Hemodynamic and renal involvement of B1 and B2 kinin receptors during the acute phase of endotoxin shock in mice.


:B1 kinin receptor (B1R) is up-regulated by endotoxins and thus may represent a therapeutic target in sepsis. We investigated the expression and role of B1R and B2R in the acute phase of lipopolysaccharide (LPS)-induced endotoxin shock in C57BL/6 mice (WT) and B1R and B2R knock out mice (B1KO, B2KO). B1R mRNA was enhanced from 6 to 48 h after LPS while B2R mRNA was further increased in B1KO. Maximal hypotension was found 24 h after LPS, and was more pronounced in B1KO, but was reduced in B2KO. Glomerular filtration rate was more reduced by LPS in B1KO than in WT and B2KO. Glycemia was reduced by LPS and particularly in B1KO and B2KO mice. Mortality was increased by LPS in B1KO. These data suggest that the up-regulated B1R plays, at least transiently, a significant beneficial role in acute LPS-induced hypotension. Conversely, supra activation of B2R could be also involved in the increased mortality observed in B1KO mice.


Int Immunopharmacol


Seguin T,Buleon M,Destrube M,Ranera MT,Couture R,Girolami JP,Tack I




Has Abstract


2008-02-01 00:00:00














  • Human bone mesenchymal stem cells-derived exosomes overexpressing microRNA-26a-5p alleviate osteoarthritis via down-regulation of PTGS2.

    abstract::Osteoarthritis (OA) is a degenerative disease characterized by synovium inflammation and articular cartilage damage. The aberrant expression profile of microRNAs (miRNAs) has been implicated in the cartilage of patients with OA. However, how microRNAs carried by exosomes derived from mesenchymal stem cells (MSCs) asso...

    journal_title:International immunopharmacology

    pub_type: 杂志文章


    authors: Jin Z,Ren J,Qi S

    更新日期:2020-01-01 00:00:00

  • HIV-1 gp120 up-regulation of the mu opioid receptor in TPA-differentiated HL-60 cells.

    abstract::Opioid abuse has been shown to exacerbate the immunosuppressive effects and pathogenesis of HIV infection. The mu opioid receptor (MOR) is present on immune cells, such as macrophages, and mediates the direct immunomodulatory effects of opioids. Through its surface glycoprotein, gp120, HIV-1 binds to surface receptors...

    journal_title:International immunopharmacology

    pub_type: 杂志文章


    authors: Beltran JA,Pallur A,Chang SL

    更新日期:2006-09-01 00:00:00

  • Low DNA damage in peripheral lymphocytes of healthy elderly individuals with inverted CD4:CD8 ratio.

    abstract::The aim of this study was to evaluate the DNA damage in peripheral lymphocytes and the frequencies of CD8+ T cells expressing CD25, CD28 and CD45ro in aged individuals with inverted CD4:CD8 ratio. Blood samples of elderly individuals (aged >65) with normal CD4:CD8 ratio (n = 8) and inverted CD4:CD8 ratio (n = 8) were ...

    journal_title:International immunopharmacology

    pub_type: 杂志文章


    authors: Dorneles GP,Heuser V,de Andrade VM,Vilela TC,da Silva J,Dalberto D,Chies JA,Peres A

    更新日期:2019-02-01 00:00:00

  • A first of its kind quantitative functional C1-esterase inhibitor lateral flow assay for hereditary angioedema point-of-care diagnostic testing.

    abstract::Hereditary Angioedema (HAE) is a rare, autosomal dominant disease caused by mutations in SERPING1 gene leading to dysfunction/deficiency of C1-esterase inhibitor (C1-INH) protein and subsequent dysregulation of the contact system and bradykinin overproduction. As functional C1-INH (fC1-INH) levels are reduced in HAE t...

    journal_title:International immunopharmacology

    pub_type: 杂志文章


    authors: Chockalingam PS,Zhou Z,Garg BK,Boehringer H,Chung R,Fait S

    更新日期:2020-06-01 00:00:00

  • Immunological evaluation of colonic delivered Hepatitis B surface antigen loaded TLR-4 agonist modified solid fat nanoparticles.

    abstract::Hepatitis B is one of the leading liver diseases and remains a major global health problem. Currently available vaccines provide protection but often results in weaker/minimal mucosal immunity. Thus the present study is devoted to the development and in-vivo exploration of the colonically delivered biomimetic nanopart...

