Progesterone as an immunomodulatory molecule.

abstract：OBJECTIVE:To evaluate the anti-inflammatory potential of ICT in LPS stimulated human innate immune cells. BACKGROUND:3, 5, 7-Trihydroxy-4'-methoxy-8-(3-hydroxy-3- methylbutyl)-flavone (ICT) is a novel derivative of icariin, the major active ingredient of Herba Epimedii, an herb used in traditional Chinese medicine. We...

journal_title：International immunopharmacology

authors： Wu J,Zhou J,Chen X,Fortenbery N,Eksioglu EA,Wei S,Dong J

更新日期：2012-01-01 00:00:00

abstract：:Curcumin, extracted from the rhizome of Curcuma longa, is known to possess anti-inflammatory activities. Despite the fact that neutrophils are key player cells in inflammation, the role of curcumin on neutrophil cell biology is not well documented and, in particular, how curcumin can alter primed neutrophils is unknow...

journal_title：International immunopharmacology

authors： Antoine F,Simard JC,Girard D

更新日期：2013-12-01 00:00:00

abstract：:Administration of oligomannose-coated liposomes (OMLs) in mice can induce Th1 immune responses against antigens entrapped in the OMLs. In the present study, we investigated the anti-allergic effect of treatment with oligomannose-coated liposomes (OMLs) with entrapped Cry j 1, a major allergen of Japanese cedar pollen ...

journal_title：International immunopharmacology

authors： Ishii M,Koyama A,Iseki H,Narumi H,Yokoyama N,Kojima N

更新日期：2010-09-01 00:00:00

abstract：:There are few studies regarding the evaluation of the kinin system in patients with systemic lupus erythematosus (SLE). In this study, we evaluated the plasma levels of high-molecular weight kininogen (HKg), low-molecular weight kininogen (LKg) and plasma kallikrein; the plasma activity of tissue kallikrein and kinina...

journal_title：International immunopharmacology

authors： Dellalibera-Joviliano R,Reis ML,Donadi EA

更新日期：2001-09-01 00:00:00

abstract：:Acute lung injury (ALI) is characterized by disruption of the alveolar-capillary membrane resulting in pulmonary edema and accumulation of associated proteinaceous alveolar exudate. Initiation of ALI upregulates tumor necrosis factor-α (TNF-α), which activates nuclear factor-kappa B (NF-κB) and mitogen-activated prote...

journal_title：International immunopharmacology

authors： Ko IG,Hwang JJ,Chang BS,Kim SH,Jin JJ,Hwang L,Kim CJ,Choi CW

更新日期：2020-06-01 00:00:00

abstract：:Human beta-defensin 2 is an antimicrobial peptide that is produced by several epithelial cells after stimulation with micro-organisms and inflammatory mediators. Gram-negative bacteria, which are typically detected in periodontal pockets in periodontitis, elicit a stronger antibacterial peptide response of human beta-...

journal_title：International immunopharmacology

authors： Rizzo A,Paolillo R,Buommino E,Lanza AG,Guida L,Annunziata M,Carratelli CR

更新日期：2008-09-01 00:00:00

abstract：:The immunomodulatory effect of metronidazole (MTZ), a nitroimidazole drug used as an antiprotozoal and antibacterial agent, was investigated using Balb/c mice and human peripheral blood lymphocytes. For in vivo studies, mice were divided into six groups, six animals per group, group I received vehicle alone while the ...

journal_title：International immunopharmacology

authors： Fararjeh M,Mohammad MK,Bustanji Y,Alkhatib H,Abdalla S

更新日期：2008-02-01 00:00:00

abstract：:Outbreaks of hand, foot and mouth disease (HFMD), which is caused by Enterovirus 71 (EV71), have erupted in recent years. Andrographolide sulfonate (Trade name: Xiyanping injection) has been recommended to treat severe HFMD in China because of its conventional antithermic and antitoxic activities, but its actual mecha...

journal_title：International immunopharmacology

authors： Li M,Yang X,Guan C,Wen T,Duan Y,Zhang W,Li X,Wang Y,Zhao Z,Liu S

更新日期：2018-02-01 00:00:00

abstract：:The protective effects of genipin against lipopolysaccharide (LPS)-induced acute lung injury (ALI) have been reported; however, the mechanism is unclear. Genipin performs its pharmacological effects via activation of the phosphatidylinositol-4,5-bisphosphate 3-kinase (PI3K)/protein kinase B (AKT) signaling pathway. In...

journal_title：International immunopharmacology

authors： Luo X,Lin B,Gao Y,Lei X,Wang X,Li Y,Li T

更新日期：2019-11-01 00:00:00

abstract：:Endometriosis is a condition characterized by the presence of endometrial tissues outside the uterus. Endometriotic stromal cells (ESCs) are known to undergo regeneration and are linked to the causation of endometriosis. Activation of stromal cells by local inflammatory cytokines is proposed to be one of the mechanism...

