resveratrol was investigated in immunocompetent mice with regards to its possible effect on lung cancer metastasis. Cytotoxicity was assessed in three melanoma cell lines (B16F10, B6, and A375) b...
journal_title:International immunopharmacology
pub_type: 杂志文章
doi:10.1016/j.intimp.2020.106905
更新日期:2020-11-01 00:00:00
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journal_title:International immunopharmacology
pub_type: 杂志文章
doi:10.1016/S1567-5769(03)00180-2
更新日期:2003-10-01 00:00:00
abstract::Herbal medicine, Herba Taraxaci (Tarazacum mongolicum Hand.-Mazz.), was administered to mice with Behcet's disease (BD)-like symptoms induced by herpes simplex virus (HSV). BD is a chronic recurrent inflammatory disease. Herba Taraxaci (6 mg) was administered alone or in combination with 2 microg of colchicine to BD-l...
journal_title:International immunopharmacology
pub_type: 杂志文章
doi:10.1016/S1567-5769(03)00071-7
更新日期:2003-05-01 00:00:00
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journal_title:International immunopharmacology
pub_type: 杂志文章,评审
doi:10.1016/j.intimp.2015.06.023
更新日期:2015-09-01 00:00:00
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journal_title:International immunopharmacology
pub_type: 杂志文章
doi:10.1016/j.intimp.2004.04.016
更新日期:2004-09-01 00:00:00
abstract::Tumor growth occurs by the imbalance between cells with effector function and cells with suppressor/regulatory functions. To investigate this scenario we administered the chemical carcinogen Urethane in BALB/c mice and followed these animals during 120 days to observe lung tumor development. In another set of experime...
journal_title:International immunopharmacology
pub_type: 杂志文章
doi:10.1016/j.intimp.2010.12.025
更新日期:2011-07-01 00:00:00
abstract:BACKGROUND:Although available evidence from clinical trials has shown that immune checkpoint inhibitors (ICIs) combination therapy can lead to a series of immune-related adverse events (irAEs), the overall risk of irAEs on combination therapy has yet not been systematically reported. Therefore, we performed a meta-anal...
journal_title:International immunopharmacology
pub_type: 杂志文章,meta分析,评审
doi:10.1016/j.intimp.2018.08.014
更新日期:2018-10-01 00:00:00