    journal_title:International immunopharmacology

    pub_type: 杂志文章


    authors: Sahu KK,Pandey RS

    更新日期:2016-10-01 00:00:00

  • Immunomodulatory effects by oral contraceptives in normal and cholestatic female rats: role of cytokines.

    abstract::Oral contraceptives (OC) may cause intrahepatic cholestasis or increase a pre-established liver damage. OC effects on hepatic injury biochemical markers remain contradictory and the role of cytokines in those processes is fairly unknown. Two doses, simple or double, of the OC combination ethinylestradiol/norgestrel we...

    journal_title:International immunopharmacology

    pub_type: 杂志文章


    authors: Fernández-Martínez E,Pérez-Soto E,González-Hernández C,Ortiz MI,Pérez-Álvarez V,Muriel P,Shibayama M

    更新日期:2014-07-01 00:00:00

  • Induction of thymic stromal lymphopoietin by a steroid alkaloid derivative in mouse keratinocytes.

    abstract::Thymic stromal lymphopoietin (TSLP) plays critical roles in inducing and exacerbating allergic diseases. Chemical compounds that induce TSLP production can enhance sensitization to antigens and exacerbate allergic inflammation. Hence, identifying such chemicals will be important to prevent an increase in allergic dise...

    journal_title:International immunopharmacology

    pub_type: 杂志文章


    authors: Weng Y,Mizuno N,Dong J,Segawa R,Yonezawa T,Cha BY,Woo JT,Moriya T,Hiratsuka M,Hirasawa N

    更新日期:2018-02-01 00:00:00

  • Functional alterations in CD11b(+)Gr-1(+) cells in mice injected with allogeneic tumor cells and treated with 2,3,7,8-tetrachlorodibenzo-p-dioxin.

    abstract::2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) exposure results in an increased percentage of CD11b(+) (Mac-1(+)) cells in the spleens of mice challenged with P815 tumor cells, coincident with a failure of the mice to generate allospecific CD8(+) CTL activity. Since CD11b(+)Gr-1(+) myeloid suppressor cells (MSC) have been...

    journal_title:International immunopharmacology

    pub_type: 杂志文章


    authors: Choi JY,Oughton JA,Kerkvliet NI

    更新日期:2003-04-01 00:00:00

  • Isolation of functional autologous collagen-II specific IL-10 producing Tr1 cell clones from rheumatoid arthritis blood.

    abstract::IL-10 producing regulatory type 1 (Tr1) cells represents a subpopulation of CD4+ regulatory cells able to prevent in vitro bystander T-cell proliferation and to inhibit a wide range of inflammatory diseases in mice. Our aim was to evaluate the frequency and function of joint specific Tr1 cells in the peripheral blood ...

    journal_title:International immunopharmacology

    pub_type: 杂志文章


    authors: Brun V,Neveu V,Pers YM,Fabre S,Quatannens B,Bastian H,Clerget-Chossat N,Jorgensen C,Foussat A

    更新日期:2011-08-01 00:00:00

  • Immunomodulating activities of acidic sulphated polysaccharides obtained from the seaweed Ulva rigida C. Agardh.

    abstract::Water-soluble acidic polysaccharides from the cell walls of Ulva rigida are mainly composed of disaccharides that contain glucuronic acid and sulphated rhamnose. The structure of disaccharides resembles that of glycosaminoglycans (GAGs) as they both contain glucuronic acid and sulphated sugars. Glycosaminoglycans occu...

    journal_title:International immunopharmacology

    pub_type: 杂志文章


    authors: Leiro JM,Castro R,Arranz JA,Lamas J

    更新日期:2007-07-01 00:00:00

  • Resveratrol attenuates HMGB1 signaling and inflammation in house dust mite-induced atopic dermatitis in mice.

    abstract::Resveratrol is a polyphenol abundantly found in red grape skin and is effective against antiaging and anti-inflammation associated with immune responses. In this study, we have investigated the effect of resveratrol on skin lesion, high mobility group box (HMGB)1 and inflammation pathway in an atopic dermatitis (AD) m...

    journal_title:International immunopharmacology

    pub_type: 杂志文章


    authors: Karuppagounder V,Arumugam S,Thandavarayan RA,Pitchaimani V,Sreedhar R,Afrin R,Harima M,Suzuki H,Nomoto M,Miyashita S,Suzuki K,Watanabe K