journal_title：International immunopharmacology

authors： Lyu D,Tang N,Wang J,Zhang Y,Chang J,Liu Z,Liu H

更新日期：2019-06-01 00:00:00

abstract：:IL-36 cytokines (IL-36Ra, IL-36α, IL-36β and IL-36γ) belong to the IL-1 family and have been linked to several autoimmune diseases. However, little is known about the relationships between systemic lupus erythematosus (SLE) and IL-36 cytokines. In this study, serum IL-36 cytokine levels were determined by enzyme-linke...

journal_title：International immunopharmacology

authors： Mai SZ,Li CJ,Xie XY,Xiong H,Xu M,Zeng FQ,Guo Q,Han YF

更新日期：2018-05-01 00:00:00

abstract：:Airway remodeling includes lung structural changes that have a role in the irreversibility of pulmonary dysfunction shown in chronic bronchial asthmatics. The current experiment investigated the effect of the mitochondrial antioxidant, tiron in comparison with dexamethasone (DEXA) on airway remodeling in chronic asthm...

journal_title：International immunopharmacology

authors： El-Sherbeeny NA,Hassan ZA,Ateyya H

更新日期：2016-10-01 00:00:00

abstract：:The presence of thrombin-cleaved form of osteopontin well correlated with various inflammatory disease activities in not only rodents, but also humans. We previously demonstrated that the blocking of the interaction of a cryptic epitope within osteopontin, which is exposed by thrombin cleavage, with its integrins by s...

journal_title：International immunopharmacology

authors： Yamamoto N,Nakashima T,Torikai M,Naruse T,Morimoto J,Kon S,Sakai F,Uede T

更新日期：2007-11-01 00:00:00

abstract：:A body of evidence indicates that the therapeutic activity of antidepressants is connected with their modulatory effect on the inflammatory response system and cell-mediated immunity. The present study was carried out to examine the effects of antidepressant agents, such as imipramne, venlafaxine, l-5-hydroxytryptopha...

journal_title：International immunopharmacology

authors： Kubera M,Kenis G,Bosmans E,Kajta M,Basta-Kaim A,Scharpe S,Budziszewska B,Maes M

更新日期：2004-02-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is an aggressive disease with poor prognosis and limited methods to predict patient survival. Immune cells infiltrating tumors are known to impact tumor progression. Here, we analyzed the phenotype and function of dendritic cells (DCs), and the frequency of IL-10-producing regulatory B c...

journal_title：International immunopharmacology

authors： Song S,Yuan P,Li P,Wu H,Lu J,Wei W

更新日期：2014-10-01 00:00:00

abstract：OBJECTIVE:We aimed to investigate the immunologic mechanisms by which arsenic trioxide (As2O3) may inhibit T helper 17 (Th17) cell differentiation while promoting regulatory T (Treg) cell generation by modulating signal transducer and activator of transcription 3 (STAT3) in treatment-naïve rheumatoid arthritis (RA) pat...

journal_title：International immunopharmacology

authors： Li C,Zhang J,Wang W,Wang H,Zhang Y,Zhang Z

更新日期：2019-08-01 00:00:00

abstract：:Effects of a topical corticosteroid drug, diflucortolone valerate, on the mRNA expressions for four CC- and four CXC-chemokines, which have been reported to be associated with recruitment of different kinds of proinflammatory and inflammatory cells, were investigated by RT-PCR in mice with 2,4,6-trinitrochlorobenzene ...

journal_title：International immunopharmacology

authors： Mitsui G,Hirano T,Niwano Y,Mitsui K,Ohara O,Yanagihara S,Kato M

更新日期：2004-01-01 00:00:00

abstract：:Recently, immunotherapy has evolved into a true treatment modality with the approval of PD-1 and PD-L1 inhibitors as the standard care for first-line treatment in patients with non-small cell lung cancer (NSCLC). Until now, for patients with advanced NSCLC, treatment of targeting immune checkpoints reveals a promising...

journal_title：International immunopharmacology

authors： Zhang S,Bai X,Shan F

更新日期：2020-03-01 00:00:00

abstract：:Icaritin, an intestinal metabolite of prenylflavonoids from Herba Epimedii, has been known to regulate many cellular processes. The purpose of this study was to investigate the protective effects of icaritin on inflammation in lipopolysaccharide (LPS) stimulated mouse peritoneal macrophages in vitro and zymosan induce...

journal_title：International immunopharmacology

authors： Lai X,Ye Y,Sun C,Huang X,Tang X,Zeng X,Yin P,Zeng Y

更新日期：2013-05-01 00:00:00

abstract：:Treatment of asthma with corticosteroids results in downregulation of eosinophilic airway inflammation. We evaluated in vitro the activity of an "inhaled" corticosteroid, mometasone furoate (MF), and of a "systemic" corticosteroid, dexamethasone (DEX), on eosinophil functions, i.e. adhesion molecule expression and cel...

journal_title：International immunopharmacology

authors： Sale R,Sabatini F,Silvestri M,Serpero L,Petecchia L,Rossi GA

更新日期：2004-12-15 00:00:00

abstract：:The present study was conducted to evaluate the efficacy of paternal lymphocyte (PL) immunotherapy and its relation with the development of mixed lymphocyte reaction blocking antibodies (MLR-Bf) and the success of pregnancy outcome in women with recurrent spontaneous abortion (RSA). A total of 124 women with unknown c...

