Anti-tumor and immunomodulatory activities of an exopolysaccharide from Rhizopus nigricans on CT26 tumor-bearing mice.


:This study was aimed to investigate the anti-tumor and immunomodulatory activities of an exopolysaccharide (EPS) from Rhizopus nigricans. Our results showed EPS could significantly inhibit the tumor growth and increase the immune organs index of CT26 tumor-bearing mice. EPS treatment increased the productions of interleukin-2 (IL-2) and tumor necrosis factor-α (TNF-α) levels in serum. The increase of percentage of CD8(+) cytotoxic T cells among total spleen T lymphocyte was also observed. Furthermore, EPS remarkably stimulate spleen lymphocytes proliferation in the absence or presence of mitogens. In addition, we found that EPS had synergistic effect with chemotherapy and improved immunosuppressive effect induced by 5-Fu. In summary, these findings indicated that the antitumor effects of EPS might be partly due to immune function activation and it might have potential to be used in the treatment for colorectal cancer.


Int Immunopharmacol


Zhu L,Cao J,Chen G,Xu Y,Lu J,Fang F,Chen K




Has Abstract


2016-07-01 00:00:00












  • Ginkgo terpene component has an anti-inflammatory effect on Candida albicans-caused arthritic inflammation.

    abstract::The Ginkgo biloba extract, EGb 761, contains flavonoid glycosides and unique terpene lactones as major active components. In this study, we determined the anti-inflammatory effect of the water-soluble portion (GH415) of the EGb 761 on the inflammation caused by Candida albicans, a major ethiological agent that causes ...

    journal_title:International immunopharmacology

    pub_type: 杂志文章


    authors: Han Y

    更新日期:2005-06-01 00:00:00

  • Chloroquine attenuates paraquat-induced lung injury in mice by altering inflammation, oxidative stress and fibrosis.

    abstract::Paraquat is one of the most extensively used herbicides and has high toxicity for humans and animals. However, there is no effective treatment for paraquat poisoning. The aim of the present study was to evaluate the effects of chloroquine on paraquat-induced lung injury in mice. Mice received a single intraperitoneal ...

    journal_title:International immunopharmacology

    pub_type: 杂志文章


    authors: Shen H,Wu N,Wang Y,Zhao H,Zhang L,Li T,Zhao M

    更新日期:2017-05-01 00:00:00

  • Effects of ghrelin on pulmonary NOD2 mRNA expression and NF-κB activation when protects against acute lung injury in rats challenged with cecal ligation and puncture.

    abstract:BACKGROUND:Many studies have shown that ghrelin can down-regulate inflammatory cytokine expression via the inhibition of NF-κB activity and therefore, its administration to septic patients is considered beneficial. However, our knowledge of ghrelin's effects on the upstream activators of the NF-κB pathway, such as NOD2...

    journal_title:International immunopharmacology

    pub_type: 杂志文章


    authors: Peng Z,Zhu Y,Zhang Y,Wilhelmsen K,Jia C,Jin J,Xue Q,Feng X,Zhang F,Yu B

    更新日期:2012-08-01 00:00:00

  • The neuro-immune interaction in airway inflammation through TRPA1 expression in CD4+ T cells of asthmatic mice.

    abstract::Asthma is an inflammatory disorder of the airways dominated by a Th2-type pattern. Recently, an emerging interest arises whether transient receptor potential ankyrin 1 (TRPA1) plays a potential role in the adaptive immune response. In this study, the role of TRPA1 in the development and exacerbation of asthma was expl...

    journal_title:International immunopharmacology

    pub_type: 杂志文章


    authors: Li M,Fan X,Yue Q,Hu F,Zhang Y,Zhu C

    更新日期:2020-09-01 00:00:00

  • The immunosuppressive mechanisms of mesenchymal stem cells are differentially regulated by platelet poor plasma and fetal bovine serum supplemented media.

    abstract:PURPOSE:Mesenchymal Stem Cells (MSCs) can interact with and modulate the functions of all immune cells, suppressing both the innate and adaptive immune responses. Currently, most of the in vitro studies which have led to the description of MSC properties have resulted from MSC culture in the presence of fetal bovine se...