    更新日期:2014-12-01 00:00:00

  • Chloroquine attenuates paraquat-induced lung injury in mice by altering inflammation, oxidative stress and fibrosis.

    abstract::Paraquat is one of the most extensively used herbicides and has high toxicity for humans and animals. However, there is no effective treatment for paraquat poisoning. The aim of the present study was to evaluate the effects of chloroquine on paraquat-induced lung injury in mice. Mice received a single intraperitoneal ...

    journal_title:International immunopharmacology

    pub_type: 杂志文章


    authors: Shen H,Wu N,Wang Y,Zhao H,Zhang L,Li T,Zhao M

    更新日期:2017-05-01 00:00:00

  • A novel chrysin thiazole derivative polarizes macrophages to an M1 phenotype via targeting TLR4.

    abstract::Tumor-associated macrophages (TAMs) are an important cause of tumorigenesis and tumor development. M2 macrophages can promote tumor growth while M1 macrophages kill tumor cells, therefore, polarizing macrophages to achieve a functional M1 phenotype could effectively play its anti-tumor role. In the current study, we s...

    journal_title:International immunopharmacology

    pub_type: 杂志文章


    authors: Feng X,Yu W,Cao L,Meng F,Cong M

    更新日期:2020-11-01 00:00:00

  • Sirolimus as a new drug to treat RIF patients with elevated Th17/Treg ratio: A double-blind, phase II randomized clinical trial.

    abstract:BACKGROUND:RIF is clinically defined as the failure of good quality embryos to implant into the uterus following at least three cycles of In Vitro Fertilization/Embryo Transfer (IVF/ET). During human pregnancy, a genetically different fetus is allowed to survive within the uterus despite the maternal recognition of fet...

    journal_title:International immunopharmacology

    pub_type: 杂志文章,随机对照试验


    authors: Ahmadi M,Abdolmohamadi-Vahid S,Ghaebi M,Dolati S,Abbaspour-Aghdam S,Danaii S,Berjis K,Madadi-Javid R,Nouri Z,Siahmansouri H,Babaloo Z,Nouri M,Yousefi M

    更新日期:2019-09-01 00:00:00

  • Transcriptional regulation of SLURP2, a psoriasis-associated gene, is under control of IL-22 in the skin: A special reference to the nested gene LYNX1.

    abstract::A novel nicotinic acetylcholine (ACh) receptor (nAChR)-mediated transduction pathway, regulating keratinocyte function, has been elucidated in studies of secreted mammalian Ly6/urokinase plasminogen activator receptor-related protein (SLURP)-1 and -2. SLURPs are members of Ly6/neurotoxin superfamily (Ly6SF) of protein...

    journal_title:International immunopharmacology

    pub_type: 杂志文章


    authors: Moriwaki Y,Takada K,Tsuji S,Kawashima K,Misawa H

    更新日期:2015-11-01 00:00:00

  • LXA4 protects against hypoxic-ischemic damage in neonatal rats by reducing the inflammatory response via the IκB/NF-κB pathway.

    abstract::Hypoxia and the resultant decreases in cerebral blood flow in the perinatal period can lead to neonatal hypoxic-ischemic (HI) brain injury, which can, in turn, cause severe disability or even death. However, the efficacy of current treatment strategies remains limited. Several studies have demonstrated that lipoxin A4...

    journal_title:International immunopharmacology

    pub_type: 杂志文章


    authors: Zhu JJ,Yu BY,Fu CC,He MZ,Zhu JH,Chen BW,Zheng YH,Chen SQ,Fu XQ,Li PJ,Lin ZL

    更新日期:2020-12-01 00:00:00

  • A review on the effect of COVID-19 in type 2 asthma and its management.

    abstract:BACKGROUND:COVID-19 is considered the most critical health pandemic of 21st century. Due to extremely high transmission rate, people are more susceptible to viral infection. COVID-19 patients having chronic type-2 asthma prevails a major risk as it may aggravate the disease and morbidities. OBJECTIVE:The present revie...

    journal_title:International immunopharmacology

    pub_type: 杂志文章,评审


    authors: Ghosh S,Das S,Mondal R,Abdullah S,Sultana S,Singh S,Sehgal A,Behl T

    更新日期:2021-02-01 00:00:00

  • Key regulators in bee venom-induced apoptosis are Bcl-2 and caspase-3 in human leukemic U937 cells through downregulation of ERK and Akt.