journal_title：International immunopharmacology

authors： Pandey MK,Agrawal S

更新日期：2004-02-01 00:00:00

abstract：OBJECTIVES:Various studies have researched the serum levels of leptin, adiponectin and resistin in patients with ankylosing spondylitis (AS), but the results were inconclusive. The purpose of this study was to systematically evaluate the correlations between serum levels of these adipokines and AS. METHODS:Electronic ...

journal_title：International immunopharmacology

authors： Yang J,Zhang X,Ma Y,Wu M,Hu X,Han R,Yuan Y,Wang M,Chen M,Jiang S,Tong J,Xu S,Xu J,Shuai Z,Zou Y,Pan F

更新日期：2017-11-01 00:00:00

abstract：:In our previous study, we reported the isolation of a novel humulene derivative, 5-hydroxyzerumbone, from Zingiber zerumbet and its inhibitory activity on lipopolysaccharide (LPS)-induced nitric oxide (NO) production in RAW 264.7 mouse macrophage cells. This study was performed to examine its mechanism of action on th...

journal_title：International immunopharmacology

authors： Min HY,Kim MS,Jang DS,Park EJ,Seo EK,Lee SK

更新日期：2009-07-01 00:00:00

abstract：BACKGROUND:Growing evidence points to the pivotal role of inflammation in the pathogenesis of diabetic kidney disease (DKD). However, as an inflammation-based prognostic score, the significance of platelet-to-lymphocyte ratio (PLR) in biopsy-proven DKD remains uncertain. Therefore, the current study aimed to evaluate t...

journal_title：International immunopharmacology

authors： Duan S,Sun L,Zhang C,Wu L,Nie G,Huang Z,Xing C,Zhang B,Yuan Y

更新日期：2021-01-29 00:00:00

abstract：AIM:The study aimed to investigate the changes in peripherallymphocyte and CD4+T subsets and to observe the regulatory effect of low-dose interleukin-2 (ld-IL2) on these cells in polymyositis or dermatomyositis (PM/DM). METHODS:Lymphocyte subsets (CD3+T, CD4+T, CD8+T, B and natural killer (NK) cells), CD4+T subsets (T...

journal_title：International immunopharmacology

authors： Feng M,Guo H,Zhang C,Wang Y,Liang Z,Zhao X,Qin Y,Wu Y,Liu G,Gao C,Luo J

更新日期：2019-12-01 00:00:00

abstract：:The potentiation of the immune system in pregnant rats was performed with Complete Freund's Adjuvant [CFA; 20μl, subcutaneous at gestation day (GD) 18] in experimentally-induced hyperthyroidism by Levo-thyroxine (L-T4; 10μg/100g of b.w., intraperitoneal from GD 2 to 17). The potential effects on the fetal neuroendocri...

journal_title：International immunopharmacology

authors： Ahmed RG,Abdel-Latif M,Mahdi EA,El-Nesr KA

更新日期：2015-12-01 00:00:00

abstract：:1.We investigated the role of Annexin (ANX)-A1 and its receptor, ALX/FPR2, in the regulation of mast cell degranulation produced by compound 48/80. 2.Both human cord-blood derived mast cells (CBDMCs) and murine bone marrow derived mast cells (BMDMCs) release phosphorylated ANX-A1 during treatment with glucocorticoids ...

journal_title：International immunopharmacology

authors： Sinniah A,Yazid S,Perretti M,Solito E,Flower RJ

更新日期：2016-03-01 00:00:00

abstract：:Pemphigus vulgaris (PV) is a rare autoimmune disease due to the production of pathogenic autoantibodies directed against desmoglein 1 and 3, usually affecting both skin and mucous membranes. Recently, rituximab, a chimeric IgG1 monoclonal antibody which targets the CD20 molecules have been regarded as a promising trea...

journal_title：International immunopharmacology

authors： Tavakolpour S,Mahmoudi H,Balighi K,Abedini R,Daneshpazhooh M

更新日期：2018-01-01 00:00:00

abstract：:Endotoxin, also known as lipopolysaccharide (LPS), is the major mediator of septic shock due to Gram-negative bacterial infections. Recently, much attention has been focused on cationic peptides which possess the potential to detoxify LPS. Limulus anti-LPS factor (LALF), a protein found in the horseshoe crab (Limulus ...

journal_title：International immunopharmacology

authors： Ren JD,Gu JS,Gao HF,Xia PY,Xiao GX

更新日期：2008-06-01 00:00:00

abstract：:Cartilage degradation is the most predominant pathological change during osteoarthritis (OA). Furthermore, accumulating evidence suggests that an excess of matrix metalloproteinase-13 (MMP-13) plays a critical role in the breakdown of cartilage. Here, the effects of Icariin on the expression of MMP-13 in IL-1β-induced...

journal_title：International immunopharmacology

authors： Zeng L,Wang W,Rong XF,Zhong Y,Jia P,Zhou GQ,Li RH

更新日期：2014-01-01 00:00:00