    journal_title:International immunopharmacology

    pub_type: 杂志文章


    authors: Silva-Carvalho AÉ,Neves FAR,Saldanha-Araujo F

    更新日期:2020-02-01 00:00:00

  • Quantitative in vivo comparisons of the Fc gamma receptor-dependent agonist activities of different fucosylation variants of an immunoglobulin G antibody.

    abstract::Although it has been shown that functions of immunoglobulin G (IgG) antibodies (Abs) that depend on binding to certain Fc gamma receptors (Fc gamma R) can be influenced by Fc glycan fucosylation, quantitative in vivo analyses comparing the effects of different levels of fucose are still lacking. We used a simple mouse...

    journal_title:International immunopharmacology

    pub_type: 杂志文章


    authors: Scallon B,McCarthy S,Radewonuk J,Cai A,Naso M,Raju TS,Capocasale R

    更新日期:2007-06-01 00:00:00

  • Transcriptional regulation of SLURP2, a psoriasis-associated gene, is under control of IL-22 in the skin: A special reference to the nested gene LYNX1.

    abstract::A novel nicotinic acetylcholine (ACh) receptor (nAChR)-mediated transduction pathway, regulating keratinocyte function, has been elucidated in studies of secreted mammalian Ly6/urokinase plasminogen activator receptor-related protein (SLURP)-1 and -2. SLURPs are members of Ly6/neurotoxin superfamily (Ly6SF) of protein...

    journal_title:International immunopharmacology

    pub_type: 杂志文章


    authors: Moriwaki Y,Takada K,Tsuji S,Kawashima K,Misawa H

    更新日期:2015-11-01 00:00:00

  • Malondialdehyde-acetaldehyde antibody concentrations in rheumatoid arthritis and other rheumatic conditions.

    abstract:OBJECTIVE:To compare anti-malondialdehyde-acetaldehyde (MAA) antibody concentrations between rheumatoid arthritis (RA) patients and healthy and rheumatic disease controls. METHODS:Anti-MAA antibody (IgA, IgM, IgG) was measured using ELISA and banked serum from patients with RA (n = 284), osteoarthritis (OA, n = 330), ...

    journal_title:International immunopharmacology

    pub_type: 杂志文章


    authors: Mikuls TR,Duryee MJ,England BR,Anderson DR,Hearth-Holmes M,Su K,Michaud K,Payne JB,Sayles H,Hunter C,McGowan JD,Klassen LW,Thiele GM

    更新日期:2018-03-01 00:00:00

  • The effects of H1-antihistamines on the nitric oxide production by RAW 264.7 cells with respect to their lipophilicity.

    abstract::H1-antihistamines are known to be important modulators of inflammatory response. However, the information about the influence of these drugs on reactive nitrogen species generation is still controversial. The main aim of the present study was to investigate the effects of selected H1-antihistamines on nitric oxide pro...

    journal_title:International immunopharmacology

    pub_type: 杂志文章


    authors: Králová J,Racková L,Pekarová M,Kubala L,Nosál R,Jancinová V,Cíz M,Lojek A

    更新日期:2009-07-01 00:00:00

  • Dendritic cells with an increased PD-L1 by TGF-β induce T cell anergy for the cytotoxicity of hepatocellular carcinoma cells.

    abstract::The effects of TGF-β on dendritic cells (DCs) in the tumor microenvironment are not well-understood. In this study, we investigated the effect of TGF-β on the induction of programmed death ligand-1 (PD-L1) expression in DCs and the underlying mechanism, and we further investigated the influence of the DCs with PD-L1 e...

    journal_title:International immunopharmacology

    pub_type: 杂志文章


    authors: Song S,Yuan P,Wu H,Chen J,Fu J,Li P,Lu J,Wei W

    更新日期:2014-05-01 00:00:00

  • Characterization of the molecular structure, expression and bioactivity of the TNFSF13B (BAFF) gene of the South African clawed frog, Xenopus laevis.

    abstract::B cell activating factor (BAFF), a member of the tumor necrosis factor family, is critical to B cell survival, proliferation, maturation, and immunoglobulin secretion and to T cell activation. In the present study, the full-length cDNA of BAFF from the South African clawed frog (Xenopus laevis, designated xlBAFF) was ...

    journal_title:International immunopharmacology

    pub_type: 杂志文章


    authors: Yang L,Zhou L,Zong X,Cao X,Ji X,Gu W,Zhang S

    更新日期:2013-03-01 00:00:00

  • Functional studies of bradykinin receptors in Chinese hamster ovary cells stably expressing the human B2 bradykinin receptor.