    abstract::Bee venom (BV) has been known to inhibit proliferation and induce apoptosis in cancer cells. However, the molecular mechanisms involved in BV-induced apoptosis are still uncharacterized in human leukemic cells. In the present study, we report that BV induces apoptosis in leukemic U937 cells through downregulation of E...

    journal_title:International immunopharmacology

    pub_type: 杂志文章


    authors: Moon DO,Park SY,Heo MS,Kim KC,Park C,Ko WS,Choi YH,Kim GY

    更新日期:2006-12-05 00:00:00

  • Dendritic cells transfected with indoleamine 2,3-dioxygenase gene suppressed acute rejection of cardiac allograft.

    abstract:BACKGROUND:Immunomodulation by indoleamine 2,3-dioxygenase (IDO) has been documented in many studies yet its underlying mechanisms remain undefined, especially in solid organ transplantation. Recent research demonstrated that the active expression of IDO in dendritic cells (DCs) regulates immune reaction. This study as...

    journal_title:International immunopharmacology

    pub_type: 杂志文章


    authors: Li C,Liu T,Zhao N,Zhu L,Wang P,Dai X

    更新日期:2016-07-01 00:00:00

  • Effect of Brazilian propolis on scratching behavior induced by compound 48/80 and histamine in mice.

    abstract::We studied the effect of Brazilian propolis on scratching behavior induced by compound 48/80 and histamine in ICR mice. Propolis granular A.P.C dose-related inhibited scratching behavior induced by compound 48/80 and significant inhibition were observed at 1000 mg/kg. However, histamine-induced scratching behavior was...

    journal_title:International immunopharmacology

    pub_type: 杂志文章


    authors: Shinmei Y,Hossen MA,Okihara K,Sugimoto H,Yamada H,Kamei C

    更新日期:2004-10-01 00:00:00

  • MicroRNA-204-GSDMD interaction regulates pyroptosis of fibroblast-like synoviocytes in ankylosing spondylitis.

    abstract:OBJECTIVE:Ankylosing spondylitis (AS) is a disease characterized by inflammation of the sacroiliac joint and the attachment point of the spine. This study aimed to investigate the effect of microRNA (miR)-204-targeted GSDMD on fibroblast-like synoviocytes (FLSs) in AS. METHODS:miR-204, GSDMD, pyrolysis-related genes (...

    journal_title:International immunopharmacology

    pub_type: 杂志文章


    authors: Gu G,Huo Y,Xu G,Li L,Yu J,Sheng L,Yin Z

    更新日期:2021-02-01 00:00:00

  • TLR2 and TLR4 expression after kidney ischemia and reperfusion injury in mice treated with FTY720.

    abstract::Ischemia and reperfusion injury (IR) is an antigen independent inflammatory process that causes tissue damage. After IR, kidneys up-regulate leukocyte adhesion molecules and toll-like receptors (TLRs). Moreover, injured kidneys can also secrete factors (i.e. heat shock protein) which bind to TLRs and trigger intracell...

    journal_title:International immunopharmacology

    pub_type: 杂志文章


    authors: Pedregosa JF,Haidar AA,Hirata AE,Franco M,Gomes GN,Bueno V

    更新日期:2011-09-01 00:00:00

  • The progress and confusion of anti-PD1/PD-L1 immunotherapy for patients with advanced non-small cell lung cancer.

    abstract::Recently, immunotherapy has evolved into a true treatment modality with the approval of PD-1 and PD-L1 inhibitors as the standard care for first-line treatment in patients with non-small cell lung cancer (NSCLC). Until now, for patients with advanced NSCLC, treatment of targeting immune checkpoints reveals a promising...

    journal_title:International immunopharmacology

    pub_type: 杂志文章,评审


    authors: Zhang S,Bai X,Shan F

    更新日期:2020-03-01 00:00:00

  • Evaluation of gene expression in human lymphocytes activated in the presence of melatonin.

    abstract::The effect of melatonin on the expression of genes previously correlated to T lymphocyte activation (HLA-DRB, thymosin beta 10 (beta-Tim)) and to Lymphokine Activated Killer (LAK) activity (beta-Tim, Tumour Rejection Antigen (TRA 1), nRap 2) was investigated in phytohemagglutinin (PHA)-stimulated human lymphocyte cult...

