Anti-tumor and immunomodulatory activities of an exopolysaccharide from Rhizopus nigricans on CT26 tumor-bearing mice.

Abstract:

:This study was aimed to investigate the anti-tumor and immunomodulatory activities of an exopolysaccharide (EPS) from Rhizopus nigricans. Our results showed EPS could significantly inhibit the tumor growth and increase the immune organs index of CT26 tumor-bearing mice. EPS treatment increased the productions of interleukin-2 (IL-2) and tumor necrosis factor-α (TNF-α) levels in serum. The increase of percentage of CD8(+) cytotoxic T cells among total spleen T lymphocyte was also observed. Furthermore, EPS remarkably stimulate spleen lymphocytes proliferation in the absence or presence of mitogens. In addition, we found that EPS had synergistic effect with chemotherapy and improved immunosuppressive effect induced by 5-Fu. In summary, these findings indicated that the antitumor effects of EPS might be partly due to immune function activation and it might have potential to be used in the treatment for colorectal cancer.

journal_name

Int Immunopharmacol

authors

Zhu L,Cao J,Chen G,Xu Y,Lu J,Fang F,Chen K

doi

10.1016/j.intimp.2016.04.033

subject

Has Abstract

pub_date

2016-07-01 00:00:00

pages

218-224

eissn

1567-5769

issn

1878-1705

pii

S1567-5769(16)30159-X

journal_volume

36

pub_type

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