    abstract::Bradykinin B1 and B2 receptors, members of the G-protein coupled receptor superfamily, are involved in inflammation and pain. Chinese hamster ovary (CHO) cells stably expressing the human B2 bradykinin receptor (CHO-B2) were used to characterize the signal transduction pathways associated with this receptor and its re...

    journal_title:International immunopharmacology

    pub_type: 杂志文章


    authors: Zhang SP,Wang HY,Lovenberg TW,Codd EE

    更新日期:2001-05-01 00:00:00

  • Characterization and immunostimulatory activity of an (1-->6)-a-D-glucan from the root of Ipomoea batatas.

    abstract::The polysaccharide PSPP (purified sweet potato polysaccharide), isolated and purified from the roots of Ipomoea batatas, was found to be a glucan with a molecular weight of 53.2 kDa and specific rotation of +115.0 degrees (ca. 0.80, H(2)O). On the basis of methylation analysis, periodate oxidation, Smith degradation, ...

    journal_title:International immunopharmacology

    pub_type: 杂志文章


    authors: Zhao G,Kan J,Li Z,Chen Z

    更新日期:2005-08-01 00:00:00

  • MDA-7/IL-24 is a unique cytokine--tumor suppressor in the IL-10 family.

    abstract::The melanoma differentiation associated gene-7 (mda-7) cDNA was isolated by virtue of being induced during melanoma differentiation. Initial gene transfer studies convincingly demonstrated potent antitumor effects of mda-7. Further studies showed that the mechanism of antitumor activity was due to induction of apoptos...

    journal_title:International immunopharmacology

    pub_type: 杂志文章,评审


    authors: Chada S,Sutton RB,Ekmekcioglu S,Ellerhorst J,Mumm JB,Leitner WW,Yang HY,Sahin AA,Hunt KK,Fuson KL,Poìndexter N,Roth JA,Ramesh R,Grimm EA,Mhashilkar AM

    更新日期:2004-05-01 00:00:00

  • Sauchinone, a lignan from Saururus chinensis, reduces tumor necrosis factor-alpha production through the inhibition of c-raf/MEK1/2/ERK 1/2 pathway activation.

    abstract::We investigated the anti-inflammatory effects of sauchinone, a lignan isolated from Saururus chinensis, and the underlying mechanism in lipopolysaccharide (LPS)-stimulated RAW264.7 cells. To assess the effects of sauchinone on LPS-induced macrophages activation, we measured the production of tumor necrosis factor (TNF...

    journal_title:International immunopharmacology

    pub_type: 杂志文章


    authors: Bae HB,Li M,Son JK,Seo CS,Chung SH,Kim SJ,Jeong CW,Lee HG,Kim W,Park HC,Kwak SH

    更新日期:2010-09-01 00:00:00

  • Aspirin modified dendritic cells are potent inducers of allo-specific regulatory T-cells.

    abstract::Salicylic acid (aspirin) is a widely used pharmacological agent with immunodmodulatory properties. Dendritic cells are key regulators of the immune response, and are capable of inducing hyporesponsiveness and regulatory activity in CD4+ T-cells. We have demonstrated that aspirin-treated dendritic cells are effective a...

    journal_title:International immunopharmacology

    pub_type: 杂志文章


    authors: Buckland M,Jago C,Fazekesova H,George A,Lechler R,Lombardi G

    更新日期:2006-12-20 00:00:00

  • Modulation of constitutive and delayed apoptosis by brefeldin A in human neutrophils.

    abstract::Neutrophil apoptosis is a constitutive process that can be enhanced or delayed by various stimuli. In this study, the effect of brefeldin A (BFA), which affects the biological process of secretion, on constitutive and delayed apoptosis of neutrophils was investigated. Neutrophil apoptosis was determined after culturin...

    journal_title:International immunopharmacology

    pub_type: 杂志文章


    authors: Lee MJ,Park JY,Lee SY,Lee JS,Jung DK,Bae YS,Kwak JY

    更新日期:2003-06-01 00:00:00

  • Establishing a high microbial load maternal-offspring asthma model in adult mice.

