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The progress and confusion of anti-PD1/PD-L1 immunotherapy for patients with advanced non-small cell lung cancer.

Abstract：

:Recently, immunotherapy has evolved into a true treatment modality with the approval of PD-1 and PD-L1 inhibitors as the standard care for first-line treatment in patients with non-small cell lung cancer (NSCLC). Until now, for patients with advanced NSCLC, treatment of targeting immune checkpoints reveals a promising survival benefit, and some patients even get long term survive, which creates a paradigm shift in NSCLC treatment. However, many issues or problems are also appearing in clinical practice, such as the lower overall efficacy rate (20-40%), treatment modes, populations choice of immunotherapy, drug resistance, and safety, etc. Thus, in this review, we will mainly summarize and discuss the recent development and confusion of PD-1/PD-L1 inhibitors for advanced NSCLC patients based on current clinical studies.

journal_name

Int Immunopharmacol

journal_title

International immunopharmacology

authors

Zhang S,Bai X,Shan F

doi

10.1016/j.intimp.2020.106247

subject

Has Abstract

pub_date

2020-03-01 00:00:00

pages

106247

eissn

1567-5769

issn

1878-1705

pii

S1567-5769(20)30007-2

journal_volume

80

pub_type

杂志文章,评审

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