    journal_title:International immunopharmacology

    pub_type: 杂志文章


    authors: Capelli E,Campo I,Panelli S,Damiani G,Barbone MG,Lucchelli A,Cuccia M

    更新日期:2002-06-01 00:00:00

  • Anti-neuroinflammatory effect of aurantiamide acetate from the marine fungus Aspergillus sp. SF-5921: inhibition of NF-κB and MAPK pathways in lipopolysaccharide-induced mouse BV2 microglial cells.

    abstract::In the course of a search for anti-neuroinflammatory metabolites from marine fungi, aurantiamide acetate (1) was isolated from marine-derived Aspergillus sp. as an anti-neuroinflammatory component. Compound 1 dose-dependently inhibited the production of nitric oxide (NO) and prostaglandin E2 (PGE2) in BV2 microglial c...

    journal_title:International immunopharmacology

    pub_type: 杂志文章


    authors: Yoon CS,Kim DC,Lee DS,Kim KS,Ko W,Sohn JH,Yim JH,Kim YC,Oh H

    更新日期:2014-12-01 00:00:00

  • Macrophage immunomodulatory activity of extracellular polysaccharide (PEP) of Antarctic bacterium Pseudoaltermonas sp.S-5.

    abstract::Antarctic bacteria are a novel source of polysaccharides which might have potential applications as biological response modifiers (BRM). A heteropolysaccharide (PEP) was isolated from the liquid culture broth of the Antarctic bacterium Pseudoaltermonas sp.S-5. PEP contained Mannose, Glucose, and Galactose in a ratio o...

    journal_title:International immunopharmacology

    pub_type: 杂志文章


    authors: Bai Y,Zhang P,Chen G,Cao J,Huang T,Chen K

    更新日期:2012-04-01 00:00:00

  • Depression linked to higher antibodies production against estrogenized insulin in type 1 diabetes.

    abstract::Depression has been commonly associated with type 1 diabetes (T1D) and insulin covalently modified with catecholestrogens (CEs) was found in serum of these T1D patients. This study aimed to know whether depression link to higher antibodies against estrogenized insulin in T1D. ELISA (direct binding and competition) and...

    journal_title:International immunopharmacology

    pub_type: 杂志文章


    authors: Khan WA,Malik A,Khan MWA

    更新日期:2020-09-01 00:00:00

  • The small molecule macrophage migration inhibitory factor antagonist MIF098, inhibits pulmonary hypertension associated with murine SLE.

    abstract::Pulmonary arterial hypertension (PAH) is a severe complication of systemic lupus erythematosus (SLE), with unclear etiopathogenesis. We evaluated the role of macrophage migration inhibitory factor (MIF), which has been implicated in idiopathic pulmonary hypertension (PH), in SLE-associated PAH. Circulating MIF was mea...

    journal_title:International immunopharmacology

    pub_type: 杂志文章


    authors: Huang H,Chen D,Pu J,Yuan A,Fu Q,Li J,Leng L,Bucala R,Ye S,Lu L

    更新日期:2019-11-01 00:00:00

  • Macrophage-derived soluble CD163 level in young patients with Gaucher disease: relation to phenotypes, disease severity and complications.

    abstract:OBJECTIVES:Bone and lung involvement are two major causes of morbidity in Gaucher disease (GD). The soluble form of CD163 (sCD163) is a valuable diagnostic biomarker for monitoring diseases with increased macrophage activation. We determined sCD163 levels in 30 children and adolescence with GD compared with 30 healthy ...

    journal_title:International immunopharmacology

    pub_type: 杂志文章


    authors: Adly AAM,Ismail EAR,Ibraheem TM

    更新日期:2015-02-01 00:00:00

  • Long-term intake of Korean red ginseng in HIV-1-infected patients: development of resistance mutation to zidovudine is delayed.

    abstract::We have observed that CD4+ T cell counts in human immunodeficiency virus (HIV)-1-infected patients treated with only Korean red ginseng (KRG) are maintained or even increased for a prolonged period. In the present study, we investigated whether the development of resistance mutations in reverse transcriptase (RT) to z...

    journal_title:International immunopharmacology

    pub_type: 临床试验,杂志文章


    authors: Cho YK,Sung H,Lee HJ,Joo CH,Cho GJ

    更新日期:2001-07-01 00:00:00