    abstract:BACKGROUND:Although it is widely accepted that the "hygiene hypothesis" explains the increased incidence of asthma, the lack of suitable animal models hinders further in-depth studies of the underlying molecular immune mechanisms. Therefore, we aimed to develop a robust mouse asthma model to investigate the role of bac...

    journal_title:International immunopharmacology

    pub_type: 杂志文章


    authors: Li Y,Tu C,Chen M,Tan C,Zheng X,Wang Z,Liang Y,Wang K,Wu J,Li H,Liu J

    更新日期:2020-06-01 00:00:00

  • Polymorphisms of endothelin 1 (G5665T and T-1370G) and endothelin receptor type A (C+70G and G-231A) in Graves' disease.

    abstract:PURPOSE:Endothelin 1 (EDN1) is a strong angiogenic and mitogenic factor, playing a key role in hypervascularization, thyroid follicle cell hyperplasia, and lymphocyte infiltration in the thyroid gland of patients with Graves' disease (GD). EDN1 induces angiogenesis and mitogenesis via endothelin receptor type A (EDNRA)...

    journal_title:International immunopharmacology

    pub_type: 杂志文章


    authors: Aydın AF,Develi-İş S,Doğru-Abbasoğlu S,Vural P,Ozderya A,Karadağ B,Uysal M

    更新日期:2014-01-01 00:00:00

  • Role of Fas/Fas ligand-mediated apoptosis in murine contact hypersensitivity.

    abstract::Apoptosis plays an important role in immune responses, but little is known about its involvement in contact hypersensitivity (CH). In this study, we have investigated the role of Fas/Fas ligand (FasL)-mediated apoptosis in the pathogenesis of CH. Mice were sensitized by one topical application of 100 microl of 3% oxaz...

    journal_title:International immunopharmacology

    pub_type: 杂志文章


    authors: Xu B,Bulfone-Paus S,Aoyama K,Yu S,Huang P,Morimoto K,Matsushita T,Takeuchi T

    更新日期:2003-07-01 00:00:00

  • Cocaine-induced HIV-1 expression in microglia involves sigma-1 receptors and transforming growth factor-beta1.

    abstract::The neuropharmacological properties of cocaine are known to be associated with the activation of sigma-1 receptors. Cocaine also has been shown to alter both cytokine production and HIV-1 expression in mononuclear phagocytes, including microglial cells. This study tested the hypothesis that sigma-1 receptors and trans...

    journal_title:International immunopharmacology

    pub_type: 杂志文章


    authors: Gekker G,Hu S,Sheng WS,Rock RB,Lokensgard JR,Peterson PK

    更新日期:2006-06-01 00:00:00

  • Myricetin inhibits IL-1beta-induced inflammatory mediators in SW982 human synovial sarcoma cells.

    abstract::Rheumatoid arthritis (RA) synovial fibroblasts produce inflammatory mediators, which destruct cartilage and bone in RA joint. The aim of this study is to investigate the effect of myricetin on inflammatory cytokine/matrix metalloproteinase (MMP) production and mitogen-activated protein kinases (MAPKs) in IL-1beta-stim...

    journal_title:International immunopharmacology

    pub_type: 杂志文章


    authors: Lee YS,Choi EM

    更新日期:2010-07-01 00:00:00

  • The hydroxy-naphthoquinone lapachol arrests mycobacterial growth and immunomodulates host macrophages.

    abstract::The present study reports the anti-mycobacterial activity of 2-hydroxy-3-(3-methyl-2-butenyl)-1,4-naphthoquinone (lapachol) as well as its influence on macrophage functions. Lapachol (L) did not induce apoptosis/necrosis of THP-1 macrophages at ≤32 μg/mL. Mycobacterium avium liquid growth was arrested by ≥32 μg/mL and...

    journal_title:International immunopharmacology

    pub_type: 杂志文章


    authors: Oliveira RA,Azevedo-Ximenes E,Luzzati R,Garcia RC

    更新日期:2010-11-01 00:00:00

  • Inhibitory effects of flavonoids extracted from Nepalese propolis on the LPS signaling pathway.

    abstract::Flavonoids, particularly those derived from plants, harbor biological effects such as anti-inflammation and the inhibition of cancer progression. In the present study, we investigated the effects of 10 kinds of flavonoids isolated from Nepalese propolis on the LPS signaling pathway in order to clarify their anti-infla...

    journal_title:International immunopharmacology

    pub_type: 杂志文章


    authors: Funakoshi-Tago M,Ohsawa K,Ishikawa T,Nakamura F,Ueda F,Narukawa Y,Kiuchi F,Tamura H,Tago K,Kasahara T

    更新日期:2016-11-01 00:00:00

  • Cord blood-derived cytokine-induced killer cells biotherapy combined with second-line chemotherapy in the treatment of advanced solid malignancies.

    abstract::This study investigated the efficacy of cord blood-derived cytokine-induced killer (CB-CIK) biotherapy combined with second-line chemotherapy in treating advanced solid malignancies after first-line chemotherapy failure. Forty patients with advanced solid malignancies after first-line chemotherapy failure were divided...

    journal_title:International immunopharmacology

    pub_type: 杂志文章,随机对照试验


    authors: Niu Q,Wang W,Li Y,Qin S,Wang Y,Wan G,Guan J,Zhu W

    更新日期:2011-04-01 00:00:00

  • MiR-130b attenuates vascular inflammation via negatively regulating tumor progression locus 2 (Tpl2) expression.

    abstract::Endothelial cell (EC) activation and dysfunction have been linked to a wide variety of vascular inflammatory diseases. However, the role of microRNAs in EC activation and inflammation remains largely unknown. In this study, we found that miR-130b was significantly decreased in human umbilical vein endothelial cells (H...

    journal_title:International immunopharmacology

    pub_type: 杂志文章


    authors: Wang P,Zhang X,Li F,Yuan K,Li M,Zhang J,Li B,Liang W

    更新日期:2017-10-01 00:00:00

  • The progress and confusion of anti-PD1/PD-L1 immunotherapy for patients with advanced non-small cell lung cancer.

    abstract::Recently, immunotherapy has evolved into a true treatment modality with the approval of PD-1 and PD-L1 inhibitors as the standard care for first-line treatment in patients with non-small cell lung cancer (NSCLC). Until now, for patients with advanced NSCLC, treatment of targeting immune checkpoints reveals a promising...

    journal_title:International immunopharmacology

    pub_type: 杂志文章,评审


    authors: Zhang S,Bai X,Shan F

    更新日期:2020-03-01 00:00:00

  • PRDM1 levels are associated with clinical diseases in chronic HBV infection and survival of patients with HBV-related hepatocellular carcinoma.

    abstract::PR domain zinc finger protein 1 (PRDM1)/B lymphocyte-induced maturation protein 1 (BLIMP1) is a transcriptional repressor involved in B and T cell responses which are implicated in chronic hepatitis B virus (HBV) infection and hepatocellular carcinoma (HCC). This study investigated the association of PRDM1 with clinic...

    journal_title:International immunopharmacology

    pub_type: 杂志文章


    authors: Li N,Fan X,Wang X,Deng H,Zhang K,Zhang X,Wang Y,Han Q,Lv Y,Liu Z

    更新日期:2019-08-01 00:00:00

  • COX-2-PGE2 signaling pathway contributes to hippocampal neuronal injury and cognitive impairment in PTZ-kindled epilepsy mice.

    abstract::Epilepsy is one of the most common neurological diseases. It adversely affects cognitive function. Neuroinflammation has been widely recognized as an important factor involved in the pathophysiology of epilepsy. Cyclooxygenase (COX) is a type of oxidoreductase enzyme that acts in the metabolic pathway converting arach...

    journal_title:International immunopharmacology

    pub_type: 杂志文章


    authors: Zhu X,Yao Y,Yang J,Zhengxie J,Li X,Hu S,Zhang A,Dong J,Zhang C,Gan G

    更新日期:2020-10-01 00:00:00

  • DNA methyltransferase inhibitor alleviates bleomycin-induced pulmonary inflammation.

    abstract::Acute lung injury (ALI) is a severe disease characterized by several inflammatory responses in the lung with high mortality. We applied a mouse model of the pulmonary inflammation induced by the intratracheal instillation of bleomycin which is widely used to induce ALI and fibrosis in animal models. We hypothesized th...

    journal_title:International immunopharmacology

    pub_type: 杂志文章


    authors: Lu CH,Chen CM,Ma J,Wu CJ,Chen LC,Kuo ML

    更新日期:2020-07-01 00:00:00